THANK YOU!

SPONSORWELCOME PACKET

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PEDALTHECAUSE.ORG

Sept. 29 & 30, 2018

As a sponsor, we hope you can attend some of our upcoming events!

Send sponsorship payment to PTC along with signed MOU no later than August 1, 2018.

Complete and return the PTC Marketing Questionnaire (see last page of this packet) to PTC Directorof Communications & Marketing Eleanor Goedeke at eleanor@pedalthecause.org.

Visit pedalthecause.org/sponsor-resources to download the PTC Asset Pack and all Tools.

Connect with PTC via Social Media and keep us updated with any PR opportunities highlightingour partnership throughout the year.

8.18 PTC Training Ride

8.3 A World Without Cancer Day

6.16 PTC Training Ride

5.22 PTC Night at the Ballpark (tickets available at ptcshop.org)

5.11 PTC Corporate Breakfast at Edward Jones HQ

9.12 Event Weekend Orientation

9.29 PTC WEEKEND - Kids Challenge, Taste the Cause and Inspirational Program

10.31 Fundraising Deadline

11.15 Check Presentation at Ballpark Village

9.30 PTC WEEKEND - Ride Day and Post-Ride Celebration

SPONSOR CHECKLIST

MARK YOUR CALENDARS

For more info visitwww.pedalthecause.org

Pedal the Cause is the St. Louis region’s premier cycling event with the mission of curing all cancers, for everyone.

100% of participant-raised funds stay in St. Louis and benefit Siteman Cancer Center and Siteman Kids at St. Louis Children's Hospital, providing direct funding for cancer research not currently eligible for federal funds.

OUR MISSION>>>

AT SITEMAN CANCER CENTER & SITEMANKIDS AT ST. LOUIS CHILDREN’S HOSPITAL.

$19,809,668$19,809,668

ALL CANCERS, FOR EVERYONECURE CANCER

101

2873

innovativecancer researchprojects funded

ADULTPROJECTS

PEDIATRICPROJECTS

1 %M O D E L100% of participant

donations fund innovativecancer research

in St. Louis

SINCE 2010

RAISED

FUNDING

17,374 �i��r�,4,965 v���n���r�

250,000 d�na�i�n��n� ����

IMPACT

ROI Report2017 Upda��

Todd Fehniger, MD, PhD received a $200,000 award from the Siteman Investment Program* (SIP) in 2015 for his project titled “Memory-like natural killer (NK) cells for cancer immunotherapy.” For patients with AML not eligible to receive a BMT, Dr. Fehniger’s team has developed a new approach (cytokine-induced memory-like, or CIML, differentiation) which involves activating immune cells (NK cells) to enhance their ability to kill leukemia cells when transferred into a patient. The goal of his SIP project was to improve the understanding of how these CIML NK cells are generated, and how they are able to better eliminate leukemia, with hopes that they could make this treatment even more effective in the future. With promising results in the laboratory, Dr. Fehniger recently received a $2 million grant from the National Cancer Institute to complete a first-in-human phase 1/2 clinical trial to test this novel approach for patients with AML not eligible for a BMT.

Todd Fehniger, MD, PhD7x Pedal the CauseRider & Fundraiser

Ryan Fields, MD received a $793,000 Cancer Frontier Fund* Team Science award in 2013 for his project titled “Identifying Mechanisms of Metastasis to Improve Outcomes in Metastatic Colorectal Cancer (mCRC).” Standard treatment of mCRC is non-specific, toxic chemotherapy. Our lack of understanding of mechanisms of tumor metastasis has prevented the identification and specific targeting of pathways necessary for the cancer to spread. In this project, Dr. Fields’ team performed a comprehensive analysis of 10 patients’ tumors with mCRC. This unprecedented analysis utilizing cutting-edge genomic techniques yielded a “mountain” of data to analyze to find out why some tumors spread and others do not. Each of the project goals have been completed and Dr. Fields’ team are in the final phase of manuscript preparation describing the clonal evolution of mCRC. These findings will challenge current paradigms of how cancers spread and evolve and may alter the staging and treatment methodologies that are current practice. To continue their research Dr. Fields has received a subsequent $1.3 million award from the National Cancer Institute, and team member, Christopher Maher, PhD, received a $792,000 American Cancer Society Research Scholar Award.

