SCHEME & SYLLABUSSCHEME & SYLLABUS B.TECH (BIOMEDICAL ENGINEERING) w.e.f. 2016-17 CREDIT BASED SYSTEM (70:30) Guru Jambheshwar University of Science and Technology, Revised Scheme

SCHEME & SYLLABUS

B.TECH (BIOMEDICAL ENGINEERING)

w.e.f. 2016-17

CREDIT BASED SYSTEM (70:30)

Guru Jambheshwar University of Science and Technology,

Hisar (Haryana) – 125001 (Established by State Legislature Act 17 of 1995)

'A' GRADE NAAC ACCREDITED UNIVERSITY

B.Tech.BME – CREDITS Semester Credits 1. I 25 2. II 25 3. III 25 4. IV 25 5. V 25 6. VI 25 7. VII 25 8. VIII 25

Total Credits 200

Revised Scheme B.Tech. (BME) SEMESTER-3 Subject Area

Course Code Course Name L T P Credits

ES-6 EVS-201-L Environmental Studies 3 - - 3 BS-6 MAT-202-L Numerical Methods 3 1 - 3.5 ES-7 BME-201-L Biomaterials 3 1 - 3.5 PC-I BME-203-L Anatomy & Physiology 3 1 - 3.5 PC-2 BME-205-L Analog Electronics-I 3 1 - 3.5 PC-3 BME-207-L Digital Electronics 3 1 - 3.5 MAT-202-P Numerical Methods Lab - - 2 1 BME-203-P Anatomy & Physiology Lab - - 2 1 BME-205-P Analog Electronics-I Lab - - 3 1.5 BME-207-P Digital Electronics Lab - - 2 1 MC-3 (Non-Credit)

BME-211-P Skills & Innovation Lab (2 unit) - - 3 --

Total 25 SEMESTER-4 Subject Area


HS-4 HUM-201-L Fundamentals of Management 3 - - 3 ES-8 BME-202-L Biochemistry 3 1 - 3.5 PC-5 BME-204-L Biomedical Instrumentation-I 3 1 - 3.5 PC-6 BME-206-L Analog Electronics-II 3 1 - 3.5 PC-7 BME-208-L Signals & Systems 3 1 - 3.5 PC-8 BME-210-L Bioelectrodes& Transducers 3 1 - 3.5 BME-202-P Biochemistry Lab - - 2 1 BME-204-P Biomedical Instrumentation-I Lab - - 2 1 BME-206-P Analog Electronics-II Lab - - 3 1.5 BME-210-P Bioelectrodes& Transducers Lab - - 2 1 MC-4 (Non Credit)

PSY-201-L Personality Development (2 unit) 2 1 - --

Total 25 SEMESTER-5 Subject Area


OE-I OE-I OE - I 4 - - 4 BS-7 BME-301-L Clinical Science 3 1 - 3.5 PC-9 BME-303-L Biomedical Instrumentation-II 3 1 - 3.5 PC-10 BME-305-L Communication Engineering 3 1 - 3.5 PC-11 BME-307-L Physiological Control Systems 3 1 - 3.5 PC-12 BME-309-L Medical Imaging Technology 3 1 - 3.5 BME-301-P Clinical Science Lab - - 2 1 BME-303-P Biomedical Instrumentation-II Lab - - 3 1.5 BME-305-P Communication Engineering Lab - - 2 1 Total 25

SEMESTER-6 Subject Area


OE-II OE-II OE - II 4 - - 4 PE-I BME--- Elective - I 3 1 - 3.5 PC-13 BME-302-L Medical Devices 3 1 - 3.5 PC-14 BME-304-L Microprocessors & Microcontrollers 3 1 - 3.5 PC-15 BME-306-L Rehabilitation Engineering 3 1 - 3.5 PC-16 BME-308-L Laser & Fiber Optics in Medicine 3 1 - 3.5 BME-302-P Medical Devices Lab - - 2 1 BME-304-P Microprocessors & Microcontrollers Lab - - 3 1.5 BME-308-P Laser & Fiber Optics in Medicine Lab - - 2 1 Total 25 Industrial / Hospital Training of 4 - 6 weeks SEMESTER-7 Subject Area


OE-3 OE-III OE - III 4 - - 4 PE-2 BME--- Elective - II 3 1 - 3.5 PC-17 BME-401-L Biomedical Signal Processing 3 1 - 3.5 PC-18 BME-403-L Medical Image Processing 3 1 - 3.5 PC-19 BME-405-L Biomechanics 3 1 - 3.5 PC-20 BME-407-L Biosignal Conditioning 3 1 - 3.5 BME-401-P Biomedical Signal & Image Processing Lab - - 2 1 BME-407-P Biomedical Signal Conditioning Lab - - 2 1 PW BME-409-P Minor Project - - 2 1 PW BME-411-P Training Seminar - - 1 0.5 Total 25 SEMESTER-8 Subject Area


PE-3 BME--- Elective - III 4 - - 4 PE-4 BME--- Elective - IV 4 - - 4 PE-5 BME--- Elective - V 4 - - 4 PE-6 BME--- Elective - VI 4 - - 4 PW BME-402-P Major Project - - 18 9 OR Industrial Training*

BME-404-P Full Semester Industrial Training* 25

Total 25

*

Full Semester Industrial Training The student will be required to submit to the department, the offer letter for the full semester industrial training, at-least 15 days before the commencement of 8th semester. The options shall be according to the following conditions: A student may opt for one semester industrial training in lieu of attending the courses of 8th semester. The credit/marks for industrial training will be equal to the total credits/marks of courses offered in 8th semester study. If the student gets selected for the job through campus placements and the employer is willing to take the student for the training for a period of full semester.

Department will offer following Open Electives for students of other

departments: o OE – I – Medical Imaging Technology(5th Semester) o OE – II – Medical Devices(6th Semester) o OE – III – Medical Image Processing(7th Semester)

List of Professional Electives:

o Elective -I (Semester - VI) BME-310-L Biomedical Ethics & Device Regulations BME-312-L Artificial Organs

o Elective -II (Semester - VII) BME-413-L Radiation Protection in Medical Technology BME-415-L Telemedicine

o Elective -III (Semester - VIII) BME-406-L Biomedical Waste management BME-408-L Biosensors

o Elective -IV (Semester - VIII) BME-410-L Advanced Medical Display Technologies BME-412-L Medical Informatics

o Elective -V (Semester - VIII) BME-414-L Medical Optics BME-416-L Robotics & Automation in Medical Instrumentation

o Elective -VI (Semester - VIII) BME-418-L Wireless Communication Assisted Medical Systems BME-420-L Introduction to Bio-Metrics

Subject Area Abbreviation Humanities & Social Science HS Basic Science BS Engineering Sciences ES Professional Subjects Core PC Professional Subjects Electives PE Open Subjects Electives OE Project Work, Seminar and/or Internship in Industry Or Elsewhere PW Mandatory Courses (Qualifying)- Non Credit MC

SEMESTER-5

BME 301 – L CLINICAL SCIENCE

Course Code: BME 301-L Course Credits: 3.5 Mode: Lecture(L) and Tutorial(T) Type: Compulsory Contact Hours: 3h (L) + 01h(T) per week Examination Duration: 03 hours.

Course Assessment Methods (Internal: 30; External: 70)Two minor test each of 20 marks, class performance measured through percentage of lecture attended (4 marks), assignments, quiz etc. (6 marks) and end semester examination of 70 marks. For the end semester examination, nine questions are to be set by the examiner. Question number one will be compulsory and based on the entire syllabus, it will contain seven short answer type question. Rest of the eight questions is to be given by setting two questions from each of the four units of the syllabus. A candidate is required to attempt any other four questions selecting one from each of the four units. All questions carry equal marks.

Prerequisite:Basic knowledge and understanding of human anatomy & physiology. Objectives:

• To impart in-depth knowledge and understanding of human physiology and common diseases. • To understand the clinical investigations & equipment for diagnosis and therapeutics.

Course Outcomes: CO-1 Understanding the normal and abnormal functioning of important systems of human body. CO-2 Understanding the indications of common diseases and clinical investigations required. CO-3 Knowledge of related equipments for diagnosis and therapeutics. CO-4 Understanding the concept of assistive devices, prostheses and orthoses.

Unit-I

Basis of common diseases and clinical investigation: Diabetes, Hypertension, RheumaticHeart disease, Ischemic Heart Disease, Asthma. Functions of clinical laboratory and tests performed. Automatic Clinical Analyzer- principle and functions.

Unit-II

Cardiology: Cardiac cycle, Heart valves, Normal and abnormal ECG, Interpretation of ECG. Cardiovascular measurements, Heart rate monitor, Heart lung machine, Cardiac pacing - diagnostic indications, temporary pacing and permanent pacing, Fibrillation- atrial and ventricular, Cardiac assist devices, Echo cardiography.

Unit-III

Respiratory System:Spirometry-measurement of lung volumes & capacity, FEV,Plethysmography- principle and applications, Blood gas analyzer, Oximeter. Nephrology:Principle& types of dialysis, Dialyzer - types and performance parameters, Membranesfor hemodialysis, Hemodialysis machine.

Unit-IV

Fracture Healing: Fractures – types, treatment & normal healing, reduction, immobilization, Dislocations, Replacements.

Support &Prosthesis:Physiotherapy-uses and principle, Short Wave diathermy, Prostheses &Orthoses. Text Books:

1. Anne Waugh&Allison Grant, “Ross and Wilson Anatomy and Physiology in Health and Illness”, Churchill Living Stone Elsevier, 12th Edition, 2014.

2. R S Khandpur, “Handbook of Biomedical Instrumentation”, Tata McGraw Hill,2nd Edition. 3. J. Maheshwari, “Essential Orthopaedics”, Mehta Publishers, 3rd Edition.

Reference Books: 1. Arthur C Guyton, John E Hall, “Textbook of Medical Physiology”, Saunders Elsevier,

Pennsylvania, 13th Edition, 2015. 2. Joseph J. Carr& John M. Brown, “Introduction to Biomedical Equipment Technology”,

Reason Education, 4thEdition .

http://www.amazon.in/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=Allison+Grant+BSc++PhD++RGN&search-alias=stripbooks

BME -303-L Biomedical instrumentation-II

Course Code:BME-303-L Course Credits: 3.5 Type: Compulsory ContactHours:4hours/week Mode: Lectures (3), Tutorials (1)

Course Assessment Methods (Internal: 30; External: 70) Two minor examinations each of 20 marks, Class Performance measured through percentage of lectures attended (4 marks), Assignment and quiz (6 marks), and end semester examination of 70 marks. For the end semester examination, nine questions are to be set by the examiner. Question number one will be compulsory and based on the entire syllabus. It will contain seven short answers type questions. Rests of the eight questions are to be given by setting two questions from each of the four units of syllabus and candidate is required to attempt any other four questions selecting one from each of the remaining four units. All questions carry equal marks.

