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    GUVIClean

    ProspectusOct.2013

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    HAI: TheProblem

    HealthcareAssociated

    Infections

    are

    aserious

    problem:

    Affect~1in20patients1

    Resultin$28B$45Bperyearinadditionalhealthcareexpenditures2,4

    In2002theestimatednumberofHAIsinU.S.hospitalswasestimatedtobe1.7M

    withnearly

    100,000

    of

    these

    HAIs

    resulting

    in

    death.

    3

    AveragecostperHAI~$20,000 $26,000.4

    HAIhasbecomesuchasignificantexpensethatsection5001(c)oftheDeficit

    ReductionActstatesthathospitalswillnolongerreceivereimbursementfromCMS

    forselectedconditionsrelatedtoHAI,addingsignificanteconomicburdento

    numerousU.S.

    hospitals.

    HAIscausedbyinfectiousagents: bacteria,fungi,virusesorotherpathogens

    HAIsareassociatedwithavarietyofriskfactors,including:

    Indwellingmedicaldevicessuchasbloodstream,endotracheal,andurinarycatheters

    Surgicalprocedures

    Injections

    Contaminationofthehealthcareenvironment

    Transmissionofcommunicablediseasesbetweenpatientsandhealthcareworkers

    Overuseorimproperuseofantibiotics

    1. http://www.hhs.gov/ash/initiatives/hai/index.html

    2. Hospitalacquired

    infections

    only:

    http://www.hhs.gov/ash/initiatives/hai/exec_summary.html

    3. Klevins,etal.EstimatingHealthCareAssociatedInfectionsandDeathsinU.S.Hospitals,2002

    4. Scott,TheDirectMedicalCostsofHealthcareAssociatedInfectionsinU.S.HospitalsandtheBenefitsofPrevention,March2009

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    HAIInPrimaryCare

    PrimaryCare

    Providers

    have

    special

    challenges

    Firstlineofcare: Dontalwaysknowwhattheyaregettingintountildiagnosis

    iscomplete

    Facilitiesaretypicallylimited

    Challengeswithpointofcaresterilizationofcommonlyusedinstruments

    BPCuffs,Stethoscopes,Otoscopes,PatellaHammers,TuningForks,

    Trays,Bottles,Ophthamoloscopes,Endoscopes,Proctoscopes,

    ExaminationLights,Thermometers,MeasuringTapes,andthelike

    Sendinginstruments/equipmentouttobesterilizedisexpensiveand

    inconvenientandrequiresmultipleredundanciesof

    instruments/equipment

    Pointofusesterilizationishighlypreferred,buttheequipment(typically

    autoclave)isexpensiveandtimeconsumingandmaydamagecertaininstruments.

    Aninexpensive,effective,simpleandfastmethodofpointofuse

    disinfection/sterilizationisneededforPrimaryCareapplications.

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    TheSolution: GUVIClean

    GUVICleanisasimple,pointofusecabinetusedto

    disinfecttypicalprimarycareinstrumentsatpointofuse.

    It

    is

    simple,

    quick

    and

    effective

    as

    well

    as

    inexpensiveGUVICleanutilizesGermicidalUVIllumination,

    combinedwithspecializedfixturing andreflectordesign

    andmaterialstomoreeffectivelydisinfect/sterilize

    commonuse

    instruments

    Additionaltreatments(ebeam,sanitizinggases,etc.)

    mayalsobeusedinGUVICleantoensuresanitary

    instrumentsin

    atimely

    manner)

    GUVICleanusesinterlocksandsmartsensorstoensure

    safetyoftheuser,enablingpointofuse

    disinfection/sterilizationin

    the

    examination

    room.

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    GUVICleanthebettersolution Patent

    Pending

    GUVI

    chamber

    Utilizingmaterialsand

    designsthat

    are

    highly

    reflectiveofUVCforfull

    internalreflectionofGUVI

    Utilizes

    fixturing materials

    anddesignsthatarehighly

    transmissive ofUVCforfull

    exposure

    of

    all

    areas

    treated FullGUVIexposuretoenable

    disinfection/sanitizationina

    simple,safe,lowcostpoint

    ofusecabinet

    GUVIClean

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    AccessoriesforGUVISterilizers

    PatentPending

    BP

    Cuff

    withextensionstringsfor

    hanginginGUVIChamber

    withoutobstructionof

    GUVItoCuff

    PatentPendingQuartz

    ClipandOtherUVC

    transparentfixturing for

    unobstructedexposureof

    itemstobe

    disinfected/sterilizedto

    GUVI FullGUVIexposureto

    enableeasyandfull

    disinfection/sterilization

    inasimple

    design. GUVICuff QuartzClip

    500

    510510

    520

    530540

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    MarketPotential: US

    PrimaryCare:

    209,000PracticingPCPs:1 62KUnitsAnnually

    Dentist

    195,941PracticingDentists:2 58KUnitsAnnually

    Totalest.

    US

    TAM

    (EAU):

    120K

    Units,

    $90M

    US

    Annually(assumes$750USEachperGUVIClean)

    Other(SpecializedCare,NonPCPClinics,Therapy,etc.)not

    included

    1. http://www.ahrq.gov/research/findings/factsheets/primary/pcwork1/index.html...Assumes3examinationroomsperPCP,oneGUVICleanper

    examinationroomand10yeartransitiontoGUVIClean

    2. http://kff.org/other/stateindicator/totaldentists/ Assumes3workroomsperDentist,oneGUVICleanperroomand10yeartransitiontoGUVIClean

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    Approach

    LicenseAvailablefromUSCIPTechTransferOffice

    (SCRF#01044)

    to

    suitable

    entrepreneurial

    designer/manufacturer

    Keystosuccess:

    Effective,low

    cost

    design

    and

    materials

    selection

    Proof

    of

    efficacy FindinganexcellentMFG/Selling/Distribution

    Partner

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    GUVICleanthe

    better

    solution

    GUVIClean

    Point

    of

    use

    simplicity Lowcostperformance

    FastandEffective

    Disinfection/Sterilization SafeandEffectiveDesign

    LessRedundantInstrument

    InventoryRequired

    LineofTransmissive

    Fixturing