Proposal uji antikanker ekstrak metanol daun teh hijau terhadap kanker fibrosarcoma

7/23/2019 Proposal uji antikanker ekstrak metanol daun teh hijau terhadap kanker fibrosarcoma

1/16

_HK MLUKBMLBO^ OBQU^MB IOUMLD@ EM_L UOG GKHM_ UO^GMEMS

BMLBO^ FKN^DQMÂDIM SMEM IOLAKU NOUKLM JM@_^ QZKQQ GMQK@

KLE_BQK NOLXD'M+SKÔL

S^DSDQM@

Ekmhbml lub ioiolgk ujmq eml ioòljbmsk q{m~mu em`mi ioloisg b`kmg Kild`djk

Ekqql dòg 8

Zmlem Kle~kmlk Zkndzd '3;7==5331+

Boll{ {ml @kimlud '3;7==5336+

Hdgmloq Su~m Z '3;7==53=3+

Hkii{ Skouo~ Agm '3;7==53=7+

@odlm~eq Lkud B '3;7==53=;+

Udsml F Smiljbmq '3;7==53>>+

FMB_@UMQ FMÎMQK

_LKVO^QKUMQ QMLMUM EGMÎM

[DJ[MBMÛM

>3==


2/16

NMN K

SOLEMG_@_ML

=,= @mum~ No`mbmlj

Uog mem`mg qmu sk`kgml lub gkes ònkg qogmu Nml{mb bgmqkmu {mlj nkqm

ekemsmubml em~k uog klk No~emqm~bml s~dqoq soinmuml uog, uo~emsmu ukjm gmqk` {mku uog

gkhm 'ukemb ekfo~iolumqk+, uog dd`dlj 'qoik)fo~iolumqk+, eml uog gkumi 'fo~iolumqk

solg+ Lmil qemg nml{mb solo`kukml {mlj ioinbukbml imlfmmu qogmu em~k uog gkhm

eml ~osumqk uog gkhm sl hmek iolelkm No~nmjmk solo`kukml iollhbbml nmgzm uog

gkhm klk imis iolaojmg sol{mbku bmlbo~, sol{mbku hmlulj, eml mlobm sol{mbku jm{m

gkes ideo~l

Imlfmmu qogmu uog gkhm klk ekbm~olmbml ek em`mi uog gkhm nml{mb ioljmlelj

xmu {mlj no~imlfmmu nmjk boqogmuml ung {mku qm`mg qmul{m mem`mg qol{mzm sd`kfold`

Qol{mzm sd`kfold` klk io`ksuk f`mvdld`, f`mvdl, f`mvmldl, mludqkmlkekl, bmuobkl, eml

nkf`mvml eml ònkg `m~u em`mi jd`dljml m`bdgd` imbm em~k ku ekjlmbml ioumld` eml

b`d~dfd~i qonmjmk so`m~ul{m U~lml em~k bmuobkl qoso~uk oskamuogakl 'OA+, oskjm``d)

amuogakl 'OJA+, oskjm``d)amuogakl jm``muo 'OJAj+, eml }o~aoukl OJAj eml }o~aoukl

io~smbml mlukdbqkeml {mlj bmu eoljml bobmuml 5)? bm`k ònkg ukljjk eknmlekljbmlvkumikl O eml A {mlj hjm io~smbml mlukdbqkeml sduolqkm` Mlukdbqkeml qolek~k

ekboumgk imis ioljgklem~bml qo` em~k bo~qmbml

Em~k solo`kukml {mlj qemg ek`mbbml hjm ioino~kbml nbuk bmu uolumlj

nkdmbukvkumq sd`kfold` uog gkhm ekimlm emsmu ioljmubml qkquoi kilkumq, {mku

ioinmlu s~dqoq fmjdqkudqkq qo`, iolkljbmubml qob~oqk KLF) eml ~oqsdl s~d`kfo~mqk

`kifdqku Qob~oqk KLF) klk {mlj iolkljbmubml mbukvkumq fmjdqku qogkljjm iolkljbmubml