Prerequisite: Basic knowledge of fundamentals of physiological measurements and

instrumentation system

Objectives: • To understand various medical instrumentation/monitoring systems. • Learning of prevention against the hazards of biomedical equipments and instrumentation

systems and to stimulate the learners for futuristic research and development in biomedical instrumentation.

Expected outcomes: • Be able to describe the components and working of medical instrumentation/monitoring

systems. • Be able to describe the components and working of biotelemetry • Learning of medical device safety standards. • Stimulation among the learners for futuristic research and development in biomedical

instrumentation/monitoring systems and their application in telemedicine.

Unit-I Patient Monitoring Systems: System Concepts, Cardiac Monitor, Bedside Patient Monitoring Systems, Central Monitors; Measurement of Heart Rate, Pulse Rate, Blood Pressure, Temperature, Respiration Rate; Arrhythmia Monitor and Ambulatory Monitoring Instruments; Foetal Monitoring Instruments: Cardiotocograph, Monitoring Foetal Heart Rate and Labour Activity.

Unit-II Oximeters: Introduction, types- Ear Oximeter, Pulse Oximeter, Skin Reflectance Oximeters, Intravascular Oximeter; Pulmonary Function Analysers: Pulmonary Function Measurements, Spirometry, Pneumotachmeters,Measurement of Volume, Pulmonary Function Analysers, Respiratory Gas Analysers; Audiometers and Hearing Aids: Measurement of Sound, Basic Audiometer, Pure-Tone Audiometer, Speech Audiometer, Audiometer System, Evoked Response Audiometry System, Hearing Aids.

Unit-III Biomedical Telemetry and Telemedicine: Introduction, Single Channel Telemetry Systems, Multi-Channel Wireless Telemetry Systems, Multi-Patient Telemetry, Implantable Telemetry Systems, Biotelemetry Application on Wimax Networks, Transmission of Physiological Signals over Telephone, Essential Parameters and Delivery Modes for Telemedicine, Clinical Data Interchange/Exchange Standards, Transmission of Still Images, Video Images and Digital Audio, Cyber Medicine, Applications of Telemedicine

Unit-IV Medical Safety and Standards: Electrical Safety of Medical Equipment and Patient, classification of medical devices and their safety standards,Physiological effects of electrical current/shock, leakage current, micro and macro shock, different types of safety circuits for medical equipments, measures to reduce shock hazards, isolated power system, advantages of isolated power system in healthcare institution, Safety Codes For Electromedical Equipment, Electrical Safety Analyser, Testing of Biomedical Equipment, Radiation Safety Instrumentation, Effects of radiation Exposure, Radiation Monitoring Instruments.

Books Recommended: 1. R.S. Khandpur, “Handbook of Biomedical Instrumentation”, McGraw Hill Education

(India) Pvt. Ltd., 2015. 2. John G. Webster, “Medical Instrumentation Application & Design”, Wiley, 2011. 3. Shakti Chatterjee&Aubert Miller, “Biomedical Instrumentation Systems”,

DelmerCengage Learning, 1St Ed, 2010. 4. Joseph J. Carr and John M. Brown, Introduction to Biomedical Equipment Technology”,

Pearson Education, Inc., 2007.

BME-305-L COMMUNICATION ENGINEERING

Course Code: BME-305-L

Course Credits: 3.5 Mode: Lecture (L) and Tutorial (T) Type: Compulsory Contact Hours: 3 hours (L) + 01 hour (T) per week. Examination Duration: 03 hours.

Course Assessment Methods (Internal: 30; External: 70) Two minor test each of 20 marks, class performance measured through percentage of lecture attended (4 marks), assignments, quiz etc. (6 marks) and end semester examination of 70 marks. \ For the end semester examination, nine questions are to be set by the examiner. Question number one will be compulsory and based on the entire syllabus; it will contain seven short answer type questions. Rest of the eight questions is to be given by setting two questions from each of the four units of the syllabus. A candidate is required to attempt any other four questions selecting one from each of the four units. All questions carry equal marks.

Prerequisite: Basic knowledge of Analog & Digital Electronics, Physics, Signals & Systems and

engineering mathematics. Objectives:

• To understand various aspects of analog communication. • Identify and develop an understanding for various digital communication techniques.

Course outcomes: CO-1 Acquire a basic knowledge in information & its transmission. CO-2 To develop an ability to understand the basics of amplitude modulation & its features. CO-3 To develop an understanding & Observation about the frequency modulation & its features. CO-4 Understanding of various digital communication techniques. Unit-I BASIC FREQUENCY THEORY: Introduction to information, messages & signals, Classification of signals. entropy of discrete systems rate of transmission redundancy. Efficiency and channel capacity. Unit-II AMPLITUDE MODULATION: Frequency Spectrum Power Relations, Basic requirements and description of variousmodulators, comparison, DSB, DSB-SC, SSB, VSB, Spectrum Modulators and Detectors. Unit-III FREQUENCY MODULATION: F.M. frequency spectrum of FM based modulation, Effect of Noise, generation of FM anddemodulation. Unit-IV PULSE MODULATION: Sampling theorem, low pas and band pass signals, Elements of PAM, PWM, PPM, PCM and Delta Modulation, FDM, TDM. A.M AND F.M. RADIO TRANSMITTERS AND RECEIVERS: Characteristics, block diagram, super- heterodyne receiver. TEXT BOOK:

1. Kennedy's Electronic Communication Systems, George Kennedy, ‎ Brendan Davis, ‎ SrmPrasanna, 2011

2. Principles of Communication System:II; Taub& Schilling, 2007 REFERENCE BOOKS:

1. Modern Digital & Analog Communication System: B.P.Lathi, 2011 2. Communication System: SymonHaykin, 2013

BME-307-L PHYSIOLOGICAL CONTROL SYSTEMS

Course Code: BME-307-L Course Credits: 3.5 Mode: Lecture (L) and Tutorial (T) Type: Compulsory Contact Hours: 3 hours (L) + 01 hour (T) per week. Examination Duration: 03 hours.

Course Assessment Methods (Internal: 30; External: 70) Two minor test each of 20marks, class performance measured through percentage of lecture attended (4 marks), assignments, quiz etc. (6 marks) and end semester examination of 70 marks. \ For the end semester examination, nine questions are to be set by the examiner. Question number one will be compulsory and based on the entire syllabus; it will contain seven short answer type questions. Rest of the eight questions is to be given by setting two questions from each of the four units of the syllabus. A candidate is required to attempt any other four questions selecting one from each of the four units. All questions carry equal marks.

Prerequisite: Basic knowledge of Signal & Systems, Physics, Electronics, and engineering mathematics. Objectives:

• To introduce system models & classifications • To introduce the mathematical modelling of systems with time domain analysis. • To understand stability &its judging criteria. • To introduce the concept frequency domain & its analysis with system mechanism.

Course outcomes: CO-1 Acquire an understanding about the models & their classifications. CO-2 Able to design mathematical models of different systems. CO-3 Gain knowledge on stability & its judging criteria. CO-4 Understand the various ways to analyze these systems in frequency domain.

Unit-I SYSTEMS BASICS: System model, types of models, examples of systems and their inputs and outputs, controller, servomechanism, regulating system, linear time-invariant (LTI) system, time-varying system, causal system, open loop control system, closed loop control system, continuous time and Discrete time systems. Effects of feedback on sensitivity (to parameter variations), stability, external disturbance (noise), overall gain. non-linear control systems. Unit-II MATHEMATICAL MODELLING: Block diagram algebra, signal flow graphs: Mason’s gain formula & its application, characteristic equation. TIME DOMAIN ANALYSIS:Time response of first order systems to various standard inputs, time response of 2nd order system to step input, relationship between location of roots of characteristics equation. Steady state error and error constants. Unit-III STABILITY: Concept of stability, pole zero configuration and stability, necessary and sufficient conditions for stability, Hurwitz stability criterion, Routh stability criterion and relative stability. Root locus concept, development of root loci for various systems, stability considerations. Unit-IV FREQUENCY DOMAIN ANALYSIS: Relationship between frequency response and time-response for 2nd order system, polar, Nyquist, Bode plots, stability, Gain-marginand Phase Margin, relative stability, frequency response specifications.

SYSTEM MECHANISM: Pupil control system, skeletal muscle servomechanism, Respiratory models and controls, cardiovascular control systems, visual fixation system,oculomotor system. Sugar level control mechanism endocrine control mechanism. TEXT BOOK:

1. Control System Engineering: I.J.Nagrath&M.Gopal; New Age, 2017 2. Automatic Control Systems: B.C.Kuo, PHI. 9 edition, 2014

REFERENCE BOOKS: 1. Ross and Vilson-Anatomy and physiology in Health and illness. 12 edition, 2014 2. Modern Control Engg: K.Ogata; PHI. 2010 3. Control Systems - Principles & Design: MadanGopal; Tata McGraw Hill. 4 edition, 2012 4. Modern Control Engineering.R.C.Dorl& Bishop; Addison-Wesley, 12 edition, 2012

BME 309 – L MEDICAL IMAGING TECHNOLOGY



Prerequisite:Basic knowledge and understanding of human anatomy & imaging principles. Objectives:

• To impart in-depth knowledge and understanding of imaging technology for disease diagnosis. • To understand the principle & working of various imaging equipment for diagnosis and

therapeutics. Course Outcomes: CO-1 Understanding the principle & working of various imaging equipment for diagnosis. CO-2 Understanding the interaction of ionising radiation with tissue and principles of radiation protection. CO-3 Knowledge of clinical applications of various medical imaging equipment. CO-4 Understanding the concept of doppler effect for medical applications.

Unit-I

Imaging with Ionizing Radiation: Interactions of Radiation with tissue, Production of X Rays,X-ray equipment, Radiation protection, Scattered radiation, Clinical applications,X-Ray Image intensifier, Angiography. Computerized Tomography: Construction, function and operation of a CT Scanner, Clinical applications. Single Photon Emission, Computed Tomography (SPECT), Positron Emission Tomography (PET).

