Pr sentation 24 juin 2015 F PIERREsplite partie 1 · 2019. 4. 29. · Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies Doris S. M. Chan

!"#$%&'()*+,$%&-.$/0$12$*.3&45647&8)9+&4:;<

!"#$%&'"()*$+,-..-!!-/0(1*$+"23*4564$*7$+"686564$9*$:&$;&4)2"6<*4=>*$1&"$:*>$?:(8*47>!!

"#$!%&&%!'()*+,-!.!/01230!45$*!60!'(7+(780!

9,:1608!02!;:1;03<!!"#$%&'!()*!+,-()*!+.$(+/$0%01$2-)*!),!!!

"3',)4&560'! )',4)! %)*! &..4057)*! +.$(+/$0%01$2-)! ),!

)8.+4$/)',&%)! .0-4! +,-($)4! ),! .4+9)'$4! %:&**05$&60'!

.0*$69)!)',4)!50'*0//&60'!()!9$&'()*!40-1)*!),!4$*2-)!

()!5&'5)4!50%04)5,&%);!

!"#$%&'"()*$+,-..-!!-/0(1*$+"23*4564$*7$+"686564$9*$:&$;&4)2"6<*4=>*$1&"$:*>$?:(8*47>!!

"#$!%&&%!'()*+,-!.!/01230!45$*!60!'(7+(780

9,:1608!02!;:1;03<!!"#$%&'!()*!+,-()*!+.$(+/$0%01$2-)*!),!!!

"3',)4&560'! )',4)! %)*! &..4057)*! +.$(+/$0%01$2-)! ),!

)8.+4$/)',&%)! .0-4! +,-($)4! ),! .4+9)'$4! %:&**05$&60'!

.0*$69)!)',4)!50'*0//&60'!()!9$&'()*!40-1)*!),!4$*2-)!

()!5&'5)4!50%04)5,&%);!

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08!(B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08 (B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&

@@3(;A08!(B803C:>(@3(;A08!(B803C:>

BBBBB**&======$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++9999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%&&&&&CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))********************************************************00000000000000000000000000000000000000999999999999999DDDDDDDDDDDDDDDDDDDDDDDDDDD&&&DD

EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;66666666666666666666;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!55555555555555555555555555555555555555FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF&&

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08 (B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&

HIJK! HLJM! HNOJM! HOIJO! HIOJN!!5&*F!NPP!PPP!

3QRD!OPPS!

@@3(;A08!(B803C:>(@3(;A08!(B803C:>



=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08 (B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&


3QRD!OPPS!

@@3(;A08!(B803C:>(@3(;A08!(B803C:>



! !!! !! !Pays ︎

d!velopp!s︎

Pays non - ︎

d!velopp!s︎

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08 (B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&


3QRD!OPPS!

@@3(;A08!(B803C:>(@3(;A08!(B803C:>



! !!! !

Conso

. de

fibre

s︎

! !Pays ︎

d!velopp!s︎

Pays non - ︎

d!velopp!s︎

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08 (B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&


3QRD!OPPS!

@@3(;A08!(B803C:>(@3(;A08!(B803C:>



*@@3(;A08!0)@?3,-012:+08!!2709*$(47*"3*45644*::*$@$&3*)$:(*4$9*$)&0>&:(72$

! !!! !

Conso

. de

fibre

s︎

! !Pays ︎

d!velopp!s︎

Pays non - ︎

d!velopp!s︎

=,01!01230!:+,-012:>(1!02!8:12?!!

<&! 50''&$**&'5)! 4)/0',)! &-! /0$'*! =! %:&'62-$,+! 14+50"40/&$')! 0>! %)*!

)?),*! (-! .%0/@! ),! (-! /)45-4)! ),! ()! ($9)4*! A! .0$*0'*! B! &'$/&-8! 0-!

9+1+,&-8!+,&$)',!(+C=!50''-*; ! !!D&*!(-!E%0/@!F!*&,-4'$*/)G!

5&'&%$*&60'! /&$*! &-**$!

.4+.&4&60'!(-!9$'!

!

=(#/9+$&>)9&$%.&*,?$+.3&/@$?&A$%&!

*@@3(;A08!(B803C:>(110++08!!!&>>6)(&564$@#$>&4>$:(*4$9*$)&0>&:(72 ! ! ! ! ! !!

=,01!01230!:+,-012:>(1!02!;:3;,1(D01E80!

@3(;A08 (B803C:>

B*&=$+9%&C)*09D&&

E;!;;6;!!5F&


3QRD!OPPS!

@@3(;A08!(B803C:>(@3(;A08!(B803C:>



$?;73301;0!608! ! !!!!#(6E+08!:1,-:7) !!!!!!!!!#(6E+08!;0++7+:,308!

@(+F@08!;A0G!+HI(--0!!

*@@3(;A08!0)@?3,-012:+08!!2709*$(47*"3*45644*::*$@$&3*)$:(*4$9*$)&0>&:(72$

! !!! !

Conso

. de

fibre

s︎

! !Pays ︎

d!velopp!s︎

Pays non - ︎

d!velopp!s︎

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

3/.&5,!()!%X&%$/)',&60'!

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

3/.&5,!()!%X&%$/)',&60'!

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

3/.&5,!()!%X&%$/)',&60'!

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

3/.&5,!()!%X&%$/)',&60'!

J$M#M'4M5!67!

cancer ;(+(30;2:+!

N0+0;>(1!608!

/0++7+08!@3?;:1;?307808!

N + >

J3(67,28!

1?(O(3-?8!L!

;(12:-,1:128!

:+,-012:,308P!

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

3/.&5,!()!%X&%$/)',&60'!

J$M#M'4M5!67!

cancer ;(+(30;2:+!

N0+0;>(1!608!

