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Your responsive CRO partner, delivering customized solutions and adaptability to changing needs. Preclinical research customized for you. MPI Research is the CRO that defines responsiveness, moving your drug development program forward with customized solutions for all your preclinical research. From discovery services to safety evaluation, including analytical and bioanalytical support, you can count on MPI Research for quick quotes, frequent updates, rapid turnaround, and scientific rigor. At every stage, and on every level, we adapt to your most exacting needs. Explore the breadth of capabilities that make us your responsive CRO at www.MPIResearch.com.

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Page 1: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Your responsive CRO partner,

delivering customized solutions and

adaptability to changing needs.

Preclinical research customized for you.

MPI Research is the CRO that defines responsiveness, moving your drug development program

forward with customized solutions for all your preclinical research. From discovery services to

safety evaluation, including analytical and bioanalytical support, you can count onMPI Research

for quick quotes, frequent updates, rapid turnaround, and scientific rigor. At every stage, and on

every level, we adapt to your most exacting needs.

Explore the breadth of capabilities that make us your responsive CRO at www.MPIResearch.com.

Page 2: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference
Page 3: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

GE HealthcareLife Sciences

For every success there’s a successor. It’s called

progress. So while we knew we had something

special in Amersham™ ECL Plus, our Western

blotting team was quietly working on the next

generation of detection reagent. The result: a new

substrate that operates with superior levels of

sensitivity, signal intensity and stability than even

its famous predecessor, making it an excellent

choice for CCD imagers.Welcome to ECL Prime.

Amersham and ECL are trademarks of GE Healthcare companies.

© 2010 General Electric Company – All rights reserved. First published November 2010.

GE Healthcare Bio-Sciences AB, Björkgatan 30, 751 84 Uppsala, Sweden.

Find out more about Amersham ECL Prime at

www.gelifesciences.com/eclprime

Comparison of Amersham ECL Prime and Amersham ECL Plus

detection of ß-catenin in NIH 3T3 whole cell lysates using different

dilutions of rabbit anti-ß-catenin and HRP-conjugated anti-rabbit IgG.

Thank you ECL™ Plus,you’ve been great.

Signal intensity sustained at higher antibody dilutions

Ab dilution Amersham ECL Prime Amersham ECL Plus

Primary Secondary 10 µg 156 ng 10 µg 156 ng

1:3000 1:300 000

1:10 000 1:500 000

Page 4: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Sample & Assay Technologies

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Contact QIAGEN today or visit www.qiagen.com/sample-technologies

Page 5: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Orders (toll-free) 1-877-616-2355 | Technical support (toll-free) 1-877-678-8324 [email protected] | Inquiries [email protected] | Environmental Commitment eco.cellsignal.com

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PathScan® Signaling Nodes

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Immunofluorescent analysis of MCF7 (human breast adenocarcinoma) cells insulin-treated for 5 minutes, using PathScan® Signaling Nodes Multiplex IF Kit #8999.

PathScan® Signaling Nodes Multiplex IF Kit #8999 from

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Page 6: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

www.neb.com

CLONING & MAPPINGDNA AMPLIFICATION

& PCRRNA ANALYSIS

PROTEIN EXPRESSION

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GENE EXPRESSION

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UNDERSTANDING CHANGE

New tools to advance epigenetics researchFor over 35 years, New England Biolabs has been committed to understanding the mechanisms of restriction and

methylation of DNA. This expertise in enzymology has recently led to the development of a suite of validated

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To learn how these products can help you to better

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Simplify DNA methylation analysis with MspJI

MspJI recognizes methylated and hydroxymethylated DNA and cleaves

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Page 7: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

biosilencing

Sigma and Sigma-Aldrich are registered trademarks belonging to Sigma-Aldrich Co. and Sigma-Aldrich Biotechnology, LP. MISSION is a registered trademark of Sigma-AldrichBiotechnology LP and Sigma-Aldrich Co. SwitchGear Genomics is a trademark of SwitchGear Genomics. GoClone is a trademark of SwitchGear Genomics

Bioidentify.Introducing the MISSION®

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Page 8: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Premier Scientific Partner

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Page 9: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

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Page 10: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Some of the Many Reasons to Attend SBS 2011:

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Page 11: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

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Page 12: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Analytical & QuantitativeLight MicroscopyMay 4 - May 13

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Gene Regulatory Networksfor DevelopmentOctober 11 - October 22

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Molecular Biology of AgingJuly 24 - August 13

Molecular Mycology:Current Approaches to FungalPathogenesisAugust 3 - August 19

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Page 13: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference
Page 14: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

1700 17 DECEMBER 2010 VOL 330 SCIENCE www.sciencemag.org/products

NEW PRODUCTS FOCUS: RNAi

LIFE SCIENCE TECHNOLOGIES AAAS/Science Business Office

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations

are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any

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Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

TRANSFECTION REAGENTS Effective and nontoxic DNA and small interfering RNA (siRNA) de-

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Polyplus Transfection

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siRNA SILENCING KITEnabling researchers to perform effi cient small interfering RNA (siR-

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an easy-to-use kit. These tools accelerate the use of RNA interfer-

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gene silencing has been demonstrated to last for more than three

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For info: 800-955-6288 www.invitrogen.com

IN VIVO TRANSFECTION KITThe PEG-Liposome siRNA In Vivo Transfection Kit is designed for

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For info: 800-658-7009 www.altogen.com/mirna.php

RNA ISOLATION When working with stored materials, researchers often need to

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Qiagen

For info: 800-426-8157 www.qiagen.com

Page 15: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

MemberCentral.aaas.org

AAASMemberCentralINTRODUCING

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Page 16: Preclinicalresearchcustomizedforyou. · 2012-10-05 · of gene expression levels. ExpressArt FFPE RNAready overcomes the limitations associated with RNA degradation and interference

Every lab needs one.

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©2010 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners.

For those who require IVD-marked devices, the 3500 Dx and the 3500xL Dx Genetic Analyzers and system accessories meet the requirements of the In Vitro Diagnostics Medical Devices

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