Unit-II

Magnetic Resonance Imaging:Physics of MRI/NMR, T1 and T2 relaxation time, MRI pulse sequences, Instrumentation of MRI, MRI slice selection and encoding, Functional MRI (f-MRI), MRI clinical applications, Fluid flow imaging, Chemical-shift and Spectroscopic imaging.

Unit-III

Ultrasound Imaging: Propagation of ultrasound waves in fluids, solids and tissue. Doppler Effect, Ultrasound transducers and instrumentation, Modes of ultrasonic imaging, Clinical applications.

Unit-IV

Thermal imaging& other techniques: Medical thermography - equipment & applications. Fluoroscopy, Endoscopy-surgery navigation, Role of nanoparticles in medical imaging. Text Books:

1. Steve Webb, “The Physics of Medical Imaging”, Taylor & Francis, New York, 2010. 2. William R Hendee, Russell Ritenour E, “Medical Imaging Physics” John Wiley, New

York, 2002. 3. Paul Suetens, "Fundamentals of Medical Imaging", Cambridge University Press, 2002.

Reference Books:

1. Joie P Jones, Manbir Singh and Cho Z.H., “Foundations of Medical Imaging”, John Wiley, 1993.

2. Mark A Brown, Richard C Semelka, “MRI: Basic Principles and Applications”, John Wiley, Third Edition, 2003

3. AtamDhawan, “Medical Image Analysis”, John Wiley, 2003

BME 301 – P CLINICAL SCIENCE LAB Course Code: BME 301-P Course Credits: 1 Type: Compulsory Contact Hours: 2hrs/week Mode: Practical session

Course Assessment Methods (Internal: 30; External: 70)Internal continuous assessment of 30 marks on the basis of class performance and attendance in practical classes. For the end semester practical examination the assessment will be done out of 70 marks by the external and internal examiners.

Prerequisite:Basic knowledge and understanding of human anatomy & physiology. Objectives:

• To impart in-depth knowledge and understanding of human physiology and common diseases. • To understand the clinical investigations & equipment for diagnosis and therapeutics.

Course outcomes: CO-1 Recording of physiological signals and measurements. CO-2 Understanding the indications of common diseases and clinical investigations required. CO-3 Knowledge of equipment for diagnosis and therapeutics. CO-4 Understanding the concept of assistive devices, prostheses and orthoses.

LIST OF EXPERIMENTS

1. Recording of vital bio-signals (ECG, BP, Respiration rate, Temperature, Oxygen saturation) using a patient monitoring system

2. Understanding the operation of autoanalyzer 3. Demonstration of Echo-cardiography to understand the heart sounds. 4. Study the operation of Pacemaker 5. Simulation and demonstration of Defibrillator 6. Demonstration of Spirometer for measurement of lung volumes & capacities 7. Study of Heart lung machine 8. Study of Dialyzers and Hemodialysis machine 9. Operationand demonstration of Physiotherapy Equipment - Diathermy unit 10. Study of Orthopedic instruments & implants

Note: At least seven experiments are to be performed by students from the above list. The course coordinator may also design and set experiments in addition to the above list/topics as per the scope and requirement of the syllabus.

BME -303-P Biomedical instrumentation-II Lab

Course Code: BME -303-P Course Credits: 1 Type: Compulsory Contact Hours: 2 hours/week Mode: Practical session of 2hours

Course Assessment Methods (Internal: 30; External: 70) Internal continuous assessment of 30 marks on the basis of class performance and attendance in practical classes. For the end semester practical examination, the assessment will be done out of 70 marks by the external and internal examiners.

Objectives:

• To understand various building blocks of medical instrumentation/monitoring systems and biotelemetry.

• To understand basic prevention methods against the electrical shock hazards while using medical equipments.

Expected outcomes:

• Be able to describe the components and working of medical instrumentation/monitoring systems.

• Be able to describe the components and working of biotelemetry • Learning of medical device safety standards. • Stimulation among the learners for futuristic research and development in biomedical

instrumentation/monitoring systems and their application in telemedicine.

List of some topics for experiments

1. Measurement of physiological parameters like- Heart Rate, Pulse Rate, Blood Pressure, Temperature, Respiration Rate etc.

2. Various building blocks patient monitoring system. 3. Realization of basic principles of operation of various types of Oximeteres. 4. Spiorometry and spirometers. 5. Various building blocks of Biotelemetry system. 6. Various analog and digital modulation techniques used in Biotelemetry. 7. Various electrical shock hazards prevention measures and methods.

Note: At least seven experiments are to be performed by the students from the above topics. The

course coordinator may also design and set experiments in addition to above topics as per the scope and requirement of the syllabus.

BME-305-P COMMUNICATION ENGINEERING LAB

Course Code: BME-305-P Course Credits: 1

Type: Compulsory Contact Hours: 2 hours/week Mode: Practical session




• To understand the linear and non-linear applications of operational amplifier. • To understand various ways of adjusting their parameters.

Course outcomes: CO-1 Able to perform basic design procedure used in communication system. CO-2 Understand the importance and functionality of these circuits. CO-3 Understand the designing and working of transmitters & receivers. CO-4 Able to understand difference in different modulations techniques.

LIST OF EXPERIMENTS: 01. Study of AM Modulation and Demodulation 02. Study of FM Modulation and Demodulation (Reactance modulator, Foster Seely and Ratio Detector Modulator) 03. Study of PAM, PPM, & PWM circuits 04. Study of PCM Transmitters/Receivers 05. Study of DM Transmitters/Receivers 06. Study of TDM Transmitters/Receivers 07. Study of AM Receiver Measurements (Sensitivity, Selectivity, Fidelity) 08. Study of ASK Modulation and Demodulation 09. Study of FSK Modulation and Demodulation 10. Study of ASK Modulation and Demodulation. Note: At-least seven experiments are to be performed by students from the above list. The course coordinator may also design and set experiments in addition to the above list/topic as per the scope and requirement of syllabus.

BOOKS SUGGESTED: 1. Kennedy's Electronic Communication Systems, George Kennedy, ‎ Brendan Davis, ‎ SrmPrasanna, 2011 2. Principles of Communication System:II; Taub& Schilling, 2007

SEMESTER-6

Elective-I

BME-310-LBIO-MEDICAL ETHICS AND DEVICE REGULATIONS

Course Code: BME-310-L Course Credits: 3.5 Type: Compulsory Contact Hours: 4 hours/week Mode: Lectures (3), Tutorials (1)


Objectives:

• To understand the medical laws, ethics and medical device regulations and standards. • To understand the importance of mental health and maintaining professional standards.

Expected Outcomes:

• To understand the role of moral and ethics of healthcare in society. • To get acquainted with medical laws and ethics for professionals in healthcare. • To get acquainted with medical device regulations and standards. • Able to present the code of ethics for the profession in biomedical engineering.

Unit-I Sources of Medical Law and Ethics: Nature and sources of medical ethics, Sources of medical law. Consent, Confidentiality and Clinical Negligence: Consent to Treatment, Confidentiality and Clinical Negligence. Unit-II Mental Health: Types of mental health, Adults with Incapacity. Issues: The law in relation to abortion, The ethics of abortion, Reproductive Technology and surrogacy, The law in relation to end of life issues, The ethics of end of life issues and Research. Unit-III Maintaining professional standards: Maintaining standards and regulation, Presenting evidence and reports, The Coroner's court,The General Medical Council, Doctors rights: Employment and other rights of doctors. Unit-IV Device regulation: Classifications and requirements of Medical devices, Harmonized standards,CE approval , Quality Assuranceand Quality Definition of quality, quality management, principles of TQM, measures for Quality Control. Safety & Testing ofMedical devices -patenting.

REFERENCE BOOKS 1. Ronald Munson's Intervention and Reflection: Basic Issues in Medical Ethics 5th Ed. 2. Ethics of Health Care: An Introductory Textbook by Benedict M. Ashley, Kevin D. O'Rourke, Georgetown University Press;3rd edition, 2002. 3. Introduction to Bio-Medical Engineering by John D. Enderle, Susan M. Blanchard & Elsevier (Academic) press, 2ndedition, 2005

Elective - I BME -312-L ARTIFITIAL ORGANS

Course Code: BME -312-L Course Credits: 3.5 Mode: Lecture(L) and Tutorial(T) Type: Compulsory Contact Hours: 3h (L) + 01h(T) per week Examination Duration: 03 hours.


Prerequisite:Knowledge and understanding of human anatomy & physiology. Objectives:

• To impart in-depth knowledge and understanding of organ replacement and substitutive medicine. • To understand the engineering design considerations of artificial organs for function replacement.

Course Outcomes: CO-1 Understanding the concept of organ replacement and substitutive medicine. CO-2 Understanding the design considerations of artificial organs for function replacement. CO-3 Knowledge ofengineering concerns and hemodynamic assessment of artificial organs. CO-4 Understanding the concept of assistive devices and support systems for vital organ replacement.

Unit-I

Introduction:Substitutive medicine, outlook for organ replacement, design consideration, evaluation process. Artificial Kidney: Renal failure, Renal transplantation, Artificial kidney, Dialyzers, Membranes for hemodialysis, Hemodialysis machine, Peritoneal dialysis equipment.

Unit-II

Artificial Heart & Circulatory Assist Devices: Engineering design of artificial heart and circulatory assist devices, Cardiac Valve Prostheses: mechanical valves, tissue valves, engineering concerns and hemodynamic assessment of prosthetic heart valves.

Unit-III

ArtificialLungs: Cardiopulmonary bypass (heart-lung machine), Artificial lung versus natural lung, Tracheal replacement devices, Laryngeal replacement devices, Artificial esophagus. Liver Functions: Hepatic failure, Liver support systems, General replacement of liver functions.

Unit-IV

Artificial Blood, Pancreas, Skin: Artificial oxygen carriers, Fluorocarbons, Hemoglobin for oxygen carrying plasma expanders, Hemoglobin based artificial blood. Structure and functions of pancreas, diabetes, insulin, insulin therapy, insulin administration systems. Vital functions of skin, current treatment of massive skin loss, design principles for permanent skin replacement. Text Books:

1. Joseph D. Bronzino, “Biomedical Engineering Handbook, Volume II”, CRC Press, 2000. 2. L. Hench & J. Jones, “Biomaterials, Artificial Organs & Tissue Engineering”, Woodhead

Publishing Limited, 2005.

