S49076 – nový vysoko-aktívny inhibítor MET, AXL a FGFR

tyrozín kináz

Mgr. Peter Šramel, Katedra organickej chémie, PriF UK

MET receptor TK

www.en.wikipedia.org

AXL receptor TK

www.en.wikipedia.org

AXL receptor TK

Linger, R. M.; Keating, A. K.; Earp, H. S.; Graham, D. K Adv. Cancer Res. 2008, 100, 35 -83.

FGFR receptor TK

www.med.nyu.edu

FGFR receptor TK

www.med.nyu.edu

Inhibítor S49067

Bulbridge, M. F. et al. Mol. Cancer Ther. 2013, 12, 1749 – 1762.

Inhibítor S49067

Bulbridge, M. F. et al. Mol. Cancer Ther. 2013, 12, 1749 – 1762.

Inhibičná aktivita S49067

Bulbridge, M. F. et al. Mol. Cancer Ther. 2013, 12, 1749 – 1762.

Inhibičná aktivita S49067

Bulbridge, M. F. et al. Mol. Cancer Ther. 2013, 12, 1749 – 1762.

Inhibičná aktivita S49067

Bulbridge, M. F. et al. Mol. Cancer Ther. 2013, 12, 1749 – 1762.

Inhibičná aktivita S49067

Bulbridge, M. F. et al. Mol. Cancer Ther. 2013, 12, 1749 – 1762.

Záver

SN

NH

HN

HN

O

O

O

O

S49076

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