POPM*3240 Epidemiology · A Dictionary of Epidemiology, 4th edition; Last JM editor. (Oxford University Press New York, NY: 2001) (Textbook) On reserve in University Library 3.2 Additional

POPM*3240 EpidemiologyWinter 2019Section(s): C01

Department of Population MedicineCredit Weight: 0.50

Version 1.00 - January 02, 2019

1 Course Details

1.1 Calendar DescriptionThe course examines the basic concepts of health and disease in populations. Methods used in descriptive and analytic epidemiological studies, including the design, analysis and interpretation of results for observational studies and field trials are presented.

(BIOL*1080 or BIOL*1090), STAT*2040Pre-Requisite(s): This is a Priority Access Course. Some restrictions may apply during some time periods. Please see the Department of Population Medicine website for more information.

Restriction(s):

1.2 Course Description

This course presents the basic concepts of health and disease in populations. Methods used in descriptive and analytic epidemiological studies, including the design, analysis and interpretation of results for observational studies and field trials are presented.

1.3 Timetable

Class schedule: Mondays, Wednesdays, Fridays – 8:30 to 9:20am

Class location: Alexander Hall, Room 200 (ALEX 200)

1.4 Final ExamFriday April 9th, 7 pm to 9 pm. Room TBD: please see WebAdvisor for the latest information.

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2 Instructional SupportEmail: [email protected] Please use this email for all course-related correspondence. We will not respond to inquiries related to information included in the syllabus. Please do not send emails directly to the email addresses of the course instructors or TAs. Using the teachepi email will allow for timely responses to questions about the course and will allow us to monitor potential areas where additional in-class discussion may be warranted. Office Hours (start Jan. 16th)– in OVC Stewart Building (www.uoguelph.ca/campus/map/stewart/)

Day

Time

Who

Place

Wednesdays

9:30 – 11:30am

Hepman / Hagen

Room 2509C

* Additional Office Hours to be held around midterm and final examinations – dates/times will be announced on Courselink

2.1 Instructional Support TeamJan SargeantCourse Co-ordinator:[email protected]:

Course Coordinator / Instructor

2.2 Teaching Assistant(s)Ben HetmanTeaching Assistant:[email protected]: Room 2509COffice: Wednesdays 9:30 - 11:30 amOffice Hours:

PhD Candidate

Briana HagenTeaching Assistant:[email protected]: Room 2509COffice: Wednesdays 9:30 - 11:30 amOffice Hours:

PhD Student

3 Learning ResourcesReadings A note regarding Readings: “need to know” topics (i.e. those that will be included in

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examinations) are those covered in class. The textbook readings are meant to help solidify or extend your learning and enable application of that material. As such, they are strongly recommended. Topics that are covered in the readings that were not touched upon in lecture will not be considered “testable” material.

Session

Topic & Notes

Readings

1

Introduction to Course

Course Syllabus

2

Introduction to Epi & Historical Approaches

Chapter 1, Gordis text

3

Foundations in Health & Disease Transmission

4

Foundations in Health & Disease Transmission


5

Screening & Diagnostic Tests I

6

Screening & Diagnostic Tests II


9

Statistical Analysis of Epidemiological Data

Review previous STAT*2040 / other

STAT notes

7

Sampling I

8

Sampling II


(up to p. 160)

10

Epidemiology in Public Health

--

11

One Health

--

12

Bias & Causation I

13

Bias & Causation II

14 Bias & Causation III

Chapters 14 & 15, Gordis text

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15

MIDTERM 1

--

16

Measures of Association & Effect I

Chapters 11 & 12, Gordis test

17

Measures of Association & Effect II

18

Cross-Sectional Studies

p. 210 – 212, Gordis text

19

Cohort Studies I

20

Cohort Studies II


21

Intervention Studies: Randomized Controlled Trials I

22

Intervention Studies: Randomized Controlled Trials II

Chapters 7 & 8, Gordis text

23

Case-Control Studies I

Chapter 10

(to p. 202) & Chapter 13, Gordis

text

24

MIDTERM 2

40th Class Day – last day to drop one semester courses

--

Chapter 10

(to p. 202) & Chapter 13, Gordis

text

25

Case-Control Studies II

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26

Interpreting Multivariable Models

Tripepi et al., 2011

(on Courselink)