Reference Books: 1. Park Joon Bu, “Biomaterials Science and Engineering”, Plenum Press, 1990.

BME -302-LMedical Devices

Course Code: BME -302-L Course Credits: 3.5 Type: Compulsory Contact Hours: 4 hours/week Mode: Lectures (3), Tutorials (1)


Prerequisite: Basic knowledge of fundamentals of physiological measurements and instrumentation system Objectives:

• To understand construction, operation and applications of various medical devices. • To stimulate the learners for futuristic research and development of medical devices

Expected outcomes:

• Be able to describe the components and working of various medical devices. • Be able to describe the applications of various medical devices. • Be able to maintain and troubleshoot thevariousmedical devices. • Stimulation among the learners for futuristic research, design and development of

medical devices

Unit-I Dialysis: Renal Function, Haemodialysis, Peritoneal Dialysis, Dialyzers, Membranes for Haemodialysis, Haemodialysis Machine Heart Lung Machine: Need and Block Diagram, Oxygenators, Blood Pumps, Traps and filters, Heat Exchangers. Anesthesia Machine: Need for Anaesthesia, construction and working of Anesthesia Machine Capnography Unit-II

Ventilators: Mechanics of Respiration, Artificial Ventilation, Types of Ventilators, Ventilator Terms, Classification of Ventilators, Pressure-Volume-Flow Diagrams, Modern Ventilators, High Frequency Ventilators, Humidifiers, Nebulizers and Aspirators Lithotriptors: The Stone Disease Problem, The Shock Wave, The First Lithotriptor Machine Modern Lithotriptor Systems, Laser Lithotripsy Unit-III Coronary Care Devices: Artificial Heart Valves, Requirements for the Design of Artificial Heart valves, Various Types and Replacement of Heart Valves; Coronary Stents, Types of Stents, Angiography, Balloon Angioplasty Endoscopes: Principles and description of electronic and optical assembly, Types of Endoscopes, Fiber optic endoscope, Laparoscope, Cystoscope. Unit-IV Intraocular Lens, Materials for Intraocular Lens, Types of Intraocular Lens Prosthetic Devices: limb prosthesis and its components, Interface between the residual limb and prosthesis, dental Prosthesis Automated Drug Delivery Systems: Infusion Pumps, Components of Drug Infusion Systems, Implantable Infusion System, Closed-Loop Control in Infusion Systems, Examples of Typical Infusion Pumps, Insulin Pumps Books Recommended:

1. R.S. Khandpur, “Handbook of Biomedical Instrumentation”, McGraw Hill Education (India) Pvt. Ltd., 2015.

2. John G. Webster, “Medical Instrumentation Application & Design”, Wiley, 2011. 3. Shakti Chatterjee&Aubert Miller, “Biomedical Instrumentation Systems”,

DelmerCengage Learning, 1St Ed, 2010. 4. Joseph J. Carr and John M. Brown, Introduction to Biomedical Equipment Technology”,

Pearson Education, Inc., 2007.

BME-304-L MICROPROCESSORS& MICROCONTROLLERS



Prerequisite: Student should have prior knowledge of digital logic, binary number systems and

arithmetic, computer operation, and assembly language programming. Objectives:

• The objective of this course is to providecomprehension of microprocessor structure: CPU, memory and input/output peripherals.

• To understand & to know how to use sets of instructions and machine language. • To develop a capacity to analyze systems architecture based on microprocessors. • To develop a capacity to use hardware description languages.

Course outcomes: CO-1 Recognizing and analyzing of the 8085 microprocessors structure, instruction set and programming. CO-2 Able to understand the design of 8086 microprocessors structure, instruction set and programming CO-3 Learn how i/o controllers works & interfaced with the microprocessor. CO-4 Able to understand the basic of microcontrollers. Unit-I 8085 MICROPROCESSORS: Introduction to microprocessor, 8085 microprocessors: Architecture, Instruction set, Interrupt structure and Assembly languageprogramming. Unit-II 8086 MICROPROCESSORS: Architecture, block diagram of 8086, details of sub-blocks such as EU, BIU; memory segmentation and physical addresscomputations, program relocation, addressing modes, instruction formats, pin diagram and description of various signals. Unit-III I/O CONTROLLERS: Features, Organization and operating modes of 8155 Multi-function device, programmableperipheral interface, 8237 Programming DMA Controller. 8259 Programmable interrupt controller, Programmable interval timer chips.

Unit-IV MICROCONTROLLER: Introduction, classification based on- Architecture, instruction set & memory. 8051 MICROCONTROLLERS: Introduction, block diagram, pin description & special features. TEXT BOOK: 1. Microprocessor Architecture, Programming & Applications with 8085: Ramesh S Gaonkar; Wiley

Eastern Ltd. 6 edition, 2012. 2. The Intel Microprocessors 8086- Pentium processor: Brey; PHI, 8 edition, 2008. REFERENCE BOOKS: 1. Microprocessors and interfacing: Hall; TMH, 2005 2. The 8088 & 8086 Microprocessors-Programming, interfacing, Hardware & Applications: Triebel&

Singh; PHI, 4 edition, 2007. 3. Microcomputer systems: the 8086/8088 Family: architecture, Programming & Design: Yu-Chang Liu &

Glenn A Gibson; PHI, 2 edition, 2015 4. Advanced Microprocessors and Interfacing: Badri Ram; TMH, 2017.

BME 306 – L REHABILITATION ENGINEERING


Course Assessment Methods (Internal: 30; External: 70)Two minor test each of 20 marks, class performance measured through percentage of lecture attended (4 marks), assignments, quiz etc. (6 marks) and end semester examination of 70 marks . For the end semester examination, nine questions are to be set by the examiner. Question number one will be compulsory and based on the entire syllabus, it will contain seven short answer type question. Rest of the eight questions is to be given by setting two questions from each of the four units of the syllabus. A candidate is required to attempt any other four questions selecting one from each of the four units. All questions carry equal marks.

Prerequisite:Knowledge and understanding of human physiology and basic electronics. Objectives:

• To impart in-depth knowledge and understanding of disability and rehabilitation required. • To understand the assistive devices and technologies available for differently abled persons to lead

a near normal life. Course Outcomes: CO-1 Understanding the concept of rehabilitation for differently abled people. CO-2 Understanding the assistive devices & technologies for sensory augmentation and substitution. CO-3 Knowledge of wheelchair engineering for personal transportation. CO-4 Understanding the concept of prostheses and orthoses for designing of artificial limbs.

Unit-I

Introduction: Rehabilitation concepts, Engineering concepts in sensory rehabilitation, motor rehabilitation, communication disorders. Sensory augmentation & substitution – visual system, auditory system, tactual system.

Unit-II

Wheel Chair Engineering: Wheeled mobility, Categories of wheel chairs, Wheel chair structure & component design, Ergonomics of wheel chair propulsion.

Unit-III

Sensory Rehabilitation: Rehabilitation of the blind – reading aids, tactile vision. Aids for the deaf- audiometry and speech therapy aids.Automatic speech synthesis & Voice recognition.

Unit-IV

Motor Rehabilitation: Orthopedic prosthetics and orthotics in Rehabilitation, Limb prostheses and orthoses for various handicapped, Spinal injury rehabilitation, Prosthetic knee, Prosthetic hand, Orthotic knee joint, FES System, Myoelectric hand and arm prostheses. Text Books:

1. Joseph D. Bronzino, “Biomedical Engineering Handbook, Volume II”, CRC Press. 2. Susan J. Garrison, “Handbook of Physical Medicine and Rehabilitation’, Lippincott

Williams & Wilkins, 2nd Edition.

Reference Books: 1. Manfred Clynes, John H. Milsum, “Biomedical Engineering Systems”, McGraw Hill.

BME-308-L LASERS AND FIBER OPTICS IN MEDICINE Course Code: BME-308-L Course Credits: 3.5 Type: Compulsory Contact Hours: 4 hours/week Mode: Lectures (3), Tutorials (1)


Objective:

• To understand the fundamentalsoflasers and fiber optics. • To understand the applications of lasers and fiber opticsin medical science.

Expected Outcomes:

• Able to describe essential optical principles and fundamentals of lasers. • Able to describe essential optical principles and fundamentals of optical fiber. • Able to utilize the basic engineering principles of fiber optics and lasers for developing

therapeutic, diagnostic, sensing and imaging devices. • Stimulation among the learners for futuristic research, design and developments.

Unit-I Introduction to fiber optics: Basic fiber link, applications, principles of light: Introduction, EM spectrum, internal & external reflections, Snell'slaw, optical fiber numerical aperture, Fresnel reflection, Optic fiber & its properties: Introduction, Basic fiber construction, propagation of light, modes of operation, refractive index profile,types of fibres, dispersion, data rate and bandwidth, attenuation, losses. Unit-II

Connectors, Splices &Couplers:Introduction, splices: mechanical, fusion, protection of splice, connectors: SMA, STC, bionic etc,coupling: passive, Stan, TEE types. Optical sources & Photo Detectors: Introduction: creation of photons, LED, laser diode, photo, detectors: introduction, PIN photodiode, avalanche photodiode, photodiode parameters, detector noise, speed of response, SNR., Modulation scheme for fiber optics transmission: Introduction, digital modulation, analog modulation schemes, multiplexing. Unit-III Laser Systems: Introduction, types of lasers: Solid state lasers, Gas lasers, Dye lasers, Lasers used in medical practice: Ruby laser,CO2 laser, Nd-Y AG laser and related solid state laser. Laser -Tissue Interaction: Terminology, spectral band designations, energy & power, irradiant & radiant exposure, fluence, thermaldiffusion fibers & contact tips, Types of laser-tissue interactions. Unit-IV Laser Application in Medical Therapy: Introduction, application in general surgery, dermatology, ophthalmology, cardiovascular &chest surgery, dentistry, neuro surgery, otolaryngology & head and neck surgery, tumor surgery, gynecologic laser, endoscopy, laproscopy, neuroendoscopy TEXTBOOKS 1.Therapeutic Lasers -Theory and practice by G. David Baxter (Churchill livingstone publications) 2. Medical Lasers and their safe use by David H Shiney, Stephen and L. Trokel (Springer-Verlag publications) REFERENCE BOOKS 1. Laser and optical fibers in medicine by Katzer and Abraham (Academic press publications) 2. An Introduction to optical fibers by A. M. Cherin (McGraw Hill publications) 3. Elements of fiber optics by S. L. Wymer (Regents-Prentice Hall publications) 4. Biomedical Electronics & Instrumentation by S. K. Venkata Ram (Galgotia publications).

