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Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
RISK ASSESSMENT AND NEUROTOXICITY STUDIES OF THE NPS
In vivo behaviour – FOB review
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
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101 98
81 74
48 41
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Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
07/2016
Running:
. MDMB-‐CHMICA
. Acetylfentanyl
Mephedrone; 2011
BZP; 2009
PMMA;2003
TMA-‐2;2004
2C-‐I, 2C-‐T-‐2, 2C-‐T-‐7;2004
10/2015 10/2015 5/2014 5/2014 5/2014
5/2014 1/2014 1/2014
Ketamine;2002
GHB; 2002
4-‐MTA; 1999
MBDB; 1999
EMCDDA RA
Produced :
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Since the number of new psychoacMve substances keeps growing, biomedical data, based on systemaMc
pharmacological and toxicological studies, will rarely be available for these NPS, making the RA a difficult task, as
requested data on NPS is usually limited.
Lisbon, 28th September 2016 EMCES-‐Álvaro Lopes
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Possible contribuMons :
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Toxicants beside inducing histopathological changes, can also alter nervous system funcMon, for example
BEHAVIOR, in profound and varied ways.
Behavioral effects -‐ May be a reflecMon of changes in nerve cell communicaMon and integraMon as well as the morphological alteraMons
Moser, Tox Pathol, 2011;39:36-‐45
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
BEHAVIOR
SensiMve indicator / the ulMmate assay
Moser, Tox Pathol, 2011;39:36-‐45
Neuronal Func%on
IntegraMon and integrity
Nervous System
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
FOB
?
2000 -‐ ICH S7A guidelines
Irwin (1962, 1968) Irwin, S. Psychopharmacologia, 1968;13:222-‐257.
1975 NaMonal Academy of Sc, government and academic scienMsts and US EPA
1989 Guidelines
A series of tests based on Irwin screen, called the FuncMonal ObservaMon Babery (1989)
1998 -‐ US EPA Human Health 870 series test
1995; 1997 -‐ OECD 1996 – Red book
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
FOB
ü Ataxia ü Retropulsion ü ExploraMon ü Convulsions ü Excessive grooming
ü Flabened body posture ü HyperacMvity ü SalivaMon
Lisbon, 28th September 2016
ü Self-‐injury ü Stereotyped head weaving ü Stereotyped circular head movements
ü Stereotyped biMng ü Stereotyped licking ü SMmulaMon
ü Tremor
ü Straub tail ü Circling
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
FOB ü Circling
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
FOB (determined 15-‐20 min post-‐injecMon)
COC – cocaine; METH – Methamphetamine; MDMA – Methylenedioxymethamphetamine; 5-‐IT – 5-‐(2-‐aminopropyl)indole; 6-‐IT -‐ 6-‐(2-‐aminopropyl)indole; 3-‐FMC – 3-‐fluoromethcathinone; 4-‐FMC – 4-‐fluoromethcathinone; MDPV – Methylenedioxyphyrovalerone; Mephe – Mephedrone; Methe – Methedrone; Methy -‐ Methylone
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016
Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network
Lisbon, 28th September 2016 CrisMna Sampayo-‐FFULisboa EMCES-‐Álvaro Lopes
Thank You