Joseph Ippolito, MD, PhD received a $100,000 award from the Siteman Investment Program* (SIP) in 2016 for his project titled “Characterizing the Effects of Sexual Dimorphism on Glioma Metabolism.” Glioblastoma Multiforme (GBM) is an extraordinarily aggressive cancer that comprises over half of all brain tumors. Within 1 year, Dr. Ippolito’s team has successfully identified sex differences in brain tumor metabolism in both animal models and clinical samples that can be detected using multiple clinical imaging modalities (CT, MRI, PET). In response, they have developed imaging strategies in the laboratory to detect these differences at the clinical level. In August 2017, Dr. Ippolito’s findings were published in JCI: Insight and he received a National Cancer Institute award to continue his research in metabolic imaging of gliomas.

*Pedal the Cause donates 100% of money raised to directly fund cancer research through The Siteman Investment Program, The Cancer Frontier Fund and The Children’s Discovery Institute. The Siteman Investment Program and The Cancer Frontier Fund are designed to award pilot funding to faculty investigators to support pioneering cancer research and produce data to leverage further external peer reviewed funding. The Children’s Discovery Institute is the result of a shared vision to change the way pediatric research is conducted with an intense commitment to bring about dramatic results in pediatric care.

Ryan Fields, MD3x Pedal the Cause Rider

& Podium Fundraiser

Joseph Ippolito, MD, PhDPedal the Cause

Virtual Rider & Fundraiser

7:1 ROI Within 5 years of investment, every $1 donated to cancer research fromPedal the Cause has on average earned an additional $7 in federal funding

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3,074Riders

850Volunteers

280Kids

Challengers

30,000Unique donors

8.7Average

donors per rider

$4 millionRaisedin 2017

44.9Average age

of riders

44%Female

ridership

56%Male

ridership

$633Average

committment per rider

$1,056Average

raised per rider

321Riders reached

incentive levels

(Raised $2,500 or more)

PEDALTHECAUSE.ORG

Sept. 29 & 30, 2018

Get to know the audience your brand is connecting with through these PTC 2017 stats:

PEDALTHECAUSE.ORG

Sept. 29 & 30, 2018

About Pedal the CausePedal the Cause is the premier cycling experience in the region and the driving force behind creating a world without cancer. Pedal the Cause is the only St. Louis event that gives 100% of participant donations to Siteman Cancer Center and Siteman Kids at St. Louis Children’s Hospital to accelerate lifesaving cancer research. Pedal the Cause will take place at the Chesterfield Amphitheater on September 29 and 30, 2018.

Founded in 2009, Pedal the Cause has grown to become the highest-grossing, single athletic-fundraising event in St. Louis, in which all donations raised stay in St. Louis to provide direct funding for cancer research, cancer discovery grants and clinical translational care not currently eligible for federal funds. In seven years, Pedal the Cause has donated over $19.8 million to fund this innovative research.

Additionally, donations from Pedal the Cause make a positive economic impact in the St. Louis community as stronger research funding will continue to support this high profile and critically important segment of the St. Louis economy.

For more info or to register for (insert your Pedal the Cause team name), visit pedalthecause.org.

Highlight Exciting Saturday 9/29 EventsTaste the Cause: St. Louis’ top chefs and restaurants will be preparing tastes of some of their most popular dishes for event attendees. Riders receive one ticket with their event registration. Additional tickets can be purchased for $50 from the Pedal the Cause online shop.

Ameren Kids Challenge: Kids can help end cancer, too! All children, ages 3 to 12, are invited to participate in our Ameren Kids Challenge on Saturday, September 29. This 1-mile, closed-circuit ride will precede Saturday evening’s Taste the Cause and inspirational program. There is a registration fee of $40 per child to participate in this fun, kid-friendly ride. Register at pedalthecause.org.

Inspirational Program: On the evening before the race, we gather together our Pedal family in the Chesterfield Amphitheater to take a moment to reflect on our mission, celebrate our victories and tell the stories of our frontline cancer fighters. It is a time when all of us who have been affected by cancer, can pull each other close and remember why the fighter to end all cancers, for everyone is so critical.

