Search for Evidence; Evidence Based Practice

UOS Medical Library

2012

HistoricallyNursing Characterized byLarge variability in practiceLack of research utilization in the implementation of nursing care

Characteristics Resulted in Number of Consequences Either

Perpetual risk of Delivering useless / harmful nursing service

OR THAT

The effective nursing practices were under-mined and under recognized because of lack of evidence to

support their therapeutic efficacy

Health Professionals NEED EBP, WHY?

To Improve Safety, Quality and demonstrate efficacy in nursing and health care services

Health Professionals NEED EBP, WHY?

In order to take a proper decisions / practices, they should keep up-to-date with the Health & Medical Literature.

To keep themselves updated, Health Professionals need to read at least 6-8 hours daily. These hours will be added to the busy schedule and work load they have daily.

Health Professionals NEED EBP, WHY?

Inadequate traditional sources

Outdated, too voluminous to be practical” (Textbooks)

Frequently wrong (Expert opinions)

Ineffective (Didactics /CME)

Evidence Based Practice (EBP)• Evidence Based Practice (EBP) model is

relatively recent, dates back to the Evidence Based Medicine movement in the 1990s

• The change from evidence-based ‘medicine’ to evidence-based ‘practice’ was a natural development.

• It was realized that Evidence Based model this system was not only relevant to medicine but to all health professional groups. EBP becomes a multi-professional issue

EBM Founding Father

Prof. Archibald Cochrane a British medical epidemiologist is the Founding Father of the Evidence Based Medicine Concept.

“The Cochrane Collaboration”, the main source for EBM, was named after him.

Evidence Based Practice (EBP)

“A problem-solving approach to clinical practice that integrates a systematic search for, and critical appraisal of, the most relevant evidence to answer a burning clinical question, one’s own clinical expertise, patient preferences and values.”

Fineout-Overholt et al.(2005:335)

Evidence Based Medicine (EBM)

Evidence-based medicine is the integration of best research evidence with clinical expertise and patient values

Sackett DL, Straus SE, Richardson WS, Rosenberg W, and Haynes RB. Evidence-Based Medicine: How to Practice and Teach EBM, 2nd Ed, Churchill Livingstone, London, 2000

Evidence Based Practice (EBP)Evidence-Based Practice is based on the principle of Rational Decision-Making’.

‘Work Things Out’ by • looking at possible options,

• consider the strength of evidence supporting options,

• and choose the one with the most likelihood to produce the best clinical

outcomes. Hamer & Collinson (2005: 9)

Evidence Based Practice

• Basis of Evidence-based care involves the integration of the best research evidence with clinical expertise and patient values.          

Best Clinical Evidence

Clinical Experience Patient’s Needs/ Preferences

The Evidence Based Cycle

• Identify and define the problem• Formulate a focused clinical

question• Identify the appropriate resources• Search for valid and relevant

information• Critical appraisal• Implement in practice

Types of Clinical Questions• Background Questions ask for general knowledge

about a disease, disease process or clinical circumstances.

• Background Questions are those questions which have been answered in the past and are now part of the “fiber of medicine”

• Ask They generally ask "who, what, when, why, where or how" about a single disease, drug, intervention or concept.

• You can find a helpful background information particular subject by searching Encyclopedias, dictionaries, textbooks, thesauri, ..etc. Bibliographies at the end of articles lead you to other books and articles on your topic, which might be very helpful.

Types of Clinical Questions

• Foreground Questions The foreground questions are the base of the EBM Search. They are more difficult to answer than background questions because they require sources that provide a wide range of knowledge and look for specific patient cases or problems.

Categories / Types of Foreground Clinical Questions

• Therapy:  solves questions about which treatment to administer, and what might be the outcome of different treatment options.

• Diagnosis: solves questions about degree to which a test is reliable and clinically useful, to decide whether the patient would benefit from it.

• Etiology:  solves problems about the relationship between a disease and a possible cause.

• Prognosis: answers questions about a patient's future health, life span and quality of life in the event one chooses a particular treatment option.

