Psychopharmacology Quiz-1

1. Which of the following drug is indicated in refractory schizophrenia?

A. Haloperidol

B. Lithium

C. Clozapine

D. Thioridazine

2. Which of the following is a tricyclic antidepressant?

A. Paroxetine

B. Escitalopram

C. Venlafaxine

D. Amitryptylline

3. Which of the following is a direct pharmacological antagonist?

A. Methadone

B. Morphine

C. Naltrexone

D. Disufiram

4. Benzodiazepines primarily act on:

A. GABA-A receptors

B. 5HT receptors

C. Dopamine receptors

D. Mu receptors

5. Which of the following is an antagonist of benzodiazepines:

A. Flumazenil

B. Naloxone

C. Flupenthixol

D. N-acetyl cystine

6. Which is NOT a long acting antipsychotic drug?

A. Haloperidol deconate

B. Zuclopenthixol deconate

C. Fluphenazine deconate

D. Pimozide

7. “Psuedoparkinsonism” is a term used to refer:

A. Post head injury parkinsonism

B. Post-encephalitic parkinsonism

C. Drug-induced parkinsonism

D. Parkinsonism with depression

8. Extrapyramidal symptoms include all, except:

A. Psuedoparkinsonism

B. Dytonia

C. Tardive dyskinesia

D. Agnosia

9. A drug which is commonly associated with orthostatic hypotension is:

A. Chlorpromazine

B. Fluoxamine

C. Buproprion

D. Lithium

10. Which of the following drug is safest in patients with cardiac conduction disorder and depression:

A. Dotheipin

B. Mianserin

C. Doxepine

D. Phenelzine

11. The most frequent cardiaovascular side effect of trazadone is:

A. Arrythmias

B. Ventricular hypertrophy

C. Valvular dysfunction

D. Syncope

12. Antimanic properties of lithium was proposed by:

A. Delay and Deniker

B. Von Meduna

C. John Cade

D. Egaz Moniz

13. The antipsychotic properties of Chlorpromazine was proposed by:

A. John Cade

B. Delay and Deniker

C. John Cade

D. Egaz Moniz

14. The first psychotropic drug introduced in the treatment of depression was:

A. Clorpromazine

B. LithiumCopyright@ www.nursingplanet.com/Quiz

C. Dothipin

D. Imipramine

15. Dry mouth, blurred vision, constipation and urinary retention are side effects due to blockade of:

A. H1 histaminic receptors

B. 5HT1 serotoninergic receptors

C. Dopaminergic receptors

D. Muscarinic-cholinergic

16. Tricyclic antidepressants act by blocking:

A. Dopaminergic receptors

B. GABA receptors

C. Reuptake of serotonin and norepinephrine

D. Cholinergic receptors

17. Therapeutic effects of typical antipsychotics are predominantly due to blockade of:

A. Dopaminergic receptors

B. GABA receptors

C. Serotoninergic receptors

D. Norepinephrine receptors

18. Pharmacokinetics refers to:

A. The processes of absorption, transport, distribution, metabolism and excretion

B. Action of drug on the body

C. Selective action of the drug on the receptors

D. The adverse effects caused by a drug on the body

19. Zolpidem belongs to which of the following class of drugs:

A. Antipsychotics

B. Antidepressants

C. Mood stabilizers

D. Hypnotics

20. Moclobimide is a:

A. SSRI antidepressant

B. Reversible MAO Inhibitor

C. TCA antidepressant

D. SNRI antidepressant

ANSWER KEY

1. C 2.D 3. C 4. A 5.A

6. D 7. C 8. D 9.A 10. D

11.A 12. C 13.B 14. D 15.D

16. C 17. A 18. A 19.D 20.B

1. The term ataractic refers to a drug that:

A. has a calming effect

B. induces sleep

C. induces drowsiness

D. cause extrapyramidal side effects

Answer Key

2. Benzodiazepines have the following effects except:

A. suppress REM sleep

B. produces respiratory depression

C. produce tolerance and dependence

D. induces seizures

Answer Key

3. An important side effect of zopiclone is:

A. respiratory depressionwww.currentnursing.com

B. Extrapyramidal symptoms

C. A bitter taste associated with excretion in saliva

D. Nystagmus and double vision

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4. Zopiclone is most appropriate for those:

A. With difficulty in initiating and maintaining sleep

B. Early morning awakening

C. Agitated and violent

D. With obstructive sleep apnoea and respiratory problems

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5. Zopiclone is most appropriate for those:

