Phenotypic Drug Discovery Special Interest Group

Society of Lab Automation and Screening

PDD SIG: Discussion Topics• Problem Statement:

– Why PDD, the Target Validation problem in Drug Discovery

• What is phenotypic? (assay or drug discovery)– Captures biological context, Mechanism/target agnostic, Close to in vivo as “practical”– Examples: right, left, center; PDD is not a TDD tertiary assay!

• Lessons Learned: Happy and Sad Endings• Concerns Issues etc

– Target Validation: Shortcoming of molecular genetics, compound-genetic phenocopy success?

– Molecular Target Identification: Requirements, helps LO, toxicity, personalized medicine, biomarkers....

– Getting/Keeping Buy-In: Expectations, perceptions, intellectual bias, PDD processes...– Academic-Industrial Collaborations: Synergy, Different Missions and Reward systems– Potential for poly-pharm and complex SAR– Chemical diversity: natural products, sp3 content, novelty