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Roch Giorgi
LERTIM EA3283, Faculty of Medicine, Mediterranean University, Marseille, France
http://lertim.fr
Estimation Methods for Relative
Survival
Presentation and Perspective of the
MESURE ProjectMethods and Application for Population Based Survival
September 21, 2010 – Frascati
email: [email protected]
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 2
Context (1)
Large utilisation of relative survival approach to estimate cancer survival (population-based studies)
Models/Methods used may vary between research centres
New developments are challenges
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 3
Context (2)
General registrySpecialised registry
FRANCIMFrench Network of Cancers Registries
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 4
Context (3) Common cancer database
Service de Biostatistiques, Hospices Civils de Lyon (SBHCL)
French teams (some) involved in methodology / epidemiology of population-based survivalLaboratoire d’Enseignement et de Recherche sur le
Traitement de l’Information Médicale, Marseille (LERTIM)
SBHCLService de Biostatistique et Informatique Médicale,
Dijon (SBIM)Laboratoire d’Epidémiologie et de Santé Publique,
Strasbourg (LESP)
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 5
Context (4) French teams (some) involved in methodology / epidemiology
of population-based survival LERTIM, Marseille SBHCL, Lyon SBIM, Dijon LESP, Strasbourg
International teams (some) involved in methodology / epidemiology of population-based survivalNon Communicable Disease Epidemiology Unit,
London (NCDEU)Centro Nazionale di Epidemiologia, Instituto
Superior di Sanita, Roma (CNE)Department of Epidemiology and Biostatistics,
Montreal (DEP)
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 6
Context (5)
NCDEULondonNCDEULondon
CENRomaCENRoma
SBHCLLyonSBHCLLyon
DEPMontrealDEPMontreal
SBIMDijonSBIMDijon
LESPStrasbourgLESPStrasbourg
FRANCIM networkFRANCIM network
Estimation Methods for
Relative SurvivalMESURE Project
Creation of a research network involving methodologists, epidemiologists
LERTIMMarseilleLERTIMMarseille
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 7
MESURE: Overall Aim
To improve the current methods for estimating cancer survival
To define required specifications for production of large-scale cancer survival statistics useful in Public Health
To obtainmore accurate estimatescomparable information on cancer survival, on its
public health impact
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 8
Funding a Network of Methodologist!
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 9
Network Funding
Some failures…
2009: Grant from the French Institute for Public Health Research (IRESP): 8,000 euros (R. Giorgi)1st seminar (Paris)
2009: Grant from the French National Research Agency (ANR-09-BLAN-0357): 378,000 euros (R. Giorgi)
but
Let’s go to work!
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 10
Description of the Work
WP1:Comparison of the current methods
WP2: Extension/Development ofstatistical methods
WP2.1:Statistical researches
WP2.2:Statistical programs
WP3: Production of guidelines
5 Deliverables
12 Deliverables
1 Deliverables
12 Deliverables
2 Tasks
4 Tasks
1 Tasks
Management
36 months
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 11
Task 0: Project Management Coordinator of the Project: R. Giorgi
Coordination between partners Management of the project, with all the partners
Leader of a task Coordination of the specific researches for the task Respect concerning the schedule/deliverables
Organisation 2 meetings a year with all the partners/external members
(Lyon Oct. 2009; Marseille Apr. 2010; Paris Nov. 2010) Invited collaborators (E. Cambois, J. Stare, M. Pohar-Perme,
…) Deliverables
1. Report of progress (every 6 months)2. Report of the meetings (every 6 months)
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 12
WP1 – Task 1: Comparisons
Leader SBHCL
Partners SBIM, LERTIM, LESP, CNE, DEP
Objectives To highlight the methodological limits and the advantages of the existing models for relative survival analyses
Subtasks 1.Methodological comparisons2.Determination of data sets3.Analyses/real data
Deliverables
1.Description of the studied models2.Determination/Constitution data sets3.Comparison based on real data4.Report indicating limits/advantages
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 13
WP1 – Task 2: Recommendations
Leader SBIM
Partners SBHCL, LERTIM, LESP, FRANCIM, NCDEU, CNE, DEP
Objectives To give advices for users of such relative survival models in their practice
Subtasks None
Deliverables
1.Report indicating advices for users
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 14
WP2 – Task 3: Life Tables
Leader LERTIM
Partners SBIM, SBHCL, LESP, NCDEU, DEP
Objectives To assess the impact of the variable used to stratify the life tables for relative survival analyses
Subtasks 1. Life tables generation2.Survival data generation3.Analyses/simulated data4.Analyses/real data
Deliverables 1.Simulations results2.Real data application
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 15
WP2 – Task 4: Spatial Variations
Leader LERTIM
Partners SBHCL, SBIM, LESP, FRANCIM, CNE
Objectives To propose a relative survival model to analyse the geographical variations in cancer survival