A. With difficulty in initiating and maintaining sleep

B. Early morning awakening

C. Agitated and violent

D. With obstructive sleep apnoea and respiratory problems

Answer Key

6. The most common side effect of benzodiazepines is:

A. Sedation

B. Seizures

C. Vomiting

D. Restlessness and agitation

Answer Key

7. The usual dose of clonazepam is: www.currentnursing.com

A. 0.25 to 2.0 mg/day

B. 5-10 mg/day

C. 15-30 mg/day

D. 0.4-0.8 mg/day

Answer Key

8. Buspirone belongs to which class of drug:

A. Benzodiazepines

B. Azapirones

C. SSRIs

D. Tricyclic

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9. Flumazenil is a drug is used in:

A. Severe agitation

B. Schizophrenia

C. Benzodiazepine overdose

D. Opiod dependence

Answer Key

10. Which of the following central dopaminergic pathway is associated with antipsychotic efficacy?Copyright@

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A. Mesocortical

B. Nigrostraiatal

C. Tuberoinfundibular

D. Mesolimbic

Answer Key

11. Which of the following central dopaminergic pathway is associated with hyperprolactinaemia and its

consequences?

A. Mesolimbic

B. Mesocortical

C. Nigrostraiatal

D. Tuberoinfundibular

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12. Fundamental property of antipsychotic drugs is:

A. Blockade of reuptake of serotonin

B. Dopamine post-synaptic receptor blockade

C. Increase the neurotransmission in GABA receptors

D. Blockade of reuptake of norepinephrine

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13. Which is not a extrapyramidal symptom?

A. Acute dystonia

B. Akathesia

C. Drug-induced parkinsonism

D. Agnosiawww.currentnursing.com

Answer Key

14. Involuntary spasmodic contraction of a group of muscles is termed as:

A. Tardive dyskinesia

B. Dystonia

C. Rabbit syndrome

D. Akathesia

15. A subjective feeling of motor restlessness develops following treatment with antipsychotics is termed as:

A. Dystonia

B. Dyskinesia

C. Akathesia

D. Agnosia

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16. Tetrabenazine is a drug used in the management of:

A. Seizures

B. Tardive dyskinesia

C. Psychotic symptom

D. Sleep disorders

17. A condition hypothesised to be due to dopamine post-synaptic supersensitivity in the basal ganglia is:

A. Neuroleptic malignant syndrome

B. Tardive dyskinesia

C. Pseudoparkinsonism

D. Akathesia

18. An antipsychotic which is known to cause fatal torsades de pointes is:

A. Chlorpromazine

B. Clozapine

C. Trihexiphenidyl

D. Thioridazine

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19. A common adverse effect shared by clozapine, olanzapine and risperidone is:

A. Seizures

B. Sialorrea

C. Agranulocytosis

D. Weight gain

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20. A drug which is particularly associated with precipitation and worsening of diabetes mellitus is:

A. Olanzapine

B. Carbamazepine

C. Amitryptylline

D. Haloperidol

Answer Key

1. A 2.D 3.C 4.A 5.D

6. A 7.A 8.B 9.C 10.D

11.D 12. B 13.D 14.B 15.C

16. B 17.B 18.D 19.D 20.A

1. The usual dose range of trifluperazine is:

A. 100-1000 mg/day

B. 10-30 mg/day

C. 2-8 mg/day

D. 80-160 mg/day

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2. Depot preparation for which of the following drugs is not available:

A. Haloperidol

B. Fluphenazine

C. Flupenthixol

D. Pimozide

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3. Which is not an anticholinegic:

A. Trihexiphenidyl

B. Procyclidine

C. Buspirone

D. Benztropine

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4. Fluoxamine belong to which class of drug:

A. TCAs

B. SSRIs

C. MAOIs

D. SNRIs

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5. A psychotropic drug commonly used in Tourette disorder is:

A. Haloperidol

B. Phenelzine

C. L-tryptophan

D. Mianserin

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6. The reference TCA, against which new antidepressants are tested in clinical trials is:

A. Clomipramine

B. Amoxapine

C. Imipramine

D. Dothiepin

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7. The commonly used TCA in obsessive compulsive disorder is:

A. Amitryplyline

B. Clomipramine

C. Nortryptyline

D. Dothiepin

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8. Which drug in the SSRI group of antidepressant has a half-life of 2-4 days:

A. Paroxetine

B. Escitalopram

C. Sertraline

D. Fluoxetine

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9. Varenicline is a:

A. Atypical antipsychotic

B. Nicotine receptor antagonist for nicotine dependence

C. Antidepressant

D. Hypnotic without hangover effect

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10. A drug which is postulated to be an inhibitor of dopamine-β-hydroxylase, which catalyzes the conversion of dopamine into

norepinephrine,leads to an increase in brain dopamine levels:

A. Disulfiram

B. Phenelezine

C. Aripiprazole

D. Desipramine

Answer Key

11. Who first proposed that lithium has antimanic properties?

A. John Cade

B. Delay and Denikar

C. Eagaz Moniz

D. Hippocrates

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12. Which of the following term refers to the way the body handles the drug?

A. Pharmacodynamics

B. Pharmacoceutics

C. Pharmacokinetics

D. Pharmacotherapeutics

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13. Rivastigmine belongs to

A. Inorganic ions

B. MAOIs

C. Butyrophenones

D. Stimulants

E. Cholinesterase Inhibitors

Answer Key

14. Which of the following statements about benzodiazepines is WRONG?

A. BDZs suppress REM sleep

B. BDZs prolongs REM sleep

C. BDZs interact strongly with alcohol to produce CNS depression

D. BDZs raise the ECT seizure threshold

Answer Key

15. The most important adverse effect of Zopiclone is:

A. Dependence

B. Bitter taste

C. Convulsion

D. EPS

E. Sedation

Answer Key

ANSWER KEY

1. B 2. D 3. C 4.B 5.A

6. C 7. B 8.D 9. B 10. A

11. A 12.C 13.E 14.B 15.B

1. Acute catatonia may be treated with:

A. Chloral hydrate

B. Rivastigmine

C. Zolpidem

D. Lorazepam

Answer Key

2. Which of the following is least sedating anxiolytic?

A. Chlorpromazine

B. Diazepam

C. Buspirone

D. Zolpidem

E. Haloperidol

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2. Which of the following drug belongs to the group of substituted benzamide?

A. Chlorpromazine

B. Thioridazine

C. Pimozide

D. Sulpride

E. Aripiprazole

Answer Key

4. A schizophrenic patient on treatment with pimozide reports that he cannot keep still and feel a compulsion to move. These

symptoms are charecteristics of

A. Acute dystonia

B. Drug-induced Parkinsonism

C. Akathisia

D. Neuroleptic Malignant Syndrome

E. Serotonin syndrome

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5. Which is NOT an intervention in the management of neuroleptic malignant syndrome?

A. Discontinuation of the antipsychotics

B. Use of bromocriptine/amentadine

C. Use of lorazepam to treat catatonia

D. Use of haloperidol to control agitation

Answer Key

6. Which of the following drug is particularly associated with precipitating/worsoning diabetic mellitus?

A. Haloperidol

B. Chlorpromazine

C. Aripiprazole

D. Thiazide & Pimozide

E. Clozapine & Olanzapine

Answer Key

7. When used in a dose exceeding 500 mg/day, thioridazine causes

A. Pigmentation of retina

B. Diabetic mellitus

C. Angle-closure glaucoma

D. Agranulocytosis

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8. Hypersalivation is a paradoxical adverse effect observed in treatment with

A. Chlorpromazine

B. Clozapine

C. Trihexyphenidyl

D. Ziprazidone

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9. Standard oral dose of risperidone is

A. 200-1000 mg/day

B. 80-160 mg/day

C. 15-30 mg/day

D. 25 mg/2-4 weeks

E. 2-8 mg/day

Answer Key

10. Caffeine interacts with following drugs, EXCEPT

A. Phenelezine

B. Lithium

C. Trazadone

D. Chlorpromazine

Answer Key

ANSWER KEY

1. D 2. C 3. D 4. C 5. D

6. E 7. A 8. B 9. E 10. C

1. Which of the following antipsychotics is known to elevate serum prolactin levels?

A. Quetiapine

B. Clozapine

C. Aripiprazole

D. Amisulpride

2. Which category of drugs are associated with neuroleptic malignant syndrome?

A. Antidepressants

B. Anticholinergics

C. Antipsychotics

D. Mood stabilizers

E. Anxiolytics

3. Tetrabenazine is found to be effective in controlling:

A. Neuroleptic-induced parkinsonism

B. Neuroleptic-induced tardive dyskinesia

C. Weight gain

D. Hyperprolactemia

4. Which neuroleptic agent has the lowest likelihood of producing tardive dyskinesia?

A. Imipramine

B. Chlorpromazine

C. Clozapine

D. Fluoxetine

E. Thiothixene

5. Which drug may be useful in the management of the neuroleptic malignant syndrome, although it can worsen the symptoms of

schizophrenia?

