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AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PulmonaryRehabilitationGuidelinesforAustraliaandNewZealand
JenniferAlison
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Alisonetal,Respirology 2017; 22(4):800–819
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
COPD• NewZealand– 14%adultsover40yearshaveCOPD(Telfar B2015)– Cost:$NZ5.6billion($484millionindirecthealthsystemexpenditure)(Telfar B2015)
–Māori:4.4xhigherhospitalisation2.2xhigherdeaths(MilneRJ2015)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PulmonaryRehabilitation• KeycomponentofCOPDmanagement(YangI2016,COPD-X)• symptoms- breathlessnessandfatigue• exercisecapacity• qualityoflife(McCarthy2015)
• hospitalreadmissions(Puhan 2016)• lengthofstay
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Whydoweneedguidelines?• Statement (ATS/ERS)aboutwhatshouldbeincludedbutnotan
evidence-basedguideline(SpruitAJRCCM2013)
• Evidence-basedguidelinespublishedinothercountries:– BritishThoracicSociety(Bolton2014)– CanadianThoracicSociety(Marciniuk 2010)
• WhatwehadalreadydevelopedinAustralia- apracticalresources– PulmonaryRehabilitationToolkitwww.pulmonaryrehab.com.au
• Supportfutureinitiatives– MBSitemnumber(currentlyunderreview)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
• Healthcarecontextaffectsdelivery
Whydoweneedguidelines?
AustraliaandEuropeareasizecomparison
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
AimToprovideevidence-basedrecommendationsforthepracticeofpulmonaryrehabilitation(PR)specifictoAustralianandNewZealandhealthcarecontexts
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Methods• GuidelinePanel:28healthprofessionals(11leadexperts)• 9PICOquestionsconsideredasmostimportantinANZcontext.• Systematicreviewmethodologyforallquestions(unlessrecentSR)
– Meta-analysesforAust/NZcontextwherepossible
• Searchstrategies(librariansUSYDandLaTrobe)– DefinitionofPRtoguidesearches:Anyin-patient,out-patient,community-basedorhome-basedrehabilitationprogrammeofatleastfourweeks’durationthatincludedexercisetherapywithorwithoutanyformofeducationand/orpsychologicalsupportdeliveredtopatientswithexerciselimitationattributabletoCOPD (McCarthy2015)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Inclusionofstudies• RCTs,systematicreviewsofPR• Hadtoreportatleastonepre-specifiedoutcomeofinterest– Exercisecapacity– HRQoL– Healthcareutilisation– Anxietyanddepression– Mortality
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Movingfromevidencetorecommendation– GRADE
• Eachrecommendationrated(basedonGRADEcriteria)for:– Qualityofevidence:strong,moderateorlow
• Strengthofrecommendation– strongorweak- considered4factors:– Trade-offsbetweendesirableandundesirableoutcomes– Confidenceinestimatesofeffect(qualityofevidence)– Valuesandpreferencesofpatients– Resourceimplications
(AndrewsJ,2013)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Implicationfor: StrongRecommendation WeakRecommendation ‘Inresearch’
recommendationPatients Almostallindividualsinthis
situationwouldwanttherecommendedintervention,andonlyasmallproportionwouldnot.
Mostindividualsinthissituationwouldwanttherecommendedintervention,butasubstantialnumberwouldnot.
Clinicians Almostallindividualsshouldreceivetheintervention.Adherencetothisrecommendationaccordingtotheguidelinecouldbeusedasaqualitycriterionorperformanceindicator.Formaldecisionaidsarenotlikelytobeneededtohelpindividualsmakedecisionsconsistentwiththeirvaluesandpreferences.
Recognise thatdifferentchoiceswillbeappropriateforindividualpatientsandcliniciansmusthelpeachpatientarriveatamanagementdecisionconsistentwithhisorhervaluesandpreferences.Decisionaidsmaybeusefulinhelpingindividualstomakedecisionsconsistentwiththeirvaluesandpreferences.
Insufficientevidencetorecommendtheinterventionandmoreresearchcouldclarifytheeffectsoftheinterventionandwouldbeworthwhile.
(AndrewsJ2013)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PICOQUESTIONSANDRECOMMENDATIONS
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PICOquestion Recommendation: PRshouldbeprovidedfor… Strength
IspulmonaryrehabilitationeffectivecomparedwithusualcareinpeoplewithCOPD?a)McCarthy2015,Cochraneb)Puhan 2016,Cochrane
a) peoplewithstable chronicobstructivepulmonarydisease(COPD)
b) peopleafteranexacerbation ofCOPD,withintwoweeksofhospitaldischarge
• Exercisecapacity, HRQoL,readmissions
Strong
Weak
Doespulmonaryrehabilitationaffecthealthcareutilisation?
peoplewithmoderate-to-severeCOPD(stableorfollowingdischargefromhospital)todecreasehospitalisations• Hospitalisation, LOS
Strong
Inpeoplewithmilddiseaseseverity,ispulmonaryrehabilitationmoreeffectivethanusualcare?
mildCOPD(basedonsymptoms)(mMRC ≤1)• Exercisecapacity,HRQoL
Weak
Hospitalisation
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
• DespitebenefitsofPR• <5-10%ofmod-severeCOPDparticipateinPR
(AIHW2013)
• Barriersinclude:– transport(KeatingA2011)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PICOquestion Recommendation:PRshouldbeprovidedfor…… Strength
Isahome-basedorcommunitypulmonaryrehabilitationprogramaseffectiveasahospital-basedpulmonaryrehabilitationprogram?
