SEIZURE The International Journal of the British Epilepsy &so&ion

INDEX TO VOLUME 7, 1998

W. B. SAUNDERS COMPANY LTD London Philadelphia Sydney

Tokyo Toronto

VOLUME 7 NUMBER 1 FEBRUARY 1998

Obituary Professor Peter Jeavons (OPO)

Original articles Epilepsy and learning disabilities-a challenge for the next millennium? Jean A. Hannah & Martin J. Brodie

Amnesia in temporal lobectomy patients: Historical perspective and revi Sallie Baxendale

Treatment of epilepsy following rejection of epilepsy surgery Peter Wolf

Juvenile myoclonic epilepsy: clinical characteristics, treatment and progn in a Norwegian population of patients Grethe Kleveland & Bernt A. Engelsen

Interictal quantitative EEG in epilepsy Miles E. Drake, Hosi Padamadan & Sharon A. Newell

Clinical observations of juvenile myoclonic epilepsy in 131 patients: A study in South India J.M.K. Murthy, Ch. Mohan Rao & A.K. Meena

Epilepsy, cerebral calcifications and clinical or subclinical coeliac disease Course and follow up with gluten-free diet Miguel A. Hernandez, Gema Colina & Luis Ortigosa

Gabapentin add-on therapy with adaptable dosages in 610 patients with partial epilepsy: an open, observational study M. Baulac, D. Cavalcanti, E Semah, A. Arzimanoglou, J.J. Portal, The French Gabapentin Collaborative Group

Misdiagnosis and treatment in juvenile myoclonic epilepsy Dilek Atakli, Dilsat Soztier, Turan Atay. Sevim Baybas & Baki Arpaci

Case Report Episodic nocturnal wandering and complex visual hallucination. A case 1 long-term follow-up Ying-Zu Huang & Nai-Shin Chu

Abstracts Abstracts of posters presented at the International League Against Epilc (British Branch) Annual Scientific Meeting Oxford, October 1997

iv VOLUME 7 NUMBER 2 APRIL 1998

Original articles Serum prolactin levels are elevated also after pseudo-epileptic seizures Jorgen Alving 85

Electrophysiologic assessment of autonomic function in epilepsy Miles E. Drake Jr, Jodie M. Andrews & Christina M. Castleberry

Photosensitivity-Better informing patients with epilepsy of their individual risk Christopher J. Millett, David R. Fish & Pamela J. Thompson

Fear of seizures: An investigation and treatment Imogen Newsom-Davis, Laura H. Goldstein & Declan Fitzpatrick

91

97

101

Seizure recurrence and risk factors after withdrawal of chronic antiepileptic therapy in children Benign0 E. Caviedes & Jose L. Herranz 107

Neuroimaging of children with partial seizures Uri Kramer, Yoram Nevo, Irit Reider-Groswasser, Eyal Sheuer, Jan J. Meyer, Yael Leitner, Aviva Phatal & Shaul Hare1 115

Ecomonic analysis of epilepsy treatment: A cost minimization analysis comparing carbamazepine and lamotrigine in the UK A. Shakespeare & G. Simeon 119

Prescribing of anti-epileptic drugs in the northern and Yorkshire region: 1992-1995 Sarah J. Roberts, Morgan Feely & D. Nicholas Bateman 127

Knowledge, attitudes and practice of epilepsy: experience at a comprehensive rural health services project Parindra Desai, M. V. Padma, S. Jain & M. C. Maheshwari

Epilepsies among twins born in families of Indian probands with epilepsy S. Jain, Menka S. Jain, M. V. Padma,A. Puri, F! Sen 8c M. C. Maheshwari

133

139

Automatic detection of epileptiform spikes in the electrocorticogram: A comparison of two algorithms M. Dtimpelmann & C. E. Elger 145

Clinical characteristics, seizure spread patterns and prognosis of seizures associated with a single small cerebral calcific CT lesion J. M. K. Murthy & V. Sreenivas Reddy 153

Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study Carol L. Read, Linda J. Stephen, Iwona H. Stolarek, Audrey Paul, Gramae J. Sills & Martin J. Brodie 159

Case Report Lamotrigine toxicity secondary to sertraline Kenneth R. Kaufman & Robert Gemer 163

Hypothalamic hamartomas causing gelastic epilepsy: Two cases and a review of the literature N. Georgakoulias, C. Vize, A. Jenkins & E. Singounas 167

VOLUME 7 NUMBER 3 JUNE 1998

Editorial Epilepsy surgery: past, present and future Heinz Gregor Wieser

Short Communication Developments in UK service provision for people with epilepsy: The impact of the NHS Executive Letter 95/120 Stephen W. Brown & Philip Lee

Original articles Who cares for students with epilepsy in mainstream education? Judith H. Lanfear & Claire Rashid

Eyelid myoclonia with absences: phenomenology in children Lindsey Kent, Alison Blake & William Whitehouse

Liverpool Seizure Severity Scale revisited Gus A. Baker, David F. Smith, Ann Jacoby, Julie A. Hayes & David W. Chadwick

An audit of topiramate use in a general neurology clinic Pamela Crawford

173

185

189

193

201

207

Heart period variability during vagal nerve stimulation Amar B. Setty, Bradley V. Vaughn, Stephen R. Quint, K. R. Robertson & John A. Messenheimer 213

Public awareness and attitudes towards epilepsy in the United Arab Emirates A. Bener, F. H. Al-Marzooqi & L. Sztriha 219

Neuropsychological patterns in pediatric epilepsy Jane Williams, May L. Griebel & Roscoe A. Dykman 223

Increases in mRNA levels for synapsin I but not synapsin II in the hippocampus of the rat kindling mode1 of epilepsy Kiyoshi Morimoto, Keiko Sato, Soichiro Sato, Shuji Suemaru, Toshiki Sato, Norihito Yamada & Toshiyuki Hayabara 229

Valproate-induced epileptic tonic status G. Capocchi, A. Balducci, M. Cecconi, M. A. Pelli, A. Picchiarelli, G. Silvestrelli & M. Zampolini 237

Clobazam in partial status epilepticus C. Corman, A. Guberman & 0. Benavente 243

Effects of flash frequency and repetition of intermittent photic stimulation on photoparoxysmal responses K. Topalkara, G. Alarcon & C. D. Binnie 249

vi VOLUME 7 NUMBER 4 AUGUST 1998

Editorial The Gowers’ Prizes T. Betts

Original Articles Improvement of seizure control by psychological methods in patients with intractable epilepsies C. Schmid-Schdnbein

Reading epilepsy: Report of five new cases and further considerations on the pathophysiology P Wolf,Th. Mayer & M. Reker

The Yelandur study: a community-based approach to epilepsy in rural South India-epidemiological aspects K. S. Mani, Geeta Rangan, H. V. Srinivas. S. Kalyanasundaram, S. Narendran & A. K. Reddy

Sudden unexpected death in epilepsy: Is carbamazepine implicated? P. L. Timmings

Long-term follow-up study of vigabatrin in pretreated children with West syndrome H. Siemes, U. Brandl, H.-L. Spohr, S. Volger & B. Weschke

Factors associated with the employment problems of people with established epilepsy J. E. Chaplin, A. Wester & T. Tomson

Driving and epilepsy in Sri Lanka S. L. Seneviratne, S. B. Gunatilake, A. A. D. N. W. Adhikari & H. J. De Silva

An insight into children’s and adolescents’ experience of seizures and epilepsy E Galletti, A. Rinna & C. Acquafondata

The neurophysiological evaluation of nocturnal frontal lobe epilepsy A. Oldani, M. Zucconi, S. Smirne & L. Fermi-Strambi

Psychiatric disorder and cognitive function in children with epilepsy in Kerala, South India R. Hackett, L. Hackett & I? Bhakta

Primary reading epilepsy A. D. Yalcin & H. Forta

The perceived rehabilitation needs of a hospital-based outpatient sample of people with epilepsy J. E. Chaplin, A. Wester & T. Tomson