BME -302-P Medical Devices Lab Course Code: BME -302-P Course Credits: 1 Type: Compulsory Contact Hours: 2 hours/week Mode: Practical session of 2hours


Objectives:

• To understand construction, operation and applications of various medical devices. • To stimulate the learners for futuristic research and development of medical devices

Expected outcomes:

• Be able to describe the components and working of various medical devices. • Be able to describe the applications of various medical devices. • Be able to maintain and troubleshoot thevariousmedical devices. • Stimulation among the learners for futuristic research, design and development of

medical devices

List of some topics for experiments 1. Demonstration of Pace maker (extent and implantable, power source of implantable

pacemaker leads and electrodes) 2. Demonstration of operation of Heart lung machine. 3. Demonstration of coronary care devices-coronary stents. 4. Operation of laser equipments 5. Various types of endoscopes 6. Various types of Intraocular lenses

Note: At least seven experiments are to be performed by the students from the above topics. The course coordinator may also design and set experiments in addition to above topics as per the scope and requirement of the syllabus.

BME-304-P MICROPROCESSORS& MICROCONTROLLERS LAB

Course Code: BME-304-P Course Credits: 1.5 Type: Compulsory Contact Hours: 3 hours/week Mode: Practical session


Prerequisite: Basic knowledge of Physics & Electronics. Objectives:

• To understand the basics of writing an assembly language programs for microprocessors. • To understand the wide functionalities of microprocessors.

Course outcomes: CO-1 Able to perform basic design procedure used in designing the microprocessors embedded circuits CO-2 Understand the importance and functionality of microprocessors. CO-3 Understand the assembly language programming for microprocessors. CO-4 Able to execute & learn the various mathematical operative programs.

LIST OF EXPERIMENTS:

1. Study of 8085 Microprocessor kit. 2. Write a program using 8085 and verify for:

a. Addition of two 8-bit numbers. b. Addition of two 8-bit numbers (with carry).

3. Write a program using 8085 and verify for: a. 8-bit subtraction (display borrow) b. 16-bit subtraction (display borrow)

4. Write a program using 8085 for multiplication of two 8- bit numbers by repeated addition method. Check for minimum number of additions and test for typical data.

5. Write a program using 8085 for multiplication of two 8- bit numbers by bit rotation method and verify.

6. Write a program using 8085 for division of two 8- bit numbers by repeated subtraction method and test for typical data.

7. Write a program using 8085 for dividing two 8- bit numbers by bit rotation method and test for typical data.

8. Study of 8086 microprocessor kit. 9. Write a program using 8086 for division of a defined double word (stored in a data

segment) by another double 10. Write a program using 8086 for finding the square root of a given number and verify. 11. Write a program for finding square of a number using look-up table and verify.

Note: At-least seven experiments are to be performed by students from the above list. The course coordinator may also design and set experiments in addition to the above list/topic as per the scope and requirement of syllabus. TEXT BOOK: 1. Microprocessor Architecture, Programming & Applications with 8085: Ramesh S Gaonkar; Wiley

Eastern Ltd. 6 edition, 2012. 2. The Intel Microprocessors 8086- Pentium processor: Brey; PHI, 8 edition, 2008.

BME-308-P LASERS AND FIBER OPTICS IN MEDICINE LAB

Course Code: BME -308-P Course Credits: 1 Type: Compulsory Contact Hours: 2 hours/week Mode: Practical session of 2hours


Objectives:

• To understand the fundamentals of lasers and fiber optics. • To understand the applications of lasers and fiber optics in medical science.

Expected Outcomes:

• Able to describe essential optical principles and fundamentals of lasers. • Able to describe essential optical principles and fundamentals of optical fiber. • Able to utilize the basic engineering principles of fiber optics and lasers for developing

therapeutic, diagnostic, sensing and imaging devices. • Stimulation among the learners for futuristic research, design and developments.

List of some topics for experiments

1. Study of light propagation through fiber optics. 2. Study of various Lasers as light source. 3. Optical signal communication set-up using fiber optics. 4. Study losses of signal through optical fiber. 5. Study of construction and operation of fiber optic based medical instruments: Endoscope,

Colonoscope, Bronchoscope, Uteroscope Note: At least seven experiments are to be performed by the students from the above topics. The

course coordinator may also design and set experiments in addition to above topics as per the scope and requirement of the syllabus.

SEMESTER-7

Elective-II

BME -413-L RADIATION PROTECTION IN MEDICAL TECHNOLOGY



Prerequisite:Knowledge and understanding of basic physics & electronics. Objectives:

• To impart in-depth knowledge and understanding of radiation physics. • To understand the engineering design considerations of devices for radiation protection and

monitoring. Course Outcomes: CO-1 Understanding the concept of interaction of radiation with matter and its biological effects. CO-2 Understanding the principles of radiation protection. CO-3 Knowledge ofengineering concerns for radiation detection and monitoring devices. CO-4 Understanding the radiation safety and handling aspects.

Unit-I

Interaction of Radiation With Matter: Interaction of X-rays and gamma rays with matter, Interaction of neutrons with matter, importance of these interactions in diagnostic radiology. Biological Effects of Radiation: Stochastic effects, Deterministic effects with examples, Short term and longterm effects.

Unit-II Radiation Protection: Exposure, Kerma, Dose, Equivalent dose, Effective dose, Ambientand personal dose equivalents. Basic Principles of Radiation Protection: Types of radiation exposures, Basic philosophy of radiation protection (Justification / Optimization / Dose Limitation), Operational dose limits, Guidance level doses. Radiation Protection Principles (Time / Distance / Shielding) Radiation Hazards Control (Methods of controlling exposures).

Unit-III

Radiation Detection Principles: Detection principles, Ion chamber detector, Proportional counter detector, GMdetector, Scintillator detector. Radiation Monitoring Devices: Radiation protection monitors (Ambient monitoring), Personal monitors (Individualmonitoring).

Unit-IV

Safety Aspects in Radiology & Radiation Oncology: Installation safety, Equipment safety. Safety in source transfer operations, Radiation warning signs.Regulatory requirements in radiology. Text Books:

1. F.M. Khan, “The Physics of Radiation Therapy”. lI Ed., Willimas& Wilkins, USA, 1994. 2. E. Podgorsak (ED.), “Radiation Oncology Physics: A Handbook for Teachers and

Students”, IAEA Vienna, 2005.

Reference Books: 1. Khandpur R S, “Handbook of Biomedical Instrumentation”, TataMcGraw Hill,

NewDelhi, 2000.

Elective-II

BME-415-L TELEMEDICINE



Prerequisite:Knowledge and understanding of human physiology and basic electronics. Objectives:

• To impart in-depth knowledge and understanding of concepts of information and data exchange. • To understand the engineering design considerations of telemedicine system.

Course Outcomes: CO-1 Understanding the concept of telemedicine and its applications. CO-2 Understanding the design considerations of telemedicine system. CO-3 Knowledge oftypes of information. CO-4 Understanding the ethical and legal aspects of telemedicine.

Unit-I

Introduction: History of telemedicine, Block diagram of telemedicine system, Definition of telemedicine, Tele health, Tele care, Organs of telemedicine, Scope, Benefits, and Limitations of telemedicine.

Unit-II Type of Information:Audio, Video, Still images, Text and data, fax, type of communications and network, PSTN, POTS, ANT, ISDN, Internet, Air/ wireless communications: GSM satellite, and Micro wave. Different Modulation techniques.Types of antennas depending on requirements.

Unit-III

Tele Radiology: Definition, System components: Image Acquisition system, Display system, Communication network, Interpretation section. Tele Pathology: Multimedia databases, Color images of sufficient resolution: Dynamic range, spatial resolution, compression methods.

Unit-IV

Applications of Telemedicine:Telecardiology, Tele-oncology, Telesurgery.

Ethical and Legal Aspects of Telemedicine: Confidentiality and the law, patient rights and consent, access to medical records, consent treatment, jurisdictional issues, intellectual property rights. Text Books:

1. Olga (EDT) Ferrer, Roca, M.Sosa (EDT) Iudicissa, “Hand book of Telemedicine” IOS Press 2002.

2. A.C. Norris, “Essentials of Telemedicine and Telecare” John Sons & Ltd, 2002.

Reference Books:

1. Leslie Cromwell, Fred J Weibell and Erich A Pfeiffer, “Biomedical Instrumentation and Measurements”, PHI, Second Edition, 2003.

2. Patranabis D, “Telemetry Principles”,TMH,New Delhi,1999. 3. Khandpur R S, “Handbook of Biomedical Instrumentation”, TataMcGraw Hill, NewDelhi,

2000.

BME-401-L BIOMEDICAL SIGNAL PROCESSING

Course Code: BME-401-L

Course Credits: 3.5 Mode: Lecture (L) and Tutorial (T) Type: Compulsory Contact Hours: 3 hours (L) + 01 hour (T) per week. Examination Duration: 03 hours.


Prerequisite: Student should have prior knowledge of signals & systems, communication

systems & transform theory. Objectives:

• The objective of this course is to providecomprehension on signals & its processing techniques.

• To understand & to know how to design digital filters. • To develop a capacity to implement & apply these processing techniques. • To develop an understanding about neurological signal processing.

Course outcomes: CO-1 Recognizing and analyzing of signal’s Characterization and Classification. CO-2 Able to understand the design methodologies & structure of digital filter. CO-3 Learn how to implement and apply these processing in medical systems. CO-4 Able to understand the basic of neurological signal processing. Unit-I CONCEPTS: Signals and Signal Processing: Characterization and Classification of Signals. Typical Signal Processing Operations, Examples of Typical Signals, Sampling theorem, Typical Signal Processing Applications. Unit-II DIGITAL FILTERS: Structures: block diagram representation, equivalent structures, basic FIR digital filters, structures, state space structures, computational complexity of digital filter structures. IIR filter Design: preliminary consideration, impulse invariance method, bilinear transform method, FIR Filters, FIR Filter Design, Computer-Aided Design of Digital Filters. Unit-III IMPLEMENTATION & APPLICATIONS: Implementation considerations: basic issues software implementation. the quantization process and errors, analysis of finite word length effects in DSP, dual- tone multi frequency signal detection, analysis of musical sound processing, digital FM stereo generation, discrete-time analytic signal generation, voice privacy system, sub band coding of speech and audio signals. Unit-IV NEUROLOGICAL SIGNAL PROCESSING: Modelling of EEG signals, detection of alpha, beta, gamma rays Cardiology signal processing-arrhythmia detection algorithms.