/0++7+08!@3?;:1;?307808!

N + >

J3(67,28!

1?(O(3-?8!L!

;(12:-,1:128!

:+,-012:,308P!

J(73K7(,!?276,03!+:!30+:>(1!:+,-012!L!;:1;03!T'!/0U)'!()!.4+9)'$4!%)!5&'5)4!(-!5V%0'W$

3/.&5,!()!%X&%$/)',&60'!

!

J3?C01>(1!!

1723,>(110++0!

X 1 6608

%.!*1:+F80!?@,6?-,(+(D,K70!

%.!*1:+F80!?@,6?-,(+(D,K70!

-G%.$#/H?&I9.$*/.)*$&J$@9$KL&&

!

%.!*1:+F80!?@,6?-,(+(D,K70!

YDRZ!N[[LJ!OPPL!

-G%.$#/H?&I9.$*/.)*$&J$@9$KL&&

!

3/.)4$&%!D0%%)1)!\0'(0'!

'(:&4$*AB&0>5C$9*$:&$:(D2"&70"*$21(928(6:6<(/0*$

%.!*1:+F80!?@,6?-,(+(D,K70!

YDRZ!N[[LJ!OPPL!D0'5%-*$0'*!1%0@&%)!&-!,4&9)4*!%X-6%$*&60'!()!

/+,&"&'&%U*)G!A,#/*?M$& %./H%H>)$& ?(#N9+/+.& O$%& *,%)O./.%& AP)+$& %,*9$&

AP,.)A$%&9+A,2$+A/+.$%&

-G%.$#/H?&I9.$*/.)*$&J$@9$KL&&

!

3/.)4$&%!D0%%)1)!\0'(0'!

'(:&4$*AB&0>5C$9*$:&$:(D2"&70"*$21(928(6:6<(/0*$

%.!*1:+F80!?@,6?-,(+(D,K70!

YDRZ!N[[LJ!OPPL!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!

Suggéré Non concluant

D0'5%-*$0'*!1%0@&%)!&-!,4&9)4*!%X-6%$*&60'!()!

/+,&"&'&%U*)G!A,#/*?M$& %./H%H>)$& ?(#N9+/+.& O$%& *,%)O./.%& AP)+$& %,*9$&

AP,.)A$%&9+A,2$+A/+.$%&

-G%.$#/H?&I9.$*/.)*$&J$@9$KL&&

!

3/.)4$&%!D0%%)1)!\0'(0'!

'(:&4$*AB&0>5C$9*$:&$:(D2"&70"*$21(928(6:6<(/0*$

%.!*1:+F80!?@,6?-,(+(D,K70!

YDRZ!N[[LJ!OPPL!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


D0'5%-*$0'*!1%0@&%)!&-!,4&9)4*!%X-6%$*&60'!()!

/+,&"&'&%U*)G!A,#/*?M$& %./H%H>)$& ?(#N9+/+.& O$%& *,%)O./.%& AP)+$& %,*9$&

AP,.)A$%&9+A,2$+A/+.$%&

-G%.$#/H?&I9.$*/.)*$&J$@9$KL&&

!

3/.)4$&%!D0%%)1)!\0'(0'!

'(:&4$*AB&0>5C$9*$:&$:(D2"&70"*$21(928(6:6<(/0*$****$$$$

R7,1!ST%U!!!!!!!!!!!!!!!!!!

V!5723,>(1!02!

@3?C01>(1!@3,-:,30!

608!;:1;038!W!STTX!

%.!*1:+F80!?@,6?-,(+(D,K70!

YDRZ!N[[LJ!OPPL!

E(:&4$9*>$2709*>$21(928(6:6<(/0*>$*47"*$)64>688&564$9*$$

1"690(7>$)&"42>$*7$"(>/0*$9*$)&")(46<*4=>*$.J:8!60!3,8K70!:88(;,?!Y!+:!;(18(--:>(1!60!C,:1608!B+:1;A0Z!!

"\&!Q&@9/+A$&*()R$&B!$'5%-,!%)!@0)-]J!%)!.045J!%X&1')&-!),!%)!57)94)&-!&$'*$!2-)!%&!9$&'()!

50',)'-)!(&'*!%)*!.%&,*!.4+.&4+*;!

"\&!A!?M/*?).$*9$!B!50/.4)'(!%&!9$&'()!,4&$,+)!.&4!]-/&1)J!*+57&1)J!*&%&$*0'!0-!&9)5!

&C0-,! (X&1)',*! 57$/$2-)*! ()! 50'*)49&60'! &$'*$! 2-)! 5)%%)! 50',)'-)! (&'*! %)*! .%&,*!

.4+.&4+*;!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


$2709*>$21(928(

)&"42>$*7$"(>/0*$70!:88(;,?!Y!+:!;(18(

$&*()R$&B!$'5%-,!%)!@0)

D0'5%-*$0'*!1%0@&%)!&-!,4&9)4*!%X-6%$*&60'!()!

/+,&"&'&%U*)G!A,#/*?M$& %./H%H>)$& ?(#N9+/+.& O$%& *,%)O./.%& AP)+$& %,*9$&

AP,.)A$%&9+A,2$+A/+.$%&

-G%.$#/H?&I9.$*/.)*$&J$@9$KL&&

!

3/.)4$&%!D0%%)1)!\0'(0'!

'(:&4$*AB&0>5C$9*$:&$:(D2"&70"*$21(928(6:6<(/0*$****$$$$

R7,1!ST%U!!!!!!!!!!!!!!!!!!

V!5723,>(1!02!

@3?C01>(1!@3,-:,30!

608!;:1;038!W!STTX!