Case Report Postictal hemifacial purpura J. J. Reis & P W. Kaplan

Symptomatic nocturnal frontal lobe epilepsy A. Oldani, L. Ferini-Strambi & M. Zucconi

259

261

271

281

289

293

299

305

309

317

321

325

329

337

341

VOLUME 7 NUMBER 5 OCTOBER 1998

vii

Original Articles A computational quantitative structure-activity relationship study of carbamate anticonvulsants using quantum pharmacological methods J. L. Knight & D. E Weaver 347

The incidence of sudden unexpected death in epilepsy (SUDEP) in South Dublin and Wicklow Y. Langan, N. Nolan & M. Hutchinson 355

Effects of gabapentin on cognition and quality of life in patients with epilepsy C. Mortimore, M. Trimble & E. Emmers 359

Non-epileptic attack disorder and clinical outcome: a pilot study H. Riaz, S. Comish, L. Lawton & B. Scheepers 365

Clinical courses of pure sleep epilepsies S. A. Park, B. I. Lee, S. C. Park, S. J. Lee, W. J. Kim, J. H. Lee & J. Y. Kim 369

The outcome of prescribing novel anticonvulsants in an outpatient setting: factors affecting response to medication R. D. Thijs & M. P. Kerr 379

Improved health care resource utilization following video-EEG-confirmed diagnosis of nonepileptic psychogenic seizures R.C. Martin, E G. Gilliam, M. Kilgore, E. Faught & R. Kuzniecky 385

Subjective perception of seizure precipitants: results of a questionnaire study J. Spatt, G. Langbauer & B. Mamoli

Prevalence of photoparoxysmal response among South Indian epilepsy patients K. Radhakrishnan, S. D. Nayak,V. S. Nandini & A. Venugopal

The misdiagnosis of epilepsy: findings of a population study B. Scheepers, P. Clough & C. Pickles

391

397

403

A note on a phrase in Shakespeare’s play “King Lear”: ‘A plague upon your epileptic visage’ T. Betts & H. Betts

John Hall and his epileptic patients-epilepsy management in early 17th century England T. Betts & H. Betts

407

411

Case Reports Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin M. Zadra, R. Grandi, L. C. Erli, D. Mirabile & A. Brambilla

Adjunctive therapy in epilepsy with new antiepileptic drugs: is it of any value? C. E. Selai & M. R. Trimble

Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) R. Kloster, H. C. Borresen & P. Hoff-Olsen

415

417

419

Abstract Abstracts of papers and posters presented at ‘Epilepsy 1998The Leading Edge’ annual scientific meeting of the British Branch of the International League against Epilepsy, Oxford, October 1998 421

. . . VIII VOLUME 7

NUMBER 6 DECEMBER 1998

Original Articles Epilepsy needs revisited: a revised epilepsy needs document for the UK S. Brown, T. Betts, I? Crawford, B. Hall, S. Sharvon & S. Wallace

Patient views on primary care services for epilepsy and areas where additional professional knowledge would be welcome B. Chappell & W. H. Smithson

Confidentiality and the management of patients with epilepsy who fail to comply with doctor’s advice not to drive: a survey of medical/legal opions in Australia R. G. Beran

A follow-up study of adults with learning disabilities and epilepsy D. Branford, S. Bhaumik, E Duncan & R. A. Collacott

Epilepsy in adults with learning disabilities D. Branford, S. Bhaumik & E Duncan

Exacerbation of epileptic seizures by carbamazepine: report of 10 cases A. Parmeggiani, E. Fraticelli & P G. Rossi

Idiopathic generalized epilepsy of late onset J. Loiseau,A. Crespel, M-C Picot, B. DuchC, N. Ayrivie, P Jallon & P Loiseau

An audit of children referred with suspected epilepsy R. Appleton, E Besag, C. Kennedy, S. Wallace & A. Hopkins