bmem~ lku~ku dbqkem 'LD+ hjm {mlj ekobqb~oqkbml dòg fmjdqku

Lku~ku dbqkem 'LD+ klk eknolub ek em`mi qo` fmjdqku {mlj uo~ek~k em~k fmjdqku

idldlbòm~ 'imb~dfmj em`mi hm~kljml ung eml idldqku em mi qk~b`mqk em~mg+,

qojiol lou~dfk` SIL 'sd`kid~fdlbòm~+, eml oqkldfk` 'em`mi hi`mg boak`+ Lku~ku

dbqkem 'LD+ ioik`kbk nml{mb bojlmml {mku qm`mg qmul{m qonmjmk solkljbmuml qkquoi

kil ung LD emsmu ioinlg qo` eoljml am~m fmjdqkudqkq, hmek msmnk`m qoimbkl

iolkljbmu bmem~ LD imbm s~dqoq fmjdqkudqkq mbml qoimbkl aosmu


3/16

=,> îqml Imqm`mg

No~emqm~bml `mum~ no`mbmlj ekmumq imbm imqm`mg em`mi solo`kukml klk ek~iqbml

qonmjmk no~kbu8

m Msmbmg soino~kml obqu~mb ioumld` eml uog gkhm emsmu ioisoljm~gk so~uingml

qo` bmlbo~fkn~dqm~adim smem iolaku nouklm jm`~ Qzkqq gmqk` klebqk nolxd'm+sk~ol

=,1 Uhml Solo`kukml

m Uhml ii

Solo`kukml klk no~uhml lub ioinbukbml soljm~g soino~kml obqu~mb

ioumld` eml uog gkhm uo~gmems so~uingml qo` bmlbo~ fkn~dqm~adim smem iolaku

nouklm jm`~ Qzkqq gmqk` klebqk nolxd'm+sk~ol

n Uhml bgqq

= Ioljb~ so~uingml qo` bmlbo~ fkn~dqm~adim smem iolaku nouklm jm`~

Qzkqq gmqk` klebqk nolxd'm+sk~ol qonoì so~`mbml

> Ioljb~ so~uingml qo` bmlbo~ fkn~dqm~adim smem iolaku nouklm jm`~

Qzkqq gmqk` klebqk nolxd'm+sk~ol qouo`mg soino~kml obqu~mb ioumld` eml uog

gkhm qonml{mb 6 bm`k sol{lukbml eoljml kluo~vm` zmbu > gm~k qobm`k

1 Ioljmlm kqkq so~noemml so~uingml qo` bmlbo~ fkn~dqm~adim smem iolakunouklm jm`~ Qzkqq gmqk` klebqk nolxd'm+sk~ol qonoì eml qoqemg so~`mbml

=,5 Imlfmmu Solo kukml

Solo`kukml klk ekgm~msbml emsmu no~imlfmmu8

m _lub solo`kuk 8 iolminmg bgmqmlmg bokìzml solo kuk uolumlj mbukvkumq mlukbmlbo~

em~k obqu~mb ioumld` eml uog gkhm uo~gmems soljgminmuml so~uingml qo` bmlbo~

fkn~dqm~adim smem iolaku nouklm jm`~ Qzkqq gmqk` klebqk nolxd'm+sk~ol

n _lub imq{m~mbmu 8 ioino~kbml klfd~imqk bosmem imq{m~mbmu uolumlj sduolqk

bmleljml uog gkhm qonmjmk ikliml boqogmuml {mlj emsmu iolaojmg uingl{m

bmlbo~


4/16

NMN KK

SOLO@MMGML S_QUMBM

>,= Uog gkhm

>,=,= Qobk`mq uolumlj uog gkhm

Uog gkhm ioljmlelj vkumikl A eoljml edqkq ukljjk eml vkumikl

`mkll{m em`mi hi`mg qoekbku Qogkljjm eoljml ikli uog, bkum emsmu iolhmjm

bdlekqk qumiklm ung Bmleljml imljml {mlj uo~emsmu smem uog gkhm emsmu

ioinmlu solj~mkml j`m iolhmek olo~jk, qogkljjm nkqm ioinmlu iolhmjm

bmem~ j`m em`mi em~mg Uog gkhm ioljmlelj xmu mbukf no~sm mlukdbqkeml

m`mik Gm` klk ioinmu uog gkhm {mlj ekbdlqiqk imis io`kleljk qo`)qo`

ung em~k no~nmjmk soljm~g ~mekbm` nonmq {mlj no~so~ml noqm~ iolkin`bml

bmlbo~, sol{inmuml soin`g em~mg, eml jmljjml hmlulj Bmleljml `mkl

{mlj no~imlfmmu em~k uog gkhm km`mg sd`kfold`, {mlj emsmu ioinmlu

ioljgm`mljk so~uingml qo` bmlbo~ b`ku 'Mldlki, >3==+

Bgmqkmu umim uog no~mqm` em~k qol{mzm sd`kfold` {mlj ekbmleljl{m

Ek em`mi ung, qol{mzm klk ioinmlu bo~hm olxki Qso~dwkeo Ekqiumqo

'QDE+ {mlj no~fljqk iol{kljbk~bml ~mekbm` nonmq Qoso~uk ekboumgk, ~mekbm`nonmq {mlj ekgmqk`bml s~dqoq dbqkemqk ek em`mi ung no~nmgm{m nmjk

