Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202

7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202

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Presenters: Justin Nice and Graham Temples

Lab members: Benjamin Green, So-jung Gwak, PhD

Advisor: Jeoung Soo Lee, Ph.D.

Clinical Mentor: Michael Lynn, MD

Drug Design, Development and Delivery(4D Lab)


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Diseased sites

Why do we need

Targeted Drug Delivery System?Magic Bullet or Guided Missiles

Conventional Targeted

Maximize the therapeutic effect Minimize systemic side effect


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Drug + Gene therapy

Combinatorial Therapy?


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Tissue-specific Delivery System

10-200 nm


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Innovative features of nanoparticle

delivery system1. Change targeting domain depending on cell

type

2. Encapsulate currently approved drugs to treatany diseases or regenerate tissue

3. Incorporate any genes to treat any diseases or

regenerate tissue


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Neuron-specific Polymeric

nanotherapeutics for neural regeneration

Traumatic brain injury

* 1.5-2 million people in the US each year

* 2.5-6.5 million people are living with the physical,

psychological and economic consequences

Spinal Cord Injury*200,000 people in the US are currently living with

spinal cord injury

*12,000-20,000 new cases each year in US

* chronic pain, spasticity, respiratory impairment,

loss of bowel or bladder control, and sexual dysfunction

No effective drug therapy


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Neonatal

Neuron

Barriers to CNS Regeneration

Adult

NeuronChanges external environment

Changes in biochemistry

Pliable

Can regenerate

Fixed

Cant regenerate


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Neuron-specific Nanoparticles

Targeting Using antibody specific to neurons

Encapsulation of Drug Increase regrowth and decrease inhibitory

molecules Gene Delivery In order to knockdown the expression of growth

inhibitory molecules


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Neuron-specific Polymeric

nanotherapeutics for neural regeneration


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Cancer and its current treatments

Cancer is the leading cause of

death

Greater than

HIV/AIDS, tuberculosisand malaria combined

Current treatments include

Radiotherapy

Surgery Chemotherapy


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Targeted Multi-functional Nanotherapeutics for

Combinatorial Therapy of Drug Resistant Cancer

Cancer is the result of

cumulative genetic

defects

It can start anywhere

Takes on a variety offorms


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Cancer Cell

Normally

Cell Dies


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Drug Resistant Cancer Cell

However

Pump Numbers IncreaseCell Lives


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Drug Resistant

Cell Dies


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How to meet the challenges?

Drug Delivered

Safely?

Drug Delivered to

Target?

Is resistanceaddressed?

Targeting moeity

sequesters drug at

desired area

Toxic drug encapsulated

Gene therapy reducespotential drug resistance

in cancer cells


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Thank You!

Drug Design, Development and Delivery(4D Lab)

Documents

Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202