( : ( 7 5 9E(: 9 27 9 2 (92 (

Red and Processed Meat and Colorectal CancerIncidence: Meta-Analysis of Prospective Studies

Doris S. M. Chan1, Rosa Lau1, Dagfinn Aune1, Rui Vieira1, Darren C. Greenwood2, Ellen Kampman3,

Teresa Norat1*

1Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, 2 Biostatistics Unit, Centre for Epidemiology

and Biostatistics, University of Leeds, Leeds, United Kingdom, 3Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands

/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!



Teresa Norat1*



/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

%%!?27608!60!;(A(320!*0',!$'5%-*)*!(&'*!%&!/+,&"&'&%U*);!!!

⇒  Q-1/)',&60'!(0*)"4+.0'*)!*$1'$^5&69)!&9)5!%&!50'*0//&60'!

()!9$&'()*!_.0-4!NPP!1FC`;!!

⇒  /0\0!:7D-012:>(1!082!60!%Q!]!@(73!+0!;:1;03!;(+(30;2:+[!60!!

SU!]!@(73!+0!;^+(1!02!&%!]!@(73!+0!30;27-Z!!



Teresa Norat1*



/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

%%!?27608!60!;(A(320!*0',!$'5%-*)*!(&'*!%&!/+,&"&'&%U*);!!!

⇒  Q-1/)',&60'!(0*)"4+.0'*)!*$1'$^5&69)!&9)5!%&!50'*0//&60'!

()!9$&'()*!_.0-4!NPP!1FC`;!!

⇒  /0\0!:7D-012:>(1!082!60!%Q!]!@(73!+0!;:1;03!;(+(30;2:+[!60!!

SU!]!@(73!+0!;^+(1!02!&%!]!@(73!+0!30;27-Z!!



Teresa Norat1*



/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

%%!?27608!60!;(A(320!*0',!$'5%-*)*!(&'*!%&!/+,&"&'&%U*);!!!

⇒  Q-1/)',&60'!(0*)"4+.0'*)!*$1'$^5&69)!&9)5!%&!50'*0//&60'!

()!9$&'()*!_.0-4!NPP!1FC`;!!

⇒  /0\0!:7D-012:>(1!082!60!%Q!]!@(73!+0!;:1;03!;(+(30;2:+[!60!!

SU!]!@(73!+0!;^+(1!02!&%!]!@(73!+0!30;27-Z!!

Meta-analysis of prospective studies of red meatconsumption and colorectal cancerDominik D. Alexandera, Douglas L. Weedb, Colleen A. Cushinga

and Kimberly A. Lowec

298 European Journal of Cancer Prevention 2011, Vol 20 No 4

/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

FG$H4*$2709*$9*10(>$:*$"&116"7$90$I;.%$$

$$$$9*$JKLL$



Fig. 1

Author and year RR and 95% CI

Bostick et al. (1994) (C) (W)Brink et al. (2005) (C)Brink et al. (2005) (R)Chao et al. (2005) (C)Chao et al. (2005) (R)Chenet al. (1998)(CRC)(M) Physicians Health StudyChen et al. (2003) (C)Cross et al. (2007) (C)Cross et al. (2007) (R)English et al. (2004) (C) English et al. (2004) (R) Flood et al. (2003) (CRC) (W)Hsing et al. (1998) (CRC) (M)Jarvinen et al. (2001) (C) Jarvinen et al. (2001) (R) Kabat et al. (2007) (C) (W)Kabat et al. (2007) (R) (W)Kato et al. (1997) (CRC) (W)Khan et al. (2004) (CRC) (M)Khan et al. (2004) (CRC) (W)Kojima et al. (2004) (C) (M)Kojima et al. (2004) (C) (W)Kojima et al. (2004) (R) (M)Kojima et al. (2004) (R) (W)Larsson et al. (2005a) (CRC)(W) Swedish Mammography CohortLee et al. (2009) (C) (W) Lee et al. (2009) (R) (W) Lin et al. (2004) (CRC) (W) Norat et al. (2005) (C)Norat et al. (2005) (R)Nothlings et al. (2009) (CRC)Oba et al. (2006) (C) (M)Oba et al. (2006) (C) (W)Pietinen et al. (1999) (CRC) (M)Sato et al. (2006) (C) Sato et al. (2006) (R) Singh and Fraser et al. (1998) (C) Tiemersma et al. (2002) (CRC) (M)Tiemersma et al. (2002) (CRC) (W)Wei et al. (2004) (C) (M)Wei et al. (2004) (C) (W)Wei et al. (2004) (R (W)Wei et al. (2004) (R) (M)

0.1 0.2 0.5 1.0 2 5 10Summary relative risk = 1.12 (1.04−1.121)

P heterogeneity = 0.014

Iowa Women's Health StudyNetherlands Cohort StudyNetherlands Cohort StudyCancer Prevention Study IICancer Prevention Study II

China Cohort StudyNIH-AARP Cohort StudyNIH-AARP Cohort StudyMelbourne Collaborative Cohort StudyMelbourne Collaborative Cohort StudyBreast Cancer Detection Demonstration ProjectLutheran Brotherhood CohortMobile Clinic Health Examination SurveyMobile Clinic Health Examination SurveyCanadian National Breast Screening SurveyCanadian National Breast Screening SurveyNew York, Florida Cohort StudyJapan Cohort StudyJapan Cohort StudyJapan Collaborative Cohort StudyJapan Collaborative Cohort StudyJapan Collaborative Cohort StudyJapan Collaborative Cohort Study

Shanghai Women's Health StudyShanghai Women's Health StudyWomen's Health StudyEPIC CohortEPIC CohortMultiethnic Cohort StudyJapan Cohort StudyJapan Cohort StudyATBC Cancer Prevention StudyMiyagi Cohort StudyMiyagi Cohort StudyAdventist Health StudyProspective Netherlands StudyProspective Netherlands StudyHealth Professionals Follow-up StudyNurses Health StudyNurses Health StudyHealth Professionals Follow-up Study

Cohort

Meta-analysis of prospective studies of red meat intake and colorectal cancer. C, colon; CRC, colorectal; M, men; R, rectal; W, women.