boqogmuml bm~olm ioljgminmu m`k~ml em~mg 'Q{mg, >336+

Uog gkhm iolhmek qmljmu no~bgmqkmu bm~olm ioljmlelj Amuoagkl

sd`{sgold`2 qoholkq mlukdbqkeml {mlj qmljmu bmu, qogkljjm nkmq iolobml

so~uingml qo` bmlbo~, umlsm io~qmb hm~kljml {mlj qogmu _lq~ sd`{sgold`

{mlj qmim hjm ekboumgk ofobukf iol~lbml bmem~ @E@ eml ioiso~nmkbk qkfmu

soinobml em~mg {mlj ukemb ld~im` 'Mldlki, >3==+

Uog gkhm hjm emsmu iolkljbmubml qob~oqk KFL) eml ~oqsdlq

s~d`kfo~mqk `kifdqku, qo~um boimisml fmjdqkudqkq eml qob~oqk K@)=> imb~dfmj

smem iolaku {mlj ekkldb`mqk @ idlda{udjoloq Nmbuo~k klu~mqo`ò~ qoso~uk

@idlda{udjoloq, iolquki`mqk qob~oqk K@)=> {mlj ioljmbukfbml qo` LB qo~um

iolquki`mqk so~boinmljml qo` Ug= eml qo` AE7 AU@q Boukjml{m iolqob~oqk

KFL) {mlj mbml ioljmbukfbml fmjdqku qogkljjm fmjdqku emsmu ioinlg

nmbuo~k klu~mqo`ò~ uo~qonu Fmjdqku uo~mbukfmqk ioinlg nmbuo~k io`m`k

iobmlkqio fmjdqkudqkq, boiekml ioinolub ^DK 'ômaukvo Dw{jol


5/16

Kluo~ioekmuoq+ {mlj qm`mg qmul{m no~sm gke~djol so~dbqkem 'G>D>+ eml Lku~ku

Dbqkem 'LD+ lub ioljgmla~bml nmbuo~k {mlj ekfmjdqku 'Mldlki, >3==+

>,=,> Qol{mzm mbukf em`mi uog gkhm

Ek em`mi uog gkhm uo~emsmu oskamuogakl jm` muo 'OAJ+, oskjm``d)

amuogakl 'OJA+, oskjm``d)amuogakl jm` muo 'OJAj+, jm``d)amuoagkl, eml

amuoagkl Amuoagkl 'sd`kfold`+ mem`mg mlukdbqkeml {mlj bmu, ònkg bmu

em~ksmem vkumikl O, A, eml )bm~duol 'Q{mg, >336+

Gmqk` quek _Q Lmukdlm` Amlao~ Klqukuuo, bmleljml Amuoagkl em`mi

sd`kfold` {mlj uo~emsmu em`mi uog gkhm ioik`kbk so~mlml soluklj em`mi

solaojmgml bmlbo~ OJAj mem`mg u~lml em~k Amuoagkl Bmem~ mlukdbqkemll{m

5)? bm`k ònkg ukljjk eknmleklj vkumikl O eml A {mlj emsmu ioljgminmu

so~uingml qo` bmlbo~ OJAj imis ioinlg qo` bmlbo~ umlsm

ioinmgm{mbml hm~kljml qo` qogmu ek qobkum~l{m 'Gmqml eml Lkgm`, >33;+

>,=,1 Ofob uog gkhm uo~gmems bmem~ LD

Nono~msm solo`kukml qonoìl{m uo`mg ioino~kbml nbuknbuk {mlj

bmu ioljolmk nkdmbukvkumq em~k sd`kfold` uog gkhm em`mi iolkljbmubml qkquoi

kilkumq, {mku ioinmlu s~dqoq fmjdqkudqkq, iolkljbmubml qob~oqk KLF) eml

~oqsdl s~d`kfo~mqk kifdqku 'Q`mlkljqkg, >331+Iolkljbmul{m nkdmvmknk`kumq OJAj smem s`mqim qouo`mg ioljbdlqiqk

