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ReZume REZUME ® is a registered trademark of AHC Ventures, Inc. 5415 NW 24th Street, Suite 103 Margate, FL 33063 • (954) 978-9290 www.cryoderm.com These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. ©2013 AHC Ventures, Corp. All Rights Reserved. TURMERIC: Provides significant anti-inflammatory and Pain Relieving benefits. A clinical review published in a February 2008 edition of "Biochemical Pharmacology," explained that curcumin found in turmeric helps to regulate biochemical processes responsible for the expression of inflammatory enzymes. Additional research shows that Turmeric has positive effects on many neurological conditions YUCCA ROOT: Provides relief for arthritis, breaks up inorganic mineral obstructions and deposits, reduces inflammation and pain. Studies have demonstrated that steroidal saponins found in Yucca are a hormonal material, a steroid, with properties similar to the adrenal hormone, cortisone. An international research team reviewed data from studies on the anti- inflammatory, anti-arthritic and pain relieving properties of Yucca. They noted strong evidence that yucca’s active components, including steroidal saponins, resveratrol and yuccaols, all seem to exert these actions. They published their findings in a 2006 issue of “Journal of Inflammation.” NARINGIN: Is a natural flavonoid glycoside compound found in most citrus fruits, however it is especially abundant in grapefruits. Naringin contains high levels of antioxidants which help repair and reduce the number of “free radical” cells created during oxidation. These harmful cells damage neighboring cells and put unneeded and unwanted stress on important cells, resulting in bodily and mental stress. Naringin is used to enhance the effects of other drugs as it increases absorption thereby increasing effectiveness HYALURONIC ACID: is present in every tissue of the body. It is most concentrated in the synovial fluid which bathes the joints. Retention of water is one of the most important biological functions of hyaluronic acid, second only to providing nutrients and removing waste from cells that do not have a direct blood supply, such as cartilage cells. The presence of HA in those cells maintains the lubrication of joints and allows them to preserve water for other tissues. This results in an activation of our body’s white blood cells, reviving the immune system to successfully decrease and combat unwanted bacteria PARACTIN®: is a patented extract of Andrographis Paniculata (containing Andrographolide, 14-Deoxyandrographolides, and Neoandrographolides). Multiple double-blind randomized controlled trials (RTC) published in PubMed demonstrated that PARACTIN® reduces the activity of COX-2 enzyme and production of TNF-α, IL-6, IL-1β and IL-10 through selective down-regulation of the genes involved in immune and inflammation processes ((TNFSF14, TNF, TNFRSF6, and IL1A, CCL8 and CXCL11, JAK3 and STAT5A, TLR4 and TLR8 and NF-κB). By inhibiting Nuclear Factor kappa B (NFkB) and other genes that participate in the inflammatory cascade, PARACTIN® inhibits the production of a range of pro-inflammatory cytokines and interleukins (signaling proteins used by our immune system) and other markers of inflammation (ESR, CRP, IgA, Rheumatoid factor) and modulates the dysregulated immune response. Studies showed that it is safe and as effective as NSAIDs or DMARDs for treating acute as well as chronic inflammation, and is excellent for long term use Natural Pain Relief That Works! ReZume A Pain Free Life REZUME and CRYODERM Work Synergistically Our Dual Modality Approach Offers Maximum Pain Relief ® ® Purchase CRYODERM ® & ReZume ® from A G l o b a l L e a d e r i n N a t u r a l H e a lt h P r o d u c t s PAIN RELIEVING & THERAPUTIC PRODUCTS From the makers of Supports Healthy Anti-Inflammatory and Pain Signal Responses

ReZume - coldtherapycream.com · REZUME & CRYODERM: A Healthier Natural Approach To Treating Pain † SCIENCE & NATURE The proprietary formula in REZUME is the result of years of

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Page 1: ReZume - coldtherapycream.com · REZUME & CRYODERM: A Healthier Natural Approach To Treating Pain † SCIENCE & NATURE The proprietary formula in REZUME is the result of years of

ReZume

REZUME® is a registered trademark of AHC Ventures, Inc.5415 NW 24th Street, Suite 103

Margate, FL 33063 • (954) 978-9290www.cryoderm.com

† These statements have not been evaluated bythe Food and Drug Administration. This product is not intended to diagnose, treat,

cure or prevent any disease.

©2013 AHC Ventures, Corp. All Rights Reserved.

