Samplicity Filtration System: The Ideal Sample Prep System

8/6/2019 Samplicity Filtration System: The Ideal Sample Prep System

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Break free fromroutine sample prepSamplicity Filtration System

EMD Millipore is a division of Merck KGaA, Damstadt, Germany
http://www.millipore.com/lab_filtration/flx4/samplicity&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SP


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Breaking the sampleprep bottleneck:Doing more with less

The overall trend in chromatography is to do more

with lessmore samples, more complex analyses,

more analyses per sample, with less volume, lower

concentrations, in less time, with fast analytical

techniques such as Ultra-High Pressure Liquid

Chromatography (UHPLC).

Even though efcient, high quality sample prep is crucial

in obtaining reliable data from these ultrasensitive

techniques, there have been few recent advances in

sample prep technology. As a result, its often sample

preparation, not analysis, thats the rate-limiting

bottleneck in chromatography.


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The rst vacuum-driven system with the designed in

exibility to lter 1 to 8 samples directly into standard

HPLC sample vials, the Samplicity Filtration System has the

potential to break the sample prep bottleneck. Just attach

a vacuum pump, load your samples, and ip the lever.

Recover your particulate-free samples in seconds.

Built upon decades of our membrane ltration expertise,

the systems Millex Samplicity lters have a unique

funnel shape for easy pipette loading and are provided

in strips of four for faster loading. The lter strips are

perforated for use with fewer samples.

The ideal sample prep systemfor most chromatographers

The Solution:EMD Millipores Samplicity Filtration SystemThe rst vacuum-driven system with the designed in fexibility to lter 1 to 8 samples directly into standard


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Over 60% of Chromatographersprocess 10 - 100 samples a day

Low Throughput(1 - 10 Samples/Day)

Medium Throughput(10 - 100 Samples/Day)

High Throughput(>96 Samples/Day)

Most chromatographers (65%, according to a recent

EMD Millipore survey) process 10-100 samples a day into

vials. For them, single-sample syringe lters, robotics and

plate-based ltration systems are equally impractical.

The Samplicity Filtration System eliminates the tedium of

syringe ltration and the space requirements and expense

of robotics.

The Samplicity Filtration System is ideal for QC and R&D

labs along with users in diverse elds, including:

Drug dissolution testing mandatory evaluation of the

dissolution rate of solid dosage forms in the digestive

tract

Food safety testing foods and beverages for unknown

and known toxins, including glycol, melamine, and

cyanobacteria

Cosmetics separation and detection of cosmetic

ingredients and formulations

Biofuels analysis and extraction of lipids from algae

and other biomass Pharmacokinetic/pharmacodynamic (PK/PD) testing

quantication of interactions of drugs with the body

with respect to time


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Faster processing time:

Up to eight samples in seconds.

No sample foaming or bubbles, for better

sample recovery and accurate autosampling.

To compare the speed of the Samplicity system with

syringe ltration, either four or eight 1.0 mL samples of

1% Pepto-Bismol (viscosity 7-10 cP) were ltered by 13

users. On average, the Samplicity system accelerated four-

sample ltration by 26%, and it accelerated eight-sample

ltration by 35%.*

In the Samplicity systems unique design, the vials are

held at an angle and the tip of the lter touches the side

of the vial as the sample is being ltered. These features

reduce foaming and sample spillover and trapping of air

bubbles at the bottom of vials. This is especially important

when working with vials containing low volumes or conical

inserts.

Ergonomic benets: Less force, more comfort.

Average user ratings of manual force required and comfort

levels for operating syringe lters vs. the Samplicity

Filtration System show the Samplicity system requires

virtually no manual force for ltration.*

*The information presented is based on preliminary development results. Device performance in specic applications may be different.

The Samplicity Filtration Systemoutperforms manual ltration.

4 Samples(26% time savings)

8 Samples(35% time savings)

0

50

100

150

200

250

300

350

Syringe Filtration

Samplicity System

AverageRatings

SamplicitySyringe

6.54

10

8

6

4

2

0

0.69


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Starting volume: 500 L Starting volume: 500 L

150 L 400 L

Syringe ltration Samplicity ltration

Built on over 40 years ofmembrane expertise,Millex Samplicity lters were designed with the best, most

versatile membrane for ltering chromatography samplesour

hydrophilic polytetrauoroethylene (PTFE) lters retain >95%

of particulate impurities.

