Rat Dual Pressure Telemetry 1

Respiratory Telemetry in

Large Species

Recording Respiratory Data, BP and ECG

CorDynamics introduces telemetry that records respiratory

parameters along with blood pressure and ECG in large animals

Multiple options

1) blood pressure, ECG, and respiratory parameters

- simultaneous and continuous recording

- combines two ICH S7 assessments in one study

2) can be used in multiple species

- rabbit, dog, pig, NHP

Pharmacological validation

- bethanechol (cholinergic agonist)

Effects of bethanechol on heart rate

0

50

100

150

200

250

300

350

-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490

HR

(b

pm

)

Time (minutes)

Effect of Bethanechol (subcutaneous) on Heart Ratein the Conscious, Telemetrized Rabbit

Vehicle (n=4)

10 mg/kg (n=4)

Effects of bethanechol on tidal volume

0

5

10

15

20

25

30

-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490

TV

(m

l)

Time (minutes)

Effect of Bethanechol (subcutaneous) on Tidal Volumein the Conscious, Telemetrized Rabbit

Vehicle (n=4)

10 mg/kg (n=4)

Effects of bethanechol on minute volume

0

500

1000

1500

2000

2500

3000

3500

-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490

MV

(m

l)

Time (minutes)

Effect of Bethanechol (subcutaneous) on Minute Volumein the Conscious, Telemetrized Rabbit

Vehicle (n=4)

10 mg/kg (n=4)

Effects of bethanechol on respiratory rate

0

50

100

150

200

250

300

-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490

Rf

(bre

ath

s/m

in)

Time (minutes)

Effect of Bethanechol (subcutaneous) on Respiratory Ratein the Conscious, Telemetrized Rabbit

Vehicle (n=4)

10 mg/kg (n=4)