27

Critical Appraisal

Young & Solomon paper

(on Courselink)

28

Genomic Epidemiology

--

29

Measures of Disease Frequency I

30

Measures of Disease Frequency II


31

Outbreak Investigations I

32

Outbreak Investigations II

Reingold paper

(on Courselink)

33

Systematic Reviews & Meta-Analysis

--

34

Disease Surveillance

--

35

Review

--

36

Last day of class – hold in case of snow day

--

3.1 Recommended Resource(s)Epidemiology 5th edition, by Leon Gordis, Elsevier Saunders Company, Philadelphia: 2014. (Textbook)

ISBN: 978-1-4557-3733-8 Strongly recommended

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Available in University Bookstore. Note: Purchase also allows online access & interactive extras

•

Also on Reserve in University of Guelph library•Yes, older versions are fine – chapters/page numbers will differ though•

Medical Epidemiology, 4th edition; Greenberg RS, Daniels SR, Flanders WD, Eley JW, Boring JR. Lange Medical Books/McGraw-Hill, New York, NY: 2005 (Textbook)

On reserve in University Library

Veterinary Epidemiology: Principles and Methods: Martin SW, Meek AH, Willeberg P. Iowa State University Press, Ames, IW: 1987 (Textbook)


Veterinary Epidemiological Research, 2nd edition: Dohoo IR, Martin SW, Stryhn H. VER Inc., Charlottetown, PEI: 2009 (Textbook)


Population Health: Concepts and Methods, 2nd edition, by Young, TK. (Oxford University Press, New York, NY: 2005) (Textbook)


A Dictionary of Epidemiology, 4th edition; Last JM editor. (Oxford University Press New York, NY: 2001) (Textbook)


3.2 Additional Resource(s)Methods in Epidemiologic Research: Dohoo I, Martin W, Stryhn H. (VER Inc., Charlottetown, PEI: 2012) (Textbook)

Critical Appraisal of Epidemiological Studies and Clinical Trials, by Elwood M. (Oxford University Press, New York, NY: 2002) (Textbook)

Epidemiology - an introductory text, 2nd edition, by Mausner JS & Kramer S. (WB Saunders: Toronto; 1985) (Textbook)

Epidemiology in Medicine, by Hennekens CH & Buring JE. (Little & Brown, Boston: 1987) (Textbook)

Epidemiology Kept Simple: an Introduction to Classic and Modern Epidemiology, by Gerstman BB. (Wiley, New York, NY: 1998) (Textbook)

Epidemiology: an Introduction, by Rothman KJ. (Oxford University Press, New York, NY: 2002) (Textbook)

Clinical Epidemiology: a Basic Science for Clinical Medicine, 2nd edition, by Sackett DL, Haynes RB, Guyatt GH, and Tugwell P. (Little & Brown, Toronto: 1991) (Textbook)

PDQ Epidemiology, 2nd edition, by Streiner DL & Norman GR. (Mosby, Toronto: 1996) (Textbook)

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4 Learning OutcomesCourse goals: The goals of this course are to present the epidemiological principles and concepts required for the collection, analysis, and interpretation of health data at the population level. Course coordinator’s goals: To help foster excitement and interest in epidemiology, in a classroom environment that is positive, engaging and intellectually challenging.

4.1 Course Learning OutcomesBy the end of this course, you should be able to:

Identify, define, calculate, and interpret common measures of association (risk difference,

attributable risk exposed, population attributable risk, relative risk, odds ratios) and

measures of disease frequency (prevalence, risks, rates) used in epidemiological

research, and cite their strengths and limitations;

1.

Describe how to select appropriately-sized samples from populations for surveys and

observational studies;

2.