Higher yields for small sample volumes: low holdup volume enables

you to do more analyses with each precious sample.

Millex Samplicity Filtersprovide maximum versatility with highest quality.


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Low extractables from hydrophilic PTFE: broad chemical

compatibility of hydrophilic PTFE means fewer leached impurities

can contaminate the sample for downstream analysis.

Mass spectrometry detects few extractable impurities from Millex syringe lter (A) con-

taining a 0.45 m pore, hydrophilic PTFE membrane. In contrast, a syringe lter containing

0.45 m pore polypropylene membrane (non-Millipore, B) shows signicant extractables.

3.0E+06

Peak

In

tensity

Highest Peak Intensity: 0.8 E5

2.5E+06

2.0E+06

1.5E+06

1.0E+06

5.0E+06

0.0E+06

100 200 300300 400 500 600

M/Z

700 800 900 1000

A. Millex Filter Unit, PTFE

3.0E+06

Peak

Intensity

Highest Peak Intensity: 2.5 E6

2.5E+06

2.0E+06

1.5E+06

1.0E+06

5.0E+06

0.0E+06

100 200 300300 400 500 600

M/Z

700 800 900 1000

B. Non-Millipore, Polypropylene


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Hydrophilic PTFE membrane consistently provides greater than 90% drug recovery in the

rst mL of ltrate, indicating low drug binding to PTFE compared to nylon. Four drug

samples were ltered through Millex lters containing PTFE or nylon.

Pre-washing Millex Samplicity Filters is easy.If your application requires pre-washing lters prior to nal ltration and analysis, a

waste tray can be inserted into the Samplicity system to facilitate this step. When pre-

washing lters using the Samplicity system, the waste tray is placed on the base in place

of the vial tray and the solvent or sample is ltered through the Millex Samplicity lters

using vacuum, similar to normal operation. Once the lters are pre-washed, the same

lters would be used for sample ltration and collection into vials.

A. PTFE

100%

PercentDrug

Recovery

Volume Filtered, mL

90%

80%

70%

60%

50%

40%

0 1 2 3 4 5 6 7 8 9 10 11

Ranitidine

Acetaminophen

Ibuprofen

Loratidine

B. Nylon

,

100%

Percent

Drug

Recovery

Volume Filtered, mL

90%

80%

70%

60%

50%

40%

0 1 2 3 4 5 6 7 8 9 10 11

Ranitidine

Acetaminophen

Ibuprofen

Loratidine

Low analyte binding: waste less sample during ltration so you can

accurately quantitate low levels of analytes present in the sample.


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Now you can truly do more with less.Combine the Samplicity Filtration System with state-of-the-art separation technologies.

Solvents through Filters

Filtered samples

from Samplicity system

Ultrapure Water

Columns

Chromatogram

Break free from routine sample prepand enjoy successful chromatography.

The Samplicity system provides higher yields with low

hold-up volume, fast processing, and ease of use. And in

addition to ergonomic benets, the system creates less

waste than syringe ltration and eliminates the need to

segregate syringe waste.

Together with EMD Millipores mobile phases, solvent

ltration systems, columns, and water purication systems,

the Samplicity Filtration System is the key to staying on

the cutting edge of chromatographic separation.


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Required Accessories for Samplicity Filtration System

Description Catalogue Number

Chemical Duty Pump, 115 V/60 Hz WP6111560



Samplicity Filtration SystemChoose the unit color to t your lab bold blue or glossy green!