Neuroimaging abnormalities in Indian patients with uncontrolled partial seizures R. K. Garg, B. Karak & A. M. Kar

Epilepsy classification and factors associated with control in Saudi adult patients M. Abduljabbar, A. Ogunniyi, A. Daif, A. Al-Tahan, M. Al-Bunyan & S. Al-Rajeh

Intraoperative electrocorticography and successful focus resection in a case of Sturge-Weber syndrome D. Hata, T. Isu, M. Nakanishi & T. Tanaka

Midazolam via the intranasal route: an effective rescue medication for severe epilepsy in adults with a learning disability M. Scheepers, B. Scheepers & P Clough

Therapeutic strategies against epilepsy in Mediterranean countries: a report from an international collaborative survey M. Baldy-Moulinier, A. Covanis, S. D’Urso, E. Eskazan, C. Fattore, G. Gatti, J. L. Herranz, S. Ibrahim,A. Khalifa, A. Mrabet, M. Y. Neufeld & E. Perucca

435

447

459

469

473

479

485

489

497

501

505

509

513

Index to Volume 7,1998

Author Index VOLUME 7

Abduljabbar, M. 501 Acombl, B. 427 Acquafondatal, C. 309 Adcockl, J.E. 79 Adhikari, A.A.D.N.W. 305 Al-Ansari, I. 426 Al-Bunyan, M. 501 Al-Marzooqi, F.H. 2 19 Al-Rajeh, S. 501 Al-Tahan, A. 501 Alarcon, G. 249 Alfat, F. 422 Allen, P 80 Alving, J. 85 Amin, D. 81 Andrews, J.M. 91 Appleton, R. 427,489 Arpaci, B. 63 Arzimanoglou, A. 55 Asherson, P. 429 Atakli, D. 63 Atay, T. 63 Ayrivit, N. 485

Baddeley, L. 75 Baker, A. 81 Baker, G.A. 201 Balducci, A. 237 Baldy-Moulinier, M. 5 13 Bartolo, R. 427 Bateman, D.N. 127 Baulac, M. 55 Baxendale, S.A. 15,424 Baybas, S. 63 Beime, M. 427 Benavente, 0.243 Bener, A. 219 Beran, R.G. 459 Besag, F. 489 Besser, R. 426 Betts, H. 8 1, 82,407,4 11 Betts, T. 76, 79, 81, 82,407, 411,422, 423,424, 425,

435 Bhakta, P 321 Bhaumik, S. 469,473 Binnie, C.D. 8 1,249 Blake, A. 193 Boniface, S. 8 1 Borresen, H.C. 419 Bowery, N.G. 77

Bradford, J. 81 Brady, M. 79 Brambilla, A. 415 Brandl, U. 293 Branford, D. 469,473 Brodie, M.J. 3, 159 Brotherstone, R. 73 Brown, J.K. 73, 74 Brown, S. 435 Brown, S.W. 185 Burkitt, E. 77

Capocchi, G. 237 Castleberry, C.M. 91 Cavalcanti, D. 55 Caviedes, B.E. 107 Cecconi, M. 237 Chadwick, D.W. 201,422 Chaplin, J.E. 299, 329 Chappell, B. 447 Chioza, B. 429 Chu, N.-S.. Clayton, C. 428 Clough, P. 403,509 Colina, G. Collacott, R.A. 469 Comish, S. 365 Corman, C. 243 Covanis, A. 5 13 Craig, J.J. 76, 421 Crawford, P. 76, 207,435 Crespel, A. 485 Cm-ran, N. 429

D’Urso, S. 5 13 Dai, H. 505 Daif, A. 501 Datta, P. 76 Davies, R.A. 78 De Silva, H.J. 305 Deadwyler, S. 428 Desai, P 133 Drake, M.E. 39,91 DuchC, B. 485 Diimpelmann, M. 145 Duncan, E 469,473 Duncan, J.S. 77 Duthie, T. 77 Dykman, R.A. 223