A. Risperidone

B. Thiothixene

C. Haloperidol

D. Bromocriptine

E. Valproic acid

6. Antagonism of which dopaminergic pathway is atributed to be the cause of therapeutic actions of antipsychotic drugs?

A. Nigrostriatal system

B. Mesolimbic–mesocortical system

C. Tuberoinfundibular pathway

D. Reticular activating system

7. A patient reports fever, sore throat, or cellulitis, after 2 weeks of starting antipsychotic therapy with clozapine. Which of the

following intervention is most important?

A. Treat the patient with a broad-spectrum antibiotic and continue the therapy

B. Discontinue the antipsychotic and conduct WBC and differential counts.

C. Inform the patient that it is common to develop fever and sore throat when taking this drug

D. Hospitalize the patient for observation

8. Which of the following is a phenothiazine?

A. Chlorpromazine

B. Clozapine

C. Olanzapine

D. Risperidone

E. Haloperidol

9. Which of the following statements about side effects of antipsychotics (AP) is NOT correct?

A. APs produce menorrhea and increased libido in women

B. APs produce decreased libido and gynecomastia in men.

C. APs cause inhibition of prolactin secretion.

D. Low-potency APs cause orthostatic hypotension

10. Which of the following mechanism is considered to be the cause of extrapyramidal reactions?

A. Alpha-adrenoceptor blockade

B. D2-receptor blockade

C. H1 histamine receptor blockade

D. D2-receptor up-regulation

11. Which of the following agents possesses pharmacological actions characterized by high antipsychotic potency and high potential

for extrapyramidal toxicity?

