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Sarah N. Boers, MD Department/Faculty: Julius Center, department of Medical Humanities, UMC Utrecht University: UMC Utrecht, Utrecht University Email address: [email protected]
Bio Sarah Boers (Rotterdam, 1988) studied medicine at the University Medical Center in Utrecht and obtained her master's degree in 2014. During her research internship in medical ethics she collaborated with prof. dr. Annelien Bredenoord on a project concerning the disclosure of genetic information to family after a patient's death. In October 2014 she started as a PhD candidate in medical ethics under supervision of prof. dr. Hans van Delden and prof. dr. Annelien Bredenoord. In her PhD project she focuses on the "Ethics of Organoid Technology". Organoid technology is a novel stem cell technology with a great promise for personalized medicine, drug development, and regenerative medicine. In this project her main emphasis is on the ethical challenges that surround biobanking: the donation, storage of use of mini-organs for scientific, clinical, and commercial aims.
As of June 2016 she combines finishing her PhD with a ZonMw funded project, entitled 'The ethics of first-in-human organoid transplantation'. In this project she shifts her focus to the translation of organoids from bench to bedside. How to design an ethically sound first-in-human organoid trial, together with a multidisciplinary team, while taking into account the needs and preferences of patients?
In addition, she is involved in teaching several courses at the faculty of medicine and the Graduate School of Life Sciences.
Key Publications
Organoid technology: Identifying the ethics. Sarah N. Boers, Johannes J.M. van
Delden, Hans Clevers, Annelien Bredenoord. EMBO Reports, 2016 (in press)
Broad consent is consent for governance
Sarah N. Boers, Johannes J.M. van Delden, Annelien L. Bredenoord American
Journal of Bioethics, 2015; 15; 53-55
Postmortem disclosure of genetic information to family members: active or
passive?
Sarah N. Boers, Johannes J.M. van Delden, Nine V. Knoers, Annelien L.
Bredenoord Trends in Molecular Medicine, 2015; 21; 148-153
Koen Braat, PhD
Assistant Professor
Department of Cell Biology, Center for Molecular medicine and
Regenerative Medicine Center
University Medical Center Utrecht
Bio Koen Braat studied biology at the Utrecht University with
specializations in molecular biology and medical microbiology.
In 1999 he obtained his PhD at the Utrecht University. He
worked in the research group for Comparative Endocrinology
and the Hubrecht Laboratory to characterize the stem cells of
the gametes (primordial germ cells) in zebrafish.
In November 2000, he joined the group of Prof. Paul
Macdonald at the division of Molecular Cell and Developmental
Biology at the University at of Texas in Austin. He investigated
regulation of the translation of oskar, a maternal mRNA, which
plays a key role in posterior body patterning and germ cell
formation in Drosophila melanogaster and revealed an
unknown regulatory mechanism by which Oskar protein is
restricted to the posterior pole of the oocyte.
In April 2003 he joined the group of Prof. Maarten van Lohuizen
at the Netherlands Cancer Institute in the Division of Molecular
Genetics. Here he focussed on in vitro functional genetic
screens to identify new oncogenes or tumor suppressor genes
involved in tumor formation and in vitro functional genetic
screens to identify new genes involved in maintenance of
pluripotency of embryonic stem cells.
In January 2008 he joined the Regenerative Medicine program
in the group of Prof. Paul Coffer at the Wilhelmina Children’s
Hospital in Utrecht. Here he focusses on mesenchymal stem
cells (MSC), a multipotent stem cell and investigates the
multipotency/differentiation capacities of these stem cells. He
also uses human induced pluripotent stem cells for disease
modeling.
He is also a lecturer and coordinator of the RM-PhD program.
Corlinda ten Brink
Senior Research Technician
Center for Molecular Medicine
Department of Cell Biology
University Medical Center Utrecht
Bio Senior research technician and microscope manager in the
department of Cell Biology at the UMC Utrecht starting
September 2005 until now.
Member of the Utrecht bio-imaging workgroup since
beginning of 2012.
