Primer on the Olfactory Bulb and Antennal Lobe

Brief comparative introduction of:

• Neurons• Synaptic interactions

Olfaction: common evolutionary problems…

…common solutions

The AL and OB: Macroscopic Relations

Brain nerve I

OB projects to various brain centers

J. H. Martin, 1989

The Mammalian Sensory Epithelium

L. Buck and R. Axel (1991)Cell 65, 175-187

Fascicles

Each olfactory receptor neuron (ORN) expresses only one gene coding an odorant receptor protein.

G. M. Shepherd, 2004

The Insect Sensory Epithelium

OB Intrinsic (local) and Principle (output) Neurons

Synaptic interactions within the OB glomeruli

PN (output)+ +

+

cholinergic ORN input

BMI-sensitiveReceptors:

GABAergic LN’s

AL glomerulus

–

D.2.2.1D.2.3.1D.2.3.3

AL’s

Synaptic interactions within the AL glomeruli

AL Intrinsic (local) and Principle (output) Neurons

AL MB

LH

-

-

+

+

+

+

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