Robert JerajAssociate Professor of Medical Physics, Human Oncology,

Radiology and Biomedical Engineering

Director of Wisconsin Oncology Network of Imaging eXcellence

University of Wisconsin Carbone Cancer Center, Madison, WI

Wisconsin Oncology Network

Aspirus Regional Cancer Center, Wausau

Aurora Cancer Care

Aurora HealthCare Network

Bellin Memorial Hospital, Green Bay

Columbia-St. Mary’s, Milwaukee

Dean Clinic Heme/Onc

Ferguson Cancer Center, Freeport, IL

Fox Valley Heme/Onc

Gundersen Lutheran, La Crosse

Holy Family Cancer Center, Manitowoc

Marshfield Clinic

Medical College of Wisconsin, Milwaukee

Mercy Health System, Janesville

ProHealth Care, Waukesha and Oconomowoc

St. Vincent Hospital, Green Bay

SwedishAmerican Hospital/SAH Regional Cancer

Center, Rockford, IL

UWCCC

UWCCC Partners, Johnson Creek, Wisconsin

Rapids

Vucurevich Cancer Center, Rapid City, SD

Wisconsin Oncology Network of Imaging Excellence (WONIX)

WONIX organizational structure

Molecular Imaging Agents Working Group

To develop molecular imaging agents and make them available to the WONIX sites. It includes development of necessary distribution infrastructure and necessary regulatory documentation for obtaining Investigator New Drug (IND) approvals.

Chairs:– Scott Perlman, Co-Chair– Rebecca Marnocha, Co-Chair

Members: John Centanni, Scott Knishka, Yongjun Yan, Todd Barnhart, Robert Jeraj, Anne Traynor, Dona Alberti

Imaging quality assurance Working Group

To establish “harmonized” imaging quality assurance program across the WONIX sites.

Chairs:– Chihwa Song, Co-Chair– Matt La Fontaine, Co-chair

Members: Robert Pyzalski, Karl Vigen, Frank Ranallo, Frank Korosec, Sean Fain, Guanghong Chen, Ed Jackson, Robert Jeraj, Nagesh Adluru, Chris Jaskowiak, Cheryl Gain

Informatics Working Group

To enable automated workflows, data collection and integration, and processes that enable scalable clinical trials within WONIX

Chairs:– Richard Bruce, Co-chair– Sean Fain, Co-Chair

Members: Gary Wendt, Andy Craven, Chihwa Song, Matt La Fontaine, Cheryl Gain, Jonathon Boott

Data Working Group

To develop common database platform and appropriate tools for data analysis and data mining

Chairs:– Umberto Tachinardi (Co-chair)– Jonathan Boott (Co-chair)

Members: Stephine Wasielewski, Mary Jane Staab, Jill Kolesar, Richard Bruce, Robert Jeraj, Dona Alberti

Imaging clinical trials Working Group

To design, coordinate and execute individual imaging clinical trial projects through the WONIX network.

Chairs:– Robert Jeraj, Co-Chair– Glenn Liu, Co-chair

Members: George Wilding, Anne Traynor, Ryan Mattison, Kari Wisinski, Scott Perlman, Jill Kolesar, Dona Alberti, Jennifer Heideman

Clinical trials

Retrospective analysis of FDG PET/CT in NSCLC– Current UW pilot (20 pts) will be extended (200 pts) through

WONIX

MITOS: FDG PET/CT in NSCLC– Comprehensive genomic analysis and CTCs– Early and late FDG PET/CT response assessment– Piloted (3 pts) at UWCCC; WONIX amendments– Soon to be activated through WONIX

NaF PET/CT in mCRPC FDG PET/CT in lymphoma FLT PET/CT in AML …

Next steps

WONIX working groups:– Molecular imaging agents: cGMP facility (Q1 2015)– Imaging QA: Automated QA/QC monitoring (Q3 2015)– Informatics: XDS data exchange platform (Q2 2015)– Data: Common databased established (Q3 2015)

WONIX site activation (Q4 2014/Q1 2015)– Gundersen, La Crosse (Q4 2014)– St. Vincent, Green Bay (Q1 2015)– Others to follow

WONIX clinical trial activation (Q1/Q2 2015)– Retrospective FDG PET/CT analysis (Q1 2015)– MITOS trial (Q2 2015)– Others to follow

WONIX Site Visit with Gundersen Health System, La Crosse

Monthly newsletter

Monthly update at the TIR meeting

WONIX Website

WONIX Wiki

Questions

wonix@lists.wisc.edu