TEXT BOOK: 1. Digital Signal Processing :Proakis and Manolakis; PHI 2. Digital Signal Processing: Salivahanan, Vallavaraj and Gnanapriya;TMH REFERENCE BOOKS: 1. Digital Signal Processing A Computer-Based Approach Sanjit K Mitra. 2. Digital Signal Processing: Alon V. Oppenhelm;PHI 3. Digital Signal processing(II-Edition): Mitra, TMH

BME-403-L MEDICAL IMAGE PROCESSING



Prerequisite: Student should have prior knowledge of signals & system, digital electronics &

transform theory. Objectives:

• The objective of this course is to providea detail introduction about image & its processing. • To understand & to know how an image model is developed and processed. • To develop a capacity to analyze the image through various segmentation techniques. • To develop a capacity to apply these processing’s in medical applications.

Course outcomes: CO-1 Recognizing and analyzing of image acquisition storage, processing, communication & display. CO-2 Able to understand the formation of image model & basics enhancements techniques. CO-3 Learn the image segmentation processing in detail. CO-4 Able to understand the basic applications of image processing in medical systems. Unit-I DIGITAL IMAGE PROCESSING SYSTEM: Image acquisition storage, processing, communication display. Visual perception: Structure of Human Eye, Image formation in human eye, brightness and contrast, adaptation and discrimination, Block’s Law and critical fusion frequency photographic film characteristics. Unit-II IMAGE MODEL: Uniform and non-uniform sampling, quantization, Image enhancement: Image smoothing, point operators, contrast manipulation, histogram modification, noise clipping image sharpening, spatial operators, frequency domain method, low pass and high pass filtering, homomorphic filtering, median filtering. Unit-III Medical Image Segmentation: Histogram-based methods, Region growing and watersheds, Markov Random Field models, active contours, model-based segmentation. Multi-scale segmentation, semi-automated methods, clustering-based methods, classification-based methods, atlas-guided approaches, multi-model segmentation. Unit-IV Biomedical application: Computer Tomography, Emission Tomography, CAT, Radon Transform CAT, MRI Images. Processing of Radiograph, Angiogram, Sonography including Doppler, Projection Theorem, Back Projection.

TEXT BOOK: 1. Rafel C Gonzalez, Richard E Woods, “Digital Image Processing”, 2nd ed, Addison - Wesley

Publishing Company, New Delhi, 2002. 2. William R Hendee, E. Russell Ritenour, “Medical Imaging Physics”, 4th ed., John Wiley & Sons,

Inc., New York, 2002. REFERENCE BOOKS:

1. Paul Suetens, “Fundamentals of Medical Imaging”, 2nd ed., Cambridge University press, 2009. 2. J. Michael Fitzpatrick and Milan Sonka, “Handbook of Medical Imaging, Vol. 2, SPIE Press, 2000

BME 405 – L BIOMECHANICS



Prerequisite:Basic knowledge and understanding of human physiology & principles of mechanics. Objectives:

• To impart in-depth knowledge and understanding of tissue and joints mechanics. • To understand the concept of flow dynamics.

Course Outcomes: CO-1 Understanding the principles of mechanics relevant to human body. CO-2 Understanding the various aspects of hard & soft tissue mechanics. CO-3 Knowledge of biomechanics of joints & locomotion. CO-4 Understanding the concept and principles of fluid mechanics.

Unit-I Introduction to mechanics: Review of the principles of mechanics, Vector mechanics- Resultant forces of Coplanar & Non-coplanar and Concurrent & non-concurrent forces, parallel force in space, Equilibrium of coplanar forces, Newton’s laws of motion, work and energy, Moment of inertia, Laminar flow, Turbulent flow,Couette flow and Hagen-Poiseuille equation.

Unit-II Hard Tissue Mechanics: Mechanical properties of bone, cortical and cancellous bones, viscoelastic properties, Maxwell &Voight models – anisotropy, Electrical properties of bone. Soft Tissue Mechanics: Pseudo elasticity, nonlinear stress-strain relationship, Viscosity, Structure, Function and mechanical properties of skin, ligaments and tendons.

Unit-III Biomechanics of Joints: Skeletal joints, Skeletal muscles, Mechanics of elbow, mechanics of shoulder, mechanics of spinal column, mechanics of hip, mechanics of knee. Locomotion: Human locomotion, Gait analysis and goniometry, Ergonomics, Foot Pressure measurements – Pedobarograph, Force platform, Mechanics of foot.

Unit-IV Flow Dynamics of Circulatory System: Ventricular pressure& volume, ECG time based cyclic variation. Determination of ventricular wall diastolic, systolic modulus vs stress properties and

their physiological connotation. Arterial impedance relating pulse pressure and flow rate, Microcirculatory flow, Transcapillary fluid movements in systemic circulation. Text Books:

1. NihatOzkaya and Margareta Nordin, “Fundamentals of Biomechanics: Equilibrium, Motion, and Deformation”, Springer- Verlag; Second Edition, 1999.

2. Susan J Hall, “Basic Biomechanics”, McGraw Hill, Columbus - OH, Second Edition, 1995. 3. Fung Y C, “Biomechanics: mechanical properties of living tissues”, Second Edition.

Springer-Verlag, 1993.

Reference Books: 1. Arthur T Johnson, “Biomechanics & Exercise Physiology”, John Wiley & Sons, NY, 1991. 2. Ghista D N, “Biomechanics of Medical Devices”, Macel Dekker, 1982.

BME-407-L BIOSIGNAL CONDITIONING

Course Code: BME-407-L Course Credits: 4 Type: Compulsory Contact Hours: 4hours/week Mode: Lectures(4)

Course Assessment Methods (Internal: 30; External: 70) Two minor examinations each of 20 marks, Class Performance measured through percentage of lectures attended (4 marks) Assignment and quiz (6 marks), and end semester examination of 70 marks. For the end semester examination, nine questions are to be set by the examiner. Question number one will be compulsory and based on the entire syllabus. It will contain seven short answers type questions. Rest of the eight questions are to be given by setting two questions from each of the four units of the syllabus. A candidate is required to attempt any other four questions selecting one from each of the remaining four units. All questions carry equal marks.

Objectives:

• To introduce Operation Amplfier and its use in signal conditioning circuits. • To introduce the methods for acquiring, modifying and conditioning of thebiosignals into

a usable format for the final stage of the measurement and display system

Expected outcomes: • To describe the aim, purpose and use of signal conditioning in biomedical

instrumentation. • To describe the various important characteristics of operational amplifiers. • To get acquainted with various popular operational amplifiers. • Able to understand and design of various signal conditioning circuits for biomedical

applications. Unit-I Biomedical Signals and Artifacts: Elements of generalised medical instrumentation system, Nature of signal and noise, types of noise, interfering and modifying signals, methods of correction for interfering and modifying inputs, Acquisition of biomedical signals, examples of biomedical noisy signals, artefacts in biomedical signals, requirement of Signal conditioning, pre amplifier and its need. Unit-II Linear Op-Amp Circuits: Introduction to OP-Amp, Inverting and non-inverting amplifier, OP-Amp parameters, equivalent circuit of Op-Amp, differential input – differential output amplifier. The 741 Op-Amp, Inverter/Noninverter circuits, differential amplifier, instrumentation amplifier, summing amplifier, current boosters, voltage controlled sources. Unit-III

Non-Linear Op-Amp Circuits: Comparators with zero and non-zero reference, Comparators with hysteresis, window comparator, Integrator, differentiator, waveform conversion, waveform generation, Triangular wave generator, active diode circuits, Unit-IV Active Filters and circuits: Introduction, Ideal responses, Advantages over passive filters, First order filters, High orders filters, VCVS Equal-component low-pass filter, VCVS High-pass filter, MFB bandpass filter, Band stop filter, All pass filter, IC 555 Timer- Functional block diagram, Application of 555 Timer asAstablemultivibrator, Monostablemultivibrator and Voltage controlled Oscillator (VCO). Books Recommended: 1. John G. Webster, “Medical Instrumentation” third edition, published by John Wiley & Sons (Asia) Pte Ltd.,2 Clementi Loop, Singapore. 2. Malvino Albert and bates David J, “Electronic Principles”, published by McGraw Hill Education Pvt. Ltd., New Delhi. 3. Sawhney A.K., “Electrical and Electronic Measurements and Instrumentation”, published by DhanpatRai and Co. Pvt. Ltd., Delhi.

BME-401-P BIOMEDICAL SIGNAL & IMAGE PROCESSING LAB

Course Code: BME-401-P Course Credits: 1 Type: Compulsory Contact Hours: 2 hours/week Mode: Practical session


Prerequisite: Basic knowledge of signal & systems. Objectives:

• To understand the basics of signal & image processing. • To understand the basis of MATLAB tool for analysis.

Course outcomes: CO-1 Able to perform basic of writing a program in MATLAB for representation of the signals. CO-2 Understand the importance and functionality of MATLAB for analysis. CO-3 Understand the ways of analyzing image through MATLAB. CO-4 Able to learn & execute various operations on signals & image through MATLAB.

LIST OF EXPERIMENTS: Perform the experiments using MATLAB:

1. To represent basic signals (Unit step, unit impulse, ramp, exponential, sine and cosine). 2. To develop a program for obtaining Fourier transform & inverse Fourier transform. 3. To develop a program for obtaining Laplace transform & inverse Laplace transform. 4. To develop a program for obtaining z- transform & inverse z-transform. 5. To develop a program for discrete convolution. 6. To develop a program for discrete correlation. 7. To develop a program for converting an RGB image to GRAY scale. 8. To develop a program for obtaining a histogram of image.

9. To develop a program for adding & removing salt n pepper noise. 10. To develop a program for performing filtering operations on images. 11. To develop a program for blurring & sharpening of an images.

