A D V A N C E D S I Z E R E D U C T I O N • P E R F O R M A N C E & F L E X I B I L I T Y

Quadro® Comil®

S I Z E R E D U C T I O N • F L U I D M I X I N G • P N E U M A T I C T R A N S F E R

L O C A L R E P R E S E N T A T I V E

CLINE12

Canada & International T 519-884-9660USA T 973-376-1266All Locations F 519-884-0253

quadrosales@idexcorp.com • www.quadrocomil.com

613 Colby Drive Waterloo, ON, CA N2V 1A1

1925 West Field Court, Suite 200 Lake Forest, IL 60045-4824

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With the engineering experience gainedfrom developing reliable application-specificsolutions for major processors in more than80 countries, our knowledge of sizereduction and dispersion is unmatched. In fact, meeting the evolving needs of ourcustomers drives the development of some

of the industry’s most advanced processing technologies andsystems – such as the Quadro®oo Comil®, Quadro®oo FlexSift,QuadroQuadroQ adro®®®oooooo Fine Grind, Quadro YtronFine Grind Quadro YtronFine Grind Q adro Ytron®®®nnnn in-line mixers, dispersersin line mixers dispersersi li i diand emulsifiers, Quadro®oo ShearFX, Quadro®oo HV-Emulsifier andQuadro Vac® vacuum transfer systems.Since 1976, Quadro has led the industry in research &development. Through the Quadro R&D Test Center we work

directly with our customers to run real-world tests of their processes on the latestQuadro equipment. The result has beentechnical breakthroughs that havechanged the way many of our customersmanufacture, and led to new globalprocessing industry standards.

As the world’s leading supplier of size reduction technology –with a vast global network of agents, distributors, OEMs andpartners – Quadro provides a level of service and technicalQ d id l l f i d h i lsupport that is unequaled in the industry. Our passion fortechnology is exceeded only by our dedication to meeting theneeds of our customers.

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QUADRO GLOBAL LOCATIONS

World Headquarters Representative Locations Local Testing Capabilities

Ucountries, the Quadro® Comil® is the

world’s leading technology for achieving

uniform size reduction, sieving, deagglomeration

dispersion and mixing. In applications throughout the

Pharmaceutical, Food, Fine Chemical, Personal Care

and Cosmetics industries, wherever process managers

seek optimum process efficiency and product

consistency – that’s where the Comil® is hard at work.

Maximum processing efficiency

Quadro invented the original conical mill in 1976. Though

simple in principle, the Comil ® was a revolutionary

concept that has since evolved into a global processing

standard adopted by market leaders around the world.

Today, the Comil®’s proprietary, advanced size reduction

technology has been refined through thousands of

applications to deliver reliable scalability, repeatability and

environmentally friendly performance. The result is

superior product quality and maximum throughput for

quick return on investment.

Versatility and control

Over the past 30 years, the Comil®’s industry

leadership has been reaffirmed with every new product

generation introduced. Our latest inline designs

incorporate a host of innovations that offer greater

application versatility along with easier cleaning

and maintenance.

Maximum performance

When you choose the Quadro® Comil® you can rely on

receiving the superior engineering and

manufacturing quality that give you maximumg q y g y

uuptime and yield. What’s more, everyy , y Comil ® is

bbacked bby the highest level of application and

teechnical support, based on more

than a quarter century of

QQuadro exxperience. Quadro®

CComil® pproducts

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Model 196First Comil® brought

to market

Model 197Small productionmodel introduced

Model 194Mid-size productionmodel introduced

Model U20Comil® underdriven

line established

Series 2000Comil® global design

Revolutionary technology that has stood the test of timeT H E Q U A D R O® C O M I L® H E R I TT A G EE

Model U3First Scalable

R&D/Lab Model Introduced

Model F10Fine Grind Series,

micron milling

The Quadro®

Comil® comes

in 35 standard

models, available with

over 200 screen types and

dozens of different impellers –

the industry’s most extensive line

of conical milling equipment.

