S144 Abstracts of the 4th Biennial Schizophrenia International Research Conference / Schizophrenia Research 153, Supplement 1 (2014) S1–S384

studies have reported, that offspring at genetic high risk for developing

schizophrenia or bipolar disorder compared to children of parents without

these disorders show delayed neuromotor development, language acquisi-

tion deficits, emotional problems, impaired social function, and cognitive

deficits regarding general intelligence, processing speed, executive func-

tions, memory, and attention. The aim of this sub study is to characterize

the neurocognitive profiles of two groups of children at genetic high risk

for developing schizophrenia spectrum psychosis or bipolar disorder. The

neurocognitive domains are: Intelligence, memory, attention, processing

speed, executive functions, and decision making. Hypotheses: 1) Children

at genetic high risk for schizophrenia or bipolar disorder will display a

broad array of cognitive deficits compared to children of parents without

these disorders. 2) Children at genetic high risk for schizophrenia will

show more severe neurocognitive impairments in general intelligence,

processing speed, memory, attention, set shifting, planning and working

memory compared to children at genetic high risk for bipolar disorder. 3)

Children at genetic high risk for bipolar disorder will display more severe

neurocognitive deficits in decision making (considered to be influenced by

emotions) compared to children at genetic high risk for schizophrenia.

Methods: We will establish a stratified cohort of 500 children aged 7 with

0, 1 or 2 parents with schizophrenia spectrum psychosis or bipolar disorder

and matched on age, gender, and urbanicity. A comprehensive neuropsy-

chological test battery is used to characterize the following neurocognitive

domains in all subgroups: Intelligence (Reynolds Intellectual Screening

Test), verbal memory (Test of Memory and Learning, second edition), visual

memory (Rey Complex Figure Test and Cambridge Neuropsychological Test

Automated Battery (CANTAB)), attention (CANTAB and Theory of Visual

Attention-based Whole Report), processing speed (Delis-Kaplan Executive

Function System (D-KEFS) and Wechsler Intelligence Scale for Children,

Fourth edition WISC-IV)), and executive functions including set shifting,

planning, verbal fluency, and working memory (CANTAB, D-KEFS, and

WISC-IV).

Results: Data collection has started December 2012 and is ongoing. 150

probands and their parents are included by December 2013. Results will be

available in 2015.

Discussion: Results will be available in 2015.

Poster #S152

PSYCHOSIS RISK IN ADOLESCENCE: CLINICAL BASELINE DIFFERENCES

BETWEEN PRODROMAL AND FAMILIAL HIGH RISK SAMPLES

Daniel Ilzarbe1, Gisela Sugranyes2, Inmaculada Baeza3,4, Elena De la

Serna5, Soledad Romero6, Vanessa Sánchez-Gistau6, Montserrat Dolz7,

Josefina Castro Fornieles6

1Department of Child and Adolescent Psychiatry and Psychology, Institute of

Neuroscience, Hospital Clínic de Barcelona; 2Hospital Clínic-IDIBAPS; 3Hospital

Clínic i Universitari de Barcelona; 4CIBERSAM; 5Hospital Clínic de Barcelona;6Department of Child and Adolescent Psychiatry and Psychology, Institute of

Neuroscience, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain;7Hospital Sant Joan de Déu

Background: Initial studies aimed at understanding psychosis risk focused

on offspring of psychotic patients, reporting an estimated lifetime risk of

psychosis of approximately 10-15%. Recent approaches have centered on

Psychosis Risk Syndrome (PRS), defined by 1) attenuated positive symp-

toms; 2) brief, limited, intermittent psychotic symptoms or 3) genetic

risk for psychosis combined with deterioration in functioning [Fusar-Poli

P 2012], yielding 1-year transition rates ranging between 9-70% [Ziermans

TB 2011]. To our knowledge no study to date has directly compared the

two approaches. The transition to psychosis has been related with baseline

and subsequent decline of Global Assessment of Funtioning (GAF) scores

[Velthorst E 2013], schizotypal traits, clinical symptoms and substance mis-

use. Although offspring studies have focused on children and adolescents,

PRS studies have mostly been undertaken in adult samples. The aim of this

study was to investigate baseline differences in clinical symptomatology,

diagnosis and GAF between adolescents at familial risk of psychosis (GHR),

adolescents with PRS and a gender and age matched community control

group (CC).

