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Roche kemiinstrumentFunktioner och mätprinciperLouise Levander, IBL Grundkurs i allmänkemi, 2016-09-09
Roche DiagnosticsHistoria
Roche kemiinstrumentUtformade för att passa alla typer av lab
Roche kemiinstrumentNomenklatur
c111
c311
c501
c502
c701
c702
e411
e601
e602
e801
cobas 4000 cobas 6000 cobas 8000
Roche kemiinstrumentAnalysmeny
α1-Acid Glycoprotein
α1-Antitrypsin
α1-Microglobulin
β2-Microglobulin
Apolipoprotein A-1
Apolipoprotein B
ASLO
T-Uptake*
D-Dimer
AT III
BicarbonatAmmonia
Albumin BCG
Albumin BCP
LDL-C
HDL-C Cholesterol Triglycerides
TiglyceridesGB
Bilirubin Direct
Bilirubin Total
Fructosamine
Creatinineenzymatic
Amikacin
Quinidine
Gentamycin
Carbamazepine
Acetaminophen
Cyclosporine
Mycophenolattotal
Phenobarbital
Phenytoin
Syphilis TreponemaPallidum Antigen
CreatinineJaffe
Lactate Glucose
N-Acetylprocainamide
Primidon Procain-amide
Thyroxine(T4)* Acid Phosphatase
Alkaline Phosphatase
CRPCRP hs
Cystatin C
Ferritin
Complement C3c
Complement C4
Albumin T
Pancreatic EDDPalpha-Amylase
α-Amylase
CK-MB
CK
Digoxin
Digitoxin
Salicylate
LSD
ValproicAcid
Methaqualone
EDDPMethadone
LidocaineTheophylline
Tobramycin
Cocaine
Ethanol
Propoxyphene
Vancomycin
Cannabinoids
Oxycodone
Benzo-diazepines
SerumBenzo-diazepines
Amphetamines
Barbiturates
SerumBarbiturates
CHEAcetylCHE
DibucaineLDH
HBDH
GLDH
AST +/- PYP
ALT +/- PYPLipasePhencyclidine
Opiates
GGT
Kappa Light ChainFree Kappa Light Chain
Lambda Light ChainFree Lambda Light Chain
Lipoprotein (a)
HbA1chemolysate
HbA1c wholeblood
Haptoglobin
RF
Pre-albumin
Trans-ferrine
SolubleTransferrinReceptor
Myoglobin
Magnesium
Total Protein Urine / CSF
Total Protein
UREA/BUN
Pre Acid
Homocysteine
Phosphorus
IgMIgGCSF
IgG
Potassium
Chloride
LithiumCalcium
Iron UIBC
Syphilis RapidPlasma Reagin
Sodium
IgA
Existing product
In development
Others• distribution in limited
countries
DATISESubstrates
ProteinsEnzymesTDM
IgMCSF
IgGurine
IgACSF
Roche kemiinstrumentAnalytisk sensitivitet
mmol/Lmg/L
GLUKOS
μg/Lμmol/L
KREATININ
mol/Lg/L
ALBUMIN
Roche kemiinstrumentcobas c111 och c311
Roche kemiinstrumentcobas c501/502 och c701/702
Roche kemiinstrumentProvpipettering
Roche kemiinstrumentProvpipettering
Roche kemiinstrumentReagenspipettering
Roche kemiinstrumentReagenspipettering
Roche kemiinstrumentReaktionsområde
Roche kemiinstrumentReaktionsområde
9 September 2016 page 17 © 2009 Roche
0 5 10
Reagenspipettering 1
Prov-pipettering
1st mixning
Reagenspipettering 2
Reagenspipettering 3
2nd mixning 3rd mixing
11
1
3570
Blank mätning
Tid/ Min
1) Prov 2) Reagens R1(0 min)3 sekunder
3) Reagens R2 (1,5 min)90 sekunder
4) Reagens R3(5 min)300 sekunder
Roche kemiinstrumentFotometri
Roche kemiinstrumentUltraljudsmixrar
9 September 2016 page 19 © 2009 Roche
Roche kemiinstrumentKolorimetri och turbidimetri
9 September 2016 page 20 © 2009 Roche
Roche kemiinstrumentFotometri
Roche kemiinstrumentFotometri, bikromatisk analys
Roche kemiinstrumentISE
Roche kemiinstrumentISE
Doing now what patients need next