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History and P.E.
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This is the case o !. B, "# years old$ale, $arried, %ilipino, Ro$anCatholic, born on &ove$ber '',()*+, currently residin at -ela
%uente St, Sa$paloc , anila and/as ad$itted in our institution on0anuary ", '1("
2eneral -ata
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3o$ittin o Blood
Chie Co$plaint
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4 $onths prior to ad$ission, patientnoticed a radually enlarin $arbleli5e $ass on both lateral nec5, non6tender, $ovable associated /ith non6
productive couh 7/hitish phle$8,odynophaia and hoarseness. Patientsouht consult at San Lazaro Hospital,Chest 96ray /as done /hich revealed
pul$onary tuberculosis thus reerred
History o Present :llness
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still /ith above sin and sy$pto$s,no/ associated /ith di;culty obreathin. Patient souht consult inour institution /here a$$ation.
Trachesto$y /as also done.
' $onths PT!
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Persistence o the above sin andsy$pto$s pro$pted the patient toonce aain see5 consult in ourinstitution. Repeat
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7?8 Hypertension6 since ())@, Losartan @1
$Atab - 7?8 Pul$onary Tuberculosis6 unrecalled year,
inco$plete $edication 7 ' $onths8
768 5idney -isease
768 !sth$a
768 C3-
7?8 previous surery6 !ppendecto$y,unrecalled year
Past edical History
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7?8 Hypertension6 $aternal side
7?8 -iabetes ellitus6 $aternal side
7?8 Pul$onary Tuberculosis6 $aternalside
768 idney disease 768 Cancer
%a$ily History
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7?8 s$o5er6 41 pac5 years
768 alchoholic beverae drin5er
768 illicit dru use
Personal and Social History
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Physical E9a$ination
7?8 patent e9ternal auditory canal,both ears
7?8 patent ty$phanic $e$brane,both ears
idline nasal septu$&o nasal dischare
&o tonsillipharyneal conestion
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"D4D' c$ $ultilobulated tracheosto$y 4D'D' c$ nontender $ovable ovable $ass
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41 pac5 years s$o5in history
dynophaia
Hoarseness
2radually enlarin nec5 $ass
ale
Salient %eatures
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-ierential -ianosis
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ESOPHAGEAL CARCINOMA(lower portion)
RULE IN
?ore co$$on in $ale
?-ysphaiaAodynophaia
?Hoarseness o voice
?S$o5er
?He$ate$esis
?Easy atiability
?Fea5ness
RULE OUT
GFeiht loss
GChest pain
GForsenin indiestionor heartburn
G&o history o acid
re>u9
G&o history o alcoholinta5e
Gbese
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L!RY&2CELE
! rare, benin dilatation o the laryneal
saccule that $ay e9tend internally into theair/ay or e9ternally throuh the thyrohyoid$e$brane.
:t $ay be conenital or ac=uired and $ay
occur at any ae
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LARYNGOCELE
RULE IN
?Hoarseness?-yspnea
?-ysphaia
?ass
?Couh
RULE OUT
GCo$$on to $iddle aeGHe$ate$esis
GEasy atiability
GFea5ness
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Rare neuroendocrine neoplas$ that $ay
develop at various sites o the body, and$ay present as a painless $ass.
!ppear rossly as sharply circu$scribedpolypoid $asses, /ith
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PARAGANGLIOMA
RULE IN
?*16+1 years old
?ass
?Hoarseness
?-ysphaiaA
odynophaia?Hypertension
RULE OUT
Gore co$$on in/o$en
G!ural sins andsy$pto$s
GHe$ate$esis
GEasy atiability
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EXTRAPULMONARY TB
RULE IN
?%ilipino
?Couh
?S$o5er?Hoarseness
?Easy atiability
?Fea5ness
?-yspnea?-ysphaia
?He$ate$esis
?Cervically$phadenopathy
RULE OUT
G&iht s/eatsGFeiht loss
GChills
GLoss o appetite
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S=ua$ous Cell Carcino$a, Laryn9,
Translottic 7T*a, &'b, 18
%inal -ianosis
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ANATOMYothe
A R Y N X
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Protectie!p"incter #tt"e inlet o$
t"e #irp#!!#%e!
&oicepro'ction
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CARTILAGES O THE
LARYNX
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&OCALPROCES
SMUSCULA
R
PROCESS
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MEMBRANES *
LIGAMENTS O THELARYNX
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MUSCLES O THE
LARYNX
EXTRINSIC MUSCLES
ELE&ATIO
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MUSCLES O THE
LARYNX
EXTRINSIC MUSCLES
+EPRESSI
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7/24/2019 SCCA of the Larynx
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Superior laryngealveins drain into thesuperior thyroid veins,
/hich e$pty into theinternal uular veins.
The inferior laryngeal
veins drain into theinerior thyroid veins,/hich both e$pty intothe let brachiocephalic
vein
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LYMPHATIC +RAINAGE
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SUPERIORLARYNGEALNER&E
otor innervation o thee9trinsic $uscles7e9ternal branch8
:nternal sensory branchsupplies the $ucosa o
the upper laryn9
NER&E SUPPLY
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RECURRENT LARYNGEAL NER&E Supplies all the intrinsic $uscles
Sensory
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The PRE-EPIGLOTTICSPACE (PES) and thePARAGLOTTIC SPACE(PGS) provide path/ays
or spread o larynealtu$ors.