Searching the Online Databases

• Choose the appropriate database • Consult at least two databases to

prevent missing a significant piece of work on the subject

• When using a new database, familiarize yourself with its language by using the online help

Develop a Search StrategyThere are seven steps to be considered for applying the

EBM principles and responding to the clinical inquiries.• Receive and analyze the clinical question by using the

PICO method• Expand your background, gather pertinent

background information• Classify the clinical question into a category (therapy,

diagnosis, etiology, prognosis)• Search for the information in the best resources• Evaluate literature for accuracy and relevance• Formulate a response• Communicate information and follow up(1)

The EBM Process

• Assess your patient• Ask clinical questions• Acquire the best evidence• Appraise the evidence• Apply the evidence to patient

care

ASK A Clinical Question• Formulate a well-built clinical questions.• In practice, well-built clinical questions

usually contain four elements abbreviated in PICO Format • P - Patient / problem : Identify the

problem of the patient • I - Intervention of Interest (such as

a drug or test)• C – Comparison / the Comparison

Intervention • O – Outcome / the Intended Outcome

PICO FORMAT

• Patient / Population – who and what?

• Intervention – how?• Comparison (if appropriate) –

what is the main alternative? • Outcome – what are you hoping to

accomplish, measure, improve, affect?

PICO FORMAT• P = Patient/Problem/Population: Ask “how would

I describe a group of patients similar to mine?”• I = Intervention: Ask “which main intervention am

I considering?” (cause, prognostic factor, treatment, etc..)

• C = Comparison/Control: Ask “which is the main alternative to compare with the intervention?” again, be specific

• O = Outcome: Ask “what can I hope to accomplish?” or “what could this exposure really affect?” again, be specific.

Types of Research Studies

1-Randomized controlled trial:  (answers therapy, prevention questions)

Randomization avoids selection bias. Clinical trials that involve one test treatment and one control treatment, concurrent enrollment and follow up of the test-and control treated groups, and in which the treatments to be administered are selected by a random process.

Types of Research Studies2-Cohort study:  (answers prognosis, etiology, prevention questions)Cohorts are defined populations that, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.   Researchers identify and compare two groups over a period of time.  At the start of the study, one of the groups has a particular condition or receives a particular treatment, and the other does not.  At the end of a certain amount of time, researchers compare the two groups to see how they did. 

Types of Research Studies3-Case control study: (answers prognosis, etiology, prevention questions)Case control studies are studies that identifies patients who already have the outcome of interest and control patients without that outcome, and look back to see if they had the exposure of interest or not.   4-Case series and case reports:  (answers prognosis, etiology, prevention questions)Consist either of collections of reports on the treatment of individual patients, or of reports on a single patient.

Search for the Best Study

Type of Question Best Type of Study to Search For

Therapy RCT>cohort > case control > case series

Diagnosis Prospective, blind comparison to a gold standard

Etiology/Harm RCT > cohort > case control > case series

Prognosis Cohort study > case control > case series

Prevention RCT>cohort study > case control > case series

Clinical Exam Prospective, blind comparison to gold standard

Cost Economic analysis

Evidence Based Practice Resources

Evidence Based Journals : Summarize the studies that are valid and clinically useful, rather than publishing original researchSystematic Reviews: Comprehensive, unbiased analysis of research findings Centers of Evidence Based Practice: Conduct original research and systematic reviews and disseminate research findingsEvidence Based Practice Guidelines: Systematically developed statements to assist health professionals in taking decisions regarding the proper health care for specific clinical case

Acquire the Best Evidence• Online databases are the most important sources for

evidence retrieval.

EBM Search Protocol Pyramid

Navigating the Maze: Information Mastery: How to lower the work of Your Information Searches: An Overview, Health Sciences Library, University of Virginia

Navigating the Maze: Information Mastery: How to lower the work of Your Information Searches: An Overview, Health Sciences Library, University of Virginia

EBM Search Protocol Pyramid

Searching Tips, to Recall Relevant Evidence

Search Strategy to build the Inquiry Strings should be implemented.

They include;• Defining appropriate Keywords from the clinical

question, Use Medical Subject Headings (MeSH) if required;

• Considering Synonyms and related terms;• Selecting the most relevant databases; • Combining keywords with Boolean Operators;• Considering the “Phrase Searching” and

Truncations.

