Upload
vivek-patel-viks
View
290
Download
3
Embed Size (px)
Citation preview
7/27/2019 ppt of m.pharm
1/13
Presented by -
Kiran Dhakane,I Sem. M. Pharm.
Guided by-Mr. Kiran Bhusare,Dept.of Pharmacology,SBCOP, Aurangabad.
1
7/27/2019 ppt of m.pharm
2/13
CONTENTS
Introduction
Manufacture techniques
Mechanism
Usefulness
Literature surveys
Requirement
Marketed preparation 2
7/27/2019 ppt of m.pharm
3/13
INTRODUCTION Mouth Dissolving tablet are solid single unit dosage forms that
are placed in mouth , allowed to disperse or dissolve in saliva
without need of water for frequently release of drug for quick
onset of action.
Mouth dissolving tablet disappears rapidly before
swallowing.
Disintegrates in less than 3 minute.
Also called as fast dissolving tablet, orodispersible tablet, melt
in mouth tablet, repimelts tablet, porous tablet. 3
7/27/2019 ppt of m.pharm
4/13
ADVANTAGES OVER THE
CONVENTIONALDOSAGE FORM Convenient for administration and compliant.
Good mouth feel can achieve.
Rapid dissolution of drug and absorption which may
produce rapid, onset of action.
Ability to provide advantages of liquid medication in the form
of solid preparation.
Improved bioavailability by pregastric absorption. 4
7/27/2019 ppt of m.pharm
5/13
IDEAL REQUIREMENT
On oral administration its dissolve/ disperse/
disintegrate in mouth in few seconds without
necessitate of water.
Have a pleasing mouth feel.
Have an acceptable taste masking property .
Be harder and less friable.
Have physical and environmental stability.
5
7/27/2019 ppt of m.pharm
6/13
MANUFACTURE TECHNIQUES
Direct compression.
Spray drying.
Moulding.
Lyophiliation.
Sublimation.
Mass extrusion. Fig. Tablet compression machine
6
7/27/2019 ppt of m.pharm
7/13
MECHANISM OF MOUTH DISSOLVIG
TABLET
Swelling .
Wicking .
Deformation.
Particle Repulsive force.
7
7/27/2019 ppt of m.pharm
8/13
USEFULNESS For bed ridden and unco-operative patients
For gediatric and pediatric patient
For psychic patients
No need of water to swallow the tablet ,which is highlyconvenient feature for patients .
Who are traveling and do not have immediate access to water.
No risk of chocking or suffocation during oral administration.
8
7/27/2019 ppt of m.pharm
9/13
LITERATURE SURAVEY
Deebjit Bhowmik et al / (2009) Fast dissolvin tablet : anoverview.
Ganesh Kumar et al / (2010) formuliion and evaluation of
fast dissolving tablet ofchlopromazine hcl
Shailendra Kumar Singh et al / (2010) fast disintegrating
combination tablets of omeprazole and domperidone.
Susijit Sahoo et al / ( 2010) Fast Dissolving Tablet: As A
Potential Drug Delivery System
9
7/27/2019 ppt of m.pharm
10/1310
Sr.
No.
Requirement Availability
1 Tablet Compression Machine Yes
2 UV -Visible Spectrophotometer Yes
3 Disintegration Test Apparatus Yes
4 Dissolution Test Apparatus Yes
5 Infra-red Spectrophotometer Yes
6 Hardness Tester Yes
7 Friability Test Apparatus Yes
REQUIREMENT FOR FORMULATION OF
MOUTH DISSOLVIG TABLET
7/27/2019 ppt of m.pharm
11/13
MARKETED PREPARTION
11
SR.NO PRODUCT NAME CONTAIN MFG.NAME
1 Tab Almox 125 DT Amoxyilline Alkem
2 Tab Gudcef 100 Cefodoxime Proxetil Lifestar
3 Tab Vomikind MD 4 Ondansetron Mankind
4 Tab Domoperi 5 DT Domperidone Ipca
5 Tab Dolonex DT Piroxicam D Pfizer
6 Tab Nimos MD Nimusulide Mankind
7 Tab Zifi 100 DT Cifixime FDC
8 Tab Odoxil 125 DT Cefadoxil Lupine
9 Tab Disnee Nimusulide , Caffine Horizon
10 Tab Pacimol XP Paracetamol Ipca
7/27/2019 ppt of m.pharm
12/13
12
REFERNCE
1)Ganesh kumar Gudas et al/ Journal of PharmaceuticalScience and Technology, Vol.2(1), 2010, 99-102
2)International Journal of Pharmacy and Pharmaceutical
Sciences, Vol. 1, Supple 1, Nov.-Dec. 2009
3)Asian Journal of Pharmaceutical and Clinical Research Vol.2
Issue 3, July-September 2009
5) Susijit Sahoo et al. / Drug Invention Today 2010,2(2),130-133
7/27/2019 ppt of m.pharm
13/13
13