Describe the application of epidemiology to disease control, outbreak investigation,

health research, and current public health, animal health and One Health issues;

3.

Describe how to select appropriately-sized samples from populations for surveys and

observational studies;

4.

Discuss the use of screening tests, identify the criteria used to evaluate tests, and explain

epidemiological sensitivity, specificity, predictive values and agreement, including how to

calculate these measures;

5.

Discuss the design, methodology and strengths/limitations of each of the common

observational and experimental study types in epidemiology;

6.

Identify and discuss the potential effects of common biases observed in epidemiological

research, including various selection biases, misclassification and confounding;

7.

Explain the concepts of incubation and latent periods, state transition models, effective

and basic reproductive numbers, and give examples of strategies to reduce the latter for

disease control.

8.

5 Teaching and Learning ActivitiesClass schedule: Mondays, Wednesdays, Fridays – 8:30 to 9:20am Class location: Alexander Hall, Room 200 (ALEX 200)

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5.1 LectureMon, Jan 7

Introduction to CourseTopic(s):

Lecturer: Dr. Sargeant

Wed, Jan 9

Introduction to Epi & Historical ApproachesTopic(s):


Fri, Jan 11

Foundations in Health & Disease TransmissionTopic(s):

Lecturer: Dr. Renaud

Mon, Jan 14

Foundations in Health & Disease TransmissionTopic(s):


Wed, Jan 16

Screening and Diagnostic Tests ITopic(s):


Fri, Jan 18

Screening and Diagnostic Tests IITopic(s):


Mon, Jan 21

Statistical Analysis of Epidemiological DataTopic(s):


Wed, Jan 23

Sampling ITopic(s):


Fri, Jan 25

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Sampling IITopic(s):


Mon, Jan 28

Epidemiology in Public HealthTopic(s):

Lecturer: Dr. Papadopoulos

Wed, Jan 30

One HealthTopic(s):

Lecturer: Dr. Parmley

Fri, Feb 1

Bias & Causation ITopic(s):


Mon, Feb 4

Bias & Causation IITopic(s):


Wed, Feb 6

Bias and Causation IIITopic(s):


Fri, Feb 8

IN-CLASS MIDTERM - try to arrive a few minutes early to get seated - the exam will start immediately at 8:30 !!

Topic(s):

Mon, Feb 11

Measures of Association & Effect ITopic(s):


Wed, Feb 13

Measures of Association and Effect IITopic(s):


Fri, Feb 15

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Cross-Sectional StudiesTopic(s):


Mon, Feb 18 - Fri, Feb 22

WINTER BREAK – NO CLASSTopic(s):

Mon, Feb 25

Cohort Studies ITopic(s):


Wed, Feb 27

Cohort Studies IITopic(s):


Fri, Mar 1

Intervention Studies: Randomized Controlled Trials ITopic(s):

Lecturer: Dr. D. Kelton

Mon, Mar 4

Intervention Studies: Randomized Controlled Trials IITopic(s):

Lecturer: Dr. Kelton

Wed, Mar 6

Case-Control Studies ITopic(s):


Fri, Mar 8

IN-CLASS MIDTERM II - Exam will start exactly at 8:30 - please come to class a few minutes early to get seated.

40th Class Day – last day to drop one-semester courses

Topic(s):

Mon, Mar 11

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Case Control Studies IITopic(s):


Wed, Mar 13

Interpreting Multivariable ModelsTopic(s):


Fri, Mar 15

Critical AppraisalTopic(s):

Lecturer: B. Hagen

Mon, Mar 18

Genomic EpidemiologyTopic(s):

Lecturer: B. Hetman

Wed, Mar 20

Measures of Disease Frequency ITopic(s):


Fri, Mar 22

Measures of Disease Frequency IITopic(s):


Mon, Mar 25

Outbreak Investigations ITopic(s):


Fri, Mar 22

Outbreak Investigations IITopic(s):


Fri, Mar 29

Systematic Reviews and Meta-analysisTopic(s):


Mon, Apr 1

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Disease SurveillanceTopic(s):