/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

FG$H4*$2709*$9*10(>$:*$"&116"7$90$I;.%$$

$$$$9*$JKLL$

OM!+,-()*!()!50704,);!!

*7D-012:>(1!67!3,8K70!60!%S!]!(-!5&'5)4!!

50%04)5,&%!&**05$+)!=!%&!50'*0//&60'!()!9$&'()*!

!40-1)*!_7$17)*,!9*!%0a)*,`!



Fig. 1








Cohort



/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

FG$H4*$2709*$9*10(>$:*$"&116"7$90$I;.%$$

$$$$9*$JKLL$

FG$M&$46564$9*$C"&)564$&D"('0&':*$

\&!]4&560'!&b4$@-&@%)!5044)*.0'(!=!%&!.40.0460'!()!

5&*!(X-')!.&,70%01$)!2-$!*)4&$,!%&!50'*+2-)'5)!(:-'!

50/.04,)/)',!0-!(:-'!]&5,)-4!()!4$*2-);!!

OM!+,-()*!()!50704,);!!

*7D-012:>(1!67!3,8K70!60!%S!]!(-!5&'5)4!!

50%04)5,&%!&**05$+)!=!%&!50'*0//&60'!()!9$&'()*!

!40-1)*!_7$17)*,!9*!%0a)*,`!



Fig. 1








Cohort



/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

FG$H4*$2709*$9*10(>$:*$"&116"7$90$I;.%$$

$$$$9*$JKLL$

FG$M&$46564$9*$C"&)564$&D"('0&':*$

\&!]4&560'!&b4$@-&@%)!5044)*.0'(!=!%&!.40.0460'!()!

5&*!(X-')!.&,70%01$)!2-$!*)4&$,!%&!50'*+2-)'5)!(:-'!

50/.04,)/)',!0-!(:-'!]&5,)-4!()!4$*2-);!!

British Journal of Cancer (2011) 105, S2 – S5

& 2011 Cancer Research UK All rights reserved 0007 – 0920/11

www.bjcancer.com

The fraction of cancer attributable to lifestyle and

environmental factors in the UK in 2010

Introduction

DM Parkin*,1

1Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

�

�

�

�

�

�

�

�

�

�

�

�

Table 3 Colorectal cancer diagnosed in 2010, attributable to meat consumption in 2000–2001

Age (years) Colon–rectum All cancers

At exposure

At

outcome PAF

Observed

cases

Excess attributable

cases PAF (%)

Men

19–24 29–34 0.27 92 24.8 26.9 1333 24.8 1.9

25–34 35–44 0.26 397 102.5 25.8 4124 102.5 2.5

35–49 45–59 0.26 2921 756.7 25.9 22 388 756.7 3.4

50–64 X60 0.25 18 643 4611.3 24.7 128 192 4611.3 3.6

All ages 22 127 5495.3 24.8 158 667 5495.3 3.5

Women

19–24 29–34 0.17 97 16.9 17.5 2248 16.9 0.8

25–34 35–44 0.14 402 57.0 14.2 8619 57.0 0.7

35–49 45–59 0.16 2292 376.0 16.4 31 631 376.0 1.2

50–64 X60 0.17 14 926 2465.6 16.5 110 403 2465.6 2.2

All ages 17 787 2915.5 16.4 155 584 2915.5 1.9

Persons

19–24 29–34 189 42 22.1 3582 42 1.2

25–34 35–44 799 160 20.0 12 743 160 1.3

35–49 45–59 5213 1133 21.7 54 019 1133 2.1

50–64 X60 33 569 7077 21.1 238 595 7077 3.0

All ages 39 914 8411 21.1 314 251 8411 2.7

Abbreviations: PAF¼ population-attributable fraction. aExcluding non-melanoma skin cancer.

S26

OM!+,-()*!()!50704,);!!

*7D-012:>(1!67!3,8K70!60!%S!]!(-!5&'5)4!!

50%04)5,&%!&**05$+)!=!%&!50'*0//&60'!()!9$&'()*!

!40-1)*!_7$17)*,!9*!%0a)*,`!



Fig. 1








Cohort



/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!;(+(30;2:+!

FG$H4*$2709*$9*10(>$:*$"&116"7$90$I;.%$$

$$$$9*$JKLL$

FG$M&$46564$9*$C"&)564$&D"('0&':*$

\&!]4&560'!&b4$@-&@%)!5044)*.0'(!=!%&!.40.0460'!()!

5&*!(X-')!.&,70%01$)!2-$!*)4&$,!%&!50'*+2-)'5)!(:-'!

50/.04,)/)',!0-!(:-'!]&5,)-4!()!4$*2-);!!

British Journal of Cancer (2011) 105, S2 – S5


www.bjcancer.com

The fraction of cancer attributable to lifestyle and

environmental factors in the UK in 2010

Introduction

DM Parkin*,1

1Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

�

�

�

�

�

�

�

�

�

�

�

�

Table 3 Colorectal cancer diagnosed in 2010, attributable to meat consumption in 2000–2001

Age (years) Colon–rectum All cancers

At exposure

At

outcome PAF

Observed

cases

Excess attributable

cases PAF (%)

