R e s e a R c h a n d G R a d u a t e s t u d i e s a t n o R t h c a R o l i n a s t a t e u n i v e R s i t y

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NC STATE UNIVERSITY

Research development at NC State took a big leap forward in 2005-06, with new broadly based research institutes and centers of excellence proposed and initiated by faculty throughout the University. “Institutes and centers play a pivotal role in enhancing our position as a leading research university for the 21st century,” said Chancellor James Oblinger. “Through key partnerships, our centers and institutes help leverage NC State’s strengths to generate new knowledge, create innovative technology, contribute to economic development and improve services and products. They also help to develop the educational experiences of our students through undergraduate and graduate research opportunities.” Institutes and centers also played an important role in generating the 5.6% increase in research awards received by NC State in 2005-06.

Joining the list of 55 existing centers and institutes at NC State (see www.ncsu.edu/sparcs/centers/), one institute and six multidisciplinary centers of excellence were initiated in 2005-06. These include:

• The Institute of Maintenance Science and Technology

• The Center for Comparative Medicine and Translational Research

• The Semiconductor Power Electronic Center

• The Forest Biomaterials and Biotechnology Research and Education Center

• The Cooperative Tourism Center

• The Center for Research of the Nano/Bio Material Interface

• The North Carolina Coastal Resources Law, Planning and Policy Center

“Centers and institutes employ highly competent faculty and students, offering partners a critical mass of talent that surpasses the capabilities of individual organizations,” explains Dr. John Gilligan, Vice Chancellor for Research and Graduate Studies. “They are usually very successful in attracting research funding from government and industry, and each supports a substantial educational component, especially at the graduate level.”

Working with Dr. Steven Lommel, Assistant Vice Chancellor for Research Development, faculty focus groups have been engaged in planning for other institutes and centers in nanotechnology, nonwoven textiles, systems biology, energy and biofuels, and neutron sciences—all areas where NC State has substantial interdisciplinary strength. These focus groups are gauging available funding at the federal or state level as well as industry partnership interest.

In general, an institute has a much larger scale mission than a center and some are made up of several centers, each with a smaller and more specific scope of work. All institutes and centers involve faculty and students in more than one department. In addition, they often include the participation of other institutions, agencies, or organizations such as hospitals, industry, foundations, or governmental bodies. “It takes a real expertise and time commitment to create a research institute or center,” says Lommel. “The faculty behind these initiatives are our best, brightest, and most committed to breaking into emerging fields of research, education and service.”

2 0 0 5 - 0 6 A N N U A L R e p O R t ww

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R e sul t s2005-06 bReeds siGnificant nc state ReseaRch initiatives

* chrOnicle facts & figures: faculty schOlarly PrOductivity index, 2005

awaRds by sponsoR federal gOvernment $148.3m 72% Private fOundatiOns $7.4m 4% state gOvernment $27.2m 13% industry $21.3m 10%Other $2.8m 1%total $207.0m 100%

fedeRal awaRds by aGency total $148.3m natiOnal science fOundatiOn $31.0m dePartment Of agriculture $27.1m dePartment Of health & human services $22.5m dePartment Of cOmmerce $15.4mdePartment Of defense $15.2m dePartment Of energy $13.6m dePartment Of educatiOn $9.8mnatiOnal aerOnautics & sPace agency $4.7m envirOnmental PrOtectiOn agency $2.7mdePartment Of the interiOr $1.9m dePartment Of hOmeland security $0.2m Other $4.2m

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96-97

Federal $148.3 M

$0.0

$20.0

$40.0

$60.0

$80.0$100.0$120.0

$140.0

Non-Federal* $58.8 M

fedeRal/non-fedeRal awaRds ten-yeaR compaRison

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TS Our faculty and

students are wOrking On thOusands Of PrOJects that will ultimately Benefit nOrth carOlina and the natiOn. tO the right are Just a few examPles Of cutting-edge research results frOm the Past year.

Associate professor of civil, construction, and environmental engineering, Dr. Joel Ducoste is researching ways to prevent sanitary sewer overflows caused by accumulation of fat, roots, oil, and grease in collection systems. Using computer simulations and pilot-scale tests, Ducoste and his team are analyzing the surface chemistry of pipe materials as well as pretreatment methodologies.

Dr. Maysam Ghovanloo, assistant professor of electrical and computer engineering, has developed the Tongue Drive system—an innovative assistive device to enable people with severe disabilities such

as spinal cord injuries or degenerative diseases to access computers using their tongues. A prototype, which communicates wirelessly with a basic PDA to control a computer, wheelchair, telephone, TV, or other device, will be tested at WakeMed Rehab Hospital in Raleigh.