Highlight Courses on 9/30Choose from six exciting courses. All courses start and finish at the Chesterfield Amphitheater in Chesterfield, MO. The shorter distances offer a mixture of flat and rolling terrain, with a few moderate hills. The Metric Century and Century Ride courses are extremely challenging with several steep climbs. Check out the course maps and a course comparison at pedalthecause.org/courses.

Distance Options10 Miles -37 Miles - 62 Miles -

20 Miles - 50 Miles - 100 Miles -

PTC CircuitTwo Bridges Metric Century

PTC ClassicBig HitterCentury

Connect With Us and Tag Us

HashtagsHere are some common hashtags we use:

Sample PostsBelow are sample social media posts - be sure to tag Pedal the Cause and our beneficiaries!

About PTCFacebook: Pedal the Cause has donated $19.8m for cancer research and the driving force behind creating a world without cancer. Learn more and register at pedalthecause.org

Twitter: @pedalthecause funds cancer research @SitemanCenter and @STLChildrens through their exciting cycling challenge for all levels. Join us! pedalthecause.org

Proud to Sponsor/ImpactFacebook: We are proud to sponsor @pedalthecause. Our sponsorship makes it possible for Pedal the Cause to use 100% of rider-raised donations to accelerate cancer research at @SitemanCancerCenter and Siteman Kids @STLChildrens. Since 2009, PTC has donated $19.8 to fund #cancerresearch! Learn more and get involved at www.pedalthecause.org/impact

Twitter: We are proud to sponsor @pedalthecause and be part of the #pedalfamily! We are making it possible for @pedalthecause to #Give100% of rider-raised donations to #cancerresearch. Learn more and get involved at www.pedalthecause.org/impact

DonateFacebook: 100% of every dollar donated to @pedalthecause funds innovative #cancerresearch projects at @SitemanCancerCenter and Siteman Kids at @STLChildrens. These projects target all different types of cancer with the goal of curing all cancers for everyone. We are proud to support this mission and this vital research and hope you will do the same: www.pedalthecause.org/donate

Twitter: 100% of every dollar donated to @pedalthecause funds #cancerresearch projects @SitemanCenter and Siteman Kids @STLChildrens. Join the #pedalfamily and support this critical research: www.pedalthecause.org/donate

Event Weekend (post before 9/29)Facebook: @pedalthecause weekend is almost here! #PTC2018 is 9/29 & 9/30. We are so proud to sponsor an amazing event that has tremendous impact. Learn more at www.pedalthecause.org

Twitter: @pedalthecause weekend is almost here - 9/29 & 9/30! We are so proud to sponsor this incredible event that has tremendous impact! www.pedalthecause.org

FACEBOOKpedalthecause

TWITTER@pedalthecause

INSTAGRAMpedalthecause

YOU TUBEpedalthecause1

#cancercuringbike#PTC2018

#pedalfamily#Give100%

#aworldwithoutcancer#cancerresearch

Use this sample press release to promote your sponsorship/team to the media.

FOR IMMEDIATE RELEASE Contact: [Insert contact name][Insert contact email and phone number] [Insert sponsor name] Joins the Fight Against Cancer at Pedal the Cause 2018

ST. LOUIS (Insert Date) – The St. Louis Community is poised to break all records at this year’s Pedal the Cause event on Sept. 29-30 at the Chesterfield Amphitheater. Riders, spinners, volunteers, virtual riders and kids will come together for the annual cycling challenge with the mission of curing all cancers for everyone. Since 2010, Pedal the Cause participants have raised $19.8 million to seed world-class cancer research right here in St. Louis. 100 percent of donations raised by Pedal the Cause participants directly fund this innovative cancer research at Siteman Cancer Center and St. Louis Children’s Hospital.

[Insert paragraph about your sponsorship or team with a quote from a stakeholder].

“As Pedal the Cause continues to grow and establish itself as the gateway to curing all cancers for everyone, our impact is truly coming into focus,” says Pedal the Cause Executive Director Jay Indovino. “We have funded studies that are advancing immunotherapy and genomics, creating vaccines and allowing patients more treatment options. It is because of deeper community and corporate involvement that we have been able to expand our riderbase and create lasting impact.”

