B I O C E R M I C A S DE ALTA

TECNOLOGIA PARA

F A B R I C A N T E S DE BIOMATERIAIS

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A THIRD GENERATION BIOMATERIAL

Vetra developed a bioglass with enhanced bioactivity. It means it can induce a specific positive response of the body and is also totally bioabsorbable, which eliminates the need for a second surgical removal procedure.

OSSEOINDUCTIVE

HIGHLY BACTERICIDAL AGENT

NO SIDE EFFECTS

GREEN FRIENDLY PRODUCTION

REGENERATES SOFT TISSUES AND NERVES

TOTALLY BIODEGRADABLE

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OUR PRODUCTS AND AVAILABLE FORMS monoliths, powder (particle size range: 5m to 2 mm), granules, 3D

shapes, scaffolds, fibers and meshes.

BIOFUNCTIONALIZATION DENTAL AND ORTHOPAEDIC

IMPLANTS

BIOACTIVES PADS AND FIBERS

COSMETIC PRODUCTS

POWDERS AND GRANULES

(BONE GRAFTING)

HIGH STRENGTH SCAFFOLDS

(HIGHLY POROUS 3D STRUCTURES)

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IN VITRO AND IN VIVO TESTS COMPENDIUM

IN VITRO Citotoxicity, genotoxicity, Immunologic (Oxidative burst), Antibacterial Test (ISO 22.196:2011), Bioactivity (ISO 23.317:2007)

IN VIVO Bone healing, skin regeneration, biofunctionalized implants.

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IN VITRO TESTS - RESULTS OVERVIEW

Osteoblasts Osteosarcoma cells Fibroblasts (animal) Human Fibroblast.

citotoxicity

Non cytotoxic Stimulates Cell Adhesion and Proliferation

Fibroblasts Osteoblast and Sistemic

genotoxicity

Biocompatible Non genotoxic (No DNA damage)

Macrophages Neutrophils

Immunologic (Oxidative Burst)

Less inflammatory reactions

Simulated Body Fluid (SBF)

Bioactivity (ISO 23.317:07)

Highly Bioactive

S. aureus S. epidermidis P. aeruginosa E. coli

Antibacterial Test (ISO 22196:11)

Bactericide for all bacteria Killed up to 99,9999% of bacteria.

IN VIVO TESTS - RESULTS OVERVIEW

tibia defects in rats

bone healing

Stimulated faster bone regeneration

Improved Mechanical Properties of newly formed bone

Higher expression of collagen type I, RANK-L and RUNX-2

Calvaria defects in rats

bone healing

Stimulated bone regeneration

denser neobone

3 Degree Burned Skin (rat study)

Skin regeneration

Stimulated faster skin regeneration

Higher expression of VEGF and TGF- factors.

Osseointegration in dogs mandible

biofunctionalized

implants

Osseointegration 1,5 faster (2weeks)

Peripheral Nerve (rat study)

nerve regeneration

Faster Nerve Regeneration

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ONGOING TESTS

Antibacterial

In Vitro

Antibacterial

In Vitro

Biofilm Reduction

Antibacterial

In Vivo

Bone Healing

Clinical

Minimum inhibitory

concentration.

E.N.T. (ears, nose

and throat)

infections

Alveolar

augumentation