Note: At-least seven experiments are to be performed by students from the above list. The course coordinator may also design and set experiments in addition to the above list/topic as per the scope and requirement of syllabus. TEXT BOOK: 1. Digital Signal Processing: Proakis and Manolakis; PHI 2. Digital Signal Processing: Salivahanan, Vallavaraj and Gnanapriya;TMH

BME-407-P BIOMEDICAL SIGNAL CONDITIONING LAB

Course Code: BME-407-P Course Credits: 1 Type: Compulsory Contact Hours: 2 hours/week Mode: Practical session of 2hours


Objectives:

• To introduce the techniques and basic design principles of electronic circuits using operational amplifiers.

• To understand the circuits for signal conditioning of physiological and biological signals in bioinstrumentation.

Expected outcomes: • To describe the aim, purpose and use of signal conditioning in biomedical

instrumentation. • To describe the various important characteristics of operational amplifiers. • To get acquainted with various popular operational amplifiers. • Able to understand and design of various signal conditioning circuits for biomedical

applications.. List of some topics for experiments

1. Design of linear op-amp circuits. 2. Design of non-linear op-amp circuits. 3. Design of active filters using op-amp. 4. Design of active diode circuits using op-amp. 5. Design of Comparators using op-amp 6. Timer IC-555. 7. Design of Astablemultiviberator ,Monostablemultiviberator and VCO using IC-555.

Note: At least seven experiments are to be performed by the students from the above topics. The course coordinator may also design and set experiments in addition to above topics as per the scope and requirement of the syllabus.

BME – 409-P MINOR PROJECT

Course Code: BME 409-P Course Credits: 1 Type: Compulsory Contact Hours: 2hrs/week Mode: Practical session


Prerequisite:Basic knowledge and understanding of principles & applications of Biomedical Engineering. Objectives:

• To impart problem solving skills. • To enhance the soft skills.

Course outcomes: CO-1 Defining a relevant problem. CO-2 Understanding the materials & methods for problem solving. CO-3 Knowledge & designing of the equipment required. CO-4 Improving the soft skills.

Students will select a topic of minor project in areas of Biomedical Engineering and work on the same independently. Each student is required to submit a project report in the department and give a presentation on the same before the internal committee for internal awards (30 marks). For external awards (70 marks) students will be examined by internal & external examiners by live demonstration of the project followed by viva.

BME – 411-P TRAINING SEMINAR

Course Code: BME 411-P Course Credits: 0.5 Type: Compulsory Contact Hours: 1hr/week Mode: Practical session

Course Assessment Methods (Internal: 100)Internal assessment of 100 marks on the basis of class performance, attendance, training report and seminar /talk delivered.

Students will go for Industrial / Hospital Training of 3 – 4 weeks at the end of 6th semester. Each student is required to submit a training report in the department and give a seminar/talk on the same before the internal examiners in the department as per the guidelines.

SEMESTER-8

Elective-III

BME-406-L BIOMEDICAL WASTE MANAGEMENT



Prerequisite:Knowledge and understanding of biomedical principles. Objectives:

• To impart in-depth knowledge and understanding of hospital & biomedical waste. • To understand the engineering considerations for biomedical waste disposal.

Course Outcomes: CO-1 Understanding the concept of biomedical waste & its classification. CO-2 Understanding the hazards of biomedical waste. CO-3 Knowledge ofengineering concerns for the treatment technologies for waste. CO-4 Understanding the laws of biomedical waste handling.

Unit-I Introduction: Definition of general and hazardous health care waste, Infectious waste, Geno-toxic waste, waste sharps, categorization and composition of Biomedical waste, major and minor sources of biomedical waste, Segregation of waste, Color coding, waste handling and disposal

Unit-II Hazards of Biomedical Waste: Need for disposal of biomedical waste, Specifically Communicable diseases, Diseases epidemiology and mode of transmission of disease, Environmental pollution by biomedical waste - causes, consequences, mitigation and remedies.

Unit-III

Treatment Technologies for Wastes: Mechanical Treatment & Chemical Disinfections, Conventional Treatment Technologies:Wet thermal technology, Incineration, Microwave Technology, Autoclave system, Hydro clave system, Electro Thermal Reactivation(ETP), Treatment Process Electron beam Technology, Plasma Pyrolysis/Gasification systems.

Unit-IV

Laws of Biomedical Waste Handling: Legislation, policies and law regarding environment on Health care waste management,Biomedical waste management and handling rules 1998 and its amendment. CPCB guidelines. World Health Organization guidelines on Management of wastes from Hospital wastes. Text Books:

1. Anantpreet Singh, SukhjitKaur, “Biomedical Waste Disposal”, 1st ed., Jaypee Publishers (P) Ltd, India, 2012.

2. SushmaSahai, “Bio-Medical Waste Management”, APH Publishing Corporation, India, 2009.

Reference Books: 1. Sanskriti Sharma, “ Hospital Waste Management and Its Monitoring”, Jaypee Publishers

(P) Ltd, India, 2002.

Elective-III

BME-408-L BIOSENSORS



Prerequisite:Knowledge and understanding of basic electronics. Objectives:

• To impart in-depth knowledge and understanding of biosensors. • To understand the engineering design considerations and principles of sensing and transduction.

Course Outcomes: CO-1 Understanding the concept of biosensors for different applications. CO-2 Understanding the design considerations of immuno-biosensors. CO-3 Knowledge ofengineering concerns of fibre-optic biosensors. CO-4 Understanding the concept of electrochemical biosensors.

Unit-I Biosensors: Introduction – amperometric enzyme electrodes-characteristics- enzyme activity determinations – biosensors for enzyme immunoassay – Potentiometric enzyme electrodes – electrode characteristics and performance –pH glass and ion-selective electrodes – solid-state pH and redox electrodes –gas electrodes.

Unit-II Immuno-Biosensors: Potentiometric immune-biosensors – immobilization techniques – analytical applications. Principle and measurements of enzyme thermistor devices. Transducer – experimental techniques – types of biological element: immobilized enzymes – immobilized cells – determination of enzyme activities in solution.

Unit-III Fiber-optic Biosensors:Introduction – sensing chemistry and materials –sensing techniques –transducer types. Transducer-based fiber optic biosensors – Optical biosensors based on competitive binding.

Unit-IV Electrochemical Biosensors: Electron conducting redox polymer in biosensors –enzyme electrodes – specific sensor examples. Hybridization at oligonucleotide sensitive electrodes: function of oligonucleotide sensitive electrodes – hybridization efficiency and sensitivity – probe oligonucleotide structure and dynamics – hybridization conditions – hybridization kinetics.

Text Books:

1. Copper J M and Cass E G A, “Biosensors ”, Second Edition, Oxford University Press, 2004.

2. Blum L J andCoulet P R, “Biosensor Principles and Applications”, Marcel Dekker Inc., 1991.

Reference Books: 1. Joseph D Bronzino, “The Biomedical Engineering Handbook”, Volume II, CRC Press,

Boca Raton, Second Edition, 2000.

ELECTIVE-IV

BME-410-L ADVANCED MEDICAL DISPLAY TECHNOLOGIES

Course Code: BME-410-L Course Credits: 3.5 Mode: Lecture (L) and Tutorial (T) Type: Compulsory Contact Hours: 3 hours (L) + 01 hour (T) per week.

Examination Duration: 03 hours.


Prerequisite: Basic knowledge of Analog & Digital Electronics, Physics, & engineering

mathematics. Objectives:

• To understand various aspects of light optics. • Identify and develop an understanding for various displays & their applications.

Course outcomes: CO-1 Acquire a basic knowledge of light optics. CO-2 To develop an ability to understand various display glasses & their features. CO-3 To develop an understanding various display screens. CO-4 Understanding of various mobile displays units. Unit-I Properties of light, Geometric optics, optical modulation; vision and perception: anatomy of eye, light detection and sensitivity, spatial vision and pattern perception, binocular vision and depth perception; driving displays: direct drive, multiplex and passive matrix, active matrix driving, panel interfaces, graphic controllers, signal processing mechanism. Unit-II Display Glasses Inorganic Semiconductor TFT Technology, Organic TFT Technology; Transparent Conductors, Flexible Displays: Attributes, Technologies Compatible with Flexible Substrate and Applications, Touch Screen Technologies: Introduction, Coatings, Adhesive, Interfaces with Computer Mechanism. Unit-III Inorganic Phosphors, Cathode Ray Tubes, Vacuum Florescent Displays, Filed Emission Displays; Plasma Display Panels, LED Display Panels; Inorganic Electroluminescent Displays: Thin Film Electroluminescent Displays, AC Powder Electroluminescent Displays; Organic Electroluminescent Displays: OLEDs, Active Matrix for OLED Displays; Liquid Crystal Displays. Unit-IV Paper like and Low Power Displays: Colorant Transposition Displays, MEMs Based Displays, 3-D Displays, 3-D Cinema Technology, Autostereoscopic 3-D Technology, Volumetric and 3-D Volumetric Display Technology, Holographic 3-D Technology; Mobile Displays: Trans-reflective

Displays for Mobile Devices, Liquid Crystal Optics for Mobile Displays, Energy Aspects of Mobile Display Technology. TEXT BOOK:

1. Janglin Chen, Wayne Cranton, Mark Fihn, Handbook of Visual Display Technology, Springer Publication, 2011.

2. Achintya K. Bhowmik, Mobile Displays: Technology and Applications, 2008. REFERENCE BOOKS:

1. Xinyu Zhu, ZhibingGe, and Shin-Tson Wu, Transflective Liquid Crystal Display Technologies, 2010.

2. BahramJavidi, Fumio Okano, Three-Dimensional Television, Video, and Display Technologies, 2002.

ELECTIVE –IV

BME-412-L MEDICAL INFORMATICS





mathematics. Objectives: • To introduce about the fundamentals of ICT applications in medicine with an introduction to health

informatics. • Identify and develop an understanding for medical standards, medical data formats and recent trends in

Hospital Information Systems.