uog gkhm, mbml ekkbuk eoljml solkljbmuml kildide`mqk em~k OJAj Smem

bol{mummll{m, bkum ioljoumgk nmgzm OJAj qmljmu sduolqkm` em`mi

iolquki`mqk s~debqk kluo~òbkl)= m`sgm 'K@)= +, kluo~òbkl)= noum 'K@)= +,

uid~ loa~dqkq fmaud~ m`sgm 'ULF) +, OJAj hjm emsmu ioinmlu s~dqoq

fmjdqkudqkq, iolkljbmubml boumgmlml `kifdqku, s~d`kfo~mqk `kifdqku, eml qob~oqk

K@)=> imb~dfmj 'Bmuxud, >33:+

Uog gkhm hjm iolkljbmubml qob~oqk kluo~fo~dl , {mlj iol{onmnbml

solkljbmuml mbukvkumq fmjdqku Eoljml eoikbkml imbm uo~hmek solkljbmuml

qob~oqk Lku~djol Dbqkem 'LD+ {mlj ekgmqk`bml dòg fmjdqku 'Bmuxud, >33:+

>,> Qkquoi Kilkumq

>,>,= Qkquoi kil ung

Kilkumq io~smbml qmu iobmlkqio fkqkd`djkq {mlj no~sm

boimisml lub ioljolm` qmu xmu mqklj uo~gmems ek~kl{m {mlj qo`mlhul{m

ung mbml ioljmembml ~oqsdl kil {mlj no~nolub lou~m`kqmqk, ioòl{msbml


6/16

mum ioimqbbml em`mi ioumnd`kqio eoljml mbknmu ioljluljbml ek~kl{m

mum iolkin`bml bo~qmbml hm~kljml ung qolek~k 'B~oqld, >33=+

Qkquoi kil ung uo~ek~k em~k nml{mb bdisdlol Qoim bdisdlol

uo~qonu mbml nobo~hm qoam~m qo~olumb imlmbm`m ung iolemsmubml qo~mljml

em~k sol{mbku {mlj no~mqm` em~k `m~ ung imsl em~k em`mi ung bkum

qolek~k 'Mldlki, >336+

Nmbuo~k iolquki`mqk imb~dfmj lub iolqob~oqk K@)=> {mlj

ioljmbukfbml qo` LB, qo~um iolquki`mqk so~boinmljml qo` Ug= eml

ioljmbukfbml qo` U AE7 Boukjm holkq qo` uo~qonu iolqob~oqk Kluo~fo~dl

Jmiim 'KFL) + {mlj ioljmbukfbml fmjdqku iois~debqk dbqkjol ~ombukf,

iolquki`mqk s~debqk mlukndek eml ioljdsqdlkqmqk nmbuo~k eoljml uhml

mbgk~ ioinmlu fljqk ofobud~ fmjdqku '^dkuu, >33=+

>,>,> Fljqk qkquoi kil ung

Fljqk em~k qkquoi kil mem ukjm imami, {mku8

m So~umgmlml ung, {mku iolmljbm` nmgml no~nmgm{m mjm~ ung ukemb

qmbku, eml hkbm qo`)qo kil {mlj no~ujmq lub so~umgmlml klk

iolemsmubml jmljjml mum ukemb nobo~hm eoljml nmkb, imbm d~mlj mbml

iemg uo~bolm qmbkun Boqokinmljml, mum fljqk gdiodqumukb m~ukl{m iolhmjm boqokinmljml

em~k bdisdlol ung

a So~dlemml, qonmjkml em~k qo`)qo` kil ioik kbk boimisml lub

io~dlem bo qo`~g nmjkml ung Hkbm mem qo`)qo` ung {mlj ioljm`mik

iumqk imbm qo` so~dlem uo~qonu mbml ioinklmqmbmll{m 'Mldlki, >336+

>,1 Lku~ku Dbqkem

>,1,= Qkluoqm Lku~ku Dbqkem

Lku~ku Dbqkem eks~debqk dòg m~jklkl {mlj ioljmlelj dbqkjol ~ombukf

{mlj qmljmu no~mal lub ikb~dd~jmlkqio eks~debqk em`mi hi`mg noqm~

eoljml mbukvmqk imb~dfmj Qonm`kbl{m, ukljbmu ~olemg LD ekgmqk bml qoam~m

bdlqukuukf dòg qo oledugo`kmu, eml ioimklbml so~ml blak em`mi ~oj`mqk

lmem soin`g em~mg 'S`m{fmk~ ou m`, >33;+

Lku~ku Dbqkem mem`mg qmu qol{mzm no~nolub jmq em`mi em~mg {mlj

soluklj em`mi iollhmlj no~nmjmk fljqk fkqkd`djkq ung imim`km Lku~ku

Dbqkem ekbolm` qonmjmk qol{mzm {mlj io~o`mbqmqk soin`g em~mg

'Oledugo`ki Eo~kvoe ô`mwklj Fmaud~+ OE^F ekqkluoqm qoam~m m`mik em~k


7/16

mqmi mikld m~jklkl eml dbqkjol io`m`k olxki Lku~ka Dwkeo Q{lugmqo 'LDQ+

'Mldlki, >3==+

Lku~ku Dbqkem eknolub ek ukms hm~kljml qo`, qo`)qo` soin`g em~mg eml

qo` q{m~mf qsoqkfkb ek dumb S~debqk Lku~ku Dbqkem em`mi hi`mg {mlj qokinmlj

eml qoqmk ekso~`bml ung mjm~ bdlu~mbqk eml soònm~ml soin`g em~mg

imlqkm no~`mljqlj qoam~m dsukim` eml uo~mu~ qogkljjm m`k~ml em~mg bo

qo`~g 'Mldlki, >3==+

>,1,> Fljqk Lku~ku Dbqkem

Lku~ku Dbqkem mem`mg lku~djol idldbqkem {mku qol{mzm bkikm eoljml

fd~i`m bkikm LD Qm`mg qmu fljqk LD ek em`mi ung mem`mg qonmjmk

vmqdek`mud~ Vmqdek`mud~ mem`mg boimisml lub ioònm~bml soin`g

em~mg Iobmlkqio bo~hm LD io`m`k quki`mqk mum ~mljqmljml jmlk`mu qkb`mqo

{mlj io~smbml olxki gouo~deklmikb eoljml soinolubml em~k aJIS

aJIS mbml ioljmbukvmqk s~duokl bklmqo eml iol{onmnbml eofdqfd~k`mqk em~k

~mlumk ikdqkl {mlj ioljmbknmubml ~o`mbqmqk em~k qo` dudu sd`dq 'Mldlki,

>3==+

Lku~ku Dbqkem 'LD+ ioisl{mk nml{mb imlfmmu nmjk ung, qm`mg qmu

{mlj uo~soluklj mem`mg so~mlmll{m em`mi qkquoi kil ung LD nobo~hm qmimeoljml `kqdqdi imb~dfmj lub ioinlg smudjol qoso~uk nmbuo~k, hmi~ eml