Edson, A. 426

ix

X

Elger, C.E. 145 Elian, M. 82 Ellis, N. 424 Emmers, E. 359 Engelsen, B.A. 3 1 Erli, L.C. 415 Eskazan. E. 5 13

Fairgrieve, S. 422 Fattore, C. 5 13 Faught, E. 385 Feely, M. 127 Fenwick, P.B.C. 78,79 Fermi-Strambi, L. 3 17,341 Fish, D. 80, 81, 97 Fitzpatrick, D. 10 1 Forta, H. 325 Fox, C. 422,423,425 Fraticelli, E. 479 French Gabapentin Collaborative Group, 55

Galletti, F. 309 Garg, R.K. 497 Gatti, G. 5 13 Georgakoulias, N. 167 Gemer, R. 163 Gilliam, F.G. 385 Glazier, S. 428 Goldstein, L.H. 101 Gouzeva, V.I. 73 Grandi, R. 415 Green, A. 75 Griebel, M.L. 223 Grigorenko, E. 428 Guberman, A. 243 Gunatilake, S.B. 305

Hackett, L. 321 Hackett, R. 321 Hagan, R. 428 Hall, B. 435 Hand, K.S.P. 77 Hanna, J. 428 Hannah, J.A. 3 Harding, G. 76,426 Hardman, M. 79 Harel, S. 115 Hayabara, T. 229 Hayes, J.A. 201 Hayward, B. 425 Hemindez, M.A. 49 Herranz, J.L. 107,5 13 Hoff-Olsen, P 419 Hopkins, A. 489 Howes, L. 79,425 Huang, Y.-Z. 67

Hutchinson, M. 355

Ibrahim, S. 513

Jackson, M.J. 422 Jackson, V, 79,425 Jacoby, A. 201 Jain, M.S. 139 Jain, S. 133, 139 Jallon, P. 485 Jarvie, S. 77 Jenkins, A. 167 Jonas, P. 422

Kalyanasundaram, S. 28 1 Kaplan, PW. 337 Kar, A.M. 497 Karak, B. 497 Kaufman, K.R. 163 Kennedy, C. 489 Kennett, R. 79 Kent, H. 77 Kent, L. 193 Kerr, M. 379,425 Khalifa, A. 5 13 Kilgore, M. 385 Kim, J.Y. 369 Kim, W.J. 369 Kittler, J. 428 Kleveland, G. 3 1 Kloster, R. 419 Knight, J.L. 347 Koepp, M.J. 77 Kramer, U. 115 Kuzniecky, R. 385 Kyle, G. 422

Lanfear, J. 189 Langan, Y. 355 Langbauer, G. 39 1 Lawton, L. 365 Leach, J.P. 422 Lee, B.I. 369 Lee, J.H. 369 Lee, P. 185 Lee, S.J. 369 Leitner, Y. 115 Lemieux, L. 80 Lindsay, M. 82 Linevich, V.V. 73 Loiseau, J. 485 Loiseau, P 485 Luxon, L.M. 78 Lynch, S. 422

Maheshwari, M.C. 133, 139 Makoff, A. 429 Mamoli, B. 391

Index xi

Mani, K.S. 281 Martin, R.C. 385 Masanori, N. 505 Mawer, G. 423 Mayer, Th. 27 1 McWilliam, R.C. 428 Meena, A.K. 43 Messenheimer, J.A. 2 13 Meyer, J.J. 115 Millett, C.J. 97 Mirabile, D. 415 Mohan Rao, Ch. 43 Molyneux, A.J. 77 Morgan, A. 425 Morimoto, K. 229 Morrison, P. 421 Morrow, J.I. 76,42 1 Mortimore, C. 359 Mrabet, A. 5 13 Murthy, J.M.K. 43, 153

Nandini, V.S. 397 Narendran, S. 28 1 Nashef, L. 428,429 Nayak, S.D. 397 Neufeld, M.Y. 5 13 Nevo, Y. 115 Newell, S.A. 39 Newsom-Davis, I. 101 Noble, M. 80 Nolan, N. 355

