RESEARCH ARTICLES, REVIEWS, AND BOOK CHAPTERS (partial list)

41. Bisacchi, G. S. “Recreating the golden age of antibiotics” Manuscript in preparation

40. Bisacchi, G. S. and Hale, M. “A double-edged” scaffold: antitumor power within the antibacterial quinolone.” Manuscript in review.

39. Bisacchi, G. S. “Origins of the quinolone class of antibacterials: an expanded “drug discovery story”. J. Med. Chem. 2015 DOI: 10.1021/jm501881c

38. Bisacchi, G. S. and Manchester, J. I. “A new-class antibacterial--almost. Lessons in drug discovery and development: a crucial analysis of more than 50 years of effort toward ATPase inhibitors of DNA gyrase and topoisomerase IV” ACS Infectious Diseases 2015, 1, 4-41. DOI: 10.1021/id500013t

37. Hangeland, J. J.; Friends, T. J.; Rossi, K. A.; Smallheer, J. M.; Wang, C.; Sun, Z.; Corte, J. R.; Fang, T.; Wong, P. C.; Rendina, A. R.; Barbera, F. A.; Bozarth, J. M.; Luettgen, J. M.; Watson, C. A.; Zhang, G.; Wei, A.; Ramamurthy, V.; Morin, P. E.; Bisacchi, G. S.; Subramaniam, S.; Arunachalam, P.; Mathur, A.; Seiffert, D. A.; Wexler, R. R.; Quan, M. L. “Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with In Vivo Antithrombotic Activity” J. Med. Chem., 2014, 57, DOI: 10.10/21/jm5010607

36. Bolton S. A.; Sutton J. C.; Anumula R.; Bisacchi G.S.; Jacobson B.; Slusarchyk W. A.; Treuner U. D.; Wu S. C.; Zhao G.; Pi Z.; Sheriff S.; Smirk R. A.; Bisaha S.; Cheney D. L.; Wei A.; Schumacher W. A.; Hartl K. S.; Liu E.; Zahler R.; Seiler S. M. “Discovery of Nonbenzamidine Factor VIIa Inhibitors Using a Biaryl Acid Scaffold” Bioorganic & Medicinal Chemistry Letters 2013, 23, 5239-5243.

35. Manchester, J.; Buurman, E. T.; Bisacchi, G. S.; McLaughlin, R. E. “Molecular Determinants of AcrB-Mediated Bacterial Efflux: Implications for Drug Discovery” J. Med. Chem., 2012, 55, 2532-2537.

34. Bisacchi, G. S. and Dumas, J. “Recent Advances in the Inhibition of Bacterial Type II Topoisomerases” in Annual Reports in Medicinal Chemistry, Volume 44, Macor, J., Ed, Elsevier, 2009.

33. Sherawat, M.; Kaur, P.; Perbandt, M.; Betzel, C.; Slusarchyk, W. A.; Bisacchi, G. S.; Chang, C.; Jacobson, B. L.; Einspahr, H. M.; Singh, T. P. “Crystal Structure of the Complex Formed Between Trypsin and a Designed Synthetic Highly Potent Inhibitor in the Presence of Benzamidine at 0.97A Resolution” Acta Crystallographica 2007, Section D: Biological Crystallography, D63(4), 500-507.

32. Shi, Y.; Zhang, J.; Stein, P. D.; Shi, M.; O’Connor, S. P.; Bisaha, S. N.; Li, C.; Atwal, K.; Bisacchi, G.; Sitkoff, D.; Pudzianowski, A. T.; Liu, E. C.; Hartl, K. S.; Seiler, S. M.; Youssef, S.; Setinbacher, T. E.; Schumacher, W. A.; Rendina, A. R.; Bozarth. J. M.; Peterson, T. L.; Zhang, G.; Zaher, R.; “Kenene Aminal-based Lactam Derivatives as a Novel Class of Orally Active FXa Inhibitiors” Bioorganic & Medicinal Chemistry Letters 2005, 15(24), 5453-5458.

31. Bisacchi, G. S.; Stein, P. D.; Gougoutas, J. Z.; Hartl, K. S.; Lawrence, R. M.; Liu, E.; Pudzianowski, A.; Schumacher, W. A.; Sitkoff, D.; Steinbacher, T. E.; Sutton, J.; Zhang, Z.;

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Seiler, S. M. “Initial Structure-Activity Relationships for a Caprolactam-based Series of Neutral Factor Xa Inhibitors: Lead Identification” Letters in Drug Design and Discovery 2005, 2(8), 625-630.