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2 0 0 1 2 0 0 3 2 0 0 5

Model U5Pilot & Development

Scale Mill

D Y N A M I C P R I N C I P L E S

1. In the conical screen chamber, a rotating impellerimparts a vortex flow pattern to the infeedproduct.

2. The product is forced outward to the screensurface by centrifugal acceleration, ensuringcontinuous delivery into the "action zone"between the screen and impeller.

3. In the "action zone" the material is uniformlysized and instantaneously passed tangentiallythrough the screen openings.

4. The finished product is discharged at the bottom of the milling chamber.

®®®®

Qy guality engineered for

reliable, low-maintenance

operation, the Comil ®’s

track record for high-efficiency inline

processing is unequaled across a vast

range of applications – from size

reduction to mixing and dispersion,

bulk density adjustment to separation and

reclaim.

Scalable performance

The Comil ® Overdriven is available

in five models, offering capacities

up to 120,000 lb/hr (54,500 kg/hr).

Specialized performance options are also

available.

Manufactured in stainless steel for

sanitary operation and easy cleanability,

the Comil® Overdriven can be flood fed

(control feeding is not necessary).

Milling action can be fine tuned

using a comprehensive selection of

interchangeable tooling, as well

as speed variation.

Low heat, low noise, low dust

The original Comil ®’s innovative,

low-speed design applies an inherently

gentle action to the product, achieving

optimum particle granulometry while

generating limited or no heat, low

noise and minimal fines. In addition to

low energy consumption, the result is

a consistent, high-quality end product,

even with heat-sensitive materials.

7

4

F E A T U R ER E SS

(1) Capacities are based on standard pharmaceutical placebo with 3% crystalline cellulose (CMC). (2) Capacities may vary significantly based on product characteristics, particle granulometry, inlet and

discharge conditions. Consult your local representative or Quadro for product testing. (3) For some products, capacities reach the following higher limits: (a)15,000 lb/h (6,800 kg/h), (b)35,000 lb/h

(15,900 kg/h), (c)60,000 lb/h (27,000 kg/h), (d)120,000 lb/h (54,500 kg/h).

S P E C I F I C A T I O N S

P R O V E N S I Z E R E D U C T I O N T E C H N O L O G Y

DELUMPING DOWN TO <500 MICRONS

"When we replaced our oscillating granulator with

a Comil® for delumping sodium and potassium

chlorides, the results were impressive. Dust levels

were minimized, and equally if not more important,

processing time was reduced by 50%."

Norgine Ltd., South Wales, U.K.

To achieve the tight particle size range required

to produce their "Movicol" product, Norgine had been

delumping chlorides in small batches using an

oscillating granulator. The Comil® performed so well,

that they purchased a second unit for sizing dried

granules for their "Camcolit" and

"Destolit" tablets.

METHOD OF OPERATION

Sodium and potassium chlorides are dried on

trays, then tipped into the inlet of the Comil®

through a specially designed feed hopper,

reducing dust levels to an absolute minimum.

Comil ® Model 197 S with standard feed hopper

2

1

3

5

6

1. Infeed chute can be customized tomeet all procecessss f feeeed requirements (manual,pneumatic or mechanical).

2. Machine housing with super-sanitary spindle assembly. Canalso be modified for clean-in-place(CIP) operation.

3. hroudSwing-away discharge shroudallows quick changeover ofallows quick chascreens, impellers, customizedtooling for special applications.Also allows for easy cleaning. Canbe custom engineered to fit anyprocess or collection vessel.

4. inine available inEnntiree maca hihinnnless steelnles of stainlevav riiouo s s grgradadesess

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driven model.)dd

6. Safety features to meet allinternational safety guidelines andstandards.

7. Stainless steel motor shield forsanitary applications.

1 4

5

6

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2

3

®®®®

Based on the same

revolutionary technology

as our overdriven model, the

ComilComil ®® Underdriven provides Underdriven provides

all the features and options of the

original Comil ® – with additional

advantages, including easier

inline integration.