Men

19–24 29–34 0.27 92 24.8 26.9 1333 24.8 1.9

25–34 35–44 0.26 397 102.5 25.8 4124 102.5 2.5

35–49 45–59 0.26 2921 756.7 25.9 22 388 756.7 3.4

50–64 X60 0.25 18 643 4611.3 24.7 128 192 4611.3 3.6

All ages 22 127 5495.3 24.8 158 667 5495.3 3.5

Women

19–24 29–34 0.17 97 16.9 17.5 2248 16.9 0.8

25–34 35–44 0.14 402 57.0 14.2 8619 57.0 0.7

35–49 45–59 0.16 2292 376.0 16.4 31 631 376.0 1.2

50–64 X60 0.17 14 926 2465.6 16.5 110 403 2465.6 2.2

All ages 17 787 2915.5 16.4 155 584 2915.5 1.9

Persons

19–24 29–34 189 42 22.1 3582 42 1.2

25–34 35–44 799 160 20.0 12 743 160 1.3

35–49 45–59 5213 1133 21.7 54 019 1133 2.1

50–64 X60 33 569 7077 21.1 238 595 7077 3.0

All ages 39 914 8411 21.1 314 251 8411 2.7

Abbreviations: PAF¼ population-attributable fraction. aExcluding non-melanoma skin cancer.

S26

OM!+,-()*!()!50704,);!!

*7D-012:>(1!67!3,8K70!60!%S!]!(-!5&'5)4!!

50%04)5,&%!&**05$+)!=!%&!50'*0//&60'!()!9$&'()*!

!40-1)*!_7$17)*,!9*!%0a)*,`!

"!IP!c!()*!5&'5)4*!),!dM!c!()*!(+5e*!.&4!5&'5)4!4+*-%,)4&$)',!

()!%X)8.0*$60'!=!($9)4*!]&5,)-4*!()!4$*2-)!+9$,&@%)*J!%$+*!=!'0*!

/0()*! ()! 9$)! ),! =! '0*! 50/.04,)/)',*! _,&@&5J! ]&5,)-4*!

'-,4$60'')%*!f`;!

"!g&'*! %)*! .&U*! 055$()',&-8J!S%]!608! ;:8! 60! ;:1;038! 67!

;^+(18! 8(12! :\3,B7:B+08! Y! +:! ;(18(--:>(1! 60!

C,:1608Z!

es P

.8 26.9

5 25.8 4

.7 2

.3 24.7

24.8 15

.9 17.5

14.2 86

.0 16.4

.6 16.5

16.4 15

0 20

77 2

1 21.1 3

1 351 35

.0 1.0 1

7 54

es Pes Pes Pes PAF (AF (AF (AF (%)%)%)%)

.8 26.9

5 25.8 4

.7 25.9

.3 24.7

24.8 15

.9 17.5

14.2 86

.0 16.4

.6 1.6 16.56.5

16.16.4 15

22.1 35

0 20.0 1

21.7 54

77 21.1

1 21.1 3

1 35

.0 1

7 54

.1 3

/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!67!@:1;3?:8!

\&! /+,&"&'& %U*)! (0*)" 4+.0'*)! _.0-4! -')!

&-1/)',&60'!()!NPP!1FC`!/0',4)!-'!4$*2-)!&554-!57)h!

%)*! 70//)*! _:7D-012:>(1! 60! Q&!]`J!-:,8! .&*! 57)h!

%)*!])//)*;!!

/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!67!@:1;3?:8!

\&! /+,&"&'& %U*)! (0*)" 4+.0'*)! _.0-4! -')!

&-1/)',&60'!()!NPP!1FC`!/0',4)!-'!4$*2-)!&554-!57)h!

%)*! 70//)*! _:7D-012:>(1! 60! Q&!]`J!-:,8! .&*! 57)h!

%)*!])//)*;!!

Red and processed meat consumption and risk of pancreatic

cancer: meta-analysis of prospective studies

SC Larsson*,1 and A Wolk1

1Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden

�

�

�

�

�

�

�

�

�

�

�

British Journal of Cancer (2012) 106, 603 – 607


www.bjcancer.com

Isaksson

First author

Stolzenberg-solomon

Stolzenberg-solomon

Coughlin

Stolzenberg-solomon

Nöthlings

Coughlin

Lin

Michaud

Inoue-choi

Larsson

Heinen

Lin

Zheng

2002

Year

2007

2007

2000

2002

2005

2000

2006

2003

2011

2006

2009

2006

1993

M/W

Sex

W

M

M

M

M/W

W

M

W

W

W

M/W

W

M

0.03 (0.00, 0.34)

0.65 (0.33, 1.31)

1.46 (1.05, 2.04)

1.11 (0.92, 1.33)

1.16 (0.72, 1.86)

1.82 (1.31, 2.52)

0.83 (0.69, 1.00)

1.93 (0.93, 3.99)

0.70 (0.37, 1.34)

1.06 (0.74, 1.52)

1.83 (0.72, 4.63)

0.78 (0.51, 1.20)

1.50 (0.72, 3.10)

1.53 (1.06, 2.22)

Relative

risk (95% CI)

/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!3,8K70!60!

;:1;03!67!@:1;3?:8!

H4*$2709*$9*10(>$:*$"&116"7$90$I;.%$9*$JKLJ$

\&! /+,&"&'& %U*)! (0*)" 4+.0'*)! _.0-4! -')!

&-1/)',&60'!()!NPP!1FC`!/0',4)!-'!4$*2-)!&554-!57)h!

%)*! 70//)*! _:7D-012:>(1! 60! Q&!]`J!-:,8! .&*! 57)h!

%)*!])//)*;!!

\&!/+,&"&'&%U*)!(0*)"4+.0'*)!_.&4!NOP!1FC`!()!\&4**0'!$.&/O&

/),!)'!+9$()'5)!710!:7D-012:>(1!8,D1,_;:>C0!67!3,8K70!

60!;:1;03!60!@:1;3?:8!60!SX]!&**05$+)!=!%&!50'*0//&60'!

()!9$&'()*!40-1)*!-'$2-)/)',!57)h!%)*!70//)*!_NN!+,-()*!