30. Bisacchi, G. S.; Slusarchyk, W. A.; Bolton, S. A.; Hartl, K. S.; Jacobs, G.; Mathur, A.; Meng, W.; Ogletree, M. L.; Pi. Z.; Sutton, J. C.; Treuner, U.; Zahler, R.; Zhao, G.; Seiler, S. M. “Synthesis of Potent and Highly Selective Non-Guanidine Azetidinone Inhibitors of Human Tryptase” Bioorganic & Medicinal Chemistry Letters 2004, 14, 2227-2231.

29. Sutton, J. C.; Bolton, S. A.; Davis, M. E.; Hartl, K. S.; Jacobson, B.; Mathur, A.; Ogletree, M. L.; Slusarchyk, W. A.; Zahler, R.; Seiler, S. M.; Bisacchi, G. S. “Solid Phase Synthesis and SAR of 4-Carboxy-2-Azetidinone Mechanism-Based Tryptase Inhibitors” Bioorganic & Medicinal Chemistry Letters 2004 14, 2233-2239.

28. Washburn, W. N.; Sun, C.-Q.; Bisacchi, G. S.; Wu. G.; Cheng, P. T.; Sher, P. M.; Ryono, D.; Gavai, A. V.; Poss, K.; Girotra, R. N.; McCann, P. J.; Mikkilineni, A. B.; Dejneka, T. C.; Wang, T. C.; Merchant, Z.; Morella, M.; Arbeeny, C. M.; Harper, T. W.; Slusarchyk, D. A.; Skwish, S.; Russell, A. D.; Allen, G. T.; Tesfamariam, B.; Frohlich, B. H.; Abboa-Offei, B. E.; Cap, M.; Waldron, T. L.; George, R. J.; Young, D.; Dickinson, K. E.; Seymour, A. A. “BMS-201620: a Selective Beta 3 Agonist” Bioorganic & Medicinal Chemistry Letters 2004, 14, 3525-3529.

27. Zhao, G.; Bolton, S. A., Kwon, C.; Hartl, K. S.; Seiler, S. A.; Slusarchyk, S. A.; Sutton, J. C.; Bisacchi, G. S. “Synthesis of Potent and Selective 2-Azepanone Inhibitors of Human Tryptase” Bioorganic & Medicinal Chemistry Letters 2004, 14, 309-312.

26. Bisacchi, G. S. “Anticoagulants, Antithrombotics, and Hemostatics” in Burger’s Medicinal Chemistry and Drug Discovery, 6th Ed., Vol. 3: Therapeutic Agents, Abraham, D., Ed., John Wiley, 2003.

25. Sutton, J. C.; Bolton, S. A.; Hartl, K.S.; Huang, M.-H.; Jacobs, G.; Meng, W.; Ogletree, M.; Pi, Z.; Schumacher, W. A.; Seiler, S. M.; Slusarchyk, W. A.; Treuner, W.; Zahler, R.; Zhao, G.; Bisacchi, G. S. “Synthesis and SAR of 4-Carboxy-2-azetidinone Mechanism-Based Tryptase Inhibitors” Bioorganic & Medicinal Chemistry Letters 2002, 12, 3229-3233.

24. Slusarchyk, W. A.; Bolton, S. A.; Hartl, K. A.; Huang, M.-H.; Jacobs, G.; Meng, W.; Ogletree, M. L.; Pi, Z.; Schumacher, W. A.; Seiler, S. M.; Sutton, J. C.; Treuner, U.; Zahler, R.; Zhao, G.; Bisacchi, G. S. “Synthesis of Potent and Highly Selective Inhibitors of Human Tryptase” Bioorganic & Medicinal Chemistry Letters 2002, 12, 3235-3238.

23. Chen, B.-C.; Bednarz, M. S.; Sundeen, J. E.; Zhang, Z. J.; Caufield, T. J.; Bisacchi, G. S. "An Improved Large Scale Synthesis of 2,3-Dihydroxyterephthalic Acid and Dimethyl 2,3-Dihydroxyterephthalate" Org. Prep Proced. Int. 1999, 31, 106-109.

22. Yamanaka, G.; Wilson, T.; Innaimo, S.; Bisacchi, G. S.; Egli, P.; Rinehart, J. K.; Zahler,R.; Colonno, R. J. “Metabolic Studies on BMS-200475, a New Antiviral Compound Active Against Hepatitis B. Virus” Antimicrobial Agents Chemother. 1999, 43, 190-193.