Since 1903 the VSVRI has been established on an area of

about 23 square hectares in the Red Mountain area of the

Abbassia district, east Cairo.

The VSVRI is one of the oldest and prestigious institutes in

the Middle East and Africa.

At the beginning, the scope of its responsibility was limited to

production of vaccine and antiserum, for protection of cattle

against Rinderpest (cattle plague).

The laboratory’s mission has continued to grow.

The next period witnessed considerable laboratory expansions and new building constructions in response to the demands.

Production of highly efficient vaccines, Sera and Diagnostic

Reagent utilizing both reference and local isolates based on the

international standards to guarantee protection of animals and

poultry from different diseases. In addition, preparation of combined vaccines to save the effort, time, stress and money.

Conducting researches for improvement and innovation of

Veterinary Vaccines, Sera and Diagnostic Reagents.

Completion of high Contemned BSl3 Laboratories for production

of FMD & Avian Influenza Vaccines.

Certified the current production facilities according to GMP

requirements for veterinary vaccine production.

Improvement and innovation of Veterinary Vaccines, Sera

and Diagnostic Reagent.

Using the molecular biology for improvement the vaccine and

diagnostic reagents.

Expanding training on up to date technologies.

Completion of high Containment BSL-3 Laboratories for production

of FMD & Avian Influenza Vaccines.

Certified the current production facilities according to GMP

requirements for veterinary vaccine production.

Improvement and innovation of Veterinary Vaccines, Sera

and Diagnostic Reagent.

Using the molecular biology for improvement the vaccine and

diagnostic reagents.

Expanding training on up to date technologies.

• Aerobic Bacterial Vaccines

Research Department .• Anaerobic Bacterial Vaccines

Research Department.• Bacterial Sera and Antigens

Research Department.• Bacterial Diagnostic products

Research Department.• Parasitic Vaccines

Research Department.

• FMD Research Department .• Rift Valley Fever Vaccine Department.• Pox Vaccines Research Department.• Rinderpest Vaccine Research Department. • Rinderpest like diseases vaccine

Research Department.• Pet animal Vaccines Research Department.• Equine Vaccines Research Department.• Newcastle and other Viral Poultry

Vaccines Department .

26

5

48

70

34

35

Senior Researchers

Chief Researchers

Researchers

Research Assistants

Assistant Researchers Consultants

Total Research Team 218

226

209 74

145

Contract EmployeesAdministrative

Workers Temporary Workers

Employees and workers 654

Attenuated Rift Valley Fever Vaccine.

Attenuated Bovine Ephemeral Fever Vaccine.

P.P.R. Vaccine (Egypt 87).

Sheep Pox Vaccine.

Camel Pox Vaccine.

African Horse Sickness Attenuated Polyvalent Vaccine.

Attenuated Canine Parvo Vaccine.

Bivalent Inactivated Foot and Mouth Disease Oil Vaccine types ( O1 & A ).

Inactivated Rift Valley Fever Vaccine.

Inactivated Bovine Ephemeral Fever Vaccine.

Inactivated Respiratory Virus Diseases Vaccine “Pneumo 3.”

Inactivated Respiratory Virus Diseases Vaccine “Pneumo 4”

Bivalent Foot and Mouth Disease Vaccine.

Inactivated Bovine Rota (BR), Corona (BC) and

Toxigenic

E. Coli K99 Vaccine (Entero-3).Bivalent Inactivated African Horse Sickness Vaccine.

Inactivated Rabies Vaccine.

Inactivated Tissue Culture Rabies Vaccine.

Monovalent Inactivated Freeze Dried Equine Influenza Vaccine.

BCG Vaccine.

Brucella Abortus Vaccine (St. 19).

Brucella Melitensis Vaccine (Rev.1).

Blackleg and Gas Gangrene Vaccine.

Polyvalent Clostridial Vaccine.

Haemorrhagic Septicaemia Oil Adj. Vaccine (For Cattle).

Oil Adjuvinated Polyvalent Pneumo bac Pasteurellosis Vaccine.

Gel Adjuvinated Polyvalent Pneumo bac Pasteurellosis Vaccine.

Tube Agglutination Brucella Antigen.

Buffer Acidified Plate Brucella Antigen.

