R=0.79, p<0.001R=0.79, p<0.001

A C

DB

R=0.77, p<0.001

Fig: Free (measured by equilibrium dialysis) versus total cortisol at baseline, 30 and 60 min after ACTH injection in the critically ill with sepsis (AC) or non-sepsis (BD), according to dichotomized levels of cortisol binding globulin (CBG; panels AB) and albumin (panels CD). R=partial correlation coefficient.