Piloting early infant male circumcision using two devices in Zimbabwe: A randomized

trial

Mavhu W, Ncube G, Hatzold K, Weiss HA, Mugurungi O, Larke N, Mufuka J, Samkange CA, Sherman J, Madidi N,

Cowan FM, Ticklay I, Gwinji G

Background and Methods

• Zimbabwe MoH piloting safety & acceptability of EIMC using devices

• Trial randomization 2:1 to either AccuCirc device or Mogen clamp

• Total sample size 150 (100 AccuCirc; 50 Mogen clamp)

• EIMC performed by doctors

Mogen clamp and AccuCirc device

Results

• 13% (150/1,151) of all eligible male infants whose parents were offered EIMC enrolled in the trial

• 150 infants aged 6-54 days circumcised 9 Jan- 19

June 2013 (23 weeks)

• 2 moderate AEs in AccuCirc arm (95% CI 0.4-7.7%); none in Mogen clamp arm (95% CI 0.0-8.9%)

Parental SatisfactionCharacteristic AccuCirc Device

(N=100)Mogen Clamp

(N=50)Mothers’ satisfaction

(0-10)<=5 1 (1%) 0 (0%)

6-8 2 (2%) 3 (6%)

9 7 (7%) 2 (4%)

10 90 (90%) 45 (90%)

Mother would recommend

98 (98%) 50 (100%)

Mother would have next son circumcised

99 (99%) 50 (100%)

Discussion

• It is feasible and safe to offer EIMC using devices in Zimbabwe

• Despite the health benefits of EIMC, actual uptake remains low

• However, parental satisfaction with the procedure and the outcome is very high

• Culturally appropriate EIMC demand-creation activities need to be developed and introduced to support scale-up

Acknowledgements

• Study staff• Research participants

• Study being conducted at Edith Opperman & Mabvuku clinics

• Study funded by BMGF through PSI-Zimbabwe

Thank You!