TURMERIC: Provides significant anti-inflammatory and Pain Relievingbenefits. A clinical review published in a February 2008 edition of "BiochemicalPharmacology," explained that curcumin found in turmeric helps to regulatebiochemical processes responsible for the expression of inflammatoryenzymes. Additional research shows that Turmeric has positive effects onmany neurological conditions†

YUCCA ROOT: Provides relief for arthritis, breaks up inorganic mineralobstructions and deposits, reduces inflammation and pain.Studies have demonstrated that steroidal saponins found inYucca are a hormonal material, a steroid, with propertiessimilar to the adrenal hormone, cortisone. An internationalresearch team reviewed data from studies on the anti-inflammatory, anti-arthritic and pain relieving properties ofYucca. They noted strong evidence that yucca’s activecomponents, including steroidal saponins, resveratrol andyuccaols, all seem to exert these actions. They published theirfindings in a 2006 issue of “Journal of Inflammation.”†

NARINGIN: Is a natural flavonoid glycoside compound found in most citrusfruits, however it is especially abundant in grapefruits. Naringin contains highlevels of antioxidants which help repair and reduce the number of “free radical”cells created during oxidation. These harmful cells damage neighboring cellsand put unneeded and unwanted stress on important cells, resulting in bodilyand mental stress. Naringin is used to enhance the effects of other drugs asit increases absorption thereby increasing effectiveness†

HYALURONIC ACID: is present in every tissue of the body. It is mostconcentrated in the synovial fluid which bathes the joints. Retention of wateris one of the most important biological functions of hyaluronic acid, secondonly to providing nutrients and removing waste from cells that do not have adirect blood supply, such as cartilage cells. The presence of HA in those cellsmaintains the lubrication of joints and allows them to preserve water for othertissues. This results in an activation of our body’s white blood cells, revivingthe immune system to successfully decrease and combat unwanted bacteria†PARACTIN®: is a patented extract of Andrographis Paniculata (containingAndrographolide, 14-Deoxyandrographolides, and Neoandrographolides).Multiple double-blind randomized controlled trials (RTC) published in PubMeddemonstrated that PARACTIN® reduces the activity of COX-2 enzyme andproduction of TNF-α, IL-6, IL-1β and IL-10 through selective down-regulationof the genes involved in immune and inflammation processes ((TNFSF14,TNF, TNFRSF6, and IL1A, CCL8 and CXCL11, JAK3 and STAT5A, TLR4 andTLR8 and NF-κB). By inhibiting Nuclear Factor kappa B (NFkB) and othergenes that participate in the inflammatory cascade, PARACTIN® inhibits theproduction of a range of pro-inflammatory cytokines and interleukins(signaling proteins used by our immune system) and other markers ofinflammation (ESR, CRP, IgA, Rheumatoid factor) and modulates thedysregulated immune response. Studies showed that it is safe and aseffective as NSAIDs or DMARDs for treating acute as well as chronicinflammation, and is excellent for long term use†

Natural Pain ReliefThat Works!†

ReZumeA Pain Free Life

REZUME and CRYODERM Work SynergisticallyOur Dual Modality Approach Offers Maximum Pain Relief

®®

Purchase CRYODERM® & ReZume® from

AGl

obal

Lead

erin

Natural Health Products

PAIN RELIEVING & THERAPUTIC PRODUCTS

From the makers of

SupportsHealthy Anti-Inflammatoryand Pain Signal Responses

Page 2: ReZume - coldtherapycream.com · REZUME & CRYODERM: A Healthier Natural Approach To Treating Pain † SCIENCE & NATURE The proprietary formula in REZUME is the result of years of

TNF-aIL-6IL-1BIL-10CRPRF

ReZumeA Pain Free Life

QUALITY ASSURANCEWe take every opportunity to meet and exceed the highest level of manufacturingto guarantee purity, quality and efficacy. Our company procedures are based onQuality Standards established by The FDA and cGMP. This ensures that youreceive only the best quality products that have the most definitive and desiredeffect.

Throughout the manufacturing process every extract is subjected to controlledtests of physical and chemical properties looking for active constituents such asbio-chemical profiles.

We use state-of-the-art extraction processes to assure higher quality, ensuringthe delivery of safe, pure and effective products. Furthermore, our productsundergo a final testing process in an independent FDA recognized analyticaltesting laboratory. The second phase of quality control is in our state-of-the-artmanufacturing facility where products are constantly monitored for quality,consistency and specification prior to packaging and shipping.