()!50704,)`;!!

!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

11 A

!!!!!"""####"""$$$%%%&&&'''(((#### !!!! &&&"""***+++(((,,,,***&&&(((****''' ----...////00000001111 000 2222'''33344444%%%!!!!!!!!!!!!!!!

&&&&&"""""*****+++++(((((,,,,,*****&&&&&(((((*****'''''

0 2'34%! -8"99%1

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

11 A

!!!!!"""####"""$$$%%%&&&'''(((#### !!!! &&&"""***+++(((,,,,***&&&(((****''' ----...////00000001111 000 2222'''33344444%%%!!!!!!!!!!!!!!!

&&&&&"""""*****+++++(((((,,,,,*****&&&&&(((((*****'''''

555(*&$2(6 ! 63772$2 -./0.100 22''3344%%!! --88""9999%%11

! 63772$2

55"39"* !! 63777222$22 ---..//////::11 00 222''344%!!! !! 637777222$22

;;66""<<==((77%% !! 6633777722$$22 --..////::11 >> 22''3344%%66!! !! 6633777722$$22

??66''""99((&& !! 6633777722$$22 --..////::11 --!!==(($$&&33''@@11 00 22''3344%%!! !! 6633777722$$22

A%66,% 5(6 4% *,+%(3 4% <$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6 4% *,+%(3 4% <$%3+%

.. 22''3344%%66GG !!

0! (<$H6 #( 92*"<(36%

0! ((++((**'' ##(( 999222***"""<<<(((333666%%%

! 63772$2

J"*

00000 2222222'''''3334444444%%%!!!!!! -------88888"""999999%%%1111111

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


!"#$%&'$(&")'

+,*#$)#,-

.,%$(&")*,(*)&/,$0*+,*1-,0/,*

+,'*-$11"-('*23.45673.*%,'*

1%0'*-8#,)('*93:;*"0*<*+8=$0(*

%,*-$11"-(*>??@A

BC)(DE',*+,'*-8'0%($('*+,'*

)"0/,%%,'*8(0+,' F*G8($H

$)$%C',I*$)$%C',*1""%8,*"0*,''$&*

+J&)(,-/,)(&")

3")#%0'&")'

!"#"$%&'(# ! &"*+(,*&(*')-./001))) 0)2'34%)!!

&"*+(,*&(*')

5(*&$2(6 ! 63772$2)-./0.1))0 2'34%! -8"99%1

! 63772$2

5"39"* ! 63772$2)-.//:1)) 0 2'34%! ! 63772$2

;6"<=(7% ! 63772$2)-.//:1)) > 2'34%6! ! 63772$2

?6'"9(& ! 63772$2)-.//:1)-!=($&3'@1 0)2'34%! ! 63772$2

A%66,% 5(6)4%)*,+%(3)4%)<$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6)4%)*,+%(3)4%)<$%3+%

.)2'34%6G !

0)! (<$H6)#()92*"<(36%

0! (+(*')#()92*"<(36%

! 63772$2

5$"6'('% 5(6)4%)*,+%(3)4%)<$%3+% 0)BC)5ID G JFJ"*)

&"*&#3(*'

I%,* 5(6)4%)*,+%(3)4%)<$%3+%0)2'34%)!

.)2'34%6)JF

J"*)

&"*&#3(*'

!"#$%&'

()*+(,&+#,)-& .

?*4"9H'$%

D+(,$%

J"*)&"*&#3(*')-./0>1))

J"*)&"*&#3(*')-./0K1))

5(6)4%)*"3+%##%6)2'34%6 J"*)

&"*&#3(*'

`,+:1<!/(18(--:>(1!60!C,:1608[!;A:3;7203,08!02!;:1;038!

11 A

!!!!!"""####"""$$$%%%&&&'''(((#### !!!! &&&"""***+++(((,,,,***&&&(((****''' ----...////00000001111 000 2222'''33344444%%%!!!!!!!!!!!!!!!

&&&&&"""""*****+++++(((((,,,,,*****&&&&&(((((*****'''''

555(*&$2(6 ! 63772$2 -./0.100 22''3344%%!! --88""9999%%11

! 63772$2

55"39"* !! 63777222$22 ---..//////::11 00 222''344%!!! !! 637777222$22

;;66""<<==((77%% !! 6633777722$$22 --..////::11 >> 22''3344%%66!! !! 6633777722$$22

??66''""99((&& !! 6633777722$$22 --..////::11 --!!==(($$&&33''@@11 00 22''3344%%!! !! 6633777722$$22

A%66,% 5(6 4% *,+%(3 4% <$%3+% 0BCDEF G ! ! 63772$2

F%,* 5(6 4% *,+%(3 4% <$%3+%

.. 22''3344%%66GG !!

0! (<$H6 #( 92*"<(36%

0! ((++((**'' ##(( 999222***"""<<<<(((333666%%%

! 63772$2

00000 2222222'''''3334444444%%%!!!!!! -------88888"""999999%%%1111111

5$"6'('% 5(6 4% *,+%(3 4% <$%3+% 0 BC 5ID G JFJ"*

&"**&&#33(*''

I%,* 5(6 4% *,+%(3 4% <$%3+%0 2'34%!

. 2'34%6 JF

J"*

&"*&#3(*'

!!""##$$%%&&

(())**++((,,&&++##,,))--&& ..

?*4"9H'$%

DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD++++((,,$$%%

J"* &"*&#3(*' -./0>1

JJ""** &&""**&&##33((**'' ----..//00KK1111

5(6 4% *"3+%##%6 2'34%6 J"*

&&""**&&##33((**''

9922**""<<<((3366%%

JJJ"*

Q!1,C0:7)!60!@307C0!!/(1C:,1;:12!