O’Regan, M.E. 73,74 Ogunniyi, A. 501 Oldani, A. 317, 341 Ortigosa, L. Oxbury, J.M. 77,79 Oxbury, S. 77

Padamadan, H. 39 Padma, M.V. 133, 139 Park, S.A. 369 Park, S.C. 369 Parmeggiani, A. 479 Parsons, L. 42 1 Patten, C. 428 Patterson, V.H. 421 Paul, A. 159 Pelli, M.A. 237 Pendleton, E. 75 Perucca, E. 5 13 Phatal, A. 115 Picchiarelli, A. 237 Pickles, C. 403 Picot, M.-C. 485 Polizzi, G. 80

Portal, J.J. 55 Pouretemad, H.R. 78 Preece, M. 75 Pm-i. A. 139

Quint, S.R. 213

Radhakrishnan, K. 397 Rangan, G. 281 Rao, P. 422 Rashid, C. 189 Read, C.L. 159 Reddy, A.K. 281 Reddy, V.S. 153 Reider-Groswasser, I. 115 Reis, J.J. 337 Reker, M. 27 1 Riaz, H. 365 Richardson, M.P. 77 Rinna, A. 309 Roberts, S.J. 127 Robertson, K.R. 213 Rogers, D. 427 Ross, C. 74 Rossi, PG. 479 Russell, A.J.C. 76,421,428

Salisbury, H. 78 Sander, J. 423 Sato, K. 229 Sato, S. 229 Sato, T. 229 Savundra, PA. 78 Scheepers, B. 365,403,509 Scheepers, M. 509 Schmid-Schonbein, C. 261 Schmitt, EC. 426 Scott, C.A. 80 Seddon, H. 75 Selai, C.E. 417 Semah, F. 55 Sen, P 139 Seneviratne, S.L. 305 Setty, A.B. 213 Shakespeare, A. 119 Sheuer, E. 115 Shorvon, S. 429,435 Siemes, H. 293 Sills, G.J. 159 Silvestrelli, G. 237 Simeon, G. 119 Singounas, E. 167 Smime, S. 3 17 Smith, D. 427 Smith, D.F. 201 Smith, K. 423 Smith, P. 424

xii

Smith, S. 81 Smith, S.J.M. 80 Smithson, W.H. 447 SCiziier, D. 63 Spatt, J. 391 Spohr, H.-L. 293 Squier, W. 78 Sreeram, N. 74 Srinivas, H.V. 28 1 Stephen, L.J. 159 Stephenson, J.B.P. 428 Stolarek, I.H. 159 Stores, G. 74 Suemaru, S. 229 Symms, M.R. 429 Sztriha, L. 219

Tatsuya, T. 505 Tedman, B. 427 Thijs, R.D. 379 Thompson, PJ. 78, 97,424 Timmings, PL. 289 Tokohiko, I. 505 Tomson, T. 299,329 Topalkara, K. 249 Trimble, M. 359,417 Trower, M. 428

Upton, D. 424

Vaughn, B.V. 213 Venugopal, A. 397 Vize, C. 167 Volger, S. 293

Walker, K. 74 Wallace, D. 428 Wallace, S. 435,489 Weaver, D.F. 347 Weschke, B. 293 Wester, A. 299, 329 White, K. 422 Whitehouse, W. 74, 75, 193,426 Wieser, H.G. 173 Wieshamnn, U.C. 429 Wiggs, L. 74 Wilkins, A.J. 81 Williams, J. 223 Wolf, P. 25, 271 Wong, I. 423 Wright, G.D.S. 79

Yalcin, A.D. 325 Yamada, N. 229

Zadra, M. 415 Zaiwalla, Z. 79, 8 1 Zampolini, M. 237 Zeman, A. 426 Zucconi, M. 317,341

Subject Index VOLUME 7

absence seizures juvenile myoclonic epilepsy, 43 perioral myoclonia with, 426

acetylcholine receptor subunits, (r4 nicotinic, asso- ciation studies of idiopathic generalized epilepsy, 429

achievement skills, childhood epilepsy, 223 acute intermittent porphyria, gabapentin, 415 adolescents, experience of epilepsy, 309 adverse drug reactions, post-marketing survey, 423 affective disorders, see depression alkaline phosphatase, monitoring on sodium valproate,