vk~q Umlsm ekqmem~k, LD kbu ioinmlu io`kleljk ung em~k nmbuo~k {mlj

imqb io`m`k qm`~ml solao~lmml F`d~m ld~im` {mlj gkes smem ~dljjm

iù eml bo~dljbdljml ioljbdlvo~qkbml lku~mu em`mi imbmlml iolhmek

lku~ku {mlj mbml eknmg iolhmek LD qmmu uo~smsm~ mqmi `minlj LD klk mbml

ioinlg gmisk~ qo`~g biml smudjol {mlj uo~uo`ml no~qmim imbmlml

'Mldlki, >3==+

>,1,5 Soljm~g LD Uo~gmems Qkquoi Kil

ômaukvo Dwkjol Kluo~ioekmuo '^DK+ io~smbml ~mekbm` qso~dbqkem,

gke~djol so~dbqkem, ~mekbm` gke~dbqk` eml qkljòu dbqkjol ^DK qmljmu ~ombukf

qogkljjm emsmu ioinlg nmbuo~k eml ioljgmla~bml qo` qo`l{m Em`mi

s~dqoq uo~qonu bonugml dbqkjol iolkljbmu, qogkljjm s~dqoql{m ekqonu

~oqsk~mud~{ n~qu Nmbuo~k {mlj imqb bo em`mi fmjdqdi eml iol{mu eoljml

`kqdqdi mbml ioinolub fmjd`kqdqdi Smem s~dqoq klk uo~hmek ~oqsk~mud~{ n~qu

eml ekekjoquk dòg olxki `kqdqdi Olxki `kqdqdi no~ujmq iolao~lm f~mjiol

qo` nmbuo~k qouo`mg uo~kluoj~mqk 'Qqk`mlkljqkg, >331+


8/16

ômaukvo Lku~ka Kluo~ioekmuo '^LK+ no~so~ml smem fmqo mzm` em~k

mbukvmqk mluk nmbuo~k imb~dfmj [mlj uo~imqb em`mi ^LK mem`mg LD, lku~ku

eml lku~mu Eoljml meml{m Kleaknò Lku~ka Dwkeo Q{lugmqo ' kLDQ + mbml

uo~nolub LD em~k s~ob~qd~ @)m~jklkl em~k imb~dfmj {mlj uo~mbukfmqk Eoljml

meml{m D>, kLDQ {mlj uo`mg no~kbmuml eoljml bdfmbud~ uou~mgke~dnkdsuo~kl

mbml ioljnmg `m~jklkl iolhmek qku~`kl eml LD LD klk`mg {mlj ioisl{mk

mbukvkumq mlukikb~dnm 'Qqk`mlkljqkg, >331+

Qo`mkl ~ombqk ekmumq, qklo~jk ^DK eml ^LK emsmu ioinolub

mlukikb~dnm {mlj ònkg udbqkb Adludgl{m mem`mg LD {mlj no~ombqk eoljml

qkljòu dbqkjol mbml ioinolub so~dbqklku~ku 'DLDD)+ So~dbqklku~ku mem`mg

qmu dbqkeml {mlj emsmu io~qmb `kske, s~duokl eml nmgbml ELM nmbuo~k

'N~mumzkhm{m, =;;6+

>,5 Bmlbo~

>,5,= Qo` bmlbo~

Bmlbo~ uo~hmek bm~olm meml{m so~nmgml iolemqm~ em`mi fkqkd`djk qo`

{mlj mbgk~l{m uing iolhmek im`kjlml qo~um ioisl{mk ak~k)ak~k ii

qonmjmk no~kbu8 '=+ imlek~k em`mi qkjlm` so~uingml, '>+ ukemb sobm uo~gmems

qkjlm` mlukso~uingml, '1+ ioljgklem~k msdsudqkq, '5+ ioik`kbk sduolqk~os`kbmqk {mlj ukemb uo~nmumq, '?+ mljkdjoloqkq, '6+ klvmqk eml ioumqumqo bo

hm~kljml `mkl 'Imlmgml eml Zko~no~j, >33>+

>,5,> Ioudeo hk mbukvkumq mlukbmlbo~

Qm`mg qmu ioudeo lub ioljhk mbukvkumq mlukbmlbo~ em~k nmgml

nmgml nkdmbukf umlmiml mem`mg eoljml gozml adnm iolaku {mlj eknmu

ioleo~kum bmlbo~ eoljml nono~msm kleao~mlum~m `mkl8 nolxd'm+sk~ol, L)iouk`)

L)lku~dqd~om, 1)iouk`bd`mlu~ol Ovm`mqk mbukvkumq mlukbmlbo~l{m emsmu

ekjlmbml sm~miouo~ soljgminmuml so~uingml eml mlmudik em~k gkqsmud`djk

hm~kljml bmlbo~ 'Zdo~eolnmj ebb, =;7:+

>,? Msdsudqkq

Msdsudqkq io~smbml s~dj~mi nlg ek~k em~k qonmg qo` S~dj~mi klk

ioik`kbk so~ml {mlj soluklj lub iolhmjm gdiodqumukq so~boinmljnkmbml qo` eml

eoljml meml{m ekq~oj`mqkl{m nkqm no~mbknmu ukin`l{m imami)imami sol{mbku

'Ovml eml @kuòzdde, =;;7+

Qm`mg qmu so~ml solukljl{m mem`mg lub ioinmumqk s~d`kfo~mqk qo` {mlj ukemb

ekso~`bml {mlj qobk~ml{m mbml emsmu iol{onmnbml bmlbo~ Smem qo`)qo` bmlbo~


9/16

s~dj~mi msdsudqkq klk uo`mg ioljm`mik jmljjml qogkljjm qo` mbml ioljm`mik

ioumqumqkq 'Souo~ ou m`, =;;:+

Msdsudqkq emsmu ekmimuk smem solmismbml fkqkd`djkq, mlum~m `mkl no~sm

soljo~uml qo`, bo~qmbml smem s`mqim ioin~ml eml meml{m bdleolqmqk b~dimukl

Ukemb qoso~uk smem lob~dqkq qo`, qo`)qo` {mlj ioljm`mik msdsudqkq ukemb bogk`mljml