E40@&@%)!


/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

g&'*! %)! 5&(4)! (X-'!

. 0 * $ 6 0 ' ' ) / ) ' ,!

.-4)/)',! ()! 8:12?!

@ 7 B + , K 7 0 J ! 5 ) b )!

4)50//&'(&60'! )*,!

.)46')',)!f;!

!

/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

g&'*! %)! 5&(4)! (X-'!

. 0 * $ 6 0 ' ' ) / ) ' ,!

.-4)/)',! ()! 8:12?!

@ 7 B + , K 7 0 J ! 5 ) b )!

4)50//&'(&60'! )*,!

.)46')',)!f;!

!

#*4N[!@:8!60!@3,80!01!;(-@20!!

.60!+a,12?3b2!1723,>(110+!()*!9$&'()*!),!.40(-$,*!

=!@&*)!()!9$&'()!G!])4J!h$'5J!9$,&/$')!#NO!),5f;!!

.60! +a,1?D:+,2?! O:;0! :7)! 30;(--:16:>(18G! *)-%!

%)*! D<E! *-.+4$)-4)*! $',e14)',! 5)! ,U.)! ()!

4)50//&'(&60'*!!

.608!;(18?K701;08!?;(1(-,K708!

4

.

#

.

=

.

%

#

.

=

.

%

#

.

=

.

/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

g&'*! %)! 5&(4)! (X-'!

. 0 * $ 6 0 ' ' ) / ) ' ,!

.-4)/)',! ()! 8:12?!

@ 7 B + , K 7 0 J ! 5 ) b )!

4)50//&'(&60'! )*,!

.)46')',)!f;!

!

N'O*)5CP$Q*D"*$*4$1:&)*$04*$&:7*"4&53*$R$)*D*$"*)688&49&564$9*$:(8(7&564$*7$9S23()564#$

#*4N[!@:8!60!@3,80!01!;(-@20!!

.60!+a,12?3b2!1723,>(110+!()*!9$&'()*!),!.40(-$,*!

=!@&*)!()!9$&'()!G!])4J!h$'5J!9$,&/$')!#NO!),5f;!!

.60! +a,1?D:+,2?! O:;0! :7)! 30;(--:16:>(18G! *)-%!

%)*! D<E! *-.+4$)-4)*! $',e14)',! 5)! ,U.)! ()!

4)50//&'(&60'*!!

.608!;(18?K701;08!?;(1(-,K708!

4

.

#

.

=

.

%

#

.

=

.

%

#

.

=

.

/(18?K701;0!608!;(1;+78,(18!60!;08!-?2:.:1:+F808!

g&'*! %)! 5&(4)! (X-'!

. 0 * $ 6 0 ' ' ) / ) ' ,!

.-4)/)',! ()! 8:12?!

@ 7 B + , K 7 0 J ! 5 ) b )!

4)50//&'(&60'! )*,!

.)46')',)!f;!

!

PNRA

ALIA

N'O*)5CP$Q*D"*$*4$1:&)*$04*$&:7*"4&53*$R$)*D*$"*)688&49&564$9*$:(8(7&564$*7$9S23()564#$

#*4N[!@:8!60!@3,80!01!;(-@20!!

.60!+a,12?3b2!1723,>(110+!()*!9$&'()*!),!.40(-$,*!

=!@&*)!()!9$&'()!G!])4J!h$'5J!9$,&/$')!#NO!),5f;!!

.60! +a,1?D:+,2?! O:;0! :7)! 30;(--:16:>(18G! *)-%!

%)*! D<E! *-.+4$)-4)*! $',e14)',! 5)! ,U.)! ()!

4)50//&'(&60'*!!

.608!;(18?K701;08!?;(1(-,K708!

4

.

#

.

=

.

%

#

.

=

.

%

#

.

=

.

9,:1608!02!;:1;03<!!"#$%&'!()*!+,-()*!+.$(+/$0%01$2-)*!),!!!

"3',)4&560'! )',4)! %)*! &..4057)*! +.$(+/$0%01$2-)! ),!

)8.+4$/)',&%)! .0-4! +,-($)4! ),! .4+9)'$4! %:&**05$&60'!

.0*$69)!)',4)!50'*0//&60'!()!9$&'()*!40-1)*!),!4$*2-)!

()!5&'5)4!50%04)5,&%);!

Epidemiologie

Viandes & Cancer:

Un projet de l’épidemiologie

… jusqu’à l’épidemiologie

ogigie

ncer:

Validation In vivo

tttiiiiiiiiiiiiiiValidIn v

Epidemiologie gie

Viandes & Cancer:



Comprendre: Mecanismes

In vitro

Validation In vivo


Epidemiologie gie

Viandes & Cancer:



Outils Biomarqueurs dans biofluides

Outils Biomarqueurs dans d biofluides


In vitro

Validation In vivo


Epidemiologie gie

Viandes & Cancer:



O tilsO til

de

l’

Outils Biomarqueurs dans biofluides Biomarqueurs dans d biofluides


In vitro

Validation In vivo


Epidemiologie gie

Outils Bi

O til

Epide

Prevention & Volontaires

sains

& es

Viandes & Cancer:



Outils Biomarqueurs dans biofluides Biomarqueurs dans d biofluides


In vitro

Validation In vivo


Epidemiologie gie

Outils Bi

O til

Prevention & Volontaires

sains

& es

Viandes & Cancer:



eEpide

#02:.:1:+F80!60!+a4-@03,:+!/(++ED0!60!=(16308!_SM/+&$.&/OT3&4:;;`!!

!c@,60-,(+(D,0!

#02:.:1:+F80!60!+a4-@03,:+!/(++ED0!60!=(16308!_SM/+&$.&/OT3&4:;;`!!

!c@,60-,(+(D,0!

