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Randomized Comparison of Adjuvant Aromatase Inhibitor <br />Exemestane plus Ovarian Function Suppression<br /> vs Tamoxifen plus Ovarian Function Suppression<br />in Premenopausal Women <br />with Hormone Receptor Positive Early Breast Cancer: <br />Joint Analysis of IBCSG TEXT and SOFT Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

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Randomized Comparison of Adjuvant Aromatase Inhibitor Exemestane plus Ovarian Function Suppression vs Tamoxifen plus Ovarian Function Suppressionin Premenopausal Women with Hormone Receptor Positive Early Breast Cancer: Joint Analysis of IBCSG TEXT and SOFT. - PowerPoint PPT Presentation

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Page 1: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Randomized Comparison of Adjuvant Aromatase Inhibitor <br />Exemestane plus Ovarian Function Suppression<br /> vs Tamoxifen plus Ovarian Function Suppression<br />in Premenopausal Women <br />with Hormone Receptor Positive Early Breast Cancer: <br />Joint Analysis of IBCSG TEXT and SOFT

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 2: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

TEXT and SOFT

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 3: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

TEXT and SOFT Worldwide Collaborative

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 4: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Premenopausal Endocrine Therapy

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 5: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

TEXT - SOFT Trials<br />Aromatase Inhibitor Question

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 6: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

TEXT and SOFT Designs

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 7: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Eligibility

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 8: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Treatments

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 9: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Study Procedures

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 10: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Endpoints

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 11: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Statistical Considerations

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 12: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Characteristics

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 13: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Exemestane+OFS Improved DFS

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 14: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Sites of First Failure

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 15: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Exemestane+OFS Reduced Recurrence

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 16: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Women Who Did Not Receive Chemotherapy

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 17: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Women Who Received Chemotherapy

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 18: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Selected Adverse Events

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 19: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Adverse Events and QOL

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 20: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Conclusions

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 21: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

More from TEXT and SOFT

Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Page 22: Presented By Olivia Pagani at 2014 ASCO Annual Meeting

Slide 22

Presented By Olivia Pagani at 2014 ASCO Annual Meeting