$160.0

summary Of sPOnsOred PrOgrams activity

PrOPOsals suBmitted 1,559 awards received 1,940 grant and cOntract dOllars requested $616.3mgrant and cOntract dOllars awarded $207.0mgrant and cOntract direct exPenditures $201.6m recOvered indirect cOst exPenditures $30.4m

* 03-04 non-federal awards include $33.5M grant from Golden LEAF Foundation.

CoLLEGE of EnGInEERInG

12

3

4

5

97-98

98-99

99-00

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01-02

02-03

03-04

04-05

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fedeRal awaRds by aGency total $148.3m natiOnal science fOundatiOn $31.0m dePartment Of agriculture $27.1m dePartment Of health & human services $22.5m dePartment Of cOmmerce $15.4mdePartment Of defense $15.2m dePartment Of energy $13.6m dePartment Of educatiOn $9.8mnatiOnal aerOnautics & sPace agency $4.7m envirOnmental PrOtectiOn agency $2.7mdePartment Of the interiOr $1.9m dePartment Of hOmeland security $0.2m Other $4.2m

awaRds by academic unit

all otheR units total $35.0mPrOvOst $8.3mresearch & graduate studies $14.0mextensiOn & engagement $9.4mchancellOr $2.3mstudent affairs $0.9mfinance & Business $39.9k

awaRds by unit total $207.0m

agriculture & life sciences $54.7m 26%

engineering $49.6m 24%

Physical & mathematical sciences $27.3m 13%

textiles $11.9m 6%

veterinary medicine $11.6m 6%

natural resOurces $7.7m 4%

humanities & sOcial sciences $4.0m 2%

educatiOn $2.9m 1%

management $1.7m 0.8%

design $0.7m 0.3%

all Other units $35.0m 17%

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Dr. Gail Jones, professor of mathematics, science and technology education, and her UNC colleague have received a $700,000 grant to study what types of experiences improve students’ ability to conceptualize size and scale. The results will lead to better student understanding of technological developments such as the telescope and the atomic force microscope, as well as future advancements in astrophysics, biotechnology, nanoscale science, and geography.

CoLLEGE of EduCATIon

Dr. Gregg Dean, professor of immunopathology and an expert on feline and human lentiviruses, is developing novel vaccine strategies for the prevention of human and feline immunodeficiency (HIV/FIV) virus infection. Dean’s lab is investigating the potential of Lactobacillus bacteria, a safe organism used in food processing, as an inexpensive, easy to manufacture, orally delivered vaccine vector.

CoLLEGE of VETERInARy MEdICInE

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2

3

4

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910

Funded by the National Institute of Allergy and Infectious Disease, mathematics professor Tom

Banks, statistics professor Marie Davidian, and their colleagues are developing mathematical and statistical models that will aid in designing new treatment strategies for HIV patients. The research could lead to new approaches for treating acutely infected patients based on their personal variables.

College of Textiles professors Alan Tonelli and Richard Kotek have developed a super-strong aliphatic nylon fiber to be used in ropes, loading straps, parachutes, and automotive tires, or to create composite materials suitable for high-temperature applications. Tonelli says these fibers are as much as 10 times stronger than typical aliphatic nylons and will probably be more economical to produce than high-strength nylons like Kevlar.

aGRicultuRe & life sciences

awaRds by academic unit

desiGn education

manaGement natuRal ResouRces physical & mathematical sciences

CoLLEGE of TExTILESWith support from NIH, NSF, and DOE, Professors Alex Smirnov and Tatiana Smirnova are developing novel approaches to studying drug molecular mechanisms. Dr. Smirnov is using his newly discovered lipid nanotube technology to develop a new generation of robust and efficient hybrid nanoscale devices and membrane protein biochips. Dr. Smirnova is using advanced spectroscopic tools to study bonding interactions in membrane proteins and principles governing assembly of transmembrane domains of enveloped viruses to assist in developing novel vaccines.

CoLLEGE of PHySICAL And MATHEMATICAL SCIEnCES

mil

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$54.7M

$.7M

$1.7M $7.7M

96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

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96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

All funds for 3-year program received in 03-04.

College of Textiles professors Alan Tonelli and Richard Kotek have developed a super-strong aliphatic nylon fiber to be used in ropes, loading straps, parachutes, and automotive tires, or to create composite materials suitable for high-temperature applications. Tonelli says these fibers are as much as 10 times stronger than typical aliphatic nylons and will probably be more economical to produce than high-strength nylons like Kevlar.