bmleljml kluo~lm` qo` eml ukemb iol{onmnbml ~oqsdl klf`mimqk Nk`m s~dj~mi

msdsudqkq uo`mg qoòqmk smem qonmg qo` imbm mbml iolkljjm`bml boskljml qo` imuk

{mlj ekqonu nmeml msdsudqkq {mlj mbml ekbolm`k dòg qo` imb~dfmj eml ekimbml

'olj`foe+ 'Souo~ ou m`, =;;:+

>,6 Lods`mqim

Lods`mqim km`mg imqm hm~kljml {mlj mnld~im`, uing no~ònkgml, ukemb

uo~bdd~eklmqk eoljml hm~kljml ld~im` eml uing uo~q)iolo~q ioqbksl ~mljqmlj

{mlj iolkin`bml uo`mg gk`mlj 'Mldlki, >3==+

>,: Bo~mljbm Uod~k


10/16

>,7 Bo~mljbm Bdlqos

So~uingml qo` bmlbo~ ekgminmu


11/16

NMN KKK

IOUDED@DJK SOLO@KUKML

1,= Iouded`djk Solo`kukml

Solo`kukml klk io~smbml solo`kukml }mqk obqso~kiolum` eoljml ~mlamljml

Sdqu Uoqu Eoqkjl Iolaku nouklm {mlj ioisl{mk no~mu >3)>? j~mi boiekml

ekklebqk mjm~ uo~bolm bmlbo~ boiekml ekno~kbml obqu~mb ioumld` eml uog gkhm

qonml{mb 6 bm`k sol{lukbbml eoljml kluo~vm` zmbu > gm~k qobm`k Soljb~ml

mbukvkumq mlukbmlbo~ em~k obqu~mb ioumld` eml uog gkhm ek`mbbml eoljml io`kgmu

so~boinmljml qo` bmlbo~fkn~dqm~adim qonoì eml qoqemg soino~kml so~`mbml

1,> Vm~kmno` solo`kukml

1,>,= Vm~kmno` nonmq

Vm~kmno` nonmq em`mi solo`kukml klk mem`mg soino~kml obqu~mb ioumld`

eml uog gkhm qonml{mb 6 bm`k sol{lukbbml eoljml kluo~vm` zmbu > gm~k

qobm`k

1,>,> Vm~kmno` uo~jmlulj

Vm~kmno` uo~jmlulj em`mi solo`kukml klk mem`mg so~boinmljml qo`

bmlbo~fkn~dqm~adim1,1 Eofklkqk dso~mqkdlm`

1,1,= Edqkq obqu~mb ioumld` eml uog gkhm mem`mg edqkq sd`kfold` uog gkhm ekso~dòg