Course outcomes: CO-1 Acquire a basic knowledge of Medical & bio Informatics. CO-2 To develop an ability to understand the various Medical Standards wrt to health informatics. CO-3 To develop an understanding of medical data storage and automation. CO-4 Understanding of recent trends in medical informatics. Unit-I MEDICAL INFORMATICS: Introduction – Medical Informatics – Bioinformatics – Health Informatics - Structure of MedicalInformatics –Functional capabilities of Hospital Information System - On-line services and Off –line services - Dialogue with the computer. Unit-II MEDICAL STANDARDS: Evolution of Medical Standards – IEEE 11073 - HL7 – DICOM – IRMA - LOINC – HIPPA – Electronics Patient Records – Healthcare Standard Organizations – JCAHO (Joint Commission on Accreditation of Healthcare Organization) - JCIA (Joint Commission International Accreditation) - Evidence Based Medicine - Bioethics. Unit-III MEDICAL DATA STORAGE AND AUTOMATION: Representation of Data, Data modelling Techniques, Relational Hierarchical and networkApproach, Normalization techniques for Data handling - Plug-in Data Acquisition and ControlBoards – Data Acquisition using Serial Interface – Medical Data formats – Signal, Image andVideo Formats – Medical Databases - Automation in clinical laboratories - Intelligent LaboratoryInformation System – PACS. Unit-IV HEALTH INFORMATICS:

Bioinformatics Databases, Bio-information technologies, Semantic web and Bioinformatics, Genome projects, Clinical informatics, Nursing informatics, Public health informatics, Education and Training recent trends in medical informatics. TEXT BOOK:

1. R.D.Lele, “Computers in medicine progress in medical informatics”, Tata McGraw Hill Publishing Ltd, 2005.

2. Mohan Bansal, “Medical informatics”, Tata McGraw Hill Publishing Ltd, 2003. REFERENCE BOOKS:

1. OrpitaBosu and SimminderKaurThukral, “Bioinformatics Databases, Tools and Algorithms”, Oxford University press, 2007.

2. Yi Ping Phoebe Chen, “Bioinformatics Technologies”, Springer International Edition, New Delhi, 2007.

ELECTIVE-V

BME-414-L MEDICAL OPTICS





mathematics. Objectives: • To understand various aspects of optics in Tissues. • Identify and develop an understanding for various applications of laser in diagnosis and therapy.

Course outcomes: CO-1 Acquire a basic knowledge of optics in Tissues. CO-2 To develop an ability to understand the various components & features of photonic. CO-3 To develop an understanding of surgical applications of lasers. CO-4 Understanding of various applications of laser in diagnosis and therapy. Unit-I OPTICAL PROPERTIES OF THE TISSUES: Refraction, Scattering, Absorption, Light transport inside the tissue, Tissue properties, LaserCharacteristics as applied to medicine and biology-Laser tissue Interaction-Chemical-Thermal-Electromechanical – Photoabalative processes. Unit-II INSTRUMENTATION IN PHOTONICS: Instrumentation for absorption, Scattering and emission measurements, excitation light sources high pressure arc lamp, LEDs, Lasers, Optical filters, - optical detectors Time resolved andphase resolved detectors. Unit-III SURGICAL APPLICATIONS OF LASERS: Lasers in ophthalmology- Dermatology –Dentistry-Urology-Otolaryngology - Tissue welding. Unit-IV NON-THERMAL DIAGNOSTIC APPLICATIONS: Optical coherence tomography, Elastography, Laser Induced Fluorescence (LIF)-Imaging, FLIMRaman Spectroscopy and Imaging, FLIM – Holographic and speckle application of lasers inbiology and medicine. THERAPEUTIC APPLICATIONS: Phototherapy, Photodynamic therapy (PDT) - Principle and mechanism - Oncological andnononcological applications of PDT - Bio stimulation effect – applications-Laser Safety Procedures. TEXT BOOK:

1. MarkolfH.Niemz, “Laser-Tissue Interaction Fundamentals and Applications”, Springer, 2007 2. Paras N. Prasad, “Introduction to Biophotonics”, A. John Wiley and Sons, Inc. Publications, 2003. REFERENCE BOOKS: 1.Khandpur R.S, “Handbook of Biomedical Instrumentation”, Tata McGraw Hill, New Delhi, 2003. 2.John G.Webster, “Medical Instrumentation Application and Design”, third edition, John Wiley and Sons, New York, 2006.

ELECTIVE-V

BME-416-L ROBOTICS & AUTOMATION IN MEDICAL

INSTRUMENTATION





• To understand various aspects of Robotics & Automation System. • Identify and develop an understanding for essential components & applications of robotics in

medical field. Course outcomes: CO-1 Acquire a basic knowledge of robotic System. CO-2 To develop an ability to understand the sensors & visionary components for robotic System. CO-3 To develop an understanding about the programing techniques of robotic systems. CO-4 Understanding of various applications of robotic systems in medical field. Unit-I Robotics, Basic components, Classification, Performance characteristics, Drives and control systems, Electric, hydraulic and pneumatic actuators, control loops using current amplifier and voltage amplifiers. Unit-II Sensors and vision systems: Transducers and sensors, Tactile sensors Proximity and range sensors, vision systems, Image processing and analysis, image data reduction, segmentation feature extraction, Object recognition. Unit-III End effects, type Mechanical grippers, vacuum cups magnetic grippers, robot end effectors interface software for industrial robots. Positive stop program, point to point program and continuous path program. Unit-IV Applications: Telepresence, Surgical Assistants, Rehabilitation Robots, Medical Transportation Robots, Sanitation and Disinfection Robots, Robotic Prescription Dispensing Systems. TEXT BOOK:

1. S. R. Deb, Robotics Technology and Flexible Automation, 2001 2. AchimSchweikard, Floris Ernst, Medical Robotics, 2015. 3. Shane (S.Q.) Xie, Advanced Robotics for Medical Rehabilitation: Current State of the Art and

Recent Advances (Springer Tracts in Advanced Robotics) 2016. REFERENCE BOOKS:

1. Mikell P. Groover, Automation, Production Systems, and Computer-Integrated Manufacturing, 2014.

2. Thomas R. Kurfess, Robotics and Automation Handbook, 2014.

ELECTIVE-VI

BME-418-L WIRELESS COMMUNICATION ASSISTED MEDICAL SYSTEMS





mathematics. Objectives:

• To understand various aspects of wireless communication. • Identify and develop an understanding the detail architectures of wireless communication for

medical systems. Course outcomes: CO-1 Acquire a basic knowledge in Wired Networks. CO-2 To develop an ability to understand the basics of wireless networks & its components. CO-3 To develop an understanding various wireless networks topology. CO-4 Understanding of hardware & application of wireless networks. Unit-I Wired Networks, Wireless Networks, Applications of Wireless Networks, RF Fundamentals & parameters, Principles of antennas, Wireless Networks organizations and standards. Unit-II Basics of Wireless Networks: Classifications, Single hop and multihop, Aggregating and non-aggregating, Structured and randomly deployed, Self-configurable and non-self-configurable. Components: End devices, Routers, Coordinators, Operating modes, Cyclic, Event driven, Polled Unit-III Network topologies, issues for topology design, Core Challenges- Power consumption and battery life time, Bandwidth and response time, Reliability and stability. Unit-IV Hardware: Single node hardware: Sensors for WSN, Microcontrollers, Transceivers, Wireless communication networks as embedded systems Wireless communication based medical instrumentation systems TEXT BOOK: 1. Wireless Communications: Theodore S. Rappaport; Pearsons, 2002.

2. Mobile Cellular Telecommunication: W.C.Y.Lee; McGraw Hill, 2008. REFERENCE BOOKS: 1. Mobile Communications: Jochen Schiller; Pearson, 2014. 2. Modern Digital & Analog Communication System: B.P.Lathi, 2011 3. Communication System: SymonHaykin, 2013

Elective-VI BME -420-L INTRODUCTION TO BIO-METRICS



Prerequisite:Knowledge and understanding of basic electronics. Objectives:

• To impart in-depth knowledge and understanding of biometric systems & components. • To understand the engineering design considerations of different types of biometric technologies

and their applications. Course Outcomes: CO-1 Understanding the concept of biometrics. CO-2 Understanding the design considerations of biometric systems & components. CO-3 Knowledge ofengineering concerns of different biometric technologies. CO-4 Understanding the applications of biometric systems and future trends.

Unit-I Introduction to Bio-Metrics: Definition of Biometric, Characteristics of Biometrics, Nature of Biometrics, Types of Biometrics, Need of Biometrics, Verification and Identification.

Unit-II Types of Bio-Metrics:Introduction of all possible biometrics such as Fingerprint, Face, Iris, Palmprint, Hand vein, Hand Shape and their features.

Unit-III Bio-Metric Technology and Systems: Fingerprint Biometric Technology, Face Biometric Technology, Iris Biometric Technology, Voice Biometric Technology. Face Bio-Metric System:Design of Face Bio-Metric using Principal Component Analysis and Discriminant Analysis

Unit-IV Applications of Bio-Metrics: Security access, Police and prison services, Patient management in hospitals, Casino facial recognition, Enterprise network security and web access, Other areas of application. Future Trends in Bio-Metrics - Multimodal Biometrics, surveillance.

Text Books: 1. Samir Nanavati, Raj Nanavati, Michael Thieme, “Biometrics: Identify Verification in a

Networked World”, Wiley-Dremtech India Pvt Ltd, 2003. 2. Paul Reid, “Biometrics for Network Security”, Prentice Hall, 2003.

Reference Books: 1. Julian Ashbourn “Biometrics: Advanced Identify Verification: The Complete Guide”,

Springer-Verlag, 2000. 2. Anil K. Jain, Patrick Flynn, Arun A. Ross, “Handbook of Biometrics”, Springer,2008.

BME – 402-P MAJOR PROJECT

Course Code: BME 402-P Course Credits: 9 Type: Compulsory Contact Hours: 18hrs/week Mode: Practical session


Prerequisite:Basic knowledge and understanding of principles & applications of Biomedical Engineering. Objectives:

• To impart problem solving skills. • To enhance the soft skills.

Course outcomes: CO-1 Defining a relevant problem. CO-2 Understanding the materials & methods for problem solving. CO-3 Knowledge & designing of the equipment required. CO-4 Improving the soft skills.

Students can start a new project or can continue their minor project taken up in 7th semester if, it is extendable. Each student is required to submit a project report in the department and give a presentation on the same before the internal committee for internal awards (30 marks). For external awards (70 marks) students will be examined by internal & external examiners by live demonstration of the project followed by viva.

Documents

SCHEME & SYLLABUSSCHEME & SYLLABUS B.TECH (BIOMEDICAL ENGINEERING) w.e.f. 2016-17 CREDIT BASED SYSTEM (70:30) Guru Jambheshwar University of Science and Technology, Revised Scheme