Boolean SearchingUse Boolean Operators to combine

search terms. These are the most common

connectors:• “And” : To narrow your search. All

terms must appear in results• “OR” : To broaden your search.

Either term should appear in results• “Not” : To narrow your search by

excluding specific terms.• “Adj” : Search for terms that appear

togetherUsing AND, OR, NOT, and ADJ to

create logical search statements is also known as Boolean searching , Boolean Operators.

Phrase SearchingYou can narrow your search by using

a “Phrase Search” instead of keywords.

Put your phrase between Quotations

(“ “)

Examples

“Evidence Based Medicine”

“Point of Care Testing”

“Physical Therapy”

TruncationTo obtain more results and broaden your

search, Truncate / Stem the word to its root.Truncation means shortening a search term by

adding a symbol to the root of a word, to retrieve its variant endings

ExamplesSearch for “child*” retrieves documents for

child, children, childhood, childbirth, …etc.

The most used Truncation Symbol is the Asterisk (*)

Tips for Smart Searching

Always be as precise as possible when selecting keywords that describe your topic

Check your spelling Use acronyms if available

(WHO – World Health Organization ) Consider differences between American

and British spelling (Hematology / Haematology – Pediatrics / Paediatrics)

Clinical Case• Jeff, a smoker of more than 30 years, has talked about

giving up smoking. He has tried unsuccessfully to quit in the past. He has heard through a friend that acupuncture was successful. Should he try it? Other interventions that you know of include nicotine replacement therapy and antidepressants.

• Clinical question• In people who smoke is acupuncture compared to

nicotine replacement therapy or antidepressants effective treatment for smoking cessation.

PICO

Population Smoker

Intervention Acupuncture

Comparison Nicotine replacement therapy OR antidepressants

Outcome Smoking cessation

Is the land-based therapeutic exercise beneficial for people with knee OA in terms of reduced joint pain or improved physical function. ?

Question Analysis / PICO Format

Patient / Population : Adults, Knee Osteoarthritis

Intervention: Land-Based Therapeutic Exercise

Comparison: Drug Therapy

Outcome: Reduce Pain / Improved Physical Function

Search String

knee$ and (osteoarthritis or OA) and (exercise or physiotherapy or "physical therapy") and ("reduc$ pain" or comfort$)

Clinical Question

Appraise the EvidenceCritical Appraisal is the process of carefully and

systematically examining research evidence to judge its trustworthiness, its value and relevance in a particular context.

The purpose of the critical appraisal is to determine whether;

• Research evidence is accurate and free of known or unknown bias,

• Evidence results are acceptable and provide the answer to the question raised

• How confidently can the evidence be applied to the practice

Critical Appraisal Process Assess the Validity

Are the results valid? A crucial question in the critical appraisal process.

The recalled / retrieved evidence should be examined for;• Well Built PICO Question• Randomization for selecting participating

patients to eliminate Bias• Research study should be blinded, or double-

blinded when possible. • Study groups must be treated equally • ensure that patients who started the trial are

accounted for until the end.

Critical Appraisal Process What are the Results?

• What are the Results?Once the validity of the study is ensured, statistical analysis should be performed on the retrieved study results to check the Values .

• Each study type, either Therapy or Diagnosis, etc. has its measures to calculate.

• The findings / Calculation Results should fall within the range of True Values.

Apply on the Patient• Decision should be taken whether to apply the

evidence on the patient or not.• Physician should ask the following questions before

Applying the evidence;• Is my patient so different from those in the

study? • Is the treatment available in my setting OR Is

the healthcare system willing to fund it • What are the alternatives available? • What are the side effects of the intervention? • Are the outcomes appropriate to my patient?

Cochrane Group Lists

New Example

In post-menopausal women, does hormone replacement treatment therapy prevent osteoporosisTermsOsteoporosis / Bone Density / Bone MassPost-menopaus$ / menopaus$ / womenHormone Replacement Therapy / HRTSearch String

Osteoporosis and menopaus$ and (“hormone treatment therapy” or hrt)

Should you have any inquiries, please send an e-mail to nadia@sharjah.ac.ae

ORContact the Medical Library at 06-

5057176 / 06-5057176

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