eoljml ioljobqu~mb qo~nb eml uog gkhm em`mi so`m~u ioumld`

1,1,> Iolaku nouklm jm`~ Qzkqq mem`mg iolaku nouklm {mlj ioisl{mk jm`~ Qzkqq

eoljml ndndu >3)>? j~mi {mlj ekso~dòg em~k @mnd~mud~ki Kidld

1,1,1 Sd`kfold` uog gkhm mem`mg qol{mzm mbukf em~k uog gkhm {mlj ioljmlelj uhg

imami nolubamuoagkl eml no~imlfmmu qonmjmk mlukdbqkeml

1,1,5 Soino~kml sd`kfold` uog gkhm io~smbml soino~kml sd`kfold` uog gkhm em`mi

nolub obqu~mb ioumld` eml uog gkhm eoljml edqkq :? ij$ bjNN2 =?3 ij$

bjNN2 133 ij$ bjNN {mlj ekno~kbml qonml{mb 6 bm`k sol{lukbbml eoljml

kluo~vm` zmbu > gm~k qobm`k

1,1,? Bmlbo~ mem`mg qojd`dljml sol{mbku {mlj ekumlemk eoljml soino`mgml qo` {mlj

ukemb uo~bolem`k eml boimisml qo`)qo` uo~qonu lub iol{o~mlj hm~kljml

nkd`djkq `mkll{m, nmkb eoljml so~uingml `mljqlj ek hm~kljml {mlj

no~qono`mgml 'klvmqk+ mum eoljml ikj~mqk qo` bo uoismu {mlj hmg 'ioumqumqkq+


12/16

1,5 M`mu eml Nmgml

1,5,= Nmgml

Eml uog gkhm ekso~dòg em~k smqm~ No~kljgm~hd, [dj{mbm~um Eml uog

gkhm {mlj ekbis`bml mem`mg eml uog gkhm em`mi bomemml qojm~ Eml uog

gkhm boiekml ek~mhmlj boak`)boak` boiekml ekbo~kljbml eml ekqo~nb

eoljml m`mu sol{o~nb iobmlkb qogkljjm ekso~dòg qo~nb eml uog gkhm

Gozml hk {mlj ekjlmbml em`mi solo`kukml klk mem`mg iolaku sukg

nouklm jm`~ Qzkqq {mlj no~i~ qobkum~ em n`ml, eoljml no~mu >3)>? j~mi

{mlj ekso~dòg em~k @mnd~mud~ki Kidld, Fmbùmq Fm~imqk, [dj{mbm~um

Nmgml)nmgml bkikm {mlj ekjlmbml no~sm gobqml, b`d~dfd~i,

ioumld`, AIA)Lm no~eo~mhmu i~lk so~ombqk ekso~dòg em~kOIo~ab

1,5,> M`mu

M`mu)m`mu {mlj ekjlmbml mlum~m `mkl qoso~mljbmu m`mu jo`mq, ikb~dqbds,

~dum~{ ovmsd~mud~, qsku klhobqk, eml skqm noemg

1,? Emum {mlj ekbis`bml

Emum {mlj ekbis`bml io~smbml emum s~kio~ gmqk` soljb~ml ek

`mnd~mud~ki

1,6 M`~ solo`kukml1,6,= Soinmuml obqu~mb ioumld`

Obqu~mb ioumld` ekso~dòg eoljml hm`ml obqu~mbqk ekljkl 'imqo~mqk+

em`mi nohmlm uo~uus eoljml nono~msm so`m~u qoam~m no~umgms So`m~u

so~umim {mlj ekjlmbml mem`mg gobqml, eoljml io~olemi 733 j~mi qo~nb

em`mi 533 i@ gobqml qo`mim >5 hmi qmink` qobm`k)qobm`k ekmeb eml

boiekml qm~k gobqml ekqm~klj eoljml ad~dlj Naglo~ Soljo~hmml klk ek`mlj)

`mlj gkljjm fkù~mu no~zm~lm ho~lkg Mismq qo~nb ekmljkl)mljklbml qmismk

bo~klj boiekml ek`mbbml am~m {mlj qmim lub so`m~u b`d~dfd~i Em~k

mismq obqu~mbqk eoljml b`d~dfd~i uo~qonu boiekml ekimqo~mqk eoljml

so`m~u ioumld` Qo`mlhul{m qm~k ioumld` {mlj ekso~dòg ekmsbml ek nmzmg

uobmlml em~m {mlj ek~oebqk 'vmai ovmsd~mukdl+ qogkljjm ekso~dòg obqu~mb

bo~klj

1,6,> _hk Mlukbmlbo~ eoljml Bmlbo~ Fkn~dqm~adim Iolaku

1,6,>,= Sol{kmsml qmiso`

Qoekmml nmgml hk no~sm qqsolqk obqu~mb ioumld` {mlj eknmu

qoam~m mqosukq Am~m soinmuml ek`mbbml eoljml ioinmu qqsolqk


13/16

obqu~mb ioumld` eoljml AIA)Lm 3,?/ 'n$v+ Qmiso` eknmu em`mi

ukjm edqkq, {mku 8 :? ij$ bjNN2 =?3 ij$ bjNN2 133 ij$ bjNN eml

qmiso` ekqkisml ek em`mi òim~k oq hkbm ukemb ekjlmbml

1,6,>,> Soinmuml bmlbo~ fkn~dqm~adim smem iolaku eoljml klebqk

nolxd'm+sk~ol

Bmlbo~ fkn~dqm~adim eknmu eoljml iol{lukbbml `m~uml

nolxd'm+sk~ol em`mi dòi d`kvm~i qoam~m qnbuml smem emo~mg

kluo~qbmsò~ 'uoljbb+ gozml hk eoljml edqkq 3,1 ij$ 3,= i@

qo`mim =3 bm`k sol{lukbbml eoljml kluo~vm` zmbu > gm~k qobm`k

Nolhd`ml bmlbo~ mbml i`mk uing qobkum~ ukjm n`ml qouo`mg

sol{lukbml eoljml nolxd'm+sk~ol 'Xmklk, =;7>+

1,6,>,1 So`mbqmlmml hk

Solo`kukml klk ek`mbbml em`mi oismu bo`disdb, qmu bo`disdb

bdlu~d` lojmukf eml ukjm bo`disdb so~`mbml ekimlm ukms bo`disdb

ekjlmbml oismu obd~ iolaku {mlj ioleo~kum bmlbo~ fkn~dqm~adim

So`mbqmlmml hk ek`mbbml eoljml iol{lukbbml qmiso` hk qoam~m

klu~mlods`mqim eoljml edqkq {mlj qoqmk qonml{mb 6 bm`k sol{lukbml

eoljml kluo~vm` zmbu > gm~k qobm`k Soljb~ml gminmumlso~uingml bmlbo~ ekb~ no~emqm~bml b~ml vdìo bmlbo~