people withCOPDas:a) home-basedasanalternativetousualcareb) home-basedasanalternativetohospital-basedc) community-basedasanalternativetousual
care• Exercisecapacity, HRQoL
WeakWeakWeak
Doesastructurededucationprogramenhancethebenefitsofpulmonaryrehabilitation?
allpeoplewithCOPD,irrespectiveoftheavailabilityofastructuredmultidisciplinarygroupeducationprogram.• Exercisecapacity,HRQoL,HCU
Weak
IspulmonaryrehabilitationeffectiveinchronicrespiratorydiseasesotherthanCOPD?
a) Bronchiectasis(PR+ACTs)(Lee2016-SystRev)b) ILD (Dowman 2014Cochrane )c) PH (Morris2016Cochrane)• Exercisecapacity,HRQoL,breathlessness
WeakWeakWeak
Structurededucation
Setting
HospitalOPD Home Community
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PICOQUESTIONSNORECOMMENDATIONS
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
PICOquestion Recommendation: Strength
Areprogramsoflongerdurationmoreeffectivethanthestandardeight-weekprograms?
Norecommendation- lackofevidence
• Exercisecapacity,HRQoL
Doesongoingsupervisedexerciseatalowerfrequencythantheinitialpulmonaryrehabilitationprogram,maintainexercisecapacityandqualityoflifeto12months?
Optimalmodelofmaintenanceexerciseprogramsnotclear• Exercisecapacity,HRQoLSupervisedmaintenance- monthly,orless -insufficienttomaintainthegainsofPRandshouldnotbeoffered• Exercisecapacity,HRQoL
Inresearch
Weak
Dopatientswhoexperienceoxygendesaturationduringexercisehavegreaterimprovementsifoxygensupplementationisprovidedduringtraining?
UncertaintyaroundeffectofO2supplementationduringtraining inCOPDwhodesaturate duringexercise- furtherresearchneeded• Exercisecapacity,breathlessness,
anxiety/depression
Inresearch
Maintainingthegains
Oxygenduringexercise
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
What’snewintheguidelines?• Recommendationforhome- andcommunity-basedPR• RecommendationforPRinpeoplewithmildCOPD(symptoms)• Clearstatementthatmonthlymaintenanceprogramsarenot
useful• PermissiontodeliverPRwithoutastructurededucationprogram• RecommendationforPRinpeoplewithbronchiectasis,ILDand
pulmonaryhypertension,intherightsetting
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Whatdotheguidelinesmeanforpatients,cliniciansandpolicymakers?
• InpeoplewithCOPD,compellingevidenceformeaningfulbenefitsfromPRprovidesastrongmandatetoimproveaccess,referralanduptake
• Todeliveronthiswillrequiremultiplestrategies:– Patientshavebetterunderstandingofroleandlikelybenefits– Cliniciansknowhowtorefer,anddosomoreoften– Programsmorereadilyavailableandaccessible– Qualitystandardsagainstwhichwecanevaluateeffectiveness
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
ForAustraliaandNewZealandcontext
• Weakrecommendationsfornewmodelsofpulmonaryrehab(eg home-based,community-based)havepotentialtoimproveaccessforpeoplelivingawayfrommajorcentres
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
ForAustraliaandNewZealandcontext
• IndigenousAustralianandNewZealandcommunitieshavedisproportionatedisadvantagefromCOPD– Importanttoimprovepulmonaryrehabaccess– Greatereffortsrequiredtoensuresafeculturalenvironmentsfordeliveryofpulmonaryrehab
– InNZ,attendanceenhancedby• pulmonaryrehabprovidedforMāoribyMāoriorganisations• informationandcommunicationinacommonMāorilanguage(Levack
VM2016)
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Limitationsoftheguidelines
• OnlyaddressedaselectednumberofPICOquestions• OtherimportantquestionsforpulmonaryrehabinAust andNZmay
nothavebeenanswered• Someexamples:
– Roleofselfmanagementtraining– Componentsofexercisetraining– Roleofnutritionalsupplementation– Inclusionofpeoplewithasthma,lungcancer,cysticfibrosis– Repeatingpulmonaryrehab
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
Conclusions– newPRguidelines
• StrongrecommendationthatpeoplewithCOPDundertakepulmonaryrehabtoimproveexercisecapacity,HRQoL andavoidhospitalisation– Nosurprise,butmandatesrenewedeffortstoimproveaccessand
uptake• Weakrecommendationsfornewmodelsofpulmonaryrehab,andrehab
innewpopulations– Maypromptchangestothepulmonaryrehabilitationmodel
• WatchthisspacefornewdevelopmentsaroundqualitystandardsandMBSitemnumber
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
AcknowledgementsPRGuidelinePanel(28),LFA,Librarians
ExpertAdvisoryPanel:ChristineJenkins,ChristineMcDonald,IanYang,KerryHancockTSANZ,ReviewersAustraliaandNewZealand
JennyAlison AnneHolland ZoeMcKeough KylieJohnston RenaeMcNamara LissaSpencer
SueJenkins CatherineHill VanessaMcDonald PeterFrith PaulCaferella KirstenPhillips JulietBrown
AcollaborationbetweenLungFoundationAustraliaandtheThoracicSocietyofAustralia&NewZealand
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