Wed, Apr 3

ReviewTopic(s):


Fri, Apr 5

Extra review (or use to cover material if a snow day during the semester)

Topic(s):


Tue, Apr 9, 7:00 PM - 9:00 PM

FINAL EXAM

Room TBA on WebAdvisor

Topic(s):

6 Assessments

6.1 Assessment DetailsOnline Quizzes (10%)

Online Quizzes (5 quizzes, each 2%, for a total of 10% of final grade; quiz with lowest mark [including missed quiz] will be dropped)

■

These quizzes are short, multiple choice quizzes available on Courselink during the following time periods, and covering the following topics:

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Quiz

Date Available

(as of 9:30am)

Date Due

(by 11:59pm)

Sessions Covered

1

Wednesday Jan. 16

Wednesday Jan. 23

1 to 6 inclusive

2

Monday Jan. 28

Monday Feb. 4

7 to 11 inclusive

3

Friday Feb. 8

Friday Feb. 15

12 to 17 inclusive

4

Friday Mar. 8

Friday Mar. 15

18 to 25 inclusive

5

Wednesday Mar. 20

Wednesday Mar. 27

26 to 30 inclusive

6

Wednesday Mar. 27

Wednesday Apr. 3

31 to 34 inclusive

The quizzes are open-book (i.e. feel free to use your notes/text) but are independent assessments (i.e. they are to be done on your own). Note: doing or discussing the quizzes with others, screen-capturing or recording quiz questions via other means, and/or sharing the quiz questions with others is prohibited and considered Academic

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Misconduct.

NOTE: Be sure to save every answer as you navigate through each quiz. That way, your answers will be on record should you have a technical problem that prevents you from finishing your quiz. If you do have a technical problem, you must email the course email account ([email protected]) immediately to inform us of the problem.

NOTE: There will be NO opportunity to write a missed online quiz. Only FIVE quizzes will count towards your final grade - the quiz with the lowest mark (including non-completed quiz) will be dropped and not count towards your final grade.

Midterm Exam 1 (25%)Fri, Feb 8, 8:30 AM - , 9:20 AM, ALEX 200Date:

This is an IN-CLASS midterm - the exam will start at exactly 8:30, so come to class a few minutes early to get seated.

This examination covers material from Sessions 1-11 inclusive. Be sure to bring your University of Guelph Student ID, own pen, pencil, eraser, and calculator - sharing of calculators will NOT be permitted and calculators will NOT be provided to you. This exam will consist of multiple choice, short answer, and short calculation questions.

Midterm Exam 2 (25%)Fri, Mar 8, 8:30 AM - , 9:20 AM, ALEX 200Date:

This is an IN-CLASS midterm - the exam will start at exactly 8:30, so come to class a few minutes early to get seated.

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This examination covers material mainly from Sessions 12-22 inclusive, but previous material may also still be tested. Be sure to bring your University of Guelph Student ID, own pen, pencil, eraser, and calculator - sharing of calculators will NOT be permitted and calculators will NOT be provided to you. This exam will consist of multiple choice, short answer, and short calculation questions.

Final Exam (40%)Tue, Apr 9, 7:00 PM - , 9:00 PM, TBADate:

This examination will cover material spanning all sessions of the course. Be sure to bring your University of Guelph Student ID, pen, pencil, eraser, and calculator - sharing of calculators will NOT be permitted and calculators will NOT be provided to you. This exam will consist of multiple choice, short answer, and short calculation questions. *Please check WebAdvisor, as it is provides official University exam scheduling

7 Course Statements

7.1 Re-grading policyThe following policy is in place for ALL requests for re-grading (NO exceptions): Marking schemes will be made available on Courselink for all midterm exams and assignments. Consult the marking scheme and carefully/thoughtfully review your answers and marks received. If you believe an error was made, write a short and specific statement indicating why you think there is an error (i.e. you must clearly justify the re-grading). Attach the statement to the original exam/assignment, and re-submit this to Dr. Sargeant by delivering it to her office mailbox in the Population Medicine main office of the OVC Stewart Building within one week (i.e. by 12:30pm on 7th calendar day) after the assignments/midterms are returned in-class. Note: all re-grading will be done by Dr. Sargeant; materials will be re-graded in entirety and all appropriate adjustments made. Students will be notified through Courselink on the status of their re-grade request.

