Regulation of carbohydrate metabolism - Univerzita of... · Regulation of gluconeogenesis and glycolysis:

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  • Regulation of carbohydrate metabolism

  • Overview of the major pathways of glucose metabolism

  • Regulation of gluconeogenesis and glycolysis: inactivation of the glycolytic enzymes and activation of the enzymes of gluconeogenesis

    1. Pyruvate PEPPyruvate kinase - inactivation by cAMP (glucagon)

    Phosphoenolpyruvate carboxykinase -induced by glucagon, epinephrine, and

    cortisol

    2. Fructose 1,6-P Fructose 6-PPhosphofructokinase - activated by fructose 2,6-P

    Fructose 1,6-bisphosphatase - inhibited by fructose 2,6-P

    3. Glucose 6-P GlucoseGlucokinase - high Km for glucose,

    induced by insulin

    Glucose 6-phosphatase - induced during fasting

  • Metabolism of glycogen

  • Regulation of glycogenolysis in the liver by glucagon: cAMP protein kinase A:

    1. inactivates glycogen synthase

    2. activates glycogen phosphorylase

  • Regulation of glycogenolysis in muscle: