Research on Viral HepatitisResearch on Viral HepatitisOrganization and FundingOrganization and Funding

JeanJean--Michel Michel PawlotskyPawlotsky, MD, PhD, MD, PhD

Department of Virology Department of Virology INSERM U635INSERM U635

HenriHenri MondorMondor HospitalHospitalUniversity of Paris XIIUniversity of Paris XII

CréteilCréteil, France, France

The Origin The Origin of of FundingFunding

•• InstitutionsInstitutions

•• HepatitisHepatitis--Targeted FundingTargeted Funding

•• External GrantsExternal Grants

•• Additional BursariesAdditional Bursaries

InstitutionsInstitutions

PublicPublicHospitalHospital INSERMINSERM

CNRSCNRS

Frame Frame for for ResearchResearchClinical settings andClinical settings and labslabs

SalariesSalariesRecurrentRecurrent BudgetBudget

UniversityUniversity

Hepatitis Targeted FundingHepatitis Targeted Funding

•• Agence Nationale de Recherches sur le SIDA Agence Nationale de Recherches sur le SIDA et les Hépatites Virales (ANRS/ANRH)et les Hépatites Virales (ANRS/ANRH)

•• European European Commission FP5 Commission FP5 and and FP6FP6

ANRS ANRS

•• French French GovernmentGovernment::MinisterMinister of of ResearchResearch,,MinisterMinister of of HealthHealth,,MinisterMinister of of ForeignForeign AffairsAffairs,,

•• Other partnersOther partners::CNRS,CNRS,INSERM,INSERM,ll ’IRD ’IRD (Institut pour la Recherche et le Développement)(Institut pour la Recherche et le Développement)Institut Pasteur.Institut Pasteur.

ANRS ANRS

•• July 1, 1992:July 1, 1992:CreationCreation of ANRS for AIDS of ANRS for AIDS ResearchResearch..

•• January January 1, 1999:1, 1999:FundingFunding for for clinicalclinical, , therapeuticaltherapeutical andand public public healthhealth researchresearch on on hepatitishepatitis C.C.

•• January January 1, 2004:1, 2004:FundingFunding for for hepatitishepatitis B B andand C C researchresearch..

ANRS Missions ANRS Missions

•• DevelopDevelop possible interactions possible interactions betweenbetween differentdifferentresearchresearch domainsdomains andand coordinatecoordinate researchresearch on AIDS on AIDS andand viral viral hepatitishepatitis. .

•• Favor Favor concertation concertation among research among research teams.teams.

•• IdentifIdentif emergingemerging teams teams thatthat maymay playplay an important an important rolerole in AIDS in AIDS andand viral viral hepatitishepatitis researchresearch..

•• AndAnd… … €€€€€€€€€€€€€€ !!!!!!!!!!€€€€€€€€€€€€€€ !!!!!!!!!!

FundingFunding

•• Budget for Viral Budget for Viral Hepatitis at Hepatitis at ANRS in 2004 :ANRS in 2004 :4.5 million €4.5 million €~ 10% of ANRS budget~ 10% of ANRS budget

•• Distribution of Distribution of funding funding in 2004 :in 2004 :74% for 74% for clinical researchclinical research20.3% for basic 20.3% for basic researchresearch2.2% for 2.2% for research research in in developing developing countriescountries3.5% for 3.5% for research research in in human and human and social sciencessocial sciences

ANRSANRS

•• FundingFunding: : Scientific Scientific Committees:Committees:

CSS4: Basic and CSS4: Basic and pathophysiologicalpathophysiological research (hepatitis),research (hepatitis),

CSS7: Clinical and epidemiological research (hepatitis),CSS7: Clinical and epidemiological research (hepatitis),

AC24: clinical trials (hepatitis),AC24: clinical trials (hepatitis),

CSS5: Research in public health and man and society CSS5: Research in public health and man and society sciences (AIDS and hepatitis),sciences (AIDS and hepatitis),

CSS6: Research in developing countries (AIDS and CSS6: Research in developing countries (AIDS and hepatitis)hepatitis)

ANRSANRS

•• Animation: Animation: Coordinated Coordinated ActionsActions::

AC24: Clinical trials,AC24: Clinical trials,

AC25: Public health,AC25: Public health,

AC29: Mechanisms of hepatitis virus entry into cells,AC29: Mechanisms of hepatitis virus entry into cells,

AC30: Mechanisms of AC30: Mechanisms of carcinogensis carcinogensis in hepatitisin hepatitis--related related cirrhosis.cirrhosis.

ANRS ANRS SummarySummary

•• ANRS ANRS funding since funding since 1999:1999:

Conception Conception andand performance of 18 performance of 18 therapeuticaltherapeutical trials trials involvinginvolving 70 70 centerscenters..

Funding Funding of 76 of 76 research lab projects research lab projects (basic (basic and and translationaltranslational).).

FundingFunding of 43 of 43 prepre-- andand postpost--doctoral doctoral fellowshipfellowship bursariesbursariesandand 12 12 clinicalclinical studystudy monitors. monitors.

Funding Funding ofof thethe French national French national cohort cohort of patients of patients with with HCVHCV-- and and HBVHBV--related cirrhosisrelated cirrhosis..

European European Commission Commission FPsFPs

•• FP5:FP5:a a numbernumber of of projects projects on on hepatitis hepatitis B B and and C: DITTO, HCV C: DITTO, HCV vaccine cluster, HBV consortium, …vaccine cluster, HBV consortium, …

•• FP6:FP6:Networks of Excellence: Networks of Excellence: –– VirGil (antiviral VirGil (antiviral resistanceresistance),),

Integrated projectsIntegrated projects: : –– None,None,

STREPs:STREPs:–– None.None.

ViRgil ViRgil NoENoE

External GrantsExternal Grants

•• RegionalRegional or local administrations:or local administrations:RegionRegion,,DepartmentDepartment,,TownTown..

•• International International grantsgrants: NIH, HHMI,: NIH, HHMI, etcetc……

•• Private Private foundations,foundations,

•• Industrial sponsors.Industrial sponsors.

Additional BursariesAdditional Bursaries

•• Ligue National contre le Cancer,Ligue National contre le Cancer,

•• Fondation pour la Recherche Médicale,Fondation pour la Recherche Médicale,

•• Local Institutions,Local Institutions,

•• Private foundationsPrivate foundations,,

•• Etc...Etc...

Hepatitis Funding at Hepatitis Funding at Henri MondorHenri Mondor

Department Department of of HepatologyHepatology

(D. (D. DhumeauxDhumeaux))

Department Department of of EpidemiologyEpidemiology

(F. (F. RoudotRoudot--ThoravalThoraval))

Department Department of of VirologyVirology

(J.M.(J.M. PawlotskyPawlotsky))INSERM U635INSERM U635

(J.M.(J.M. PawlotskyPawlotsky))

•• Clinical facilities and labsClinical facilities and labs::HospitalHospitalUniversityUniversity

•• Salaries:Salaries:HospitalHospitalUniversityUniversityANRSANRSEuropean European CommissionCommissionInstitutional bursariesInstitutional bursariesPrivate foundations

•• FundingFundingINSERMINSERMUniversityUniversityANRSANRSEuropean European CommissionCommissionInstitutional bursariesInstitutional bursariesPrivate foundationsPrivate foundationsIndustrial partnersIndustrial partners

Private foundations