A. Thioridazine

B. Haloperidol

C. Flumazenil

D. Clozapine

E. Carbamazepine

12. Tardive dyskinesia after long-term antipsychotic administration is thought to be due to

A. A decrease in dopamine synthesis

B. Enhanced stimulation of D2 dopamine autoreceptors

C. Loss of cholinergic neurons in striatum

D. Up-regulation of striatal dopamine receptors

E. Increased tolerance to antipsychotic agents

13. What is the chlorpromazine (100 mg) equivalent oral dose of haloperidol?

A. 2 mg

B. 10 mg

C. 30 mg

D. 100 mg

E. 300 mg

14. Which of the following manifestations is NOT caused by blockade of Muscarinic cholinoreceptor?

A. Dry mouth

B. Blurred vision

C. Urinary retention

D. Constipation

E. Amenorrhea

15. Which of the following is a butyrophenone?

A. Pimozide

B. Haloperidol

C. Fluphenazine

D. Trifluoperazine

E. Prochlorperazine

1. D 2. C 3. B 4.C 5.D

6. B 7. B 8. A 9.C 10. B

11. B 12. D 13. A 14. E 15. B

1. Which antidepressant is contraindicated in a patient with seizure disorder?

A. Nefazodone

B. Fluoxetine

C. Venlafaxine

D. Mirtazapine

E. Bupropion

Answer Key

2. Which of the following antidepressants is most selective for inhibition of neuronal reuptake of serotonin?

A. Mirtazapine

B. Venlafaxine

C. Bupropion

D. Sertraline

E. Imipramine

Answer Key

3. Which of the following condition is associated with long-term use of lithium in mood disorders?

A. Hypothyroidism

B. Hyperprolactinemia

C. Hypoglycemia

D. Hypertension

E. Tardive dyskinesia

Answer Key

4. Which of the following antidepressants requires therapeutic blood monitoring for safe use?

A. Paroxetine

B. Phenelzine

C. Nortriptyline

D. Venlafaxine

E. Bupropion

Answer Key

5. Combining MAOIs with SSRIs may cause

A. Serotonin Syndrome

B. Extrapyramidal Symptoms (EPS)

C. Neroleptic Malignant Syndrome (NMS)

D. Agranulocytosis

Answer Key

6. Penile priapism is known to be associated with use of

A. Buproprion

B. Venlafaxine

C. Escitalopram

D. Trazadone

E. Mirtazapine

Answer Key

7. Highest rates of sexual dysfunction is reported with:

A. Bupropion

B. Mirtazapine

C. Citalopram

D. Paroxetine

Answer Key

8. Sedation associated with use of antidepressants is attributed to the

A. Blockade of histamine H1 receptor

B. Blockade of muscarinic acetylcholine receptors

C. Blockade of alpha-1-receptors

D. Antagonism of 5-HT2 receptors

Answer Key

9. Which is a clinician-rated scale for monitoring outcome of depression treatment?

A. Beck Depression Inventory (BDI)

B. Zung Depression Scale

C. Geriatric Depression Scale (GDS)

D. Hamilton Depression Rating Scale (HAM-D)

Answer Key

10. Therapeutic options for refractory depression include all, EXCEPT:

A. Lithium Augmentation

B. Thyroid hormone supplementation

C. Stimulant augmentation

D. Transcranial magnetic stimulation

E. Glucocorticoid therapy

Answer Key

11. Which of the following is NOT associated with use of Tricyclic Antidepressants (TCA)?

A. Dry mouth

B. Constipation

C. Blurred vision

D. Urinary Incontinance

Answer Key

12. The recommended dose of duloxetine for major depressive disorder is

A. 40–60 mg/day

B. 75-150 mg/day

C. 300–600 mg/day

D. 37.5-75 mg/day

Answer Key

13. Which of the following is known to have least cardiovascular side effects?

A. Amitriptyline

B. Imipramine

C.Citalopram

D. Clomipramine

Answer Key

14. A common adverse effect of Venlafaxine is

A. Increase in blood pressure

B. Decrese in blood pressure

C. Hypersalivation

D. Bradycardia

E. Tinnitus

Answer Key

15. Which of the following antidepressants has relatively short biological half-life?

A. Mirtazapine

B. Fluoxetine

C. Trazodone

D. Citalopram

E. Imipramine

Answer Key

16. Which of the following antidepressant is approved by FDA for Smoking cessation?

A. Fluvoxamine

B. Bupropion

C. Paroxetine

D. Venlafaxine

Answer Key

17. Which of the following is a RIMA—reversible inhibitor of monoamine oxidase group of antidepressant?

A. Phenelzine

B. Isocarboxazid

C. Tranylcypromine

D. Moclobemide

Answer Key

18. What is the best antidepressant prescribed for a patient with hypotension and cardiac disease?

A. Escitalopam

B. Duloxetine

C. Venlafaxine

D. Mirtazapine

1. A 2. D 3.A 4.C 5. A

6. D 7. B 8.A 9. D 10. E

11.D 12. A 13.C 14.A 15. C

16. B 17. D 18. C

1. Naltrexone occupies which of the following opiod receptors?

A. Sigma Copyright @ www.nursingplanet.com/Quiz

B. Kappa

D. Beta

Answer Key

2. All are side effects of valproic acid, except:

A. Ataxia

B. Tremor

C. Fulminant hepatitis

D. Polycystic ovaries

Answer Key

3. One of the following drug causes least gain in weight:

A. Quetiapine

B. Ziprasidone

C. Olanzapine

D. Risperidone

Answer Key

4. The drug used in nicotine addiction includes:

A. Naloxone

B. Naltrexone

C. Buspirone

D. Bupropion Copyright @ www.nursingplanet.com/Quiz

Answer Key

5. Low doses of clozapine (10-25 mg/day) are used in the treatment of:

A. PAnic attack

B. Dementia

C. Conduct disorders

D. Alcohol dependence

Answer Key

6. Which of the following is considered as the best antidepressant fro a patient with hypotension and cardiac disease?

A. Duloxetine

B. Mirtazapine

C. Venlafaxine

D. Clomipramine

Answer Key

7. One of the following drug causes least gain in weight:

A. Quetiapine

B. Ziprasidone

C. Olanzapine

D. Risperidone

Answer Key

8. Which is NOT a side effect of lamotrigine?

A. Diplopia

B. Dizziness

C. Decreased cognition

D. Rash

Answer Key

9. Adverse effect of valproic acid include:

A. Alopecia

B. Fulminant hepatitis

C. Pancreatitis

D. All of the above

Answer Key

10. Side effects of phenytoin are all except:

A. Gum hypertrophy

B. Hisutism

C. Microcytic anemia

D. Osteomalacia

1. C 2. D 3. B 4. D 5. A

6. C 7. B 8. C 9. D 10. C