Saturday, March 26, 2011 · K.I.T. Congress Incentives GmbH Dresden • Münzgasse 2 • 01067 Dresden • Tel.: 0351-4967540 Fax: 0351-4956116 • E-Mail: [email protected] •

K.I.T. Congress Incentives GmbH Dresden • Münzgasse 2 • 01067 Dresden • Tel.: 0351-4967540

Fax: 0351-4956116 • E-Mail: [email protected] • www.kitdresden.de

(Status: February 2011)

Saturday, March 26, 2011

Satellite Symposia

● Alfried Krupp Symposium 2011: “Role of ion channels in chronic disease”

9:30 -15:45, Hall 22 Chair: Birgit Liss, Institute of Applied Physiology, University of Ulm, Germany

Time

Speakers Title

09:00-09:55 Prof. Thomas Jentsch, FMP and MDC Berlin, Germany

The need for proton-driven vesicular Cl- accumulation: insights from designer mice and biophysics

09:55-10:50 Prof. Frances M. Ashcroft (FRS) University of Oxford, UK

KATP channels, neonatal diabetes and neurological disorders: from molecule to malady

10:50-11:45 Prof. Jochen Roeper, Goethe University Frankfurt, Germany

To burst or not to burst! The role of KATP channels in dopamine neurons

11:45-13:00 Lunch Break

13:00-13:55 Prof. Michel Lazdunski, Université de Nice Sophia Antipolis, Valbonne, France

Sensing with ionic channels

13:55-14:50 Prof. Jörg Striessnig, University of Innsbruck, Austria

L-Type Ca2+ Channels in Human Disease

14:50-15:45 Prof. Christian Alzheimer, University of Erlangen-Nuremberg, Germany

Regulation of Na+ channels by ß-secretase BACE1



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● At the heart of physiology: “New horizons in cardiovascular research” 09:00 -16:00, Hall 2

Chairs: Prof. Cor de Wit, University of Lübeck Prof. Markus Hecker, University of Heidelberg

9:00 - 9:05 Welcome

9:05 - 10:30 Session 1: "Myocardial signaling in health and disease" Chairs: G. Pfitzer, Köln; K. Schlüter, Gießen

9:05 - 9:25 M. Krüger: Molecular regulation of titin-based myocardial stiffness

9:25 - 9:45 P. Sasse: Disease-modeling with cardiomyocytes derived from disease-specific induced pluripotent stem cells

9:45 - 10:05 K. Boengler et al.: Mitochondria in cardioprotection

10:05 - 10:25 W. A. Linke: Novel functions of the Z-disc/I-band based stress-transmitting protein network

10:30 - 10:45 Coffee Break 10:45 - 12:10 Session 2: "Cell-to-cell interactions in the cardiovascular system" Chairs: C. de Wit, Lübeck; M. Kuhn, Würzburg

10:45 - 11:05 H. Oberleithner: Functional nanomechanics of the vascular

endothelium

11:05 -11:25 H. Schnittler et al.: Dynamics and regulation of endothelial cell junctions

11:25 - 11:45 M. Cattaruzza: Interplay between wall tension and fluid shear stress in vascular cells

11:45 - 12:05 V. Randriamboavonjy, I. Fleming: Understanding the diabetic platelet - identification of new calpain substrates using proteomics



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12:10 - 12:40 Lunch break 12:40 - 14:05 Session 3: "Cardiovascular communication II: Hormones and

mediators in the cardiovascular system" Chairs: K. Brixius, Köln; U. Pohl, München 12:40 - 13:00 M. Klaiber et al.: Local, cardiac effects of atrial natriuretic

peptide

13:00 - 13:20 D. Wenzel et al.: Regulation of vascular tone by the extracellular matrix in the systemic and pulmonary circulation

13:20 - 13:40 R. Schubert et al.: Plasticity of vasoregulatory mechanisms: contribution to blood pressure regulation during maturation

13:40 - 14:00 T. Korff et al.: Controlling inflammatory responses: How ephrinB2 uppor

14:05 – 14:20 Coffee break 14:20 - 15:45 Session 4: "Redox signaling in the cardiovascular system" Chairs: H. Morawietz, Dresden; G. Heusch, Essen 14:20 - 14:40 R. P. Brandes: Nox4 – A special NADPH oxidase 14:40 - 15:00 T. Gloe et al.: Low blood pressure in mice lacking “Fibroblast

Growth Factor”-2: Vasoactive properties of an angiogenic growth factor

15:00 - 15:20 A. E. Loot et al.: Forgotten but not gone: eNOS - biological regulation and implications

15:20 - 15:40 A. Görlach: Oxygen as signaling molecule in the cardiovascular

system: From hypoxia to oxidative stress 15:45 - 16:00 Wrap-up and conclusions



4

Open Cerimony 16:30 – 18:00, Audimax

Program:

• Welcome Address by Professor Armin Kurtz, President of the Meeting • DuBois-Reymond Prices 2011 to Dr. Jens Hallermann, Dr. Christoph Schmidt-

Hieber and Dr. Katrin Schröder

• Lecture by Dr. Martin Arlt, BMW-Project Management: “Projekt i- die Antwort der BMW Group auf die zukünftigen Anforderungen der nachhaltigen Mobilität“

(Kindly note: this talk will be held in German language)



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Sunday, March 27, 2011

Symposia - Morning Session

● Epigenetic Control of the Cardiovascular System

8:30 – 10:30, Hall 2

Chairs: Wolfgang A. Linke, Ruhr University Bochum, Germany Gabriele Pfitzer, University of Cologne, Cologne, Germany 8:30 – 9:00 Leon de Windt, Maastricht University, The Netherlands

“MicroRNA regulation inheart failure” 9:00 – 9:30 Thomas Thum, Hannover Medical School, Hannover, Germany

“MicroRNA-based therapeutics in cardiovascular disease – Quo vadis?”

9:30 – 10:00 Elisabeth Zeisberg, Harvard Medical School, Boston, USA

“The role of hypermethylation in tissue fibrosis” 10:00 – 10:30 Johannes Backs, University of Heidelberg, Germany

“Coupling of PKA and CaMKII signaling to the cardiac genome via Histone Deacetylase”



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● The Beta-cell: Function and Failure supported by:

8:30 – 10:30, Hall 3 Chair: Giesela Drews, University of Tübingen, Germany 8:30 – 8:54 Jean-Claude Henquin, University of Louvain, Brussels, Belgium

“The KATP channel- independent pathways of insulin secretion” 8:54 – 9:18 Mark Dunne, University of Manchester, Manchster, UK

“Altered KATP Channel Function and Congenital Hyperinsulinism of Infancy (CHI)”

9:18 – 9:42 Martina Düfer, University of Tübingen, Germany

“KATP channels and protection against type 2 diabetes mellitus” 9:42 – 10:06 Lena Eliasson, Lund University, Malmö, Sweden

“Regulation of exocytosis in insulin-secreting pancreatic beta-cells”

10:06 – 10:30 Erik Renström, Lund University, Malmö, Sweden

“Voltage-dependent Ca2+-channels in the regulation of insulin secretion”



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Symposia – Afternoon Session

● Joint symposium with the Swiss Physiological Society: “Novel genetic approaches to renal physiology”

15:30 – 17:30, Hall 3 Chairs: Carsten Wagner, University of Zurich, Switzerland Richard Warth, University of Regensburg, Germany 15:30 – 16:00 Iris Heid, University of Regensburg, Germany

“Genome-wide association studies for obesity: Do we gain from increasing the sample size in meta-analyses?”

16:00 – 16:30 Carsten Böger, University of Regensburg, Germany

“Genome Wide Association Studies of Renal Function and CKD: Results from the CKDGen Consortium”

16:30 – 17:00 Olivier Devuyst, University of Zurich, Switzerland

“GWAS: Relevance for kidney disease progression” 17:00 – 17:30 Olivier Bonny, University of Lausanne, Switzerland

“Uric acid homeostasis: how GWAS help moving GLUT9 on the right tracks”



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● Role of glial cells in sensory systems

15:30 – 17:30, Hall 4 Chairs: Swen Hülsmann, University of Göttingen, Germany Frank Kirchhoff, Department of Molecular Physiology, University of Saarland, Homburg, Germany 15:30 – 16:00 Mike Francke, University of Leipzig, Germany

“Why it is essential to have retinal glial (Müller) cells if you want to see?”

16:00 – 16:30 Thomas Hassenklöver, University of Göttingen, Germany

“Glial supporting cells of the olfactory epithelium mediate intraepithelial communication”

16:30 – 17:00 Arthur M. Butt, University of Portsmouth, UK

“Axon glial signalling in the optic nerve” 17:00 – 17:30 Christian Lohr, University of Hamburg, Germany

“Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling”

● Exercise Physiology: Cellular and Molecular Aspects

15:30 – 17:30, Hall 10 (The Program will be available within a few days)



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Plenary Lectures

11:00 – 12:00, Audimax

Prof. William E. Balch The Scripps Research Institute, La Jolla, USA

“Proteostasis: Balancing the Proteome in Human Health and Disease”

14:00 – 15:00, Audimax

Prof. Ralf Adams Max Planck Institute for Molecular Biomedicine, Münster, Germany

“Angiogenesis: Growth of new blood vessels and beyond”



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Oral Presentations – Morning Session

● Renal Physiology: Transporters – Channels

8:30 – 10:35, Hall 4

8:30 Welcome and Introduction 8:35 SGK1 stimulates ENaC in outside-out patches from early and late

parts of the aldosterone-sensitive distal nephron (ASDN) microdissected from mouse kidney *Nesterov V.1, Diakov A.1, Dahlmann A.2, Korbmacher C.1 1Friedrich-Alexander Universität Nürnberg-Erlangen, Institut für Zelluläre und Molekulare Physiologie, Erlangen, Germany 2Friedrich-Alexander Universität Nürnberg-Erlangen, Medizinische Klinik 4, Nephrologie und Hypertensiologie, Erlangen, Germany

8:50 S-nitrosylation of TonEBP/NFAT5 during endotoxemia contributes

to reduced urinary concentration via downregulation of solute transporters and aquaporin-2 *Küper C.1, Beck F.-X.1, Neuhofer W.1,2 1LMU München, Physiologisches Institut, München, Germany 2LMU München, Nephrologie, München, Germany

9:05 Requirement of PKB/SGK-dependent GSK3 phosphorylation for

stimulation of renal tubular phosphate reabsorption by dietary phosphate depletion *Föller M.1, Pathare G.1, Michael D.1, Wagner C.2, Lang F.1 1Eberhard-Karls-Universität Tübingen, Physiologisches Institut, Tübingen, Germany 2University of Zurich, Institute of Physiology and Zurich Center for Integrative Human Physiology, Zurich, Switzerland



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9:20 The ammonia transporter RhCG contributes to but is not critical

for renal ammonium excretion during high protein intake *Bounoure L.1, Bourgeois S.1, Wagner C.A.1, Druart S.2, Devuyst O.1,2 1UZH, Physiology, Zürich, Switzerland 2Université Catholique de Louvain, Nephrologie, Brussels, Belgium

9:35 Sensitivity of renal proximal tubular transporters for organic

anions to dicarboxylates *Hagos Y.1, Krick W.1, Kaufhold M.1, Henjakovic M.1, Burckhardt G.1, Burckhardt B.C.1 1Zentrum Physiologie und Pathophysiologie, Vegetative Physiologie, Göttingen, Germany

9:50 Electrophysiological und molecular genetic characterization of

two-pore-domain potassium channels in murine fibroblast of renal cortex. Influence of growth factors on channel activity. *Kacik M.1, Kaistha B.1, Hoyer J.1 1Philipps-University-Marburg, Nephrology, Marburg, Germany

10:05 Expression of ANO1 and ANO6 in mouse and human kidney

*Faria D.1, Witzgall R.2, Bierer S.3, Schlatter E.4, Heitzmann D.5, Grahammer F.6, Kunzelmann K.1, Schreiber R.1 1University of Regensburg, Institute of Physiology, Regensburg, Germany 2University of Regensburg, Institute for Molecular and Cellular Anatomy, Regensburg, Germany 3Universitätsklinikum Münster, Klinik und Poliklinik für Urologie, Münster, Germany 4Universitätsklinikum Münster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Münster, Germany 5Universitätsklinikum Münster, Medizinische Klinik und Poliklinik D, Münster, Germany 6Universitätsklinikum Freiburg, Nephrologie und Allgemeinmedizin, Freiburg, Germany

10:20 The lipocalin 2 receptor: A novel receptor mediating endocytosis

of metal-protein complexes and cadmium-metallothionein toxicity in the kidney

*Langelueddecke C.1, Wolff N.A.1, Lee W.-K.1, Thévenod F.1 1University of Witten/Herdecke, Physiology and Pathophysiology, Witten, Germany



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● Hypoxia 8:30 – 10:35, Hall 10

8:30 Welcome and Introduction 8:35 The Tyrosine Phosphatase SHP-1 regulates Hif-1α protein level in human

microvascular endothelial cells during hypoxia

*Alig S.1, Mannell H.1, Pircher J.1, Sohn H.-Y.1, Pohl U.2, Krötz F.1 1Ludwig-Maximilians-University, Cardiology, Medical Policlinic, Munich, Germany 2Ludwig-Maximilians-University, Walter Brendel Centre of Experimental Medicine, Munich, Germany

8:50 Subcellular localization and differential expression of two novel Anti-Hif-

1α variants

*Forster H.1, Tug S.1, Callau D.1, Simon P.1 1Faculty of Social Science, Media and Sports, Department of Sports Medicine, Mainz, Germany

9:05 Systematic computational and experimental identification of trans-

factors that modulate posttranscriptional gene expression of the hypoxia inducible factor 1 alpha (HIF-1α)

*Mrowka R.1, Bondke Persson A.2, Steege A.3, Patzak A.1, Persson P.2, Fähling M.2 1Universitätsklinikum Jena, Exp. Nephrologie, Jena, Germany 2Charite- Universitätsklinikum Berlin, Veg. Physiologie, Berlin, Germany 3Uniklinik, Nephrologie, Regensburg, Germany

9:20 The impact of HIF-1 signaling in skeletal muscle injury and repair

*Scheerer N.1, Gottstein E.1, Swoboda S.1, Fandrey J.1 1University of Duisburg-Essen, Institute of Physiology, Essen, Germany



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9:35 Regulation and transcriptional activities of four HIF-3α splice variants

Heidbreder M.1, Jöhren O.1, Depping R.2, Vierke G.1, *Dendorfer A.3 1University of Lübeck, Inst. of Exp. and Clin. Pharmacology and Toxicology, Lübeck, Germany 2University of Lübeck, Institute of Physiology, Lübeck, Germany 3Ludwig-Maximilians-Universität, Walter-Brendel-Center, München, Germany

9:50 Expression of the integral membrane protein 2A (Itm2a) in the heart is

stimulated by hypoxia and the Wilms’ tumor transcription factor, Wt1. *Kirschner K.M.1, Scholz H.1 1Charité-Universitätsmedizin Berlin, Institut für Vegetative Physiologie, Berlin, Germany

10:05 The unfolded protein response controls induction and activation of

ADAM17/TACE by severe hypoxia and ER-stress

Rzymski T.1, *Petry A.1, Kračun D.1, Pike L.2, Harris A.L.2, Görlach A.1 1German Heart Center Munich at the TU Munich, Experimental and Molecular Pediatric Cardiology, Munich, Germany 2University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom

10:20 Redox-sensitivity of the oligomerization and cell-cell interaction of

occludin *Blasig I.E.1, Castro V.1, Bellmann C.1 1FVB, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin-Buch, Germany



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● Transport processes and barrier function

8:30 – 10:35, Hall 22

8:30 Welcome and Introduction 8:35 Comparing CO2 permeabilities of artificial lipid bilayers and of

various cell membranes

*Endeward V.1, Itel F.2, Al-Samir S.1, Gros G.1 1Medizinische Hochschule Hannover, Zentrum Physiologie, Hannover, Germany 2University of Basel, Dept. Chemistry, Basel, Switzerland

8:50 Molecular basis of epithelial cell response to streptococcal

exotoxin: Role of STIM1 and Orai1 proteins

*Usmani S.M.1, Von Einem J.2, Dietl P.1, Wittekindt O.H.1 1University of Ulm, Institute of General Physiology, Ulm, Germany 2University of Ulm, Institute of Virology, Ulm, Germany

9:05 Target cell killing at the immunological synapse: Mechanisms of

transport, docking and exocytosis of lytic granules

Qu B.1, Pattu V.2, *Junker C.1, Schwarz E.1, Bhat S.1, Kummerow C.1, Marshall M.2, Matti U.2, Neumann F.3, Pfreundschuh M.3, Becherer U.2, Rieger H.4, Rettig J.2, *Hoth M.1 1Saarland University, Biophysics, Homburg, Germany 2Saarland University, Physiology, Homburg, Germany 3Saarland University, Internal Medicine II, Homburg, Germany 4Saarland University, Theoretical Physics, Saarbrücken, Germany

9:20 Vesicular P2X4 controls exocytic post-fusion phase

Miklavc P.1, Wittekindt O.1, Felder E.1, Dietl P.1, *Frick M.1 1University of Ulm, Department of General Physiology, Ulm, Germany



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9:35 Epidermal differentiation and tight junction formation - a

chicken-egg question

*Kirschner N.1, Zorn-Kruppa M.1, Moll I.1, Brandner J.M.1 1University Hospital Hamburg-Eppendorf, Department of Dermatology and Venerology, Hamburg, Germany

9:50 The tight junction protein claudin-17 forms a paracellular anion

channel in kidney tubule cells

*Krug S.M.1, Rosenthal R.1, Günzel D.1, Amasheh S.1, Schulzke J.2,3, Fromm M.1 1Charité Berlin, Institute of Clinical Physiology, Berlin, Germany 2Charité Berlin, Dept. of Gastroenterology, Berlin, Germany 3Charité Berlin, Dept. of General Medicine, Berlin, Germany

10:05 The plant alkaloide berberine prevents claudin-1- and -2-based

cytokine-induced paracellular barrier impairment *Amasheh S.1, Amasheh M.2, Fromm A.1, Krug S.M.1, Fromm M.1, Schulzke J.2,3 1Charité - Campus Benjamin Franklin, Institute of Clinical Physiology, Berlin, Germany 2Charité - Campus Benjamin Franklin, Department of General Medicine, Berlin, Germany 3Charité - Campus Benjamin Franklin, Department of Gastroenterology, Berlin, Germany

10:20 Nuclear Permeability Barrier - What is the Structural and

Molecular Basis?

*Meyring A.1, Liashkovich I.1, Shahin V.1 1University of Münster, Institute of Physiology II, Münster, Germany



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● Angiogenesis, Tumor Physiology, white blood cells

8:30 – 10:35, Hall 22

8:30 Welcome and Introduction 8:35 Proteolytic fragments of matrix protein laminin modulate endothelial

proliferation and differentiation via induction of oxygen radical formation and anoikis. *Gloe T.1, Pohl U.2 1University of Heidelberg, Med. Fakultät Mannheim, Cardiovascular Physiology, CBTM, Mannheim, Germany 2Ludwig-Maximilians-University, Walter-Brendel-Centre of experimental Medicine, Munich, Germany

8:50 ARNO initiates angiogenesis through regulation of VEGF receptor 2

levels

*Mannell H.1, Pircher J.1, Chaudhry D.1, Pohl U.2, Krötz F.1 1Med. Policlinic, Cardiology, Munich, Germany 2Walter-Brendel-Centre, Experimental Medicine, Munich, Germany

9:05 The serum- and glucocorticoid-inducible kinase-1 (SGK1) regulates

expression and function of membrane androgen receptors (mAR) as well as migration in tumor cells

*Gehring E.-M.1, Gu S.1, Konstantinidis G.2, Alevizopoulos K.2, Föller M.1, Lang F.1, Stournaras C.2 1Eberhard-Karls-Universität Tübingen, Physiologisches Institut, Tübingen, Germany 2University of Crete Medical School, Department of Biochemistry, Heraklion, Greece

9:20 Role of acidosis-induced ROS formation in the signalling cascade of

tumour cells

*Riemann A.1, *Ihling A.1, Schneider B.1, Thews O.1, Gekle M.1 1MLU Halle, Julius-Bernstein-Institut für Physiologie, Halle (Saale), Germany



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9:35 An adipocyte-derived lipid increases angiotensin-converting enzyme

(ACE) expression and modulates macrophage polarization

*Kohlstedt K.1, Trouvain C.1, Namgaladze D.2, Fleming I.1 1 Goethe-University, Institute for Vascular Signalling, Frankfurt, Germany 2Institute of Biochemistry I, Frankfurt, Germany

9:50 Control of HIF-1α synthesis during macrophagocytic differentiation by

posttranscriptional mechanisms

*Fähling M.1, Bondke Persson A.1, Steege A.2, Patzak A.1, Benko E.1, Persson P.B.1, Mrowka R.1,3 1Charité - Universitätsmedizin Berlin, Institut für Vegetative Physiologie, Berlin, Germany 2Universitätsklinikum Regensburg, Klinik und Poliklinik für Innere Medizin II, Regensburg, Germany 3Universitätsklinikum Jena, Klinik für Innere Medizin, Jena, Germany

10:05 The Wilms’ tumor transcription factor Wt1 regulates the Interleukin-10

gene

*Bondke Persson A.1, Sciesielski L.K.1,2, Scholz H.1, Kirschner K.M.1 1Charité Universitätsmedizin Berlin, Institut für Physiologie CCM, Berlin, Germany 2University of Oxford, Oxford, United Kingdom

10:20 ORAI1 and STIM1 play an essential role in calcium signaling following T

cell receptor stimulation in CD8+ T lymphocytes

*Mangerich C.1, Schwarz E.C.1, Hoth M.1, Kummerow C.1 1Universität des Saarlandes, Biophysik, Homburg, Germany



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Oral Presentations – Afternoon Session

● Cardiac hypertrophy and response to injury

15:30 – 17:35, Hall 2 15:30 Welcome and Introduction 15:35 Common microRNA signatures in cardiac hypertrophic and atrophic

remodeling induced by changes in hemodynamic load *Schwoerer A.1, El-Armouche A.1, Neuber C.2, Emmons J.3, Biermann D.2, Christalla T.4, Grundhoff A.4, Eschenhagen T.2, Zimmermann W.-H.3, Ehmke H.1 1University Medical Center Hamburg, Institute of Vegetative Physiology, Hamburg, Germany 2University Medical Center Hamburg, Institute of Experimental Pharmacology, Hamburg, Germany 3University of Göttingen, Institute of Pharmacology, Göttingen, Germany 4Heinrich Pette Institute, Hamburg, Germany

15:50 Characterisation of ventricular myocyte remodelling in RacET mice

*Kaestner L.1, Oberhofer M.1, Tian Q.1, Körbel C.2, Hammer K.1,3, Hui X.1, Wang J.1, Reil J.4, Neuberger H.-R.4, Lipp P.1 1Saarland University, Institute for Molecular Cell Biology, Homburg, Germany 2University Hospital, Experimental Surgery, Homburg, Germany 3UC Davis, Pharmacology, Davis, United States 4University Hospital, Cardiology, Homburg, Germany

16:05 Chronic β-adrenergic agonist induced regulation of proteasome

function in cardiac remodeling

*Drews O.1,2, Tsukamoto O.3,2, Liem D.2, Streicher J.4, Wang Y.4, Ping P.2 1University of Heidelberg, Physiology and Pathophysiology, Heidelberg, Germany 2University of California, Los Angeles, Physiology and Medicine, Los Angeles, United States 3National Cardiovascular Center, Cardiovascular Medicine, Osaka, Japan 4University of California, Los Angeles, Anesthesiology, Los Angeles, United States



19

16:20 Phosphorylation of muscle LIM protein participates in hypertrophic

signaling via the mitogen activated protein kinase and calcineurin signaling pathways

*Klede S.1, Kötter S.1, Redfield M.M.2, Knöll R.3, van Eyk J.E.4, Linke W.A.1 1Ruhr-Universität Bochum, Cardiovascular Physiology, Bochum, Germany 2Mayo Clinic, Division of Cardiovascular Disease, Rochester, MN, United States 3National Heart and Lung Institute, Imperial College , Myocardial Genetics, London, United Kingdom 4Johns Hopkins University, Department of Medicine, Baltimore, MD, United States

16:35 Functional effects and adaptational processes triggered by familial

hypertrophic cardiomyopathy related ß-myosin mutation ARG723GLY in human cardiomyocytes

*Kraft T.1, Boontje N.M.2, Paalberends E.R.2, Tripathi S.1, Francino A.3, Navarro-Lopez F.3, Brenner B.1, Stienen G.2, van der Velden J.2 1Hannover Medical School, Molecular and Cell Physiology, Hannover, Germany 2VU University Medical Center, Amsterdam, Netherlands, Netherlands 3University of Barcelona, Hospital Clinic, Barcelona, Spain

16:50 Baseline phenotype of mice with targeted deletion of the Epidermal

growth factor receptor in vascular smooth muscle cells (VSMC) and cardiomyocytes (CM)

*Schreier B.1, Rabe S.1, Schneider B.1, Ruhs S.1, Rueckschloss U.1, Sibilia M.2, Gotthardt M.3, Grossmann C.1, Gekle M.1 1University of Halle-Wittenberg, Julius-Bernstein-Institute, Halle/Saale, Germany 2Medical University of Vienna, Institute for Cancer Research, Vienna, Austria 3Max Delbrück Center for Molecular Medicine , Neuromuscular and Cardiovascular Cell Biology, Berlin, Germany

17:05 Postconditioning protects cardiomyocytes against reperfusion injury by

inhibiting mitochondrial permeabilty transition pore and delaying pH recovery in early reperfusion

*Shahzad T.1, Iraqi W.2, Kasseckert S.A.2, Micoogullari M.2, Scharbrodt W.1, Örtel M.1, Schlüter K.-D.2, Piper H.M.3, Abdallah Y.4 1Universitätsklinikum Gießen und Marburg GmbH, Neurochirurgie, Gießen, Germany 2Justus-Liebig-Universität, Gießen, Germany 3Heinrich-Heine-Universität, Düsseldorf, Germany 4Universitätsklinikum Gießen und Marburg GmbH, Med. Klinik I, Kardiologie/Angiologie, Gießen, Germany



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17:20 Modulation of Immune Response by CD73-derived Adenosine during

Myocardial Remodeling after Ischemia/Reperfusion

*Bönner F.1, Borg N.1, Christoph J.1, Bongardt S.1, Flögel U.1, Schrader J.1 1Herz/Kreislaufphysiologie, Düsseldorf, Germany



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● Central nervous system 15:30 – 17:35, Hall 22

15:30 Welcome and Introduction 15:35 Human amygdalar network in the generation and maintenance of

epileptiform activity

*Graebenitz S.1, Kedo O.2, Gorji A.1, Pannek H.W.3, Pape H.-C.1, Zilles K.2, Speckmann E.-J.1 1Institute of Physiology I, Münster, Germany 2Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medecine, Jülich, Germany 3Epilepsy Center Bethel-Bielefeld, Bielefeld, Germany

15:50 Long-term potentiation is impaired in a rat model of anti-NMDA

receptor encephalitis

*Kirschstein T.1, Tokay T.1, Rohde M.1, Würdemann T.1, Porath K.1, Bien C.2, Köhling R.1 1University of Rostock, Institute of Physiology, Rostock, Germany 2Hospital Mara, Bielefeld, Germany

16:05 Bloody cerebrospinal fluid from patients with intraventricular

haemorrhage induces calcium overload and necrosis in cultured astrocytes of human origin

*Shahzad T.1, Örtel M.1, Scharbrodt W.1, Micoogullari M.2, Abdallah Y.3, Kasseckert S.A.2 1Uniklinikum Gießen und Marburg, Neurochirurgie, Gießen, Germany 2Justus-Liebig-Universität, Gießen, Germany 3Universitätsklinikum Gießen und Marburg GmbH, Med. Klinik I, Kardiologie/Angiologie, Gießen, Germany

16:20 A non-enzymatic transport metabolon enhances lactate flux in

astrocytes

*Becker H.1, Stridh M.2, Alt M.2, Wennemuth G.3, Deitmer J.2 1TU Kaiserlsautern, Zoology / Membrane Transport, Kaiserslautern, Germany 2TU Kaiserslautern, General Zoology, Kaiserslautern, Germany 3Saarland University, Department of Anatomy and Cell Biology, Homburg/Saar, Germany



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16:35 Atropin-sensitive hippocampal theta oscillations are modulated by

Cav2.3 Ca2+ channels

*Weiergräber M.1, Müller R.2, Struck H.3, Hescheler J.3, Schneider T.3 1Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany 2University of Cologne, Department of Psychiatry and Psychotherapy, Cologne, Germany 3University of Cologne, Institute of Neurophysiology, Cologne, Germany

16:50 The number of release-ready vesicles increases rapidly during

homeostatic plasticity

*Weyhersmüller A.1, Hallermann S.1, Wagner N.2, Eilers J.1 1Carl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig, Germany 2Institute of Physiology, Medical Faculty, Würzburg, Germany

17:05 Dopamine metabolism drives deletions of mitochondrial DNA, probably

leading to dopaminergic neuron death during aging and Parkinsons disease

*Wiesner R.1,2,3, Neuhaus J.1,3, Baris O.1, Moser N.4, Schroeder H.-J.4 1University of Cologne, Medical Faculty , Institute for Physiology , Cologne, Germany 2University of Cologne , Cologne Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany 3University of Cologne , Center for Molecular Medicine (CMMC), Cologne, Germany 4University of Cologne, Medical Faculty , Department II of Anatomy, Cologne, Germany

17:20 A role of STIM1/TRPC3 for synaptic Ca2+ signaling in cerebellar Purkinje

cells

*Hartmann J.1, Henning H.A.1, Karl R.M.1, Adelsberger H.1, Rühlmann C.1, Sakimura K.2, Baba Y.3, Kurosaki T.3, Konnerth A.1 1TU München, Institut für Neurowissenschaften, München, Germany 2Niigata University, Niigata, Japan 3RIKEN, Yokohama, Japan



23

● Blood Cell Biology

15:30 – 17:35, Hall 23

15:30 Welcome and Introduction 15:35 The AMP-activated protein kinase α2 subunit is involved in platelet

signaling as well as clot retraction and thrombus stability *Randriamboavonjy V.1, Isaak J.1, Frömel T.1, Fisslthaler B.1, Fleming I.1 1Goethe University, Institute for Vascular Signalling, Frankfurt am Main, Germany

15:50 The inflammatory chemokine CXCL16 mediates platelet activation and

adhesion via PI3K/AKT signaling pathway

*Borst O.1, Münzer P.1, Gehring E.-M.1, Gatidis S.1, Paul A.2, Schönberger T.2, Towhid S.1, Rose M.2, Seizer P.2, May A.2, Gawaz M.2, Lang F.1 1Eberhard-Karls-Universität Tübingen, Physiologisches Institut, Tübingen, Germany 2University of Tübingen, Medizinische Klinik III, Department of Cardiology, Tübingen, Germany

16:05 Endothelial cell activation in arteriogenesis - a new role for platelet

receptors

Pagel J.-I.1, von Bruehl M.-L.2, Farschtschi S.2, Schaper W.3, Massberg S.2, *Deindl E.1 1Walter-Brendel-Centre of Exp. Medicine, Munich, Germany 2Deutsches Herzzentrum, Department of Experimental Cardiology, Munich, Germany 3Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany

16:20 The new hydrogen sulfide-releasing aspirin-derivative ACS14 is a highly

effective platelet inhibitor in vitro and in vivo

*Fochler F.1, Pircher J.1, del Soldato P.2, Mannell H.1, Pohl U.3, Sohn H.-Y.1, Krötz F.1 1Med. Poliklinik der LMU, Kardiologie, München, Germany 2CTG Pharma, Milan, Italy 3Walter-Brendel-Zentrum, München, Germany



24

16:35 New insights in the consequences of calcium influx in human

erythrocytes

*Kaestner L.1, Steffen P.2, Wang J.1, Makhro A.3, Jung A.2, Nguyen D.B.4, Bernhardt I.4, Bogdanova A.3, Lipp P.1, Wagner C.2 1Saarland University, Institute for Molecular Cell Biology, Homburg, Germany 2Saarland University, Technical Physics, Saarbrücken, Germany 3University of Zürich, Institute of Veterinary Physiology, Zürich, Switzerland 4Saarland University, Biophysics, Saarbrücken, Germany

16:50 Oxygen-regulated expression of the erythropoietin gene in a human

renal cell line REPC

*Frede S.1, Freitag P.1, Geuting L.1, Konietzny R.1, Fandrey J.1 1Universität Duisburg-Essen, Institut für Physiologie, Essen, Germany

17:05 Alterations of the Red Blood Cells NOS System after Blood Donation And

Re-Infusion In Moderately Trained Subjects

*Brixius K.1, Willkomm L.1, Konou T.1, Balakirski G.1, Wilden M.1, Bloch W.1, Hinrichs T.2, Platen P.2 1German Sport University Cologne, Cardiovascular Research and Sport Medicine, Cologne, Germany 2University of Bochum, Sport Medicine and Nutrition, Bochum, Germany

17:20 Leukocyte rolling in vivo is regulated by RAGE

*Sperandio M.1, Pruenster M.1, Kamphues A.2, Lukic I.K.3, Nussbaum C.1, Lange-Sperandio B.4, Moser M.5, Bierhaus A.3, Frommhold D.2 1Ludwig-Maximilians-Universität, Walter-Brendel-Centre of Experimental Medicine, München, Germany 2Universität Heidelberg, Children's Hospital, Heidelberg, Germany 3Universität Heidelberg, Internal Medicine I, Heidelberg, Germany 4Ludwig-Maximilians-Universität, Dr. von Haunersches Kinderspital, München, Germany 5Max-Planck-Institut für Biochemie, München, Germany



25

Poster Viewing Session - Overview

12:00 – 14:00, Foyer

P001 – P011 Signalling in Cardiac Myocytes

P012 – P023 Cardiac Electrophysiology

P045 – P056 Endothelial cell biology

P068 – P078 Smooth muscle cells: Vascular tone and beyond

P079 – P089 Stem cells, Progenitor cells and Myeloid derived cells

P090 – P099 Vascular signal transduction in physiology

P115 – P126 Renal Physiology: Juxtaglomerular apparatus and renal blood flow

P137 – P145 Renal response to stress

P146 – P155 Neuronal excitability & glial function

P156 – P162 Motor System

P197 – P206 Biology of blood cells

P219 – P229 Organic Transporters

P230 – P235 TRP Channels

P236 – P248 K+ Channels

P249 – P260 Structure-Function Relation of Ion Channels

P294 – P303 Cellular biology: Tight junctions and Signalling

P317 – P324 Immune system and tumor

P325 – P335 Mechanotransduction and Exercise



26

Monday, March 28, 2011

Symposia – Morning Session

● Hippocampal Signaling – Focus on Mossy Fibers and the CA3 Region

8:30 – 10:30, Hall 3 Chairs: Christian Alzheimer, University of Erlangen, Germany Jörg Geiger, Charité Berlin, Germany

8:30 – 9:10 Dimitri Kullmann, University College London, UK Keynote “GABAA receptors at mossy fibre synapses”

9:10 - 9:30 Henrik Alle, Charité Berlin, Germany

“Energy as design constraint for action potential implementation”

9:30 – 9:50 Christian Alzheimer, University of Erlangen, Germany

“Muscarinic modulation of CA3 synapses “

9:50 – 10:10 Jörg Breustedt, Charité, Berlin

“The role of Munc 13-2 in synaptic short-term and long-term plasticity at the hippocampal mossy fiber synapse”

10:10 – 10:30 Jose Guzman, University of Freiburg, Germany

“Synaptic transmission and plasticity between CA3 pyramidal neurons”



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● Tight Junctions: More than Barriers

8:30 – 10:30, Hall 4 Chair: Dorothee Günzel, Charité, Berlin 8:30 – 8:54 Hartwig Wolburg, University of Tübingen, Germany

“The tight junctions of the blood-brain barrier” 8:54 – 9:18 Markus Bleich, University of Kiel, Germany

“Electrophysiological approaches to tight junction physiology in the kidney”

9:18 – 9:42 Johanna Brandner, University Hospital Hamburg-Eppendorf,

Germany “The functions of tight junction proteins in mammalian epidermis”

9:42 – 10:06 Jörg Piontek, Leibnitz-Institut für Molekulare Pharmakologie, Berlin,

Germany “Elucidating the molecular organization of tight junction strands”

10:06 – 10:30 Alan Yu, Keck School of Medicine, University of Southern

California, Los Angeles, USA “Structure-function studies of the claudin-2 paracellular pore”



28

Symposia – Afternoon Session

● Mediators and Mechanisms of long-term nociceptor sensitization

15:30 – 17:30, Hall 3 Chairs: Martin Schmelz, Rolf-Detlef Treede, Medical Faculty Mannheim, University of Heidelberg, Germany 15:30 – 16:00 Stephen McMahon, Kings College, London, UK

“Sodium channels and nociceptor sensitization” 16:00 – 16:30 Marlen Petersen, Medical Faculty Mannheim, University of

Heidelberg, Germany “An in vitro model for functional investigation of sensory nerve terminals and keratinocytes”

16:30 – 17:00 Torsten Frings, Medical Faculty Mannheim, University of

Heidelberg, Germany “The role of calcium activated chloride channels for nociceptor sensitization”

17:00 – 17:30 Peter Reeh, University of Erlangen-Nuremberg, Germany

“The role of axonal channels for nociceptor sensitization”



29

● Joint symposium with the German Society of Nephrology (DGfN):

“Translational kidney physiology”

15:30 – 17:30, Hall 4 Chairs: Armin Kurtz, University of Regensburg, Germany Kai-Uwe Eckardt, RWTH Aachen University, Germany 15:30 – 16:00 Kai-Uwe Eckardt, University of Erlangen-Nuremberg, Germany

“Renal hypoxia – from pathophysiology to clinical application” 16:00 – 16:30 Michael Köttgen, University of Freiburg, Germany

“Polycystic Kidney Disease: from bedside to bench - and back” 16:30 – 17:00 Pontus B. Persson, Charité Berlin, Germany

“Contrast media induced acute kidney injury: from the pathophysiology to clinics”

17:00 – 17:30 Volker Vallon, University of California San Diego, USA

“Glomerular hyperfiltration and the salt paradox in early diabetes mellitus”



30

● Joint symposium with the Scandinavian Society of Physiology:

“Brain plasticity by AMPA receptor mechanisms: basic mechanisms and addiction”

15:30 – 17:30, Hall 10 Chairs: Georg Köhr, MPI Heidelberg, Germany Esa R. Korpi, University of Helsinki, Finland 15:30 – 16:00 Rolf Sprengel, MPI Heidelberg, Germany

“New endogenous modulators of the fast excitatory signal transmission”

16:00 – 16:30 Eric Hanse, University of Göteborg, Sweden

“AMPA receptors determining synaptic functions” 16:30 – 17:00 Matthew T.C. Brown, University of Geneva, Switzerland

“Selective dopamine neuron stimulation mimics drug-driven AMPA receptor redistribution”

17:00 – 17:30 Esa R. Korpi, University of Helsinki, Finland

“AMPA receptor adaptations in early steps of drug addiction”



31

Plenary Lectures

11:00 – 12:00, Audimax

Prof. Bernd Nilius Catholic University Leuven, Belgium

Expanding TRPs: from unique cells sensors to human diseases

14:00 – 15:00, Audimax

Prof. Genevieve Nguyen INSERM, Paris, France

The (pro)renin receptor: a reappraisal of its functions



32

Oral Presentations – Morning Session

● Endothelial biology and vascular tone 8:30 – 10:35, Hall 2

8:30 Welcome and Introduction 8:35 Nitration of endothelial cell CD40: Selectivity and functional

consequences

*Wagner A.H.1, Hildebrandt A.1, Jungmann A.2, Müller O.J.2, Sharov V.S.3, Schöneich C.3, Hecker M.1 1University of Heidelberg, Institute of Physiology and Pathophysiology, Heidelberg, Germany 2University of Heidelberg, Department of Internal Medicine III, Heidelberg, Germany 3University of Kansas, Department of Pharmaceutical Chemistry, Lawrence, United States

8:50 Downregulation of endothelial angiotensin-converting enzyme (ACE)

expression in response to shear-stress is mediated via AMPK

*Kohlstedt K.1, Trouvain C.1, Fleming I.1 1Goethe-University, Institute for Vascular Signalling, Frankfurt, Germany

9:05 AMP-activated protein kinase (AMPK) induces vasodilation of hamster

microvessels by activating the BKCa channel *Schubert M.1, Kreutz C.1, Mederos y Schnitzler M.2, Gudermann T.2, Pohl U.1 1Ludwig-Maximilians-University, Walter-Brendel-Centre of Experimental Medicine, Munich, Germany 2Ludwig-Maximilians-University, Walther-Straub-Institute of Pharmacology and Toxicology, Munich, Germany



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9:20 The AMP-activated protein kinase modifies gene expression in

endothelial cells by interfering with protein lysine acetylation

*Fisslthaler B.1, Loot A.1, Fleming I.1 1Goethe University Frankfurt, Institute for Vascluar Signalling, Frankfurt, Germany

9:35 Functional connexin40 protein is mandatory for conduction of

endothelium-dependent dilations in arterioles and blood pressure control Jobs A.1, Lübkemeier I.2, Willecke K.2, *de Wit C.1,3 1Universität zu Lübeck, Institut für Physiologie, Lübeck, Germany 2Universität Bonn, Institut für Genetik, Bonn, Germany 3,, Germany

9:50 Vasoconstrictor potential of aspirate from stented saphenous vein

aorto-coronary bypass grafts and its pharmacological attenuation -insight into the no-reflow phenomenon-

*Kleinbongard P.1, Böse D.2, Baars T.2, Möhlenkamp S.2, Konorza T.2, Schöner S.1, Elter-Schulz M.1, Eggebrecht H.2, Degen H.3, Haude M.3, Levkau B.1, Schulz R.1, Erbel R.2, Heusch G.1 1Universitätsklinikum Essen, Institut für Pathophysiologie, Essen, Germany 2Universitätsklinikum Essen, Westdeutsches Herzzentrum, Essen, Germany 3Lukaskrankenhaus Neuss, Medizinische Klinik I, Neuss, Germany

10:05 Cortical actin meshwork dynamics determine the function of vascular

endothelium

*Fels J.1, Kusche-Vihrog K.1, Oberleithner H.1 1University of Münster, Institute of Physiology II, Münster, Germany

10:20 CD40-CD154 interaction induces phospholipase C-dependent

endothelial cell release of von Willebrand factor in vitro and in situ

*Möller K.1, Schwarz M.1, Nobiling R.1, Wieland T.2, Schneider S.W.3, Wagner A.H.1, Hecker M.1 1University of Heidelberg, Institute of Physiology and Pathophysiology, Cardiovascular Physiology, Heidelberg, Germany 2University of Heidelberg, Institute for Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Mannheim, Germany 3University of Heidelberg, Department of Dermatology, Medical Faculty Mannheim, Mannheim, Germany



34

● Transporters and Channels: Anion Transport and TRP channels 8:30 – 10:35, Hall 10

8:30 Welcome and Introduction 8:35 CFTR induces acid sensing and H+ activated Cl- transport

*Kongsuphol P.1, Schreiber R.1, Kraidith K.1, Kunzelmann K.1 1Regensburg University, Physiology Institute, Regensburg, Germany

8:50 Disease-associated missense mutations in bestrophin-1 affect cellular

trafficking and anion conductance

*Milenkovic V.1, Röhrl E.2, H.F. Weber B.2, Strauß O.1 1Eye Hospital, University Medical Center Regensburg, Experimental Ophthalmology, Regensburg, Germany 2University of Regensburg, Institute of Human Genetics, Regensburg, Germany

9:05 Sildenafil acts via the cGMP pathway on wt-CFTR whereas ∆F508-CFTR

restoration is cGMP independent *Leier G.1, Bangel-Ruland N.1, Sobczak K.1, Solbach J.1, Bender K.1, Antfang J.1, Weber W.-M.1 1University of Münster, Institute of Animal Physiology, Münster, Germany

9:20 Membrane expression of F508del mutant increases epithelial HCO3-

secretion via functional Cl-/HCO3-exchanger(s)

*Xiao F.1, Li J.1,2, Sultan A.1, Wang J.1, Riederer B.1, Engelhardt R.1, Rausch B.1, Lamprecht G.3, De Jonge H.R.4, Scholte B.J.5, Seidler U.1 1Medizinische Hochschule Hannover, Gastroenterology, Hepatology and Endocrinology, Hannover, Germany 2Tongji Hospital, Tongji medical college, Nephrology, Wuhan, China 3 University of Tübingen, 1st. Dept. of Medicine, Tübingen, Germany 4Rotterdam University, Dept. of Biochemistry, Rotterdam, Netherlands 5Rotterdam University, Cell Biology, Rotterdam, Netherlands



35

9:35 The role of TRPC6 in chemotactic signaling of murine neutrophils

*Lindemann O.1, Umlauf D.2, Bertrand J.2, Fabian A.1, Pap T.2, Dietrich A.3, Schwab A.1 1University of Münster, Institute of Physiology II, Münster, Germany 2University of Münster, Institute of Experimental Musculoskeletal Medicine, Münster, Germany 3LMU München, Walther-Straub-Institute for Pharmacology und Toxicology, München, Germany

9:50 Loss of TRPC1 increases endothelium-derived hyperpolarising factor-

type dilations in mice *Schmidt K.1, Dubrovska G.2, Fesüs G.2, Dietrich A.3, Gollasch M.2, Köhler R.4, de Wit C.1 1Universität zu Lübeck, Institut für Physiologie, Lübeck, Germany 2Charité Campus Virchow, Dep. of Medicine, Division of Nephrology, Berlin, Germany 3Ludwig-Maximilians-Universität München, Walther-Straub-Institut für Pharmakologie und Toxikologie, München, Germany 4University of Southern Denmark, Institute for Molecular Medicine, Cardiovascular and Renal Research, Odense, Denmark

10:05 TRPM7 is a receptor for natural and synthetic modulators of SKCa

channels

*Chubanov V.1, Mederos y Schnitzler M.1, Meißner M.1, Schäfer S.1, Abstiens K.1, Heilmair R.1, Hofmann T.2, Gudermann T.1 1Ludwig-Maximilians-Universität München, Walther-Straub-Institut für Pharmakologie und Toxikologie, München, Germany 2Philipps-Universität Marburg, Institut für Pharmakologie und Toxikologie, Marburg, Germany

10:20 TRPV4 channels in mouse skeletal muscle: their role for Ca2+

homeostasis, muscle fatigue and motor function

*Pritschow B.W.1, Princk M.1, Lange T.1, Zhang Y.X.1, Kasch J.1, Liedtke W.2, Brinkmeier H.1 1University of Greifswald, Institute of Pathophysiology, Karlsburg, Germany 2Duke University, Center for Translational Neuroscience, Durham. NC, United States



36

● Renal Physiology: Endocrine – Regulatory 8:30 – 10:35, Hall 22

8:30 Welcome and Introduction 8:35 TASK3 potassium channels are involved in the regulation of aldosterone

secretion in mice

*Penton Ribas D.1, Bandulik S.1, Tauber P.1, Sterner C.1, Tegtmeier I.1, Reichold M.1, Haubs S.1, Lalli E.2, Barhanin J.2, Lesage F.2, Warth R.1 1University of Regensburg, Medical Cell Biology, Regensburg, Germany 2CNRS, Université de Nice Sophia Antipolis, Nice, France

8:50 Tonicity affects the WNT/β-catenin pathway in rat renal inner medullary

collecting duct cells

*Jardzejewski M.1, Klokkers J.1, Pavenstädt H.1, Schlatter E.1, Edemir B.1 1University Hospital Münster, Department of Internal Medicine D, Experimental Nephrology, Münster, Germany

9:05 Cyclooxygenase-2 knock-out mice display increased central

vasopressin stores and impaired urine concentrating ability

*Madsen K.1, Nørregaard R.2, Hansen P.B.1, Bie P.1, Thvalingam S.1, Frøkiær J.2, Jensen B.L.1 1University of Southern Denmark, Department of Cardiovascular and Renal Research, Odense, Denmark 2University of Aarhus, The Water and Salt Research Center, Aarhus, Denmark

9:20 Preventive ROCK-Inhibition attenuates renal ischemia-reperfusion

injury-related changes in the gene expression profile

*Kentrup D.1, Reuter S.1, Edemir B.1, Grabner A.1, Pavenstädt H.1, Schlatter E.1, Büssemaker E.1 1Universitätsklinikum Münster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Münster, Germany



37

9:35 Regulation of renal renin release by Proteinase-activated receptors

*Höcherl K.1, Schweda F.1 1Universität Regensburg, Institut für Physiologie, Regensburg, Germany

9:50 Nitric oxide-dependent modulation of the myogenic response in the

renal circulation in eNOS- and nNOS-deficient mice

*Dautzenberg M.1, Keilhoff G.2, Just A.1

1Albert-Ludwigs-Universität Freiburg, Physiologisches Institut 1, Freiburg, Germany 2Otto-von-Guericke-Universität Magdeburg, Institut für Biochemie u. Zellbiologie, Magdeburg, Germany

10:05 Sex-related differences in vasoactivity of mouse interlobar arteries

*Viegas V.1, Sendeski M.1, Regitz-Zagrosek V.1, Patzak A.1 1Charité-Universitätsmedizin Berlin, Institute of Vegetative Physiology, Berlin, Germany

10:20 The Connexin40 A96S Loss-of-Function mutation from a patient suffering

from atrial fibrillation causes renin dependent hypertension in mice *Machura K.1, Lübkemeier I.2, Kurtz A.1, Willecke K.2 1University of Regensburg, Department of Physiology, Regensburg, Germany 2University of Bonn, Department of Genetics, Bonn, Germany



38

● Sensory systems

8:30 – 10:35, Hall 23

8:30 Welcome and Introduction 8:35 TRPC-channels modulate reciprocal GC-MC signaling in the OB

Stroh O.1, Freichel M.2, Hartmann J.3, *Egger V.1 1LMU, Physiological Institute, München, Germany 2Universität des Saarlandes, Bad Homburg, Germany 3TUM, Friedrich-Schiedel-Institute, München, Germany

8:50 Establishment of a co-culture system to study the interaction of murine

macrophages and dorsal root ganglia neurons in vitro

*Massier J.1, Segond von Banchet G.1, Schaible H.-G.1 1Hospital of the University Jena, Physiology I, Jena, Germany

9:05 Role of S1P1 receptor in nociceptor sensitization and inflammatory pain

*Mair N.1, Benetti C.1, Andratsch M.1, Leitner M.1, Constantin C.1, Camprubi-Robles M.1, Quarta S.1, Biasio W.1, Kuner R.2, Gibbins I.3, Haberberger R.3, Kress M.1 1Medical University of Innsbruck, Department of Physiology and Medical Physics, Division of Physiology, Innsbruck, Austria 2University Heidelberg, Department of Pharmacology, Heidelberg, Germany 3Flinders University, Flinders Medical Science and Technology, Centre for Neuroscience, Adelaide, Australia

9:20 Prostaglandin E2 directly activates cultured rat dorsal root ganglion

(DRG) neurons

Drumea A.1, *Babes A.1 1University of Bucharest, Faculty of Biology, Anatomy, Physiology and Biophysics, Bucharest, Romania



39

9:35 Busy behind the scenes - chronic pain without organic etiology leads to

higher oscillations of the human brain’s resting state

*Noll-Hussong M.1, Otti A.2,3, Guendel H.1 1Universitätsklinikum Ulm, Klinik für Psychosomatische Medizin und Psychotherapie, Ulm, Germany 2Technische Universität München, Clinic for Psychosomatic Medicine/Klinikum rechts der Isar, München, Germany 3Klinikum rechts der Isar der TU München, Abteilung für Neuroradiologie, München, Germany

9:50 Saturation properties of LTD- and LTP-like human pain plasticity

Lehmler J.-M.1, Pfau D.2, Magerl W.2, Treede R.-D.2, *Klein T.2 1Universität Heidelberg, Heidelberg, Germany 2Medizinische Fakultät Mannheim der Universität Heidelberg, Zentrum für Biomedizin und Medizintechnik Mannheim, Lehrstuhl für Neurophysiologie, Mannheim, Germany

10:05 Differential effects of lidocaine and a specific Nav1.7 blocker on the

conductive properties of C-fibers, in pig skin

*Hirth M.1, *Obreja O.1, Ringkamp M.2, Rukwied R.1, Nystroem J.-E.3, Raboisson P.3, Hägglöf B.3, *Schmelz M.1 1Anästhesiologie, Schmerzforschung, Mannheim, Germany 2Johns Hopkins School of Medicine, Neurosurgery, Baltimore, United States 3Astra-Zeneca AB, R&D Södertälje, Sweden



40

Oral Presentations – Afternoon Session

● Reactive oxygen species and Redox regulation 15:30 – 17:35, Hall 2

15:30 Welcome and Introduction 15:35 The SH2-domain containing protein tyrosine phosphatase 1 (SHP-1)

mediates antithrombotic effects in endothelial inflammation in vivo

*Koch E.1, Pircher J.1, Mannell H.1, Sohn H.-Y.1, Pohl U.2, Krötz F.1 1Med. Poliklinik der LMU, Kardiologie, München, Germany 2Walter-Brendel-Zentrum, München, Germany

15:50 NOX2 is a novel HIF1 target gene: Involvement in Urotensin-II-induced

angiogenesis

*Diebold I.1, Petry A.1, Hess J.1, Görlach A.1 1German Heart Center Munich at the TU Munich, Experimental and Molecular Pediatric Cardiology, Munich, Germany

16:05 Myeloperoxidase acts as a mediator of angiotensin II-dependent

increase in vascular tone

*Seniuk A.1, Schwoerer A.1, Klinke A.2, Baldus S.2, Ehmke H.1 1UKE, Institut für vegetative Physiologie und Pathophysiologie, Zentrum für experimentelle Medizin, Hamburg, Germany 2UKE, Universitäres Herzzentrum Hamburg, Klinik und Poliklinik für Allgemeine und Interventionelle Kardiologie, Hamburg, Germany

16:20 The H2O2-producing NADPH oxidase Nox4 protects against Angiotensin

II induced vascular hypertrophy and inflammation

*Schröder K.1, Benkhoff S.1, Mieth A.1, Zhang M.2, Shah A.M.2, Brandes R.P.1 1Goethe-Universität, Institut für kardiovaskuläre Physiologie, Frankfurt, Germany 2King's College London, The James Black Centre, London, United Kingdom



41

16:35 Angiotensin II-induced stimulation of NADPH oxidase activity depends

on Rho kinase in isolated vascular smooth muscle cells but not in renal resistance arteries

*Schlüter T.1, Reimer N.1, Steinbach A.1, Rettig R.1, Grisk O.1 1University of Greifswald, Physiology, Karlsburg, Germany

16:50 Redox insensitive ORAI3 Ca2+ channels regulate Ca2+ dependent ROS

production in human monocytes

*Saul S.1, Pasieka B.1, Conrad D.1, Kappl R.1, Hoth M.1, Niemeyer B.1, *Bogeski I.1 1University of Saarland, Biophysics, Homburg, Germany

17:05 Rac1 activation is important for cannabinoid receptor mediated

protection of coronary endothelial cells against reperfusion injury

*Micoogullari M.1, Shahzad T.1, Woste A.1, Abdallah Y.2, Piper H.M.3, Schlüter K.-D.1, Kasseckert S.A.1 1Justus-Liebig-Universität, Gießen, Germany

17:20 Characterization of primary vascular smooth muscle cells from mice

with targeted deletion of the Epidermal growth factor receptor (EGFR∆/∆

VSMC)

*Schreier B.1, Bretschneider M.1, Rabe S.1, Schneider B.1, Schwerdt G.1, Sibilia M.2, Gotthardt M.3, Grossmann C.1, Gekle M.1 1University of Halle-Wittenberg, Julius-Bernstein-Institute, Halle/Saale, Germany 2Medical University of Vienna, Institute for Cancer Research, Vienna, Austria 3Max Delbrück Center for Molecular Medicine , Neuromuscular and Cardiovascular Cell Biology, Berlin, Germany



42

● Cell biology - Exercise – muscles

15:30 – 17:35, Hall 22

15:30 Welcome and Introduction 15:35 Evidence that force-generating myosin heads in muscle can assume

both a pre- and post-power stroke conformation

Kraft T.1, Radocaj A.1, *Brenner B.1 1MHH, Molecular and Cell Physiology, Hannover, Germany

15:50 Probing skeletal muscle crossbridge configurations in isolated myofibrils

with second harmonic generation microscopy

*Schürmann S.1,2, von Wegner F.2, Fink R.H.A.2, Friedrich O.1, Vogel M.2,3 1University of Erlangen-Nuremberg, Institute of Medical Biotechnology, Erlangen, Germany 2 University of Heidelberg, Institute of Physiology and Pathophysiology, Heidelberg, Germany 3Max-Planck-Institute of Biophysics, Frankfurt, Germany

16:05 High glucose supply partially affects gene regulation involved in slow-

to-fast fiber-type transformation in skeletal muscle cells in culture

*Meissner J.1, Hanke N.1, Scheibe R.2, Manukjan G.1, Umeda P.3, Chang K.-C.4, Kubis H.-P.1,5, Gros G.1 1Hannover Medical School, Department of Physiology, Hannover, Germany 2Hannover Medical School, Department of Biochemistry, Hannover, Germany 3University of Alabama, Department of Medicine, Birmingham, United States 4University of Nottingham, School of Veterinary Medicine and Science, Nottingham, United Kingdom 5Bangor University, College of Health and Behavioural Sciences, Bangor, United Kingdom



43

16:20 Interleukin-1 interferes with sarcoplasmic Ca2+ release through the

skeletal muscle ryanodine receptor: a new mechanism explaining muscle failure in critical illness myopathy

Yi B.1, Edwards J.N.2, Weber C.1, Cully T.R.2, Lee A.2, Launikonis B.S.2, Polyak F.1, Liu I.1, v Wegner F.1, Völkers M.3, Most P.3, *Friedrich O.4,1,2 1University of Heidelberg, Institute of Physiology & Pathophysiology, Heidelberg, Germany 2University of Queensland, School of Biomedical Sciences, Brisbane, Australia, Germany 3University of Heidelberg, Department of Medicine III: Cardiology, Angiology and Pneumonology, Heidelberg, Germany 4Friedrich-Alexander-University Erlangen-Nuremberg, Institute of Medical Biotechnology, Erlangen, Germany

16:35 Signs of a decrease in sarcolemmal excitability due to muscle disuse

during bed rest *Shushakov V.1, Maassen N.1, Zange J.2 1Hannover Medical School , Institute of Sports Medicine, Hannover, Germany 2German Aerospace Center, Institute of Aerospace Medicine, Space Physiology, Cologne, Germany

16:50 Mechanical impacts induce phosphorylation of the ryanodine receptor

in skeletal muscles of rats

*Suhr F.1,2, Braun K.1, Bloch W.1,2 1German Sport University Cologne, Department of Molecular and Cellular Sport Medicine, Cologne, Germany 2German Sport University Cologne, The German Reserach Center of Elite Sport, Cologne, Germany

17:05 Phosphorylation Pattern of AKT and ERK In human Skeletal Muscle In

Response To Different Modes Of Resistance Exercise *Gehlert S.1, Gutsche K.1, Bloch W.1, Schiffer T.1 1German Sport University Cologne, Molecular and Cellular Exercise Physiology, Cologne, Germany

17:20 Epigenetics in Sports: A potential strong confounder in genetic

association studies

*Ehlert T.1, Tug S.1, Simon P.1 1Faculty of Social Science, Media and Sports, Department of Sports Medicine, Mainz, Germany



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Poster Viewing Sessions - Overview

12:00 – 14:00, Foyer P024 – P034 Myocardial Function

P035 – P044 Ischemia reperfusion injury

P057 – P067 Vascular disease: Pathophysiology, treatment & prevention

P100 – P114 Renal Physiology: Transporter – Channels

P127 – P136 Renal signaling

P163 – P173 Neuronal networks & plasticity

P174 – P185 Sensory systems

P186 – P196 Lung and Respiration

P207 – P218 Hypoxia and Red Blood Cells

P261 – P269 Transporter/Channel Trafficking

P270 – P281 Regulation of Transporter/Channel Function

P282 – P293 Channels and Transporters: Pharmacology and External Environment

P304 – P316 Cellular biology: Ca2+signaling & pathophysiology

P336 – P347 Gastrointestinal function and hormones

P348 – P351 Teaching and Research Management



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Tuesday, March 29, 2011

Symposia

● Joint symposium with The Physiological Society (UK):

“Cannabinoids in endocrinology and metabolism”

8:30 – 10:30, Hall 3 Chairs: Simon Luckman, University of Manchester, UK Beat Lutz, University of Mainz, Germany 8:30 – 9:00 Beat Lutz, University of Mainz, Germany

“CB1 receptor in the control of the noradrenergic system and adipocyte functions”

9:00 – 9:30 Marta Korbonits, Queen Mary, University of London, UK

“Hormonal regulation of AMPK by ghrelin and glucocorticoids - the role of the cannabinoids”

9:30 – 10:00 Carsten Wotjak, Max Planck Institute of Psychiatry, Munich,

Germany “Cannabinoid regulation of corticosteroids”

10:00 – 10:30 Simon Luckman, University of Manchester, UK

“Appetite regulation by hemopressins”



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● Blood doping #

8:30 – 10:30, Hall 4 Chairs: Wolfgang Jelkmann, University of Lübeck, Germany Carl Müller-Platz, Bundesinstitut für Sportwissenschaft, Bonn, Germany 8:30 – 8:50 Carsten Lundby, University of Zurich, Switzerland

“Role of red cell mass in physical performance” 8:50 – 9:10 Jon Wehrlin, Swiss Federal Institute of Sports, Magglingen,

Switzerland “Effect of live high-train low for sea level performance”

9:10 – 9:30 Giuseppe Banfi, University of Milan, Italy

“Reticulocytes in sports medicine” 9:30 – 9:50 Jakob Sehested Morkeberg, Bispebjerg Hospital Copenhagen,

Denmark “Detection of autologous blood doping”

9:50 – 10:10 Wolfgang Jelkmann, University of Lübeck, Germany

“Epo gene doping: Facts and fictions” 10:10 – 10:30 Anja Berninger, NADA, Bonn, Germany

“Legal aspects of WADA´s Athlete Biological Passport”



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● Symposium of the Special Interest Group: “Sensorimotor Systems”

Hand movement, gait and rehabilitation 8:30 – 10:30, Hall 10 Chairs: Johann P. Kuhtz-Buschbeck, Christian-Albrechts-University of Kiel, Germany Florian P. Kolb, Ludwig-Maximilians-University of Munich, Germany 8:30 – 9:00 Dieter F. Kutz, Institute of Physiology, Ludwig-Maximilians-University

of Munich, Germany “Decomposition of an isometric precision grip task in patients with degenerative cerebellar disease”

9:00 – 9:30 J. Hermsdörfer, Neuropsychology Research Group (EKN),

University of Technology of Munich, Germany “ Predictive versus reactive modes of force control following dysfunction of the cerebellum and of the basal ganglia”

9:30 – 10:00 J.P. Kuhtz-Buschbeck, Institute of Physiology, Christian-Albrechts-

University of Kiel, Germany “Arm movements during human gait: active or passive phenomenon?”

10:00 – 10:30 F.P. Kolb, Institute of Physiology, Ludwig-Maximilians-University of

Munich, Germany “An attempt for rehabilitation treatment of cerebellar patients presenting with postural ataxia; an electrophysiological and biomechanical approach”



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Plenary Lecture

11:00 – 12:00, Audimax

Prof. Heiko Luhmann University of Mainz, Germany

Role of electrical activity in developing cortical networks



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Oral Presentations

● Endothelial Biology. Vasculogenesis, Mechanotransduction 8:30 – 10:35, Hall 2

8:30 Welcome and Introduction 8:35 Biomechanical stretch triggers varicose vein remodeling in mice

through activation of activator protein 1

*Otto H.1, Feldner A.1, Hecker M.1, Korff T.1 1Institute of Physiology and Pathophysiology, Cardiovascular Physiology, Heidelberg, Germany

8:50 Deregulated angiogenesis as the cause of cerebral cavernous

malformations *Fischer A.1, Wüstehube J.1, Liebler S.1, Brütsch R.1, Bartol A.1, Augustin H.1 1Universität Heidelberg, Medizinische Fakultät Mannheim, Vaskuläre Biologie, Mannheim, Germany

9:05 A Kinase Anchoring Protein (AKAP) 12 deficiency impairs angiogenic

responses in cultured endothelial cells and in vivo

*Loot A.1, Dillinger N.1, Zippel N.1, Alber K.1, Fleming I.1 1Goethe University, Institute for Vascular Signalling, Frankfurt/Main, Germany

9:20 Role of the focal adhesion protein Zyxin in wall tension-induced

endothelial signaling

*Suresh Babu S.1, Kuhn M.2, Hecker M.1, Cattaruzza M.1 1Universität Heidelberg, Institut für Physiologie und Pathophysiologie, Heidelberg, Germany 2Universität Würzburg, Institut für Physiologie, Würzburg, Germany



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9:35 The polarity protein Scrib is essential for directed endothelial cell

migration

*Michaelis U.R.1, Chavakis E.2, Jungblut B.3, Potente M.2, Tjwa M.4, Kaluza D.2, Urbich C.2, Kruse C.1, Wandzioch K.1, Borg J.-P.5, Brandes R.P.1 1Goethe-Universität, Institut für Kardiovaskuläre Physiologie, Frankfurt am Main, Germany 2Goethe-Universität, Institut für Kardiovaskuläre Regeneration, Frankfurt am Main, Germany 3MPI für Herz- und Lungenforschung, Bad Nauheim, Germany 4Goethe-Universität, Institut für Transfusionsmedizin/Immunhämatologie, Frankfurt am Main, Germany 5Université de la Méditerranée, Centre de Recherche en Cancérologie , Marseille, Germany

9:50 Intermedin enhances macrovascular endothelial barrier function while

it disrupts coronary microvascular barrier via differential regulation of Rac1

*Aslam M.1, Guenduez D.2, Rohrbach S.1, Piper H.M.1,3, Tillmanns H.2, Noll T.1 1Justus-Liebig-Universität, Physiologisches Institut, Gießen, Germany 2Universitätsklinikum Gießen und Marburg, Zentrum f. Innere Medizin, Abt. Kardiologie/Angiologie, Gießen, Germany 3Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany

10:05 PI3K and PKC regulate cardiac and vascular differentiation of Flk-1+

cells derived from mouse embryonic stem cells upon VEGF treatment Bekhite M.1, Finkensieper A.1, Binas S.1, Figulla H.-R.1, Sauer H.2, *Wartenberg M.1 1Friedrich Schiller University, Department of Internal Medicine I, Cardiology Division, Jena, Germany 2Justus Liebig University Gießen, Department of Physiology, Gießen, Germany

10:20 Increased circumferential wall tension elicts the nuclear export of

myocardin in vascular smooth muscle cells

*Pfisterer L.1, Feldner A.1, Hecker M.1, Korff T.1 1University of Heidelberg, Institute of Physiology and Pathophysiology, Departement of Cardiovascular Research, Heidelberg, Germany



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● Methods in Physiology 8:30 – 10:35, Hall 22

8:30 Welcome and Introduction 8:35 Making waves: Optogenetic probing of slow-wave-associated calcium

network spikes in vivo

*Stroh A.1, Adelsberger H.1, Fischer S.1, Rühlmann C.1, Schierloh A.1, Deisseroth K.2, Konnerth A.1 1Technical University Munich, Institute of Neuroscience, Munich, Germany 2Stanford University, Stanford, United States

8:50 ORAI channel-dependent calcium microdomains at the immunological

synapse are important for T-cell signaling

Quintana A.1, Pasche M.2, *Junker C.1, Al-Ansary D.1, Kummerow C.1, Nunez L.3, Villalobos C.3, Becherer U.2, Rettig J.2, Niemeyer B.1, *Hoth M.1 1Saarland University, Biophysics, Homburg, Germany 2Saarland University, Physiology, Homburg, Germany 3University of Valladolid, Biology and Molecular Genetics, Valladolid, Spain

9:05 Contractile Properties of Cardiac Myofibrils Isolated from Adult Zebrafish

Ventricles

*Iorga B.1, Neacsu C.D.2, Neiss F.W.3, Wagener R.2, Paulsson M.2, Stehle R.1, Pfitzer G.1 1Klinikum der Universität zu Köln, Institut für Vegetative Physiologie, Köln, Germany 2Klinikum der Universität zu Köln, Center for Biochemistry, Köln, Germany 3Klinikum der Universität zu Köln, Department of Anatomy, Köln, Germany



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9:20 Human organotypic heart slices as an electrophysiological long-term

model of adult myocardium *Wenzel J.1, Brandenburger M.1, Bogdan R.2, Richardt D.3, Reppel M.4, Hescheler J.5, Dendorfer A.1,6, Terlau H.1,7 1University of Lübeck, Institute of Pharmacology, Lübeck, Germany 2Sanofi-Aventis, R&D TD Cardiovascular , Frankfurt / Main, Germany 3University of Lübeck, Department of cardiac and thoracic vascular surgery, Lübeck, Germany 4University of Lübeck, Medical Clinic II / Cardiology, Lübeck, Germany 5University of Cologne, Institute for Neurophysiology, Cologne, Germany 6LMU Munich, Walter-Brendel-Centre for Experimental Medicine, Munich, Germany 7University of Kiel, Institute of Physiology, Kiel, Germany

9:35 Shedding light onto the enigmatic nuclear delivery process of herpes

simplex virus genome

*Shahin V.1, Meyring A.1, Hafezi W.2, Kühn J.2, Oberleithner H.1, Liashkovich I.1 1University of Münster, Institute of Physiology II, Münster, Germany 2University of Münster, Institute of Clinical Virology, Münster, Germany

9:50 Lentiviral targeting of endothelial cells in arteries by the application of

magnetic nanoparticles and radially symmetric magnetic fields

Wenzel D.1, *Vosen S.1, Rieck S.1, Zimmermann K.2, Heidsieck A.3, Mykhaylyk O.3, Gleich B.3, Plank C.3, Pfeifer A.2, Fleischmann B.1 1University of Bonn, Institute of Physiology I, Bonn, Germany 2University of Bonn, Institute of Pharmacology and Toxicology, Bonn, Germany 3TU München, München, Germany

10:05 Tracking of mesenchymal stem cells after infusion in mice

Werner F.1, Fröhlich W.1, Pösel C.1, *Deten A.1 1FhG IZI, Ischemia Research, Leipzig, Germany

10:20 Real-time monitoring of cell elasticity reveals oscillating myosin activity

Wälte M.1, Urbanova K.1, *Schillers H.1 1University of Münster, Institute of Physiology II, Münster, Germany



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● Transporters and Channels: Cation Transport

8:30 – 10:35, Hall 23

8:30 Welcome and Introduction 8:35 A fluorescent GIRK1/GIRK4 dimer

Timpert M.1, Hertel F.1, Seebohm G.2, Pott L.1, *Kienitz M.-C.1 1Ruhr-Universität Bochum, Abteilung Zelluläre Physiologie, Bochum, Germany 2Ruhr-Universität Bochum, Lehrstuhl für Biochemie I, Bochum, Germany

8:50 BLINaC - another epithelial Na+ Channel?

*Wiemuth D.1, Gruender S.1 1University Hospital RWTH Aachen, Department of Physiology, Aachen, Germany

9:05 Action potentials in osteoblasts

Pangolos M.1, Bintig W.1, Dreyer L.1, *Ngezahayo A.1 1Leibniz University Hannover, Institute of Biophysics, Hannover, Germany

9:20 Activation of the human epithelial sodium channel by plasmin

*Haerteis S.1, Krappitz M.1, Rauh R.1, Korbmacher C.1 1Universität Erlangen-Nürnberg, Institut für Zelluläre & Molekulare Physiologie, Erlangen, Germany

9:35 How subunits cooperate in homotetrameric HCN2 pacemaker channels

*Kusch J.1, Thon S.1, Schulz E.2, Biskup C.3, Nache V.1, Zimmer T.1, Schwede F.4, Benndorf K.1 1Uniklinikum Jena, Institut für Physiologie 2, Jena, Germany 2Fachhochschule Schmalkalden, Fakultät Elektrotechnik, Schmalkalden, Germany 3Uniklinikum Jena, Arbeitsgruppe Biomolekulare Photonik, Jena, Germany 4BIOLOG Life Science Institute, Bremen, Germany



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9:50 Focal adhesion complexes feature their own pH nanoenvironment

*Ludwig F.T.1, Schwab A.1, Stock C.1 1University of Münster, Institute of Physiology II, Münster, Germany

10:05 Dexamethasone-induced activatin of epithelial Na+ channels does not

correlated with increase phosphorylation of endogenous Nedd-4/2 in H441 human airway epithelial cells

*Ismail N.1, Watt G.1, Land S.1, Wilson S.1 1University of Dundee, Centre for Cardiovascular and Lung Biology, Dundee, United Kingdom

10:20 Novel roles of NHE1 in motility of serum-starved MCF7 breast cancer

cells expressing truncated ErbB2 (∆NErbB2)

*Pedersen S.F.1, Lauritzen G.1, Gorbatenko A.1, Lund S.F.1, Dybboe R.1, Schwab A.2, Stock C.2 1University of Copenhagen, Department of Biology, Copenhagen, Denmark 2University of Münster, Institute of Physiology II, Münster, Germany

Documents

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