10-yeaR compaRison 1996-2006

education enGineeRinG humanities & social sciences

physical & mathematical sciences textiles veteRinaRy medicine

CoLLEGE of TExTILESAssistant professor of anthropology and co-director of the new NC Program for Forensic Science, Dr. Ann Ross is conducting research on the classification of human skulls using modern three-dimensional methods in order to improve current identification standards. Ross was the recipient of the 2005 International Human Rights Award for her work in identifying Hurricane Katrina victims and investigating forced disappearances, tortures, and arbitrary executions in Bosnia and her native Panama.

CoLLEGE of HuMAnITIES And SoCIAL SCIEnCES

$49.6M

$4.0M

$2.9M

$11.9M

$11.6M

$27.3M

mil

liO

ns

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96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

Textiles professor Stephen Michielsen and collaborators at Emory University have developed a novel, permanent nano-coating for filters to kill or inactivate most viruses and bacteria when exposed to visible light. Early tests have shown that the coating kills 99.9% of influenza and vaccinia viruses. Potential uses will include hospital areas and waiting rooms, airplanes, businesses, and anti-viral masks for first responders and the military.

All funds for 3-year program received in 03-04.

Two years’ funding for National Textile Center received in 05-06.

GRaduate enRollment

fall 1996-2005 GRaduate applicants fall 1996-2005

deGRees awaRded 1997-2006

*Doctor of Veterinary Medicine

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Microbiology Professor Scott Laster, working with Erimos Pharmaceuticals, has discovered that a small molecule named EM-1421—currently in clinical trials for treatment of malignant tumors—also reduces the often fatal complications of multiple flu strains, possibly including avian flu. An R&D facility for Houston-based Erimos is located on NC State’s Centennial Campus.

CoLLEGE of AGRICuLTuRE And LIfE SCIEnCES

7,770

96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

10,000

9,000

8,000

7,000

6,000

5,000

4,000

3,000

2,000

1,000

0

7,270

95-96 96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05

8,000

7,000

6,000

5,000

4,000

3,000

2,000

1,000

0

3,354

1997

1,600

1,400

1,200

1,000

800

600

400

200

0

CoLLEGE of dESIGn

Architecture professor Georgia Bizios oversees a partnership with the Lumbee Tribe of North Carolina to promote quality home designs and an increase in home ownership among members. Architecture graduate students work with Bizios and tribe members to generate design guidelines and prototypes for affordable, energy-efficient, culturally appropriate homes and neighborhoods. Lumbee Home Designs is part of the College of Design’s Home Environments Design Initiative—a vehicle for helping improve the quality of residential architecture in North Carolina.

With funding from NIH and the National Academies, assistant professor of genetics Dr. Philip Awadalla and his research team are resequencing the Plasmodium falciparum genome from parasites around the world to discover novel vaccine and drug targets. Plasmodium falciparum is the most lethal agent of malaria, which kills two to four million people each year.

Total

Women

1998 1999 2000 2001 2002 2003 2004 2005 2006

Master

Doctor

DVM*

*Beginning with Fall 1998, counts include distance education enrollment.

Wood and Paper Science professors Hasan Jameel, Hou-min Chang, and Richard Venditti have developed a process to recover and recycle 60% of the enzymes required during various phases of producing ethanol from wood and other waste paper. This process has the potential to significantly decrease the cost of ethanol production.

invention u.s. patent u.s. disclosuRes applications patents license staRt-up Received filed issued aGReements companies

96-97 115 49 25 54 397-98 101 53 28 39 598-99 144 79 31 83 899-00 170 97 45 47 600-01 211 110 25 60 701-02 188 140 35 55 502-03 206 172 49 67 703-04 176 139 46 62 404-05 178 75 49 75 405-06 208 117 41 81 6 total 1,697 1,031 374 623 55

technoloGy tRansfeR and economic development

staRt-up companies in 05-06:

innOvative faBrics, llc

nirvana Pharmaceuticals

illumina, inc.

laam science, inc.

trana discOvery, inc.

ultrasePtics, inc.

top inventoRs in 05-06 (numbeR of patents awaRded):

dr. JOn s. lindsey (7)

dr. veena misra (4)

dr. Paul d. franzOn (3)

dr. saad a. khan (3)

dr. geOrge w. rOBerts (3)

patent Royalties*

*Includes a one time ~$5 million payment in 98-99

CoLLEGE of nATuRAL RESouRCES

96-97 97-98 98-99 99-00 00-01 01-02 02-03 03-04 04-05 05-06

$9.0

$8.0

$7.0

$6.0

$5.0

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$3.0

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$1.0

$0.0

CoLLEGE of dESIGn

As one of the pioneers of an emergent discipline, accounting professor Dr. Mark Beasley is the director of the Enterprise Risk Management Initiative. The Initiative provides leadership in managing the portfolio of risks that face organizations, boards of directors, senior executives, and other stakeholders seeking to preserve and enhance entity value.