VU Medical Centre Amsterdam Department of Otolaryngology
1993-1999.
Veterinary Medicine Utrecht Department of Immunology 1999-
2005.
Joost de Bruijn, PhD
Chair, Biomaterials
Queen Mary University
London, United Kingdom
Professor of Regenerative Medicine & Entrepreneurship
Twente University, The Netherlands
Bio Joost D de Bruijn holds the Chair of Biomaterials at Queen
Mary University of London, United Kingdom and is Professor of
Regenerative Medicine and Entrepreneurship at Twente
University, The Netherlands. His current research focuses on
tissue instructive materials (bone, cartilage) and mesenchymal
stem cells. Prof de Bruijn is also founder and CEO of the Dutch
biotech start-ups Xpand Biotechnology BV and Progentix
Orthobiology BV that focus on stem cell expansion bioreactor
technology and bone inducing ceramic materials. To date, he
has published 135 papers in peer-reviewed journals and is
inventor of 28 international patents
Name: Massimiliano Caiazzo Department/Faculty: Dep. Of Pharmaceutical Sciences University: Utrecht University Email address: [email protected]
BIO: Massimiliano Caiazzo started his studies in Naples at the Institute of Genetics and Biophysics, CNR, “A.
Buzzati-Traverso” and at CE.IN.GE. Biotecnologie Avanzate where he was involved in the study of the role of
the transcription factors that drive induction and differentiation of midbrain dopaminergic neurons that are
crucial in the pathogenesis of Parkinson’s disease (PD). During his PhD he started to be interested in the field of
embryonic and neural stem cells that led him to an internship at Montreal Neurological Institute (McGill
University, Montreal) and subsequently at hospital San Raffaele in Milano where he performed pioneering
studies in the field of cell reprogramming and transdifferentiation. He finally completed his training at EPFL in
the Laboratory of Stem Cell and Bioengineering where he combined the use of 3D hydrogels to cell
reprogramming and organogenesis. In 2016 he moved to Utrecht University as assistant professor to start his
own research lines focused on cell therapies.
Period From 2016 Institute Utrecht University, Dep. of Pharmaceutical Sciences
Position Assistant Professor
Period From 2014 to 2016
Institute EPFL, Lausanne, Switzerland (Prof. Matthias Lutolf Lab).
Position Post-doctoral fellow
Period From 2010 to 2013
Institute San Raffaele Scientific Institute, Milan, Italy (Dr. Vania Broccoli Lab).
Position Post-doctoral fellow
Period 2009
Institute Neurology Clinic “Hermitage-Capodimonte”, Naples, Italy (Prof. Giuseppe Sorrentino Lab).
Position Post-doctoral fellow
Period 2008
Institute McGill University, Montreal, Canada (Prof. Stefano Stifani Lab).
Position Visiting PhD student
Period 2005 to 2008
Institute CE.IN.GE. Biotecnologie Avanzate, Naples, Italy (Prof. Francesco Ramirez Lab).
Position PhD student, enrolled in the European School of Molecular Medicine (SEMM) PhD program.
Period 2002 to 2004
Institute Institute of Genetics and Biophysics, CNR, Naples, Italy (Dr. Umberto di Porzio Lab).
Position Student/Fellow
Joost O. Fledderus, PhD
Director of Administration, UMC Utrecht RM Center
Postdoc
Department of Nephrology & Hypertension
University Medical Center Utrecht
Email address: [email protected]
Bio Dr. Joost O. Fledderus is currently working in a dual function as the Director of Administration at the UMC Utrecht Regenerative Medicine Center and as assistant professor at the Department of Nephrology and Hypertension of the UMC Utrecht. After obtaining his master’s degree in Biology at Utrecht University, he did his PhD at the Academic Medical Center (AMC) of the University of Amsterdam, studying signal transduction and whole genome gene expression in endothelial cells, smooth muscle cells and macrophages in the healthy and atherosclerotic vessel wall. In 2008 he was appointed as a postdoctoral fellow for the cardiovascular nucleus within the Regenerative Medicine strategic programme of the UMC Utrecht. In 2010, he received a pilot grant from the Dutch Diabetes Fund for a study on molecular mechanisms impairing the Nrf2-Keap1 pathway in the diabetic vascular wall. From 2011 he is working as a postdoc in the Department of Nephrology and Hypertension, supervising PhD students with projects in heart valve and blood vessel tissue engineering and autologous stem cell therapy for peripheral vascular disease and systemic sclerosis. In addition, he has a supportive role with the management team of the UMC Utrecht strategic research program Regenerative Medicine & Stem Cells (RM&SC), teaches in various courses at bachelor/master/PhD level, and is the course coordinator of the course “Introduction to RM&T” within the UU master’s programme Regenerative Medicine and Technology. From 2013-2015, he was project leader for the transition of RM&SC research labs to the UMC Utrecht Regenerative Medicine Center in the new laboratory building of the Hubrecht Institute and coordinated the move in late 2015.
Debby Gawlitta, PhD
Associate Professor
Dept. of Oral and Maxillofacial Surgery & Special Dental Care
University Medical Center Utrecht
Coordinator
Master’s Programme ‘Regenerative Medicine and Technology’
Utrecht University/ University Medical Center Utrecht/
Eindhoven University of Technology
[email protected] www.uu.nl/masters/rmt
Bio Debby Gawlitta was trained as a biomedical engineer at the
Eindhoven University of Technology. Her PhD thesis was focused on
generating engineered skeletal muscle tissue and assessing the origin
of deep tissue injury (pressure ulcers). Then, in 2007, she moved to
the department of Orthopaedics, University Medical Center in Utrecht,
to work on bone and cartilage tissue regeneration in the lab of Prof.
Dhert. During her postdoc, she received a prestigious Veni grant
(Dutch innovation grant) to pursue (endochondral) bone regeneration
from a cartilage template with bone marrow-derived stem cells. Her
second research line is directed at co-culturing of different
stem/progenitor cells for vascularization of engineered bone. In 2014,
she was appointed at the department of Oral and Maxillofacial
Surgery to direct the research on craniofacial bone regeneration. The
group consists of four PhD students. Together they aim to apply
different RM strategies to regenerate bone of the skull, maxilla and
mandible: direct bone formation and indirect (via cartilage) bone
formation. Keywords include clinical translation, biomaterials,
stem/progenitor cells, bioreactors, and 3D bioprinting.
Further, Debby Gawlitta developed and coordinates the 2-year
Master’s program RMT – Regenerative Medicine and Technology.
Since 2012, RMT is a collaborative program of the UMCU, Utrecht
University and Eindhoven University of Technology.
Niels Geijsen, PhD
Professor of Regenerative Medicine
Hubrecht Institute
Faculty of Veterinary Medicine
Utrecht University
Bio Niels Geijsen received his PhD from Utrecht University in
The Netherlands in 2000 studying cytokine signaling in the
hematopoietic system. He completed his post-doctoral
training in the lab of Dr. George Daley at MIT and the
Whitehead Institute for Biomedical Research where he
pioneered a method for the in vitro generation of germ cells
from embryonic stem cells. Following his post-doc, he
became Assistant Professor at Massachusetts General
Hospital/Harvard Medical School and the Harvard Stem Cell
Institute. In 2010, he relocated to The Netherlands and is
Professor of Regenerative Medicine and Group Leader at the
Hubrecht Institute, with a joint position at the Faculty of
Veterinary Medicine, Utrecht University.
Dr. Geijsen's research focuses on understanding the biology
of pluripotent stem cells and developing new stem-cell
based tools to explore human development and oncogenic
transformation.
Most recently, Dr. Geijsen develop a novel, proprietary
technology that enables intracellular delivery of proteins
and oligonucleotides into primary (stem) cells. He is co-
founder of Ntrans Technologies, a spin-off company of the
Hubrecht Institute (KNAW).
Karin Gerritsen, MD
Nephrologist
Dept Nephrology & Hypertension
UMC Utrecht
Bio Karin Gerritsen has been working at the UMC Utrecht since
2007. She studied medicine at Utrecht University and obtained
her medical degree in 2001. She conducted her training in
Internal Medicine at St. Antonius Hospital in Nieuwegein. In
2007 she started her PhD research on the pharmacokinetics of
the connective tissue growth factor, an important growth factor
in the pathogenesis of fibrosis, under supervision of Prof. Dr.
Goldschmeding R. (Department of Pathology, University
Medical Center Utrecht), Dr. R.J. Cook (Division of
Biopharmaceutics, UU) and Dr. J.A. Joles (Division of
Nephrology, UMC Utrecht). She obtained her doctorate in 2012.
Since 2010 she has been working at the Department of
Nephrology and Hypertension; in 2012 she completed her
specialist training as an internist and nephrologist currently
operates.
Since 2012 Karin Gerritsen is closely involved in the
development of a wearable artificial kidney, a joint initiative of
the Kidney Foundation, several universities, companies and
TNO. A portable artificial kidney will be a major step forward for
the quality of life of dialysis patients. It provides dialysis
patients more freedom and autonomy. The aim is to better and
more gradual than with standard blood dialysis treatment. The
research at the UMC Utrecht focuses on the development of
effective strategies to remove waste from dialysis fluid.
Riccardo Levato
Department Orthopaedics Biofabrication Facility Regenerative Medicine Center Utrecht The Netherlands Email: [email protected]
Bio Dr. Riccardo Levato is a postdoctoral researcher in Biofabrication and Regenerative Medicine at the Department of Orthopaedics, University Medical Center Utrecht (UMCU) and at the Regenerative Medicine Center Utrecht. His main research focus are in the design of cell-instructive biomaterials to tune stem cell behavior and differentiation. At UMCU, he focuses on the development of novel Biofabrication strategies to treat cartilage and osteochondral defects. Dr. Levato is an experienced researched and worked in several research groups across Europe: 3Bs, University of Minho, (Portugal); BioMatLab, Technical University of Milan (Italy), Institute for Bioengineering of Catalonia (Spain), in the field of Tissue Engineering and Regenerative Medicine. Dr. Levato holds a cum laude PhD in Bioengineering (awarded by the Technical University of Catalonia, Spain), and for his doctoral research he was conferred the 2015 Julia Polak award by the European Society for Biomaterials. For his research on Biofabrication and bioprinting he has been awarded the 2016 Wake Forest Institute for Regenerative Medicine Young Scientist Award.
Simon Mastbergen, PhD
Associate Professor
University Medical Center Utrecht
Bio Dr. Simon C. Mastbergen is associate professor at the
department Rheumatology & Clinical Immunology of the
University Medical Center Utrecht, The Netherlands and
affiliated with the Regenerative Medicine Center Utrecht.
He studied Medical Biology and obtained his PhD in 2005. He
has a strong interest in translational rheumatology research
with a focus on osteoarthritis.
Central theme of his research is modulation of cartilage,
synovium, and bone to prevent and when possible cure joint
damage. Within this theme he is involved in several research
lines including “causes of development and progression of
osteoarthritis”, “effects NSAIDS and DMOADS in treatment of
osteoarthritis”, and “Joint distraction in treatment of severe
osteoarthritis".
Anna van Rhenen Department/Faculty: Hematology Cancer Center UMC Utrecht University: UMC Utrecht Email address: [email protected]
Bernard Roelen, PhD
Associate Professor
Faculty of Veterinary Medicine
Utrecht University
Bio Bernard Roelen (1968) studied Biology at Utrecht University
and subsequently performed a PhD study at the Hubrecht
Institute (Utrecht) under the supervision of Christine
Mummery. He worked for another 3 years as a junior
researcher at the same institute. Afterwards he worked as a
postdoctoral fellow at Massachusetts General Hospital/
Harvard Medical School in Boston (USA). After returning to
the Netherlands he worked as a postdoctoral researcher at the
Netherlands Cancer institute in Amsterdam. In 2003 he
became Assistant professor and later Associate professor at
the Department of Farm Animal Health, Faculty of Veterinary
Medicine, Utrecht University in Utrecht, the Netherlands. His
research is focused mammalian germ cells, stem cells and
pluripotency. He is author of >90 scientific publications.
Together with Christine Mummery and Anja van de Stolpe he
wrote the book ‘ Stamcellen’ (in Dutch) published by Veen. In
2011 together with Christine Mummery, Anja van de Stolpe
and Ian Wilmut he wrote an English updated version of this
book ‘Stem Cells’ that was published by Elsevier. In the same
year the book was awarded the ‘Medical Book Award’ by the
British Medical Association. A new updated edition of this
book with Hans Clevers as co-author was published in 2015.
Gerben Schaaf, Ph. D.
Department of Pediatrics, Center for Lysosomal and
Metabolic Diseases (CLMZ)
Erasmus MC, 3000 CA
The Netherlands
Tel: +3107043357
Email: [email protected]
Bio Dr. G. J. Schaaf graduated (cum laude) at the Utrecht
University in pharmacology and toxicology. Ever since he
developed a specific interest in self-renewal and stem cell
fate choices. During his postdoctoral work he identified
genes/pathways that modulate transformation of myogenic
cells into rhabdomyosarcoma tumor cells (an aggressive
pediatric cancer). With a VENI award from NWO he visited Dr.
Thomas Rando’s laboratory at the Stanford School of
Medicine (USA) to be trained in muscle stem cell biology.
Since 2008 he uses this knowledge to study healthy muscle
stem cells and their behavior/role in the development of
Neurodegenerative Diseases. Since 2012 Dr. Schaaf is
appointed at the CLMZ (Erasmus MC) and focuses on
mechanisms of muscle regeneration in Neuromuscular
disease, in particular Pompe Disease. The current focus of his
research is to identify the molecular determinants of the
regenerative potential of muscle stem cells with the aim of
developing a cell-based based therapy for muscle diseases.
Bart Spee, PhD
Assistant Professor
Faculty of Veterinary Medicine
Utrecht University
Bio Dr. Spee has more than 10 years experience in Molecular
Biology and Veterinary Medicine, and is (co)author of 28 peer-
reviewed scientific publications.
Following a PhD in Molecular Biology on pathways of
regeneration and fibrosis of liver diseases, he took up a
position as post-doc at the department of pathology at the
University of Leuven, Belgium, under guidance of prof. Tania
Roskams. Here he used molecular tools and combined these
with the vast tissue bank at the pathology department,
resulting in an increased knowledge on the activation of the
adult stem cell of the liver including its neoplastic offspring.
After an internship at the Laboratory of Experimental
Carcinogenesis (NIH, Bethesda, VS) with Dr. Thorgeirsson, were
he worked on cholangiocarcinomas, he returned to Utrecht
University as an assistant professor.
Currently he is investigating the use of stem cells, ranging from
adult stem cells (organoids) to mesenchymal stem cells and
induced pluripotent stem cells (iPS) for functional recovery of
liver diseases. To prove the efficacy and safety of these stem
cell therapies, he uses a unique large animal model, the dog, to
bridge fundamental science to human clinics.
Magda Ulrich PhD
Title: Head preclinical research
Department: Preclinical research
Organization: Association of Dutch Burn Centres
Email address: [email protected]
Bio I studied biology at the University of Utrecht and performed my
PhD training at the Maastricht University and the New England
Medical Centre of Tufts University in Boston.
After obtaining my PhD degree I worked as a post doc at the
pathology department of the Maastricht University, The
Netherlands where I worked on cardiovascular wound healing.
During that period I did an internship at the Falk Cardiovascular
Research Center, Stanford University School of Medicine in
Stanford CA, USA. Since 2001 I work at the Association of Dutch
Burn Centres in Beverwijk were I lead the preclinical research
group. We perform research on wound healing and scar
formation in burn wounds.