Samplicity Systems and Accessories Catalogue Number

Samplicity Filtration System, Glossy Green SAMPSYSGR

Samplicity Filtration System, Bold Blue SAMPSYSBL

Samplicity Filtration System Vial Trays, 2/pack SAMVIALTR

Samplicity Filtration System Waste Trays, 5/pack SAMWASTTR

Samplicity Filtration System Tube Set Assembly SAMTUBING

Samplicity Filtration System Replacement Lid SAMSYSLID

Millex Samplicity Filters Catalogue Number

Millex Samplicity Filters, 0.20 m Hydrophilic PTFE, 96/pack SAMPLG001

Millex Samplicity Filters, 0.45 m Hydrophilic PTFE, 96/pack SAMPLCR01

Millex Samplicity Filters, 0.20 m Hydrophilic PTFE, 384/pack SAMPLG004

Millex Samplicity Filters, 0.45 m Hydrophilic PTFE, 384/pack SAMPLCR04

To place your order or for complete product informationvisit www.millipore.com
http://www.millipore.com/catalogue/item/WP6111560&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6122050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6110060&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSGR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSBL&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMVIALTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMWASTTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMTUBING&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMSYSLID&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG001&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR01&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG004&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR04&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6110060&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6122050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6111560&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR04&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG004&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR01&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG001&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMSYSLID&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMTUBING&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMWASTTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMVIALTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSBL&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSGR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SP


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Related Products: Featured Mobile Phases and Columns for Liquid ChromatographyAvailable from www.emdchemicals.com

Description Catalogue Number or URL

Acetonitrile, LiChrosolv Gradient Grade 1.00030

Ethanol, LiChrosolv Gradient Grade 1.11727

Methanol, LiChrosolv Gradient Grade 1.06007

Acetonitrile, LiChrosolv Hypergrade for LC-MS 1.00029

Methanol, LiChrosolv Hypergrade for LC-MS 1.06035

Purospher STAR RP-18 Endcapped UHPLC Columns 1.50650

Chromolith monolithic ready-to-use HPLC columnswww.emdchemicals.com/

chromatography

Related Products: Mobile Phase Filtration

Disc FiltersAvailable from www.millipore.com

Filter Holders


0.2 m Durapore PVDF Membrane Filter, 47 mm GVWP04700

0.2 m Durapore PVDF Membrane Fi lter, 90 mm GVWP09050

0.2 m Millipore Express PLUS PES membrane Filter, 47 mm GPWP04700

0.2 m Millipore Express PLUS PES membrane Filter, 90 mm GPWP09050

0.2 m Omnipore PTFE Membrane Filter, 47 mm JGWP04700

0.2 m Omnipore PTFE Membrane Filter, 90 mm JGWP09025

0.2 m Nylon Membrane Filter, 47 mm GNWP04700

0.2 m Fluoropore Membrane Filter, 47 mm FGLP04700

Stericup-GP Filter, 500 mL SCGPU05RESteritop-GP Filter, 500 mL SCGPS05RE


47 mm, all glass lter holder with 250 mL funnel XX1504700

90 mm glass lter holder with stainless steel screen,

with 1 L funnel

XX1009020

Filter forceps, blunt-tipped, sterilizable XX6200006P
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LiChrosolv, Chromoligh and Purospher are registered trademarks and EMD Millipore and the M logo aretrademarks of Merck KGaA, Darmstadt, Germany.Durapore, Stericup, Millex, Milli-Q, Millipore Express are registered trademarks and Samplicity, Millex Sam-plicity, Omnipore, Fluoropore, Millivac and LC-Pak are trademarks of Millipore Corporation.Lit. No. PB0018EN00 07/2011 LS-SBU-11-04354 Printed in the U.S.A.2011 Millipore Corporation. All rights reserved.

Use Milli-Q ultrapure water purication systems to ensure that your mobile phases are

free of organic contaminants, for the best, most reproducible chromatographic results.

Especially when tted with a 0.2 m nal lter, Milli-Q systems are the ideal water source

for UHPLC, LC-MS, and other ultrasensitive analyses.

Laboratory Water Systems for ChromatographyLearn more at www.millipore.com/labwater.


Milli-Q Integral 15 Pure (15 L/hour) and Ultrapure Water Production Unit with built-in resistivity

and TOC meter

ZRXQ015T0*

Milli-Q Advantage A10 Ultrapure Water Purication System Z00Q0V0WW*

LC-Pak point-of-use polisher for the production of at least 500 L of ultrapure water for organictrace analysis

LCPAK0001*

*Contact your local EMD Millipore sales representative for a country-specic part number.

High Quality Ultrapure WaterCan Improve Chromatographic Performance

www.millipore.com

To Place an Order or ReceiveTechnical AssistanceIn the U.S. and Canada, call toll-free 1-800-645-5476

For other countries across Europe and the world,

please visitwww.millipore.com/ofces

For Technical Service, please visit

www.millipore.com/techservice

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Samplicity Filtration System: The Ideal Sample Prep System