Methods: GHR (N=22): Adolescent offspring of patients with a psychotic

disorder were recruited through adult mental health services. PRS (N=23):

Adolescents meeting prodromal criteria according to the Structured Inter-

view for Prodromal Syndromes (SIPS) were recruited through primary care

and child and adolescent mental health services. CC (N=30) were recruited

from the same geographic area through schools and adverts. Assessment of

socio-demographic data and clinical diagnoses (DSM-IV; Kiddie-Schedule

for Affective Disorders and Schizophrenia/K-SADS) was undertaken by ex-

perienced child and adolescent psychiatrists and psychologists. In addition,

depressive (Hamilton Rating Scale of Depresion/HRSD), manic (Young Scale

of Mania/YSM), attenuated psychotic symptoms (SOPS), and GAF were also

evaluated.

Results: A total of 75 subjects (50,7% female) aged 12-17 (15,09±1,78) were

included. No differences were found in age or gender between groups.

There were significant differences in rates of overall lifetime diagnoses:

95,2% for PRS, 59,1% for GHR and 20% for CC (p=0,005) and in exter-

nalizing disorders (55%, 18,2% and 0% respectively; p=0,015). Only PRS

showed significantly higher rates of affective and anxiety disorders (>50%;

p=0,013) relative to the other groups (both <20%). PRS subjects also had

a significantly higher prevalence of substance use (47,80%; p=0,035) in

comparison to the other groups (GHR:18,20%; CC:13,30%); mainly for al-

cohol (36,4%, 4,5% and 10%, respectively; p=0,009), but also for cannabis

(non-significant trend). PRS had a significantly higher score in the HRSD

(13,54±7,12; F=57,921; p<0.001), YSM (4,32±3,6; F=17,48; p<0.001) and

SOPS (38,3±10,70; F=154,96; p<0.001) scales; but no statistical differences

were found between the GHR and CC groups. PRS group had the worst

global functioning (GAF: 47,9±11,69; F=105,411; p<0.001) in comparison

to both GHR (80,94±10,4) and CC (82,20±6,95).

Discussion: This study illustrates differences in severity of clinical symp-

toms, axis-I co-morbidiy and substance use prevalence in two different

adolescent psychosis risk groups relative to community controls. Longitu-

dinal follow-up of this sample will allow to identify baseline characteristics

predictive of transition to psychosis. Further studies in high risk adolescents

are warranted in order to fully characterise psychosis risk status during this

age period.

Poster #S153

CLINICAL AND FUNCTIONAL COURSE OF YOUTHS AT ULTRA-HIGH RISK

FOR PSYCHOSIS: OUTCOMES OF NON-CONVERTERS IN JAPAN

Masahiro Katsura1, Noriyuki Ohmuro2, Chika Obara1, Tatsuo Kikuchi3,

Yumiko Hamaie4,1, Emi Sunakawa2, Fumiaki Ito5, Tetsuo Miyakoshi6,

Atsushi Sakuma3, Hiroo Matsuoka7, Kazunori Matsumoto8

1Dept. of Psychiatry, Tohoku University Graduate School of Medicine; 2Dept. of

Psychiatry, Tohoku University Hospital; 3Tohoku University Graduate School of

Medicine Department of Psychiatry; 4Dept. of Psychiatry,Tohoku University

Hospital; 5National Hospital Organization Hanamaki Hospital; 6Chiba prison;7Dept. of Psychiatry, Tohoku University Hospital, Department of Psychiatry,

Tohoku University Graduate School of Medicine; 8Dept. of Preventive

Psychiatry, Tohoku University Graduate School of Medicine

Background: While At-Risk Mental State (ARMS) was essentially conceptu-

alized to predict future development of psychosis, previous ARMS research

has been known to include a considerable proportion of non-converters.

When delivering clinical services to ARMS individuals, however, there is a

need to provide treatment suitable for non-converters as well as converters.

However, reported rates of non-converters vary among studies, and their

nature has not yet been sufficiently elucidated, especially in non-Western

countries. In this study, we conducted an exploratory examination of the

clinical course and features of non-converted ARMS in our specialized clinic

in Japan.

Methods: Youths at ultra-high risk (UHR) for psychosis (N=106; mean age,

20 years; male, 40%) were recruited for this study; each was followed

up with naturalistic treatment at a specialized clinic for early psychosis

in Japan, and therapeutic sessions were continued according to individual

needs. In the first three years after intake, participants who had not de-

veloped psychosis were regularly re-evaluated using the Comprehensive

Assessment of ARMS (CAARMS) and Global Assessment of Functioning (GAF)

to ascertain whether they met UHR criteria. In order to examine severity of

functional impairment and subjective depression of non-converters, Social

and Occupational Functioning (SOFAS) and Beck Depression Inventory (BDI)

scores at Year 1 were compared among three groups: (1) those who were

remitted from ARMS, (2) those who met ARMS criteria, and (3) those who

converted to psychosis.