CoLLEGE of MAnAGEMEnT

$3.6 M

Results: Research and Graduate Studies at North Carolina State University is published four times yearly by the Office of the Vice Chancellor for Research and Graduate Studies. Text may be reprinted

provided credit is given. Photographs and artwork may not be reprinted without written permission from the editor. Comments and queries should be addressed to Editor, Results, NCSU Box 7570,

Raleigh, NC 27695-7570. Phone: 919/513-0141, e-mail: jaine_place@ncsu.edu.

w w w. n c s u . e d u / r e s e a r ch / r e s u l t s

R e sul t sR e s e a R c h a n d G R a d u a t e

s t u d i e s a t n c s u

Vice chancellor for research and Graduate studies

John G. Gilligan

dean, Graduate school and associate Vice chancellor,reasearch and Graduate studies Terri L. Lomax

associate Vice chancellor for sponsored proGrams and reGulatory compliance serVices

Matthew K. Ronning

associate Vice chancellor for

technoloGy deVelopment & innoVation

David Winwood

assistant Vice chancellor for research deVelopment

Steven A. Lommel

director, contracts and Grants

Earl N. Pulliam

director, research proposal deVelopment

Jaine P. Place

associate deans for research:

aGriculture and life sciences

Steven W. Leath

desiGn

Arthur R. Rice education

Samuel S. Snyder enGineerinG

John S. Strenkowski

natural resources

J. B. Jett

humanities and social sciences

Walt A. Wolfram (interim)

manaGement

Steven G. Allen

physical and mathematical sciences

Raymond E. Fornes

textiles

Harold S. Freeman Behnam Pourdeyhimi

Veterinary medicine

Neil C. Olson

NC STATE UNIVERSITY

© 2007 NC State University CPrinted on recycled paper.

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I n n o v a t i o n i n A c t i o n

nc state in top Ranks of u.s. public univeRsities2nd in Best Overall PuBlic university value ❧3rd in life sciences Patent PiPeline POwer ✽5th in Best Overall PuBlic university value ❂

6th in tOtal research exPenditures amOng PuBlic universities withOut medical schOOls ♦6th in industry-funded research ✽9th in tOtal Patent PiPeline POwer ✜15th in undergraduate engineering PrOgrams ❂16th in PuBlic university liBraries ✭19th in graduate students in science and engineering fields in dOctOrate-granting institutiOns ✤20th in Overall cOmmercializatiOn index amOng u.s. and canadian universities ❅

27th in Overall lOmBardi center ranking Of PuBlic universities ❖36th in tOtal research exPenditures amOng PuBlic universities ♦4th amOng all u.s. engineering cOlleges in numBer Of B.s. degrees awarded ❁4th amOng all u.s. engineering cOlleges in numBer Of B.s. degrees awarded tO wOmen ❁5th amOng all u.s. engineering cOlleges in numBer Of B.s. degrees awarded tO african americans ❁tier 1 ranking amOng “tOP 100 entrePreneurial cOlleges” fOr nc state’s entrePreneurshiP educatiOn initiative ✾

RankinGs of GRaduate pRoGRams amonG public univeRsities ✪

souRces

❧ The PrinceTon review, 2006✽ The ScienTiST, June 2005❂ US newS and world rePorT, august 2006♦ nSF reSearch exPendiTUreS, 2005✜ ieee sPectrum, nOvemBer 2006✮ aSSociaTion oF reSearch librarieS MeMberShiP index, 2004✤ naTional Science FoUndaTion, 2006❅ mind tO market: a glOBal analysis Of university BiOtechnOlOgy transfer and cOmmercializatiOn, milken institute, 2006❖ the tOP american research universities, the center at the university Of flOrida, nOv. 2005❁ american assOciatiOn Of engineering PrOfiles, 2005✾ enTrePreneUr Magazine, 2006✪ U.S. newS and world rePorT, aPril 2006

aerOsPace engineering (21)agricultural engineering (6)aPPlied mathematics (11)Business (30)chemical and BiOmOlecular engineering (11)city management and urBan POlicy (14)civil engineering (16)cOmPuter engineering (17)cOmPuter science (27)ecOnOmics (26)

electrical engineering (20)entOmOlOgy (4)*graPhic design (2)industrial engineering (9)materials engineering (11)mechanical engineering (23)nuclear engineering (5)sOciOlOgy (30)textiles (1)veterinary medicine (3)

* chrOnicle facts & figures: faculty schOlarly PrOductivity index, 2005