Regulation of carbohydrate metabolism - Univerzita of... · Regulation of gluconeogenesis and glycolysis:

Regulation of carbohydrate metabolism

Overview of the major pathways of glucose metabolism

Regulation of gluconeogenesis and glycolysis: inactivation of the glycolytic enzymes and activation of the enzymes of gluconeogenesis

1. Pyruvate PEPPyruvate kinase - inactivation by cAMP (glucagon)

Phosphoenolpyruvate carboxykinase -induced by glucagon, epinephrine, and

cortisol

2. Fructose 1,6-P Fructose 6-PPhosphofructokinase - activated by fructose 2,6-P

Fructose 1,6-bisphosphatase - inhibited by fructose 2,6-P

3. Glucose 6-P GlucoseGlucokinase - high Km for glucose,

induced by insulin

Glucose 6-phosphatase - induced during fasting

Metabolism of glycogen

Regulation of glycogenolysis in the liver by glucagon: cAMP protein kinase A:

1. inactivates glycogen synthase

2. activates glycogen phosphorylase

Regulation of glycogenolysis in muscle: