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VisionofTheBrainRestorationCenter
� As a center, we direct, facilitate, and organize the cooperation of individual expertise to promote the improvement in patient care and therapeutic outcomes for neurology and neurosurgery patients.
StrategicFocus
Clinical Trials Discovery Research
Pre-clinical Research GLP Testing in Animal Models
Patient Care
• Clinical Trials focus on advancing patient care
• Pre-clinical research provides initial safety data and establishes protocol design
• Animal research validates clinical findings
• Discovery research identifies potential novel therapies
BrainRestorationCenter
CoreLeaders/Directors
FacultyandStaff
R&DDiscovery
Strategicplanningandfunding
AdvisoryBoard
Pre-operativeanalysisDBSReferral Surgery DBS
programmingCommunicationwithreferringphysicians
ServiceLine
GLPStudies
ExecutiveLeadership
o ExternalAdvisoryBoardo Dr. Lee Toddo Mr. Henry Evanso Mr. Thomas Dupree, Jr.
o Internal Advisory Panelo Phillip Tibbs, MD: Neurosurgeryo Larry Goldstein, MD: Neurologyo Jim Geddes, PhD: Spinal Cord and Brain Injury Center
o Directorso Craig van Horne, MD, PhD: DBSo John Slevin, MD: Clinical Neurologyo Greg Gerhardt, PhD: Basic and Translational Research
FacultyandStaff
AssociatedFaculty• CraigvanHorne• GregGerhardt• DonGash• PhilTibbs• JohnSlevin• SarahSalles• JulieGurwell• AmeliaAnderson• RichardGrondin• LukeBradley• ZhimingZhang
AssociatedStaff• DavidChapman• GeorgeQuintero•MikeHilvers• JoshPatton• FrancoisPomerleau•MarleneMcClure• RobinLindsay• AnnHanley
Trainees• AndrewWelleford,MD,PhDStudent• JustinPhillips,NeurologyFellow• WeifengLu,MDNeurosurgeryFellow
Deep Brain Stimulation volume: ranked #9 in the United States by Medtronic
Parkinson’s disease Essential TremorDystonia Huntington’s diseaseEpilepsyParkinson’s disease dementia
Translational Research
Peripheral Nerve GraftPhase I: complete in JulyPhase II: 3 subjects implanted
Asleep DBS SurgeryProject in progressFavorable outcomes
Nerve Graft for Cognitive Impairment
First patient implantedSecond patient enrolledApproved for 6 patients
Unique Destination Services
Reversed staged proceduresAsleep DBS surgeryCellular therapy
DBS Service Line:
CoreInitiatives:
� Parkinson’s disease¡ Deep Brain Stimulation¡ Cellular Therapies¡ Growth factor delivery¡ Drug discovery & development
� Cognitive impairment¡ Patient Identification¡ Data tracking and quantification¡ Diagnostic biomarkers ¡ treatment strategies – cell therapy
� Epilepsy¡ Responsive Neurostimulation (RNS)¡ Electrode development¡ FDA post approval study (NeuroPace)