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8/8/2019 RESUMO - Daily Exercise Reduces Measures of Heart Rate and Blood Pressure Variability in Hypertensive Rats
1/1
http://informahealthcare.com/doi/abs/10.1081/CEH-120003202
Daily Exercise Reduces Measures of Heart Rate and Blood Pressure Variability in
Hypertensive Rats
Read More: http://informahealthcare.com/doi/abs/10.1081/CEH-120003202
2002, Vol. 24, No. 3 , Pages 221-234
S. E. DiCarlo1, H. L. Collins1, D. W. Rodenbaugh1, M. R. Smitha2, R. D. Berger2 and V. K. Yeragani3
1Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, U.S.A.
2Department of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, U.S.A.
3Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine,
Detroit, MI, 48201, U.S.A.
This study was designed to test the hypothesis that daily spontaneous running (DSR) reduces measures of
heart rate and blood pressure variability in spontaneously hypertensive rats (SHR). After 8 weeks of DSR or
sedentary control, rats were chronically instrumented with arterial catheters. Daily exercise reduced most
measures of heart rate (HR) and blood pressure variability. Specifically DSR decreased heart rate, Low
Frequency Power (LF: 0.190.61 Hz), and Low Frequency/High Frequency (HF: 1.22.5 Hz) ratio of HR.
Furthermore, Total Power (TP), LF power, and LF/HF ratio of systolic blood pressure were reduced by dailyspontaneous running. Finally, TP, LF and HF powers and LF/HF ratios of diastolic blood pressure were
reduced by daily spontaneous running. These data demonstrate that daily exercise reduces sympatheticactivity and possibly increases cardiac reserve in hypertensive animals.
Keywords
Exercise training, Power spectral analysis, Hypertension
Este estudo foi desenhado para testar a hiptese de que a execuo espontnea dirio (DSR) reduz
medidas da freqncia cardaca e variabilidade da presso arterial em ratos espontaneamente hipertensos
(SHR). Aps 8 semanas de DSR ou sedentrio controle, os ratos foram instrumentados com cateter arterial.
O exerccio dirio reduziu a maioria das medidas da freqncia cardaca (FC) e variabilidade da presso
arterial. Especificamente DSR diminuio do ritmo cardaco, baixa freqncia (LF: 0.19 -0.61Hz), e baixa
freqncia / alta freqncia (HF: 1.2-2.5Hz) proporo de RH. Alm disso, a Total Power (TP), o poder LF e
LF / HF de presso arterial sistlica foram reduzidos atravs da execuo espontnea diria. Finalmente,
TP, LF e HF poderes e as razes BF / AF da presso arterial diastlica foram reduzidos pela execuo
espontnea diria. Estes dados demonstram que o exerccio dirio reduz a atividade simptica e,possivelmente, aumenta a funo cardaca em animais hipertensos.