Rose Bengal Brucella Antigen.

Milk Ring Test Brucella Antigen.

Rivanol Brucella Antigen. Rivanol solution.

Mammalian P.P.D. Tuberculin.

Bovine P.P.D. Tuberculin Rift Valley Fever Antigen.

Antitetanic Serum

Newcastle Vaccine (Hitchner B1).

Newcastle Vaccine (LaSota).

Newcastle Vaccine (Komarov).

Lasota & IB.

Hitchner B1 and Infectious Bronchitis Vaccine.

Infectious Bursal Disease Vaccine (D78 Strain).

Infectious Bursal Disease Vaccine (Bursa Vac. strain) .

Fowl Pox Vaccine.

Pigeon Pox Vaccine.

Duck Virus Hepatitis Vaccine.

Duck Plague Vaccine.

Inactivated Newcastle And Gumboro Vaccine.

Inactivated Newcastle , IB and EDS.

Inactivated Newcastle Vaccine (Oil adj.).

Inactivated Oil Emulsion Avian Influenza Vaccine.

Inactivated Pigeon Paramyxo Vaccine.

Inactivated Rabbit Haemorrhagic Virus Vaccine.

Polyvalent Fowl Cholera Vaccine (Oil Adj.)

Polyvalent Rabbit Pasteurellosis Vaccine (Formalized).

Polyvalent Rabbit Pasteurellosis Vaccine (Oil Adj.).

Rabbit Clostridial Entertoxaemia Bloat Vaccine

Infectious Coryza (Oil Adj.) Vaccine.

Inactivated Spirochetosis Vaccine.

Chicken Necrotic Oil Vaccine.

Chicken Necrotic Gel Vaccine.

Salmonella Pullorum Antigen (Tube Agglutination).

Salmonella Pullorum Stained Antigen (polyvalent) .

Paratyphoid Antigen.

Avian P.P.D. Tuberculin.

US Naval American Medical Research Unit (NAMRU 3).

Us Department of State Biosecurity Engagement Program

Food and Ogriculture Organization (FAO).

Offices of International Epizootic (OIE).

World Health Organization ( WHO )

The First HPAI outbreak was announced on February 2007.

The disease is now endemic.

Vaccine started on March 2007 depending on importation of H5N1 and H5N2 inactivated Vaccines from different counters.

The key to preventing human infections with AI is to control poultry outbreaks of AI .

Developing of national laboratory for vaccine production to produce AI vaccine from local isolates is must.

Laboratory location.

Wipe – clean surface.

Heating , ventilation and air – conditioning (HVAC) System .

Directional airflow and cascade negative pressure .

Laboratory furniture and equipment.

Laboratory rooms , size and orientation . Sample reception .

Double door autoclave and decontamination Chamber for solid waste materials.

Water supply and sewerage system.

Electrical system.

Primary containment barriers is the barriers between agent and man.

Gloves, gownt, masks Biosafety cabinet, Respiratory protection Vaccines & autoclaves

Walls Fences, Security Quarantine

Tertiary containment barrier

Secondary containment barrier is the barrier between agents and Environment to provide protection for individual outside the lab. Air tight rooms.

Air handling.Air locks. Showers, laundry.Sewage treatment .

Waste disposal. Sterilization. Equipment.

The potential threat of Avian flu and need for

appropriate facilities to work with HPAI raise

design issues of protection.

Compact areaBlending & Filling & Capping

Electric room

Exit

WashingW.C W.C

Kitchen Control Hall

Inac

tivat

ion

L

ab.

Refrigerator

Electricity room

Ref. Ref.

Dressing Room

Electricity Room

Dressing Room

Ref.

Pre Inoculation Incubator

Compact area

After Inoculation Incubator

DoctorsOffice Closet

Receiving egg

Compact area

Freez.

InoculationLab.

Harve

statio

n

Steril.

All personnel must met the institutional

expectation in term of high containment

practices

Training of all personnel entering a containment

facility must be done and documented

Training program specific to scientists needs and

knowledge

Training and evaluation should occur before

personnel starts the job

- U.S National Academy of Sciences.

- U.S Department of States Biosecurity Engagement Program.

-Turkish Academy of Sciences