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Pathway to a new treatment
17
Screen
100 000
drugs
Keep all the
cells growing
for testing
Rescreen
independent
tumors
DNA, RNA data
before, after
treatment,
analysis
Test
Dr Alman’s
desmoid mice,
more cell lines
Test
combinations in
cells and in Dr
Alman’s desmoid
mice
30-50
3-10 drugs
Patient trial(s)
10 mo 8 mo 18 mo 6 mo
Drug dispo
analysis
µM DEX
Vehicle Dexamethasone
Control
Treatment
Dasatinib
Dasatinib FAK inhibitor
Dasatinib PI3K inhibitor FAK inhibitor
0
20
40
60
80
100
120
Control Dex Fak-I Dex & Fak-I
Tumor volume mm3
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