*Computer-Aided Lung Informatics for Pathology Evaluation and Rating

CALIPER

NormaleLow

AtenuatonAreas (LAA)

Ground Glass Retcolazioone Honey-

combiong

Lioevio LAA

Severe LAA

Moderate LAA

TC volumetrioca

Qua

ntfc

azioo

ne

Rapp

rese

ntaz

ioone

Normale Lioevio LAA

Ground Glass

Retcolazioone Honey-combiong

Severe LAAModerate LAA

Figure 17. Axial CT slices, axial CALIPER-derived color image overlays, 3-dimensional (3D) CALIPER coronal rendering and Glyph of the lung parenchymal pattern as various colors (dark green = normal lung, light green = mild LAA, yellow = ground-glass opacity, orange = reticular pattern, brown = honeycombing). A, i–iiii, Imaging results of a 79-year-old male no smoker, with IPF. Mean visual scores of the CT: 20% reticulation, 15% honeycombing, no ground-glass opacity, fibrotic score 35%. CALIPER characterized 9% reticular pattern, 1% honeycombing, 20% ground-glass opacity, 5% Vessels, and 29% ILD. B, i-iiii Same patient after 1-year of follow-up without treatment. Mean visual scores of the CT: 25% reticulation, 20% honeycombing, no ground-glass opacity, fibrotic score 45%. CALIPER characterized 16% reticular pattern, 1% honeycombing, 34% ground-glass opacity, 8% Vessels and 51% ILD.

A B

Figure 17. Axial CT slices, axial CALIPER-derived color image overlays, 3-dimensional (3D) CALIPER coronal rendering and Glyph of the lung parenchymal pattern as various colors (dark green = normal lung, light green = mild LAA, yellow = ground-glass opacity, orange = reticular pattern, brown = honeycombing). A, i–iiii, Imaging results of a 79-year-old male no smoker, with IPF. Mean visual scores of the CT: 20% reticulation, 15% honeycombing, no ground-glass opacity, fibrotic score 35%. CALIPER characterized 9% reticular pattern, 1% honeycombing, 20% ground-glass opacity, 5% Vessels, and 29% ILD. B, i-iiii Same patient after 1-year of follow-up without treatment. Mean visual scores of the CT: 25% reticulation, 20% honeycombing, no ground-glass opacity, fibrotic score 45%. CALIPER characterized 16% reticular pattern, 1% honeycombing, 34% ground-glass opacity, 8% Vessels and 51% ILD.

A B

Figure 17. Axial CT slices, axial CALIPER-derived color image overlays, 3-dimensional (3D) CALIPER coronal rendering and Glyph of the lung parenchymal pattern as various colors (dark green = normal lung, light green = mild LAA, yellow = ground-glass opacity, orange = reticular pattern, brown = honeycombing). A, i–iiii, Imaging results of a 79-year-old male no smoker, with IPF. Mean visual scores of the CT: 20% reticulation, 15% honeycombing, no ground-glass opacity, fibrotic score 35%. CALIPER characterized 9% reticular pattern, 1% honeycombing, 20% ground-glass opacity, 5% Vessels, and 29% ILD. B, i-iiii Same patient after 1-year of follow-up without treatment. Mean visual scores of the CT: 25% reticulation, 20% honeycombing, no ground-glass opacity, fibrotic score 45%. CALIPER characterized 16% reticular pattern, 1% honeycombing, 34% ground-glass opacity, 8% Vessels and 51% ILD.

A B

Figure 17. Axial CT slices, axial CALIPER-derived color image overlays, 3-dimensional (3D) CALIPER coronal rendering and Glyph of the lung parenchymal pattern as various colors (dark green = normal lung, light green = mild LAA, yellow = ground-glass opacity, orange = reticular pattern, brown = honeycombing). A, i–iiii, Imaging results of a 79-year-old male no smoker, with IPF. Mean visual scores of the CT: 20% reticulation, 15% honeycombing, no ground-glass opacity, fibrotic score 35%. CALIPER characterized 9% reticular pattern, 1% honeycombing, 20% ground-glass opacity, 5% Vessels, and 29% ILD. B, i-iiii Same patient after 1-year of follow-up without treatment. Mean visual scores of the CT: 25% reticulation, 20% honeycombing, no ground-glass opacity, fibrotic score 45%. CALIPER characterized 16% reticular pattern, 1% honeycombing, 34% ground-glass opacity, 8% Vessels and 51% ILD.

A B

ViosualiozzaziooneClassiofcaziooneLocaliozzazioone

RU=LSDxRM=LMRL=LIDxLU=LSSnLM=lingulaLL=LISn

Right Left % volume

Normal 650cc 920cc 50%

Ground Glass 500cc 700cc 38%

Reticular 150cc 100cc 8%

Honeycombing 70cc 40cc 3.5%

Low Attenuation 0cc 0cc 0%

Pulmonary Vessel 100 cc 70 cc 5.4%

SeriesDesc StudyDate Scanner Recon SliceThickness

Total_MildLA

Total_ModerateLA

Total_SevereLA Total_GG Total_HC Total_N Total_R Total_Vess Total_

Volume

SOFT 1.25 20200316 GE MEDICAL SOFT 1.25 1446.95 1.20 0.12 365.73 0.33 2736.64 212.27 177.69 4940.93

PRIMA TC16/03/2020Il pz ha un volume totale di 4940 ml e di questo 365 ml di ground-glass e 212 ml di retcolazione. Il suo polmone normale è circa 4200 ml. Il volume dei vasi é di 178 ml

Normale Miold LAAGround Glass Retcolazioone Honey-

combiong Severe LAAModerate LAA

SECONDA TC23/03/2020Dopo una setmana di terapia il pz ha un volume totale di quasi 5300 ml (dovuto alla riduzione dei consolidament dovut al COVID e non inclusi nel volume in esame, 548 ml di ground-glass derivato dal miglioramento delle aree di retcolazione che infat misurano 135 ml. Il suo polmone normale é circa 4500 ml. Il volume dei vasi è sceso a 156 ml

SeriesDesc StudyDate Scanner Recon SliceThickness

Total_MildLA

Total_ModerateLA

Total_SevereLA Total_GG Total_HC Total_N Total_R Total_Vess Total_

Volume

SOFT 1.25 20200323 GE MEDICAL SOFT 1.25 1819.01 0.91 0.12 548.91 0.09 2638.14 135.73 156.14 5299.05

Normale Miold LAAGround Glass Retcolazioone Honey-

combiong Severe LAAModerate LAA

PRIMA TC16/03/2020

SECONDA TC23/03/2020

Si nota la riduzione di densità del consolidamento dovuto al COVID che nella prima TC appare arancione (retcolazione), mentre nella seconda maggioremente giallo (ground-glass)

PRIMA TC16/03/2020

SECONDA TC23/03/2020

Di nuovo si ossera la riduzione delle aree arancioni (retcolazione), che si «trasforma» in giallo (ground-glass)