Compact design, increasedthroughput

This mill’s advanced, compact design

and extremely short head height

provide for easy integration into

processing environments where head

room is limited. A large-diameter infeed

and “straight through” housing (with no

offset between inlet and

outlet) promote unhindered inline

product flow for quicker discharge.

Available in four models, the Comil ®

Underdriven is scalable in capacity from

several ounces (grams) to 35,000 lb/hr

(15,900 kg/hr).(15 900 kg/hr)

Innovative "quick change"tooling

Fine tuning the mill for optimum

granulometry is simplified by means

of an innovative spacerless design,

which allows for quick changeover of

impellers and screens. Specialized

tooling is available to meet all process

requirements. A variable-speed feature

provides for even greater control of

process performance.

2

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from100 gm or

3 oz batches

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S P E C I F I C A T I O N S

(1) Capacities are based on standard pharmaceutical placebo with 3% crystalline cellulose (CMC). (2) Capacities may vary accordingly based on product characteristics, particle granulometry, inlet and

discharge conditions. Consult your local representative or Quadro for product testing. (3) For some products, capacities reach the following higher limits: (a)15,000 lb/h (6,800 kg/h),

(b)35,000 lb/h (15,900 kg/h).(4) U3 model is generally designed for lab and research purposes.

B

F E A T U R E S

H I G H C A P A C I T Y I N A C O M P A C T F O O T P R I N T

5

1. Extremely short housinnnnnnnnnnnggg g g heheheheigigigighthththtfor installation in produucucuucuctitititiononononenvironments where space ispace islimited.

2. Large infeed diameter for up to50% higher capacity thanconventional mills.

3. Spacerless design providesoptimum impeller/screen

clegap for superior particlegranulometry and performance.ggranulometry and

4. Minimum surface arearesulting in maximum productflow and lower cleaning costs.

55. esigneysy-clean, sanitary deEaEasssryryludes all sanitaryiincl

tra-sanitaryconnections and ultrconautomaticgearbox. Fully au

available.CIP capability a

angeover of screensQuick chanmpellers, no special toolsand imp

equired.requ

7. Inlet and outlet can be customized to fit anyprocess conditions.

8. Safety features to meetall international guidelines and standards.

The Comil® Underdriven’s cGMP

design and minimum surface

area of contact make it easy

to clean, as well as offering

quick disassembly and

assembly for autoclave

applications.

1

4

5

6

8

7

2

3

"Not only did the Quadro® Comil® meet our moststringent requirements for use in hazardouslocations, the portable design of the systemallowed for remarkable flexibility, along with easyoperation and cleaning."

Pfizer Inc., Michigan, U.S.A.

When Pfizer required a portable inert mill for usethroughout their new, state-of-the-art researchfacility in Michigan, they turned to Quadro. We engineered a custom solution that included an air-purge electrical panel, inert gas inlet and outletports, a closed-loop oxygen control system, and infeedchutes for both inline and hand feeding.

Prior to starting, the Comil® is purged with N2 inorder to produce inert operating conditions. Duringmilling, should the oxygen level rise to the presetmaximum, the N2 purge is activatedautomatically to halt the rise. Shouldthis continue, an alarm will sound andthe Comil® will shut down.

Comil ® Model U10

METHOD OF OPERATION

SAFE, VERSATILE INERT MILLING

S O L U T I O N P R O F I L E

DRY MILLING

SIZE REDUCTION

Dry granulation in tablet manufacturing. Drysolubles. High-throughput bulk density fine tuning.Sizing dry granules. Sizing compacted product.

WET MILLING

SIZE REDUCTION

Size reduction and milling of wet or soaked products to produce liquid with wet suspended particulate. Powders into pastes. Wet blending.Uniform sizing of wet granulation in tablet manufacturing.

DRY MIXING

DISPERSION

Ideal for a broad range of dry mixing, finishing anddispersion tasks. Lump-free homogeneous blendingto precise size requirements. Low heat buildup andprecise screen size ensure complete dispersion atdesired particle size.

