Results

Aim of the study A specific quality of life questionnaire can identify specific aspects that can be improved for the hypertensive

patients in order to have a better life. The aim of the study is to create and validate a new and specific questionnaire to evaluate the hypertensive

patients. Material and Method

It is a prospective, observational and non-interventional study on hypertensive patients whose specific new questionnaire responses are compared with those of the healthy adults.

The questionnaire provide a complete view of the factors that influence patients response tothe hypertensive treatment.The analyse of these factors can improve the results of the therapy and also their quality of life. Validation tests were within the accepted values in theliterature, therefore the questionnaire can be used on population scale in clinical practice,butalso in research.

Conclusion

By 7 days readministration of the questionnaire, for the study patients, resulted in no significant differences between the results. The kappa coefficient which validates the “test-retest” method for all domains of the questionnaire shows above 0.75 values. The Cronbach alpha coefficient which assesses internal confidence of the survey reached a value of 0.675 .

The development and validation of a specific questionnaire for assessing quality of life in patients with essential hypertension in Romania

Liana Suciu1, C. Polinicencu2, Maria Suciu1, Lavinia-Lia Vlaia3, Raluca Mureșan4 , Laura Sbârcea5, Liana Drăgan6, Carmen Cristescu1

1Universitatea de Medicină și Farmacie “Victor Babeș” Timișoara, Farmacologie-Farmacie Clinică, Facultatea de Farmacie, Timișoara, Romania2Universitatea de Medicină și Farmacie “Iuliu Hațieganu” Cluj-Napoca, Management și Marketing Farmaceutic, Cluj-Napoca, Romania3Universitatea de Medicină și Farmacie “Victor Babeș” Timișoara, Tehnologie Farmaceutică, Biofarmacie și Farmacinetică, Timișoara, Romania4 Universitatea de Vest Timișoara, Matematică, Romania5Universitatea de Medicină și Farmacie “Victor Babeș” Timișoara, Analiza medicamentului, Timișoara, Romania6Universitatea de Medicină și Farmacie “Victor Babeș” Timișoara, Legislație, Management și Marketing Farmaceutic, Timișoara, Romania

The initial study group (no=157 patients, 97 female -

61.78%)Average age: 62.74±12.6

years

The control group (no=148 patients, 90 female -

60.81% )Average age: 60.41±11.18

years

Figure2. The initial groups of patients

Results of the validation methods for the new questionnaire (kappa and alpha Chronbach coefficient)

The domains of the

questionnaire

Kappa coefficient

p

D1 0.860 0.0001

D2 0.895 0.0001

D3 0.766 0.0001

D4 0.823 0.0001

D5 0.875 0.0001

D6 0.831 0.0001

D7 0.858 0.0001

The remaining questions of the

questionnaire

The finale value of Chronbach

coefficient

D11 0.625D12 0.701D13 0.646D21 0.657D22 0.686D31 0.629D33 0.666D35 0.648D51 0.63D52 0.657D53 0.615D61 0.678D63 0.685D71 0.674

Comparing the two groups of patients were observed significant differences regarding the impact of cardio-vascular pathology on physical functions, on professional, social and intimate relationships (p<0.0001).

ReferencesKaplan RM, Fryback DG. Health related quality of life and health status. National Institutes of Health. 2010;Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009; 16;119(23):3028-35;Schulz RB, Rossignoli P, Correr CJ, Fernandez-Llimos F, Toni PM. Validation of the short form of the spanish Quality of Life Questionnaire (MINICHAL) for Portuguese (Brazil). Arq Bras Cardiol. 2008; 90(2): 127-31;

Figure1. The domains of specific quality of life questionnaire