Renal Manifestations of Tuberous Sclerosis Complex

Program Goal

What Is TSC?

“Végétations Vasculaires” (1835)

“Sclérose Tubéreuse des Circonvolutions Cérébrales” (1880)

Manifestations of TSC

TSC Clinical Diagnostic CriteriaNIH Consensus Conference, Annapolis, Maryland, 1998

TSC Clinical Diagnostic Criteria (cont)

Genetics of TSC

Pathobiology of TSC

Clinical Manifestations of TSC

Onset of TSC Symptoms With Age

Angiomyolipomas and Development

Cell-of-Origin Hypothesis

PEComas: Angiomyolipomas

TSC Proteins and Cell Growth

TSC Renal Cystic Disease

Other Solid Renal Lesions

Common Presentation of TSC

Diagnosis of TSC

Angiomyolipomas: Ultrasound Images

Angiomyolipomas: CT Scan

Angiomyolipomas: MRI

Role of Biopsy

TSC Prognosis

TSC Prognosis (cont)

Management of TSC

Angiomyolipoma Treatment: Sirolimus

Changes in Volume of Angiomyolipomasa

Everolimus