TUMOR SPREA+
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Case -iscussion
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ost co$$on
I)@J o Laryneal carcino$as
aleK%e$ale *6@K(
!ccounts or '@J o head and nec5 cancers
!ppro9. (A4 eventually die
ost prevalent in the "thand +thdecades
S=ua$ous Cell Carcino$ao the Laryn9
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S,o-in%
E.ce!!ie #lco"ol con!,ption E9posure to Hu$an Papillo$a 3irus (" M(#
Chronic 2astric Re>u9
ccupational e9posures
Prior history o head and nec5 irradiation
Ris5 %actors
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Environ$ental e9posure, viral inection, spontaneous
$utation.
!lteration in the P@4
Loss o cellular sinalin $echanis$s
alinant transor$ation
Carcinoenesis
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Glottic Spr#%lottic S/%lottic Tr#n!%lottic
:nvolves truevocal cords Con
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2lotticK $oority o laryneal cancers 7@1J6
"1J8 SupratlotticK 41J6*1J
SublotticK N@J
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Spr#%lottic Glottic S/%lottic
6 ore !ressive6 -irect e9tensioninto pre6epilottic
space Ly$ph node$etastasis -irect e9tensioninto lateralhypopharny9,
lossoepilottic old,and tonue base
6 ro/ slo/er and tendto $etastasize lateo/in to a paucity o
ly$phatic drainae6 $etastasize ater theyhave invaded adacentstructures /ith better-rainae6 E9tend superiorly into
ventricular /alls orineriorly into sublotticspace6 Can cause vocal cord
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Spr#%lottic Glottic S/%lottic
Chronic sorethroat-ysphonia-ysphaia&ec5 $ass
secondary toreional$etastasis
Hoarseness!ir/ayobstruction
late sy$pto$
3ocal cordparalysis!ir/ayco$pro$ise
aniestations
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!ssess$ent o vocal cord $obility as /ell as
local tu$or e9tension Larynoscopy
used to assess the e9tent o local spread.
Radioraphic i$ain by CT andAor R:
Cartilae erosion or invasion and e9tensioninto the preepilottic or paralottic spaces.
-ianosis and Stain
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TD 6 ini$u$ re=uire$ents to assess
pri$ary tu$or cannot be $etT1 6 &o evidence o pri$ary tu$or
Tis 6 Carcino$a in situ
T& Stain
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T( li$ited to one subsite o supralottis /ith nor$al vocal cord$obility
T' involves $ucosa o $ore than one adacent subsite osupralottis or lottis, or reion outside the supralottis/ithout
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T( Tu$or li$ited to the vocal cord 7s8 7$ay involve anterioror posterior co$$issure8 /ith nor$al $obilty
T(a
Tu$or li$ited to one vocal cord
T(b
Tu$or involves both vocal cords
T' Tu$or e9tends to supralottis andAor sublottis, andAor
/ithi$paired vocal cord $obility
T4 Tu$or li$ited to the laryn9 /ith vocal cord
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T0 Tu$or li$ited to the sublottis
T' Tu$or e9tends to vocal cord 7s8 /ith nor$al ori$paired$obility
T4 Tu$or li$ited the laryn9 /ith vocal cord
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&1 &o cervical ly$ph nodes positive
&( Sinle ipsilateral ly$ph node 4c$
&'a Sinle ipsilateral node I 4c$ and "c$
&'b &'b ultiple ipsilateral ly$ph nodes, each"c$
&'c &'c Bilateral or contralateral ly$ph nodes,each "c$
&4 &4 Sinle or $ultiple ly$ph nodes I "c$
Stain 6 &odes
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1 &o distant $etastases
( -istant $etastasespresent
Stain 6 etastasis
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Stae 2roupin
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C' Laser
ResectionK severedysplasia andcarcino$a in situ
Radiotherapy
Che$otherapy PartialATotal
Larynecto$yKadvanced tu$ors
Treat$ent
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Radiotherapy or surery alone
#@6)@J cure rate
T(6T'
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Total Larynecto$y
S$all T4 and lesser sized tu$ors can betreated /ith partial larynecto$y
T46T* Lesions
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:ndicationsK
T* pri$ary BoneAcartilae invasion
3ascular invasion
ultiple positive nodes
&odal e9tracapsular e9tension
Sublottic e9tension o pri$ary tu$or
Post6op Radiation
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!dvanced stae cancers
Cisplatinu$ and @6>ourouracil
Che$otherapy
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:nection
3oice alterations Loss o taste and s$ell
Tracheosto$y dependence
Co$plications
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1 2e#r
!ri#lStae ( I)@J
Stae ' #@6)1J
Stae 4 +16#1MStae * @16"1J
Pronosis
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Patients considered cured ater bein
disease ree or
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Than5 youQ