Philippe DunetonDeputy Executive Director

17 June 2013

Top HIV diagnostics for small labs in Africa

Long term goal of the Global Health Community

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• HIV/AIDS– GOAL: Reaching 15 million

people with ARVs by 2015

WHO New 2013 Guidelines – CD4: 500 cells/mm3 from 350– FDCs – 1 pill a day (Tenofovir based)– Patient monitoring

Low access to HIV treatment: Only 9 million of 25 million people in need are now on ART

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Monitoring diagnosticsCD4 Viral Load Early Infant Diagnostics

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• Large modern laboratories• Sophisticated equipment• Highly trained staff

• Benefit: High volume• 4,500 tests a months

• Samples need to be transported

• Result returned to patient

Nyumbani, Karen, Kenya

Pediatric University Hospital, Lusaka, Zambia

The reality of low resource settings• Limitation in health infrastructure

– Crowded facilities– Basic laboratory facilities– Irregular power and water supply

• Limitation in human resources– Few doctors– Health workers with limited training

carry out most consultations

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Quality, simple to usediagnostic and medicines are needed to assure rapid effective treatmentKiboga Referral Hospital, Uganda

District Hospital, Meconta, Mozambique

Point of care testing

• Small devices• Easy to use outside

central laboratories• Rapid results• Back up power supply• HIV patient

monitoring– CD4– Viral Load– Early Infant Diagnosis

1er maio, MaputoMozambique

Benefits to Patients

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Phebe Hospital, Liberia

• Ideal for resource limited settings

– both urban and rural• Decreases turn-around time

– results available on same day• Improves patient outcomes

– prompt treatment• Reduces loss to follow up

– no need to return for results• Reduces workload of the central laboratory

UNITAID's new Point of Care Projects

• CHAI/UNICEF• Medecin Sans Frontiere• FEI –OPP-ERA• London School of Hygiene and Tropical Medicines

AIM: Increase CD4 testing to 80% and Viral load testing to 50% in low income countries

Good monitoring of patients = better care and treatment

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2009 2010

PointCount NOW™PointCare

Technologies

CyFlow® CD4 miniPOCPartec Daktari™

CD4 Counter

Visitect® CD4Omega/Burnet MBio CD4 System

BD FACSPresto™BD Biosciences

ZyomyxCD4 Test

2014

Disposable Instruments

2013

Pima™ AnalyserAlere

DisposableInstruments

*Estimated as of March 2013 - timeline and sequence may change.

CD4 Product Pipeline*

2013 2014 2015 2016

Alere QAlere

LYNX Viral Load PlatformNWGHF

LYNX HIV p24 AntigenNWGHF

SAMBA VLDDU/Cambridge

Liat™ AnalyserIQuum

EOSCAPE HIV™ Rapid RNA Assay System

Wave 80 Biosciences

Gene Xpert® System Cepheid

Micronics

Cavidi AMP

*Estimated as of March 2013 - timeline and sequence may change. No market launch date set by company.

SAMBA EIDDDU/Cambridge

Viral Load Assay with

BART Lumora

Gene-RADAR®

Nanobiosym

RT CPA HIV-1 Viral Load

Ustar

BioHelix

ALL

Truelab™ PCRMolbio/bigTec

Viral Load and EID Product Pipeline*

Call for LOIs

• UNITAID is pleased to announce the first Call for Letters of Intent (LOI) of its new strategic period

• Deadline: 22 Sep 2013• http://www.unitaid.org

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