Subtasks 1.Development of the model2.Survival data generation3.Analyses/simulated data4.Analyses/real data5.Specific statistical program
Deliverables 1.Model for spatial survival data2.Simulations results3.Real data applications4.Specific statistical program
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 16
WP2 – Task 5: Frailty
Leader SBHCL
Partners LERTIM, LESP, SBIM, FRANCIM, NCDEU, DEP
Objectives To take benefits from random effect framework in relative survival
Subtasks 1. Development of the model2. Comparison fixed/random effect3. Analyses/real data4. Specific statistical program
Deliverables 1.Flexible frailty relative survival model2.Comparison of fixed & random effect models3.Real data applications4.Specific statistical program
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 17
WP2 – Task 6: Statistical Programs
Leader LESP
Partners LERTIM, SBHCL, NCDEU, DEP
Objectives To propose a statistical package to perform relative survival analyses using approaches studied and developed in this project
Subtasks 1.Specific packages/Programming2.Assessment existing programs3.Common package/Language4.Common package/Programming
Deliverables
1.Specific programs for Tasks 4 to 62.Common statistical program
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 18
WP3 – Task 7: Synthesis
Leader FRANCIM
Partners LERTIM, SBHCL, SBIM, LESP, NCDEU, CNE, DEP
Objectives To produce guidelines for cancer survival analysis with population-base data
Subtasks None
Deliverables
1.Synthesis and recommendations
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 19
PlanningPlanning Task Description M 3 M 6 M 9 M 12 M 15 M 18 M 21 M 24 M 27 M 30 M 33 M 36
T0 Project Management
T1 Comparisons current methods
ST1.1 Methodological comparisons
ST1.2 Determination of data sets
ST1.3 Analyses/real data
T2 Recommendations
T3 Life tables
ST3.1 Life tables generation
ST3.2 Survival data generation
ST3.3 Analyses/simulated data
ST3.4 Analyses/real data
T4 Spatial variations
ST4.1 Development of the model
ST4.2 Survival data generation
ST4.3 Analyses/simulated data
ST4.4 Analyses/real data
ST4.5 Specific statistical program
T5 Frailty
ST5.1 Development of the model
ST5.2 Comparison fixed/random effect
ST5.3 Analyses/real data
ST4.4 Specific statistical program
T6 Statistical programs
ST6.1 Specific packages/Programming
ST6.2 Assessment existing programs
ST6.3 Common package/language
ST6.4 Common package/Programming
T7 Synthesis
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 20
PlanningPlanning
Task Deliverables Delivery date Partner in chargeT0 Project management D0.1 Biannual and final reports M6:M36 each 6M LERTIM
D0.2 Biannual meetings with report M6:M36 each 6M LERTIM
T1 Comparisons D1.1 Description of the studied models M3 SBHCL of current methods D1.2 Determination/Constitution datasets M6 SBHCL
D1.3 Comparisons based on real data M12 SBHCLD1.4 Report indicating limits/advantages M15 SBHCL
T2 Recommendations D2.1 Report indicating advices for users M18 SBIM
T3 Life tables D3.1 Simulations results M15 LERTIMD3.2 Real data application M18 LERTIM
T4 Spatial variations D4.1 Model for spatial survival data M18 LERTIMD4.2 Simulations results M27 LERTIMD4.3 Real data applications M30 LERTIMD4.4 Specific statistical program M30 LERTIM
T5 Frailty D5.1 Flexible frailty relative survival model M18 SBHCLD5.2 Comparison of fixed & random effect models M24 SBHCLD5.3 Real data applications M30 SBHCLD5.4 Specific statistical program M30 SBHCL
T6 Statistical Programs D6.1 Specific programs for Task 4 to 6 M30 LESPD6.2 Common statistical package M33 LESP
T7 Synthesis D7.1 Synthesis and recommendations M36 FRANCIM
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 21
Brief Point 2009-2010
Master’s degree in science C. Danieli: Comparison of methods for estimating net survival N. Graffeo: Assessment of the impact of variables used to
stratify the mortality tables involved in the analysis of relative survival
Communication A. Belot, R. Giorgi. Joint frailty excess hazard model for
recurrent events and death. 31th annual conference of International Society for Clinical Biostatistics, Montpellier, Septembre 2010.
2010-…PhD degree
N. Graffeo: Modelling spatial cancer survival with relative survival models
M. Mounier: Contribution of relative survival methods in the prognosis of follicular lymphomas
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 22
For the Future…
ANR grant for the MESURE projectFirst grantUseful to apply for other grant applications
Project open to other collaborators, funders…
Need toDeepen even more some tasksGo ahead on other themes Increase methodological / epidemiological
collaborations for cross-national comparisons with direct application for public health decision makers
© Roch Giorgi, LERTIM, Faculty of Medicine, Mediterranean University 23
MESURE Members
LERTIM – Marseille Roch Giorgi Catherine Jean Gaudart Nathalie Graffeo
SBHCL – Lyon Nadine Bossard Jacques Estève Laurent Remontet Aurélien Belot Laurent Roche
LESP - Strasbourg -> INRS - Nancy
Guy Hédelin
NCDEU – London Michel Coleman Bernard Rachet
CNE – Roma Franco Berrino Ricardo
Capocaccia DEP - Montreal
Michal Abrahamowicz
Amel Mahboubi
http://cybertim.timone.univ-mrs.fr/recherche/projets-recherche/MESURE
SBIM - Dijon Catherine Quantin Christine Binquet
FRANCIM Pascale Grosclaude Marc Colonna Valérie Jooste Anne-Marie Bouvier Morgane Mounier