RESITRARed de EStudiode la Infección

en el TRAsplante

Research network for the study of infection in transplantation

Dr Jordi CarratalaHospital de Bellvitge. Barcelona

DEFINITIONAND

OBJECTIVES

RESITRA

• Network of specialists in different fields of transplantation medicine, belonging to the main hospitals that perform SOT and BMT in Spain.

• Sponsored by Spanish Ministry of Health

• 16 participating centers and 3 reference laboratories

• Surveillance began September 2003

• All transplant recipients were recorded in the database

HVHClinic

BellvitgeSant Pau

Tries i PujolDoce OctubreRamón y Cajal

Gregorio MarañónPuerta de Hierro

Princesa

JUANCANALEJO

CRUCES

LA FE SON DURETA

VIRGEN DEL ROCÍOREINA SOFIA

16 centers50% BMT

OBJECTIVES

1. Infection knowledge in the transplant setting

2. Use of new immunological and molecular tools for the diagnosis and treatment of infection in transplant recipients

3. High-level training in biomedical research for physicians, nursing staff and technicians

4. Network for clinical trials

5. Contact with other european groups or networks

RESITRA

I nf or mat ion and Document at ion U nit

GE N E RA L S E CRE T A RY

Dr . J oan Gavaldà

H ospit al U niver sit ar i Vall d ' H ebr on

S CI E N T I F I C CO M M I T T E E

Dr s. A guado, A usina, Bouza, Car r er as, Cuer vas-M on,

Pahissa, Pumar ola, Rodr íguez -T udela

Clinical Coor dinat or

Dr . J osé M ª A guado

H ospit al Doce de O ct ubr e

L abor at or y Coor dinat or

Dr . T omàs Pumar ola

H ospit al Clínic

M et hodology/ E pidemiology A ssessor

Clinical I nvest igat or

Clinical I nvest igat or

L abor at or y T echnician

Coor dinat ing A dvisor f or t he S it e Labor at or y

CN M - I S CI I I

D r . J uan L uis Rodr íguez T udela

Clinical I nvest igat or

Clinical Resear ch N ur se

L abor at or y T echnician

Coor dinat or S it e 1 -H ospit al x

Clinical I nvest igat or

Clinical Resear ch N ur se

L abor at or y T echnician

Coor dinat or S it e 2 - H ospit al x

Clinical I nvest igat or

Clinical Resear ch N ur se

L abor at or y T echnician

Coor dinat or S it e 3 -H ospit al x

Clinical I nvest igat or

clinical Resear ch N ur se

L abor at or y T echnician

Coor dinat or S it e n -H ospit al x

GE N E RA L CO O RDI N A T O R

Dr . A lber t Pahissa

H ospit al U niver sit ar i Vall d ' H ebr on

METHODS

Tools for developping the network

DATABASE

BANKSerumPlasmaDNAMicroorganismsTissues

Levels of Information

Basic: Registry

Advanced: formulate new hypothesis

Dissemination knowledge

Interconnection basic research Teaching

European groups

Clinical trials

DATABASE

PRETRANSPLANT

PERITRANSPLANT

FOLLOW-UP

to

2 y

Bacterial Infection

Viral Infection

Fungal Infection

Other Infection

REJECTION

Other medical-surgical complications

Sample BankDATABASE

INFORMATIC TOOLWeb

INFORMATIC TOOLApplicative

HERRAMIENTA INFORMATICAApplicative on-line

HERRAMIENTA INFORMATICAApplicative on-line

INFORMATIC TOOLDatabases Forms

INFORMATIC TOOLDatabases Forms

0

2703

35894179

5596

0

2000

4000

6000

1-9-03 31-09-04 1-3-05 1-6-05 15/01/2006

Est

1-09-03//1-03-05 * 30-04-05//15-01-06

1330

979

167

283

944

PANCREAS 53

RESITRA. 1-09-03 // 01-03-05

RESULTS

RESITRA• San-Juan R, Aguado JM, Lumbreras C, Fortun J, Len O, Muñoz P, Montejo M,

Moreno A, Cordero E, Blanes M, Ramos A, de la Torre-Cisneros J, Lopez-Medrano F, Carratala J, Moreno E; RESITRA-REIPI Network, Spain. Universal Prophylaxis With Fluconazole for the Prevention of Early Invasive Fungal Infection in Low-Risk Liver Transplant Recipients. Transplantation. 2011 Aug 15;92(3):346-350.

• Fortun J, Martin-Davila P, Pascual J, Cervera C, Moreno A, Gavalda J, Aguado JM, Pereira P, Gurguí M, Carratala J, Fogueda M, Montejo M, Blasco F, Bou G, Torre-Cisneros J; RESITRA Transplant Network. Immunosuppressive therapy and infection after kidney transplantation. Transpl Infect Dis. 2010 Oct;12(5):397-405.

• Torre-Cisneros J, Doblas A, Aguado JM, San Juan R, Blanes M, Montejo M, Cervera C, Len O, Carratala J, Cisneros JM, Bou G, Muñoz P, Ramos A, Gurgui M,Borrell N, Fortún J, Moreno A, Gavalda J; Spanish Network for Research in Infectious Diseases. Tuberculosis after solid-organ transplant: incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) cohort. Clin Infect Dis. 2009 Jun 15;48(12):1657-65.