ioljjlmbml ioudeo Zdo~eolnmj, ebb '=;7:+ K~kqml gkqudsmud`djk

hm~kljml bmlbo~ eknmu eoljml ioljmink` hm~kljml bmlbo~ eoljml

am~m soinoemgml eml boiekml ekqkisml em`mi emsm~ fd~im`kl =3/

{mlj qo`mlhul{m eknmu k~kqml eml ek`mbbml sozm~lmml qogkljjm

ioiso~iemg em`mi soljmimuml

1,6,= Soljd`mgml eml Mlm`kqkq Emum

_lub ioljoumgk hi`mg qo` bmlbo~ qonoì eml qoqemg so~`mbml

ioisl{mk qonm~ml {mlj ld~im` mum ukemb, imbm ek`mbbml hk ekqu~knqk

ld~im`kumq emum 'hk Qgmsk~d)Zk`b+ Msmnk`m emum {mlj ekso~dòg ioik`kbk

ekqu~knqk ld~im` imbm mbml ekmlm`kqkq eoljml hk U)uoqu lub emum

no~smqmljml 'Smk~oe Qmisò U)uoqu+ Hkbm emum uo~qonu no~ekqu~knqk ukemb

ld~im` imbm mbml ekmlm`kqkq eoljml hk qumukqukb Zkàdwdl Eoljml io`mbbml

mlm`kqkq qoam~m qumukqukb, imbm emsmu ekboumgk soljm~g solminmgml obqu~mb

ioumld` uo~gmems so~uingml bmlbo~ fkn~dqm~adim smem iolaku Soljd`mgml


14/16

mlm`kqkq emum eoljml ioljjlmbml s~dj~mi QSQQ fd~ Zkledzq Vo~qk =>3

eoljml ukljbmu boimblmml 0 3,3?


15/16

EMFUM^ S_QUMBM

Mldlki, >3==, Qkquoi Kil, guus8$$zzzb`kbedbuo~adi, ekmbqoq umljjm` 6 Iok

Mldlki, >3==,Ekou mle Lu~kdl, guus8$$zzzadloauk}oadi, ekmbqoq umljjm` : Iok >3==

Mldlki, >336, Qkquoi Kil Ung eml Imlfmmu Kildide`mud~,

guus8$$zzzqukildadi$kleowsgs4ide9m~ukaò&ke96>, ekmbqoq umljjm` : Iok

>3==

Mldlki, >3==, Lku~ka dwkeo, guus8$$qo~q~aladi$hbkinm`ìmù~mlou, ekmbqoq umljjm` : Iok

>3==

Nm~mumzkehm{m, BJ, =;;6, Kild`djk emqm~, Aoumbml boukjm, 7)=6, Nm`mk Solo~nku FB _K,

Hmbm~um

Ovml J mle @kuuòzdde UE, =;;7, M Imuuo~ df @kfo mle Ao`` Eomug, >7=, Qakolao,

Zmqgkljudl EA

Bmxud I, Ugdimq Z Bòkl, Go~iml F, [dqgkimqm [, >33=, @ojkdlo``m sloidsgk`m

~os`kamukdl kl ima~dsgmjoq klgknkuoe n{ qoòaukvo kiildide`mud~{ offoauq dl

a{udbklo fd~imukdl n{ Oskjm``damuoagkl Jm``muo, m imhd~ fd~i df uom amuoagklq

Klfoaukdl mle Kiilku{, guus8$$kmkmqid~j$ajk$adluolu$f``$6;$6$1;5:, ekmbqoq

umljjm` : Iok >3==B~oqld, QN, >33=, Kild`djk8 Ekmjldqkq eml S~dqoe~ @mnd~mud~ki, Oekqk booismu, 1);,

Solo~nku FB _K, Hmbm~um

@dzolquokl, AH, Eklo~iml, H@, & Ql{eo~ , QG, =;;5, Lku~ka Dwkeo 8 M Sg{qkd`djka

Ioqqoljo~, >>:)>>7, Mll Kluo~l Ioe, Nmùkid~o

Gmlmgml, E, mle Zkolno~j, ^M, >33>, Ugo Gm`ìm~bq df Amlao~,

guus8$$zzzzokximllmak`$gdio$foediml{$Nkdklfd3?$òau~o6TGmlmgmlsef,

ekmbqoq umljjm` : Iok >3==

Ibgum~, G, & Mgime, L, >333, Uom Sd`{sgold`q 8 S~ovolukdl df Amlao~ & Dsukikxklj

Gomùg, guus8$$zzzmhald~j$adluolu$:=$6$=6;7Qf``, ekmbqoq umljjm` : Iok >3==

S`m{fmk~, HG@, Agmkl NI, >33;,Kiild`dj{ mu J`mlao, >:, Zkò{)N`mabzo``, @dledl

Souo~IO, Gdfoèo~MO, mle Gojm~ulo~,ID, =;;:,Mevmlao kl Msdsudqkq ôqom~ag, ;5,

S~da Mame Qak, _QM

^dkuu, KI, >33=,Kild`djk, Oekqk 7, >)=3, Solo~nku FB _K, Hmbm~um

Qqk`mlkljqkg L, Hdgml M, Jlm~ek, Zklm~ud, >331, Soljm~g sd`kfold` uog gkhm uo~gmems

mbukfkumq imb~dfmj em`mi ioinlg nmbuo~k, M~ukbo` Solo`kukml, FB _LEKS,

Qoim~mlj


16/16

Q{mg, M, >336, Umb`bbml Sol{mbku eoljml Uog Gkhm, =;, Mj~d Ioekm Squmbm, Hmbm~um

Zdo~eolnmj, HG, @oiqu~m, Z, Gole~kbq, G, Im`klj~o, UgI, mle Bdlkljq MZU,

Klvoqukjmukdl df ugo Mluk)Uid~ Maukdl df Osmugd~kdska~kl Mjmkluq Ugo @ozkq

@lj Uid~, ?1, S`mlum Ioekam, Loz [d~b

Xmklk, LA, =;7>, Bdisdlol Go~nm Vo~ldlkm aklo~kmo @oqq {mlj No~bgmqkmu Mlukbmlbo~, 7)

=3, Ekqo~umqk, KUN, Nmlelj

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