USJV3&SWB&4:;;&

=08!-?2:.:1:+F808!

-(123012!

710!:7D-012:>(1!

60!SU]!@:3!%TTDLd!

;(18(--?!;(18(--?!

#02:.:1:+F80!60!+a4-@03,:+!/(++ED0!60!=(16308!_SM/+&$.&/OT3&4:;;`!!

!c@,60-,(+(D,0!

USJV3&SWB&4:;;&

=08!-?2:.:1:+F808!

-(123012!

710!:7D-012:>(1!

60!SU]!@:3!%TTDLd!

;(18(--?!;(18(--?!

+60"$'(*4$1"23*4("$)*$"(>/0*T$(:$C&07$:*$)681"*49"*$

J:8!6a:88(;,:>(1!!!!<-'!$.&/OTJ!OPNO!Y$'()U!$.&/OTJ!OPNO!!!!!

J:8!6a:88(;,:>(1!

*88(;,?08!:7!3,8K70!

!!!<-'!$.&/OTJ!OPNO!Y$'()U!$.&/OTJ!OPNO!!!!!

!!!!D40**!$.&/OTJ!OPNP!i7)'1!$.&/OTJ!OPP[!

J:8!6a:88(;,:>(1!

*88(;,?08!:7!3,8K70!

<)/@%)',!j,4)!$/.%$2-+!(&'*!

%X,1,>:>(1!),!%&!@3(-(>(1!



g&9$*!$.&/OTJ!OPNO!

J:8!6a:88(;,:>(1!

*88(;,?08!:7!3,8K70!

<)/@%)',!j,4)!$/.%$2-+!(&'*!

%X,1,>:>(1!),!%&!@3(-(>(1!

<)/@%)!j,4)!$/.%$2-+!(&'*!%&!

@3(-(>(1!



g&9$*!$.&/OTJ!OPNO!

E$)44)!$.&/OTJ!OPPdJ!OPPI!

J:8!6a:88(;,:>(1!

*88(;,?08!:7!3,8K70!

<)/@%)',!j,4)!$/.%$2-+!(&'*!

%X,1,>:>(1!),!%&!@3(-(>(1!

<)/@%)!j,4)!$/.%$2-+!(&'*!%&!

@3(-(>(1!



g&9$*!$.&/OTJ!OPNO!

E$)44)!$.&/OTJ!OPPdJ!OPPI!

()*! /0(e%)*! )'! *0-%$1'&',! ()-8!

.4$'5$.)*!G!!

\:0-94&1)!()!k5D-%%&17!),!l)%()4!*-4!%)*!/0(e%)*!%$'+&$4)*!_N[S[`!

)*,! -')! *0-45)! (:$']04/&60'! .4+5$)-*)! *-4! %)*! /0(e%)*!

/&,7+/&62-)*!),!(+54$,!!

2-)%2-)*!.4$'5$.)*!(:&..%$5&60'!

=08!-(6E+08!:1,-:7)!02!;0++7+:,308!U!(4>1("*"$9*>$869=:*>$8&7B28&5/0*>V$

#S$!ceN*!!! ! ! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!9016306,!%f!N0@20-B30!ST%T!

"m0-*!%)*!/0(e%)*!*0',!]&-8J!/&$*!5)4,&$'*!*0',!.%-*!!

-6%)*!2-)!(:&-,4)*;!

!

"l)!.&*!*:)'657)4!(:-'!/0(e%)!=!%:)85%-*$0'!()*!&-,4)*;!!

!

()*! /0(e%)*! )'! *0-%$1'&',! ()-8!

.4$'5$.)*!G!!

\:0-94&1)!()!k5D-%%&17!),!l)%()4!*-4!%)*!/0(e%)*!%$'+&$4)*!_N[S[`!

)*,! -')! *0-45)! (:$']04/&60'! .4+5$)-*)! *-4! %)*! /0(e%)*!

/&,7+/&62-)*!),!(+54$,!!

2-)%2-)*!.4$'5$.)*!(:&..%$5&60'!

=08!-(6E+08!:1,-:7)!02!;0++7+:,308!U!(4>1("*"$9*>$869=:*>$8&7B28&5/0*>V$

#S$!ceN*!!! ! ! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!9016306,!%f!N0@20-B30!ST%T!

"m0-*!%)*!/0(e%)*!*0',!]&-8J!/&$*!5)4,&$'*!*0',!.%-*!!

-6%)*!2-)!(:&-,4)*;!

!

"l)!.&*!*:)'657)4!(:-'!/0(e%)!=!%:)85%-*$0'!()*!&-,4)*;!!

!

()*! /0(e%)*! )'! *0-%$1'&',! ()-8!

.4$'5$.)*!G!!

\:0-94&1)!()!k5D-%%&17!),!l)%()4!*-4!%)*!/0(e%)*!%$'+&$4)*!_N[S[`!

)*,! -')! *0-45)! (:$']04/&60'! .4+5$)-*)! *-4! %)*! /0(e%)*!

/&,7+/&62-)*!),!(+54$,!!

2-)%2-)*!.4$'5$.)*!(:&..%$5&60'!

=08!-(6E+08!:1,-:7)!02!;0++7+:,308!U!(4>1("*"$9*>$869=:*>$8&7B28&5/0*>V$

M1! 8a082! :8873?! 60! +:! @03>101;0! 60! 1(8!-(6E+08! @:3!

3:@@(32!Y!+:!8,27:>(1!A7-:,10Z!

!

M1!:!:88(;,?!6,g?30128!-(6E+08!

#S$!ceN*!!! ! ! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!9016306,!%f!N0@20-B30!ST%T!

Documents

Pr sentation 24 juin 2015 F PIERREsplite partie 1 · 2019. 4. 29. · Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies Doris S. M. Chan