BOSWELLIA: Has Anti-inflammatory andAnti-Arthritic actions in acute and chronicmodels of inflammation. Boswellia reducesswelling, increasing mobility, therebyeffectively reducing pain. Triterpenes inboswellic acid reduce the synthesis ofleukotrienes in intact neutrophils by

inhibiting 5-lipoxygenase,the key enzyme involvedin the biosynthesis ofleukotrienes, whichmediate inflammation†

MSM: Is a naturally occurring, essential nutrient found inhealthy tissue and joints. Studies at The University of Oregon

Medical School reported that: MSM has a wide range of pharmacologic actionsincluding topical membrane penetration, anti-inflammation and local analgesia.In a double-blind study of MSM's impact on degenerative arthritis, it was foundthat patients who ingested a standardized dose of MSM every day for six weeksfelt an improvement in their pain reduction by 82 percent, on average†

I’m allergic to Sulfa drugs. Can I take MSM?Sulfur is the eighth most prevalent element in the human body. No one is allergicto sulfur itself. Sulfa drugs are sulfonamides. Sulfur (MSM) and Sulfa drugs arecompletely unrelated and only share similar sounding names†

YERBA MATE “ILEX”: Is an Herbal extract from the South American Holly shruband has been used for centuries to reduce pain, inflammation and loosen stiffjoints†

DEVIL’S CLAW: Is approved as a nonprescription medicineby the German Commission E, an expert panel of physiciansand pharmacists who advise Germany's counterpart of theU.S. Food and Drug Administration. Recently publisheddouble blind studies have shown that Devil's Claw iseffective in relieving pain from arthritis, back, hip, knee andjoint pain, as well as pain from osteoarthritis, rheumatoid arthritis, gout, bursitis,tendonitis and soft tissue pain (muscle aches)†

WHITE WILLOW: Is a species of the willow tree. Hippocrates noted theeffectiveness of the powder, extracted from willow bark to ease aches and painand to reduce fever. The University of Maryland Medical Center points out a studyof about 200 people with lower back pain, which found that the participants whotook white willow bark experienced a significant improvement in pain comparedto those who received placebo†

ULVA LACTUCA: A green alga that has anti-inflammatory effects as evidencedby the reduction in the inhibition of edema in a clinical trial as compared with thepositive control drug and control. PMID: 20143726(PubMed - indexed for MEDLINE)†

FINALLY AN ALL NATURAL SCIENTIFICALLY PROVEN PAIN RELIEF FORMULA THAT WORKS!†

REZUME & CRYODERM: A Healthier Natural Approach To Treating Pain†

SCIENCE & NATUREThe proprietary formula in REZUME is the result of years of research which blendsScience and Nature. Utilizing patented extracts with other well-known documentedherbal extracts a proprietary blend was created that maximizes the effects of eachindividual ingredient. Together these anti-inflammatory pain relievers create a naturalformula so powerful that just two caplets can bring relief within 30 minutes. REZUMEalso incorporates all natural C27H32O14 to enhance absorption and increase efficacy†

REZUME & CRYODERM:A DUAL MODALITY APPROACH TO PAIN MANAGEMENTCRYODERM Topical and REZUME Tablets are formulated to work together when atopical alone doesn’t provide sufficient relief. Their synergistic blends work togetheron several levels to ensure Maximum Pain Relief.†

CRYODERM Topical, when applied to the area of pain, begins to Stop Pain instantlyby blocking the pain signal and numbing the general area. At the same time Arnica,Boswellia, MSM and Ilex begin to soak into the tissue reducing bruising, swelling and

restoring blood flow to the area, setting your body upto heal while providing hours of relief.†

REZUME Tablets work on a cellular, systemic level,delivering and reinforcing some of the same great AllNatural ingredients found in CRYODERM. REZUMEalso contains other powerful Natural Ingredients thatsupport Healthy Anti-Inflammatory and Pain SignalResponses. These ingredients can only be deliveredin an oral tablet.†

This new dual approach to pain management is amajor scientific breakthrough being endorsed bymany physicians…. As the new standard for painmanagement.†

Molecular mechanismof andrographolide ininflammation.Andrographolideshows inhibitory effect(x) on the PI3K/Aktpathway, ERK1/2MAPK, NF-κB, NFAT,AP-1 and STAT3, andincreases the JNKphosphorylation.

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