8 University Statements

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8.1 Email CommunicationAs per university regulations, all students are required to check their e-mail account regularly: e-mail is the official route of communication between the University and its students.

8.2 When You Cannot Meet a Course RequirementWhen you find yourself unable to meet an in-course requirement because of illness or compassionate reasons please advise the course instructor (or designated person, such as a teaching assistant) in writing, with your name, id#, and e-mail contact. The grounds for Academic Consideration are detailed in the Undergraduate and Graduate Calendars. Undergraduate Calendar - Academic Consideration and Appeals https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-ac.shtml Graduate Calendar - Grounds for Academic Consideration https://www.uoguelph.ca/registrar/calendars/graduate/current/genreg/index.shtml

8.3 Drop DateCourses that are one semester long must be dropped by the end of the fortieth class day; two-semester courses must be dropped by the last day of the add period in the second semester. The regulations and procedures for course registration are available in the Undergraduate and Graduate Calendars. Undergraduate Calendar - Dropping Courses https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-drop.shtml Graduate Calendar - Registration Changes https://www.uoguelph.ca/registrar/calendars/graduate/current/genreg/genreg-reg-regchg.shtml

8.4 Copies of Out-of-class AssignmentsKeep paper and/or other reliable back-up copies of all out-of-class assignments: you may be asked to resubmit work at any time.

8.5 AccessibilityThe University promotes the full participation of students who experience disabilities in their academic programs. To that end, the provision of academic accommodation is a shared responsibility between the University and the student. When accommodations are needed, the student is required to first register with Student Accessibility Services (SAS). Documentation to substantiate the existence of a disability is required; however, interim accommodations may be possible while that process is underway. Accommodations are available for both permanent and temporary disabilities. It should be noted that common illnesses such as a cold or the flu do not constitute a disability.

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Use of the SAS Exam Centre requires students to book their exams at least 7 days in advance and not later than the 40th Class Day. More information can be found on the SAS website https://www.uoguelph.ca/sas

8.6 Academic IntegrityThe University of Guelph is committed to upholding the highest standards of academic integrity, and it is the responsibility of all members of the University community-faculty, staff, and students-to be aware of what constitutes academic misconduct and to do as much as possible to prevent academic offences from occurring. University of Guelph students have the responsibility of abiding by the University's policy on academic misconduct regardless of their location of study; faculty, staff, and students have the responsibility of supporting an environment that encourages academic integrity. Students need to remain aware that instructors have access to and the right to use electronic and other means of detection. Please note: Whether or not a student intended to commit academic misconduct is not relevant for a finding of guilt. Hurried or careless submission of assignments does not excuse students from responsibility for verifying the academic integrity of their work before submitting it. Students who are in any doubt as to whether an action on their part could be construed as an academic offence should consult with a faculty member or faculty advisor. Undergraduate Calendar - Academic Misconduct https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-amisconduct.shtml Graduate Calendar - Academic Misconduct https://www.uoguelph.ca/registrar/calendars/graduate/current/genreg/index.shtml

8.7 Recording of MaterialsPresentations that are made in relation to course work - including lectures - cannot be recorded or copied without the permission of the presenter, whether the instructor, a student, or guest lecturer. Material recorded with permission is restricted to use for that course unless further permission is granted.

8.8 ResourcesThe Academic Calendars are the source of information about the University of Guelph’s procedures, policies, and regulations that apply to undergraduate, graduate, and diploma programs. Academic Calendars https://www.uoguelph.ca/academics/calendars

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Documents

POPM*3240 Epidemiology · A Dictionary of Epidemiology, 4th edition; Last JM editor. (Oxford University Press New York, NY: 2001) (Textbook) On reserve in University Library 3.2 Additional