DEAGGLOMERATION

DELUMPING & SEPARATION

Reducing difficult, sticky, heat-sensitive agglomerates into pieces, crumbs or powders ofuniform size, continuously without excessive heatbuildup or screen blockage. Preserves quality offragile products. Replaces labor intensive, expensive manual processes.

RECLAIM

Gentle breaking action enables the Comil ® topowderize heat-sensitive products such asshortening and cream filled products. Hard,compacted products can also be size reduced withminimal fines.

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For more than 30 years,

Quadro has been continually

refining and improving

Comil ® technology. During this time, we

have partnered with our customers,

successfully developing thousands of

custom applications to provide

increased productivity, versatility

and reliability.

Application problem solving

Unparalleled experience enables us

to offer a level of application problem-

solving expertise second to none –

whether you’re reclaiming

pharmaceutical powders from gelatin

capsules, performing closed-loop inert

milling, granulating freeze-dried food

products with minimum retention time or

delumping wet, sticky materials.

Processing knowledge

In designing for your application,

Quadro engineers draw on one of

the most comprehensive databases of

processing knowledge. Our industry-

leading global test center includes a full

range of the latest lab equipment,

a product preparation area and a state-

of-the-art analysis area, as

well as a fully equipped customer

training and testing facility, all

dedicated to optimizing your

production process.

Try before you buy

To enable our customers to evaluate the

Quadro® Comil ® in a real-world

production environment, we offer a

"try before you buy" trial tooling and

rental program. Our confidence in the

Comil ®’s ability to meet or exceed your

expectations, and perform

trouble-free processing, enables us

to offer a full money-back guarantee.

In our state-of-the-art testing center, Quadro performs advanced application testing and

analysis for our customers, at no charge.

F

A P P L I C A T I O N S H O W C A S E

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GENERAL • COSMETIC • CHEMICAL

Quadro excels in custom

engineering. From simple

dimensional changes

of our standard models to complete

prototype development, we offer

unmatched application expertise that

enables us to build to your exact

process requirements.

Performance, repeatability,flexibility

Our experience in conical-screen size

reduction is unequaled. Every Comil ® is

engineered for superior performance and

reliability. No matter what your

application, the Comil ® consistently

delivers the batch-to-batch repeatability

required to comply with the most

demanding FDA standards.

Since 1976, the Comil ® line has

expanded to include thirty-five base

models. Model selection is tailored to

meet your specific performance and

volume demands. For example, by

interchanging tooling you can alter size

reduction, blending or dispersion

parameters to handle varying product

requirements, or even completely

different applications, all using the same

machine.

An array of specialized options

We offer a comprehensive selection

of specialized options for customizing

the Comil ® to your exact needs.

Options include:

• Special materials and surface

finishes

• Portable, height-adjustable and slide-

rail mounted frames

• Pressure-vessel, explosion proof, fully

inert, totally contained glove-box and

cryogenic mill designs

• Computerized control for complete

process monitoring and reporting.

Available in USDA approved, CIP, SIP and

WIP designs, the Quadro® Comil®

conforms to all international standards

including UL, CSA and Halal

certifications, and complies with

OSHA, FDA, CE, cGMP, ATEX and

21CFR11 guidelines and directives.

Detailed documentation, such as

compliance certificates and IQOQ

documents, is available in various

languages to make your validation

process easier.

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Dry Milling and ConveyingDry Milling and Conveying

T Y P I C A L S Y S T E M

Milling and BlendingMilling and Blending

The unmatched flexibility of the Comil® design enables

Quadro custom engineered this integrated

milling solution incorporating the Comil®

with a Carlisle Extract crossflow system.

Quadro to provide highly customized solutions for integration into your most demanding processing environments.

An inverted fluid-bed dryer bowl directly discharges into a Comil® U30 on a portable

stand, feeding a stainless steel drum.

gBulk Discharge Station

g ( )Finishing (Feed from Blender)

Pressure Vessel (meets ASME code)Pressure Vessel (meets ASME code)

Hazardous ContainmentH d C t i tComplete Inert Milling SystemComplete Inert Milling System

Integrated Wet Sizing

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C O N F I G U R A T I O N S