In this period of diminished federal funding where support typically gets funneled to already proven concepts, many potentially new ideas get passed over. Pedal the Cause donations “seed” these innovative ideas to allow the cultivation of proof of concept and critical data. Within five years of investment, for every $1 donated by Pedal the Cause to cancer research an additional $7 is obtained, on average, in federal funding. Not only has this led to accelerated developments in the cancer treatment, but it is a robust tool for Siteman Cancer Center, St. Louis Children’s Hospital and the Washington University School of Medicine as they seek to recruit and retain the brightest minds in the scientific world.

Fundraising for 2018 continues until October 31st, 2018. Visit www.pedalthecause.org to make a donation to team [Insert team name if applicable] and support St. Louis’ efforts to create a world without cancer.____________________________________________________________________________

About Pedal the Cause: Pedal the Cause is the premier cycling experience in the region, with the mission of curing all cancers, for everyone. Pedal the Cause is the only St. Louis event that gives 100 percent of participant donations to Siteman Cancer Center and Siteman Kids at St. Louis Children’s Hospital to accelerate lifesaving, world class cancer research being performed right here in St. Louis. Pedal the Cause 2018 will take place on September 29 & 30, 2018 at the Chesterfield Amphitheater.

###

CORPORATE CHALLENGE

Lead the Way

Pillars

Become a Rider ChampionDistinguish your company as a leader in the fight against cancer by supporting your Pedal the Cause team through matching corporate gifts for donations, or by covering all or part of your team’s registration fees. Strive to raise $50,000+ and earn a team tent in Ride Village at event weekend!

Build a Top Corporate TeamPedal the Cause builds company moral and employee satisfaction asyour employees have the chance to work together on fundraising, training and team activities. ,Everyone can join the fight against cancer — with cycling distances ranging from 10 to 100 miles, a spin zone, virtual rider option and volunteer opportunities; there is truly something for everyone.

Pedal the Cause is St. Louis' premier cycling event, where thousands of riders, spinners and volunteers come together to raise money to fund research that will ultimately lead to a cure for cancer – all cancers, for everyone.

1 %M O D E L100% of participant

donations fund innovativecancer research

in St. Louis

pedalthecause.org

• Health & Wellness• Team Building• Community Engagement (Philanthropy & Community Service)

For more information on becoming a Rider Champion contactPedal the Cause Chief Operating Officer Carrie Sweigart at314.787.1984 or carrie@pedalthecause.org

YOUR GIFT COULD SUPPORT 80 RIDERS BY COVERING THEIR REGISTRATION FEES.

POTENTIAL FUNDRAISINGFOR A TEAM OF 80

$40,000-$100,000$10,000

YOUR GIFT COULD SUPPORT 40 RIDERS BY COVERING THEIR REGISTRATION FEES.

POTENTIAL FUNDRAISINGFOR A TEAM OF 40

$20,000-$50,000$5,000

YOUR GIFT COULD SUPPORT 100 RIDERS WITH A $100 IN CORPORATE MATCH FOR DONATIONS

POTENTIAL FUNDRAISINGFOR A TEAM OF 100

$50,000-$125,000$10,000

YOUR GIFT COULD SUPPORT 50 RIDERS WITH A $100 IN CORPORATE MATCH FOR DONATIONS.

POTENTIAL FUNDRAISINGFOR A TEAM OF 50

$25,000-$60,000$5,000

Pedal the Cause is St. Louis' premier cycling event, where thousands of riders, spinners and volunteers come together to raise money to fund research that will ultimately lead to a cure for cancer – all cancers, for everyone.

Support your Corporate TeamYour company’s corporate Pedal the Cause team has the potential to do something great! Support your team members by offering a registration promo code to the team. By covering all or part of their registration fee, your support will allow your team to take their recruitment and fundraising to the next level and motivate them to raise as much money as possible for cancer research.

Matching FundsSupport your team members by offering a corporate match for any donations they bring in to the team. These matches are an incredible motivator for your team to fundraise to team incentive levels.

1 %M O D E L100% of participant

donations fund innovativecancer research

in St. Louis

RIDER CHAMPION