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Useful pKa values: Compound pK a (H 2 O) pK a (DMSO) H 2 SO 4 -9 HCl -6 1.8 H 3 O + -1.76 Acetic acid 4.76 12.6 Phenol 10.02 18 H 2 O 15.7 32 CH 3 OH 16 29 Anilinium (Ph-NH 3 + ) 4.87 Pyridinium (C 6 H 5 NH + ) 5.23 3.4 Methyl Ammonium 10.6 11 Ammonia 41 Diisopropylamine 36 44 2,4-Pentanedione 9 13.3 Methyl Acetoacetate 11 14 Dimethyl Malonate 13 16 Acetone 20 26.5 Ethane 50 Ethylene 44 55 Acetylene 24 Source: http://www.chem.wisc.edu/areas/reich/pkatable/index.htm You should know the H 2 O pK a values within 1 pKa unit. The DMSO values are provided for comparison, but you don't need to know these exactly.

PKa Values

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Pka Values Drug synthesize pharmacy

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  • Useful pKa values: Compound pKa (H2O) pKa (DMSO) H2SO4 -9 HCl -6 1.8 H3O+ -1.76 Acetic acid 4.76 12.6 Phenol 10.02 18 H2O 15.7 32 CH3OH 16 29 Anilinium (Ph-NH3+) 4.87 Pyridinium (C6H5NH+) 5.23 3.4 Methyl Ammonium 10.6 11 Ammonia 41 Diisopropylamine 36 44 2,4-Pentanedione 9 13.3 Methyl Acetoacetate 11 14 Dimethyl Malonate 13 16 Acetone 20 26.5 Ethane 50 Ethylene 44 55 Acetylene 24 Source: http://www.chem.wisc.edu/areas/reich/pkatable/index.htm You should know the H2O pKa values within 1 pKa unit. The DMSO values are provided for comparison, but you don't need to know these exactly.