Pre Conditioning Exercise

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Pre-Conditioning exercise

New concept of balance indynamic stress response

Bambang Purwanto

Friday, January 11, 13


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Human body organization!function

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Each level has it own balance

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One to another are connected dynamically!balancing system

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Function is a result of balancing system

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Function is a result of balancing system Mall- & dysfunction is result of balancing

disorder/ failures!clinical features

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Stress: challenge on balancing system

Stress disturb balancing system; if

It meet a new (re-)balance!eustress

Its failed!imbalance!distress; if

It is reversible!compensated

Its not!de-compensated

Response to stress

Acute!survival & repairing Chronic!adaptation & conditioning

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Example: muscle contraction

O2

O2

O2*

O2* ROS Ca

Ca

Troponin C

Xanthin oxidase

AMPK

Cathepsin

Calpain

Caspase

NOX

SR

Membrane depolarization

AchAch-R

Chemistry

Stretch

Electrical

Reflex

ROS

RyR

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Other perspective

Muscle contraction isnt independentmechanism in order to locomotive, butalso co- with

Defense mechanism!prevent myofibrildetachment

Energy reproduction!glucose uptake viaAMPK & Glut-1 expression

Last scenario!suicide/ apoptosis

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Muscle contraction: could be danger..?!

Yes, if the balancing system disturb!

.. How can we control the radical oxidant effect?

How can we sure that Ca is only bound troponin C?

Thats why Allah create!

. SERCA, activated by ATP from energy reproduction!limit SRCa release

Na/K ATP pump, activated by ATP!limit depolarization

Hsp 27/72, activated by p38MAPK, MAPKAP & akt!preventapoptosis & myofibril repair

Antioxidant system, as target and neutralize oxidative stress

These molecules controls intracellular environment keep in balance

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Also, supports are given by

Hormone, especially GH!stimulate akt,prevent apoptosis, muscle repair

Macrophage!cytokine release!stimulate

akt, prevent apoptosis, muscle repair Satellite cells!pro genitor in situ stem cells,

replace & regenerate a new muscle tissue

These are back up plan when muscle destruction occur

Distress imbalance redirect to reversible repair

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Now, are u afraid to move!?

U should not!

..

There is another scenario!

What if we could increase

the defense stress response

fitness capacity & stress threshold

Than, we will able to defense againststress, not only in similar magnitude butalso bigger than before

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Make sure that u always ready!

Pre-conditioning is specific intervention before atruly stress coming

Specific intervention Specific target

Mimic with the truly stress

Pre-conditioning let our body adapt to the stress

Pre-conditioning needs times, depends on the

target Seconds to minutes

Minute to hours

Days to weeks

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Pre-conditioning

Various, depends on it modalities Physical, exercise, chemistry, medicine, radiation,

ionized

Evidences:

2ndbout exercise isnt given any stress as seen atsimilar 1stbout exercise a week before

Allopurinol which is taken orally an hour beforeexercise increases endurance two fold at maximum

stress test 11 minutes of stretching and/ or 5 minutes treadmill

(static cycling) reduce muscle injury at maximumstress test

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Pre-conditioning exercise

Goals : increasing the amount of stress the body can endure before

experiencing injury

preventing injury because they get the body to become moretolerant of sustained effort

Targets: Strength, maintain control and keeps it from stretching to the

injury point

Flexibility, accommodate more stretching before reaching itslimits and tearing

Molecular defense: block the XO, increase (hsp27, Glut-1,antioxidant system) expression,!!

Modalities, Exercise, physical activities

Medicines, supplements 12



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Exercises used for conditioning

Mimic with the actual stress activity Include these programs

Weight training

Aerobic exercise

Anaerobic exercise plyometrics

Response are vary

2ndbout with a week interval in anaerobic strenuous

exercise More than 30 minutes, 3-5 times a week needs minimum

3 weeks in low intensity aerobic exercise

Do not took any NSAIDs such as diclofenac during conditioning programs13



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Exercise!(cont)

High intensity interval exercise induce muscleinjury Needs 4-7 days to recover

Satellite cells differentiate to the muscle cells

Increase number of muscle fiber

Hypertrophy is a result in adaptation to similarstrenuous activity

Conditioning is a recovery phase after destruction

Do not pre conditioning with prolonged strenuous exercise

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Supplements used for conditioning

Specific target, a certain predicted mechanism

Dose dependent, time exposure dependent

Example:

Allopurinol which is given half until an hour priorincrease endurance in strenous exercise!helpsathlete to maintain his/her top perform duringcompetition

When allopurinol is given more than hour prior thecompetition !muscle lost it strength

When allopurinol is taken more than 100 mg, causingabdominal discomfort

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Supplement & strategy to win

the pre conditioning exercise has done Use it to protect muscle from injury before

having exercise for very first time

Joining competition in sport

Strategy in feeding is important key to win We should check pre treatment data such as

(Resting, maximum and target) heart rate, glucose level (min2 hours before start), blood uric acid, blood lactic acid

Consider to check also muscle injury marker, such as serumCK, sTnI

Creatine, vitamins, allopurinol,!!!

Be careful, use only legal supplements

(look at WADA & IOC anti doping regulation)16



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Summary

Allah create our body always able to adapt inevery condition

We must be prepared before stress coming

Pre-conditioning exercise is a method to beprepared

Please choose your suitable modalities:physical, exercise or supplement

Pay attention the protocol, rules & forbidden

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Become a winner

against stress is a must

----the end----


Documents

Pre Conditioning Exercise