RESITRA5. Len O, Gavaldà J, Blanes M, Montejo M, San Juan R, Moreno A, Carratalà J, de la

Torre-Cisneros J, Bou G, Cordero E, Muñoz P, Cuervas-Mons V, Alvarez MT, Borrell N, Fortun J, Pahissa A; Spanish Research Network for the Study of Infection in Transplantation. Donor infection and transmission to the recipient of a solid allograft. Am J Transplant. 2008 Nov;8(11):2420-5.

6. San Juan R, Aguado JM, Lumbreras C, Fortun J, Muñoz P, Gavalda J, Lopez-Medrano F, Montejo M, Bou G, Blanes M, Ramos A, Moreno A, Torre-Cisneros J, Carratalá J; RESITRA Network of the Spanish Study Group of Infection in Transplantation. Impact of current transplantation management on the development of cytomegalovirus disease after renal transplantation. Clin Infect Dis. 2008 Oct 1;47(7):875-82. .

7. Ramos A, Asensio A, Muñez E, Torre-Cisneros J, Blanes M, Carratalá J, Segovia J, Munoz P, Cisneros JM, Bou G, Aguado JM, Cervera C, Gurgui MM. Incisional surgical infection in heart transplantation. Transpl Infect Dis. 2008 Jul;10(4):298-302.

8. Ramos A, Asensio A, Muñez E, Torre-Cisneros J, Montejo M, Aguado JM, Cofán F, Carratalá J, Len O, Cisneros JM. Incisional surgical site infection in kidney transplantation. Urology. 2008 Jul;72(1):119-23.

RESITRA• Len O, Gavaldà J, Aguado JM, Borrell N, Cervera C, Cisneros JM, Cuervas-Mons V,

Gurguí M, Martin-Dávila P, Montejo M, Muñoz P, Bou G, Carratalà J, Torre-Cisneros J, Pahissa A; RESITRA. Valganciclovir as treatment for cytomegalovirus disease in solid organ transplant recipients. Clin Infect Dis. 2008 Jan 1;46(1):20-7.

• Moreno A, Cervera C, Gavaldá J, Rovira M, de la Cámara R, Jarque I, Montejo M, de la Torre-Cisneros J, Miguel Cisneros J, Fortún J, López-Medrano F, Gurguí M, Muñoz P, Ramos A, Carratalá J. Bloodstream infections among transplant recipients: results of a nationwide surveillance in Spain. Am J Transplant. 2007 Nov;7(11):2579-86.

• Len O, Gavaldà J, Blanes M, Montejo M, San Juan R, Moreno A, Carratalà J, de la Torre-Cisneros J, Bou G, Cordero E, Muñoz P, Cuervas-Mons V, Alvarez MT, Borrell N, Fortun J, Pahissa A; Spanish Research Network for the Study of Infection in Transplantation. Donor infection and transmission to the recipient of a solid allograft. Am J Transplant. 2008 Nov;8(11):2420-5.

• San Juan R, Aguado JM, Lumbreras C, Fortun J, Muñoz P, Gavalda J, Lopez-Medrano F, Montejo M, Bou G, Blanes M, Ramos A, Moreno A, Torre-Cisneros J, Carratalá J; RESITRA Network of the Spanish Study Group of Infection in Transplantation. Impact of current transplantation management on the development of cytomegalovirus disease after renal transplantation. Clin Infect Dis. 2008 Oct 1;47(7):875-82.

RESITRA• Aguilar-Guisado M, Givaldá J, Ussetti P, Ramos A, Morales P, Blanes M, Bou G, de la

Torre-Cisneros J, Román A, Borro JM, Lama R, Cisneros JM; RESITRA cohort. Pneumonia after lung transplantation in the RESITRA Cohort: a multicenter prospective study. Am J Transplant. 2007 Aug;7(8):1989-96.

• San Juan R, Aguado JM, Lumbreras C, Díaz-Pedroche C, López-Medrano F, Lizasoain M, Gavalda J, Montejo M, Moreno A, Gurguí M, Torre-Cisneros J; RESITRA Network, Spain,. Incidence, clinical characteristics and risk factors of late infection in solid organ transplant recipients: data from the RESITRA study group. Am J Transplant. 2007 Apr;7(4):964-71.

• Garrido RS, Aguado JM, Díaz-Pedroche C, Len O, Montejo M, Moreno A, Gurguí M, Torre-Cisneros J, Pareja F, Segovia J, Garcia M, Lumbreras C. A review of critical periods for opportunistic infection in the new transplantation era. Transplantation. 2006 Dec 15;82(11):1457-62.

• Gavalda J, Len O, San Juan R, Aguado JM, Fortun J, Lumbreras C, Moreno A, Munoz P, Blanes M, Ramos A, Rufi G, Gurgui M, Torre-Cisneros J, Montejo M, Cuenca-Estrella M, Rodriguez-Tudela JL, Pahissa A; RESITRA (Spanish Network for Research on Infection in Transplantation). Risk factors for invasive aspergillosis in solid-organ transplant recipients: a case-control study. Clin Infect Dis. 2005 Jul 1;41(1):52-9.