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Goals The goal of this project is to design a catheter that can efficiently remove an embolism from the pulmonary artery. The main goals of the project are: To research and evaluate current technology in pulmonary embolism extraction To design a catheter that can successfully remove embolisms percutaneously and completely without damage to the patient To produce a feasible prototype of our design
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Pulmonary Embolism Extraction Catheter Development
Trip CothrenLauren NicholsDustin Temple
Advised by: Dr. Michael Barnett, VUMC Cardiology
Problem There are over 600,000 cases of
pulmonary embolisms annually in the United States, which result in nearly 60,000 fatalities.
Systemic thrombolytics can be dangerous Need a catheter that can quickly and
effectively remove pulmonary embolisms
Goals The goal of this project is to design a catheter that
can efficiently remove an embolism from the pulmonary artery. The main goals of the project are:• To research and evaluate current technology in pulmonary
embolism extraction
• To design a catheter that can successfully remove embolisms percutaneously and completely without damage to the patient
• To produce a feasible prototype of our design
Our Design Combined ideas from multiple existing
medical products• Inferior vena cava filter• Absorbable hemostat• Local clot busting drug administration
Security from multiple backups
Filter Based off inferior vena
cava filter Umbrella-like device Expandable to various
sizes Use of Nitinol
Nitinol Different Nickel/Titanium composition Can be easily annealed and set Is used in orthodontics Biocompatible Advantageous price and strength
Preliminary CAD
Surgicel or Gelita Material that attracts clots
• Oxidized cellulose polymer• Used clinically for over 50 years
Coat prongs of filter Prevent clots pieces
from going downstream Made by Ethicon
Trellis Catheter Device Inflatable back-end
“clot-catching” device
Local drug delivery
Use of guide wire
Design Parameters Approximately 2 m in length Umbrella-like filter that deploys from tip Device expands to15 mm in diameter Clot attracting material coating filter Local thrombolytic injection to break up
clot
Function Parameters Time frame of < 1 hr Embolus located via x-ray angiography Typically done by interventional
radiology or cardiothoracic For use when systemic thrombolytics are
not viable option
Potential Problems Hemolysis causes release of adenosine
when cells lyse Bradycardia or heart failure Renal failure Unpredictable thrombolytic tolerance Mechanical damage to vessel wall
Current Work Decide local
thrombolytic elution Choose best type of
Surgicel or Gelita Develop Nitinol usage Refine model using
Pro Engineer
Future Work Meet with Dr. Barnett and Dr. Bream to
discuss feasibility of ideas Calculate force of push of memory wire
against vessel wall Ensure biocompatibility of all materials Meet with Ethicon sales representative
References http://www.medgadget.com/archives/img
/sidcath.jpg http://www.socalcardiology.com/media/a
ngiojet.jpg http://www.lexmed.com/images/
cathphoto2.jpg