Schizophrenia Spectrum Disorders [Instructor Name] [Class and Section Number]

Schizophrenia Spectrum Disorders

[Instructor Name][Class and Section Number]

Overview – Pt. 1

• Activity: Quiz about Schizophrenia• Phenomenology of Schizophrenia• Activity: The Disordered Monologue• The Cognitive Neuroscience of Schizophrenia

Activity: Quiz about Schizophrenia

True or False:

1.Schizophrenia is a rare illness.2.Schizophrenia is a brain disease. 3.Schizophrenia usually strikes older people. 4.More males than females develop schizophrenia. 5.Schizophrenia is caused by poor parenting.

Activity: Quiz about Schizophrenia

True or False:

6.Schizophrenia is caused by street drugs. 7.People who have schizophrenia are usually violent and dangerous.8.People with schizophrenia have multiple or split personalities.9.Schizophrenia can be successfully treated. 10.People with schizophrenia are developmentally disabled, i.e., they have a low level of intelligence.

Overview – Pt. 1


Phenomenology of Schizophrenia

John Nash, mathematicianEugen Bleuler, psychiatrist


Delusions - False beliefs that are often fixed and hard to change even when the person is presented with conflicting information.


Types of Delusions Persecutory Grandiose Reference Thought Insertion


Hallucinations - Perceptual experiences that occur even when there is no stimulus in the outside world generating the experiences


Types of Hallucinations Auditory Visual Olfactory Gustatory Somatic


Disorganized Speech Disorganized Behavior


Negative Symptoms Anhedonia Amotivation Flat Affect Alogia

Overview – Pt. 1


Activity: The Disordered MonologueDiscussion:

People with schizophrenia’s reactions to others’ perceptions of them?

Seemingly bizarre and meaningless sentences meaningless to them?

Frustrations for someone with schizophrenia trying to communicate with others?

Common Disturbances

Loose associations

Neologisms

Perseveration

Clanging

Thought insertion/thought withdrawal

Delusions of being controlled

Overview – Pt. 1


The Cognitive Neuroscience of Schizophrenia

Problems with cognitive function Episodic Memory Working Memory Processing Speed

Cognitive deficits = RISK for schizophrenia

The Cognitive Neuroscience of Schizophrenia

Ventral Striatum Hippocampus Dorsolateral Prefrontal Cortex

Anterior Prefrontal Cortex

Schizophrenia Spectrum Disorders

Part 2: Risk Factors & Treatment

Overview – Pt. 2

• Risk Factors for Schizophrenia• Treatment of Schizophrenia

Risk Factors for Schizophrenia

Genetic No “schizophrenia gene” Heterogeneous disorder Genes associated with other mental health

conditions


Environmental Problems during pregnancy Complications at birth Children born to older fathers Cannabis use Urban settings Minority status


Attenuated Psychotic Syndrome – Diagnosis added to DSM-V (Section III) describing individuals who show attenuated (milder) symptoms of psychosis.

Developed recently Distress/Disability

Elyn Saks

Overview – Pt. 2

• Risk Factors for Schizophrenia• Treatment of Schizophrenia

Treatment of SchizophreniaAtypicalAntipsychotics

TypicalAntipsychotics

Treatment of Schizophrenia

Cognitive Enhancement Therapy (CET)

Cognitive remediation treatment

Improves cognition & social cognition

Prevents gray matter loss

Appendix A: Symptoms

Photo AttributionSlide 1 & 18

Photo Credit: Marco Castellani http://upload.wikimedia.org/wikipedia/commons/a/a6/Schizophrenia_image.jpg http://creativecommons.org/licenses/by-sa/2.0/deed.en

Slide 6Photo Credit: http://commons.wikimedia.org/wiki/File:Eugen_bleuler.jpg#mediaviewer/File:Eugen_bleuler.jpg http://en.wikipedia.org/wiki/Public_domain

Slide 6Photo Credit: Peter Badge http://commons.wikimedia.org/wiki/File:John_Forbes_Nash,_Jr._by_Peter_Badge.jpg http://creativecommons.org/licenses/by-sa/3.0

Slide 7

Photo Credit: Craig Finn http://commons.wikimedia.org/wiki/File:Artistic_view_of_how_the_world_feels_like_with_schizophrenia_-_journal.pmed.0020146.g001.jpg http://creativecommons.org/licenses/by/2.5

Slide 8Photo Credit: Tim Shields BC https://www.flickr.com/photos/45203414@N02/4241490089/ https://creativecommons.org/licenses/by-nc/2.0/

Slide 9

Photo Credit: August Natterer http://commons.wikimedia.org/wiki/File:August_Natterer_Meine_Augen_zur_Zeit_der_Erscheinungen.jpg http://en.wikipedia.org/wiki/Public_domain

Slide 10Photo Credit: http://commons.wikimedia.org/wiki/File:Itch_02.jpg#mediaviewer/File:Itch_02.jpg http://creativecommons.org/licenses/by-sa/3.0

Slide 11Photo Credit: http://commons.wikimedia.org/wiki/File:Cloth_embroidered_by_a_schizophrenia_sufferer.jpg http://creativecommons.org/licenses/by/2.0

Slide 11Photo Credit: http://commons.wikimedia.org/wiki/File:Flexibilitas_cerea.JPG#mediaviewer/File:Flexibilitas_cerea.JPG http://en.wikipedia.org/wiki/Public_domain

Slide 12Photo Credit: Wes Washington http://commons.wikimedia.org/wiki/File:Portrait_of_acute_anxiety.JPG#mediaviewer/File:Portrait_of_acute_anxiety.JPG http://creativecommons.org/licenses/by-sa/3.0

Slide 17Photo Credit: Kim J, Matthews NL, Park S http://commons.wikimedia.org/wiki/File:Schizophrenia_fMRI_working_memory.jpg http://creativecommons.org/licenses/by/2.5

Slide 20 Photo Credit: https://openclipart.org/detail/58543/dna-by-kumar35885 http://creativecommons.org/publicdomain/zero/1.0/

Slide 21Photo Credit: https://openclipart.org/detail/48349/warning-sign-by-palomaironique http://creativecommons.org/publicdomain/zero/1.0/

Slide 24Photo Credit: http://commons.wikimedia.org/wiki/File:Thorazine_advert.jpg#mediaviewer/File:Thorazine_advert.jpg http://creativecommons.org/publicdomain/zero/1.0/

Slide 24Photo Credit: Housed http://commons.wikimedia.org/wiki/File:Risperdal_tablets.jpg#mediaviewer/File:Risperdal_tablets.jpg http://creativecommons.org/licenses/by-sa/3.0

Slide 25Photo Credit: http://commons.wikimedia.org/wiki/File:AFNI_screenshot.png#mediaviewer/File:AFNI_screenshot.png http://creativecommons.org/licenses/by-sa/3.0/

Slide 26Photo Credit: http://commons.wikimedia.org/wiki/File:Insulin_shock_therapy.jpg#mediaviewer/File:Insulin_shock_therapy.jpg http://creativecommons.org/publicdomain/zero/1.0/

Slide 27Photo Credit: John D. and Catherine T. MacArthur Foundation http://commons.wikimedia.org/wiki/File:ELYN_SAKS_9.JPG http://creativecommons.org/licenses/by/4.0/deed.en

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Schizophrenia Spectrum Disorders [Instructor Name] [Class and Section Number]