75 ammonia, monitoring on sodium valproate, 75 amnesia

intra-carotid sodium amytal, 77 temporal lobectomy, 15,424 transient epileptic, 426

amygdala kindling model, synapsin I vs synapsin II, mRNA, 229

anoxic seizures, cardiac pacing for, 74 antidiuretic hormone, see syndrome of inappropriate

ADH secretion antiepileptic drugs

on cognitive function, elderly patients, 159 and learning disabilities, 3 pregnancy, register, 76,42 1 after rejection of surgery, 25 use in Mediterranean countries, 5 13 withdrawal from children, recurrence of seizures,

107 anxiety, see seizure phobia aromatherapy, 79 arrhythmias, sudden unexpected death in epilepsy, 289 artefacts, functional MRI and EEG, 80 association studies, idiopathic generalized epilepsy,

429 attention, childhood epilepsy, 223 attitude to epilepsy, United Arab Emirates, 219 audits

appropriateness of EEG requests, 427 children as new patients, 489 epilepsy services, 75 lamotrigine

as first-line monotherapy, 424 rashes, 423

topiramate in neurology clinic, 207 autohypnosis, and conditioned odour memory, 79 automatic spike detection, electrocorticography, 145

autonomic function, 9 1 autoradiography, vs proton emission tomography, tem-

poral lobe epilepsy, 77 autosomal dominant nocturnal frontal lobe epilepsy,

association studies, 429

beat-to-beat variations, heart rate, vagal nerve stimula- tion, 213

behaviour, evaluation, childhood epilepsy, 223 brain lesions, partial seizures, children, 115 brain stem inhibition, sudden unexpected death in

epilepsy, 289 British Epilepsy Association, survey of NHS, 185

calcific lesions with coeliac disease, 49 computed tomography, seizures, 153,497

carbamates, structure-activity relationships, 347 carbamazepine

exacerbation of seizures, 479 vs lamotrigine, costs, 119 reading’ epilepsy, 27 1 sudden unexpected death in epilepsy, 289

SIADH, 419 carbon- 1 I-flumazenil proton emission tomography,

vs hydrogen-3-flumazenil autoradiography, temporal lobe epilepsy, 77

cardiac pacing, for reflex anoxic seizures, 74 cardiac rhythm, vagal nerve stimulation, 213 cardiac syncope, misdiagnosis of epilepsy, 428 cardiorespiratory changes, epileptic seizures, 73 cDNA microarray hybridization, epileptic tissue, 428 cerebral calcifications

with coeliac disease, 49 computed tomography, seizures, 153,497

charges for medication, non-epileptic seizures, 385 children, see also school nursing

antiepileptic therapy withdrawal, recurrence of seizures, 107

differential diagnosis, 74 experience of epilepsy, 309 imaging, partial seizures, 115 neuropsychological patterns in childhood epilepsy,

223 new patients, audit, 489

choreoathetosis, paroxysmal dystonic, 427 circadian rhythm, juvenile myoclonic epilepsy, 43 classification of epilepsy, Saudi Arabia, 501 clinics, see also outpatients

fast track, 425

. . . x111

xiv

clobazam partial status epilepticus, 243 quality of life, 417

coeliac disease, with cerebral calcifications, 49 cognitive-behaviour therapy, seizure phobia, 101 cognitive function, see also learning disabilities

antiepileptic drugs on, elderly patients, 159 carbamazepine-induced seizures, 479 childhood epilepsy, 223

developing countries, 32 1 gabapentin on, 359

calorimetry, intuitive, 8 1 community learning disability epilepsy nurse special-

ists, 3 computed tomography, calcific lesions, seizures, 153,

497 computer software, electrocorticography, automatic

spike detection, 145 conditioned odour memory, on spike-wave discharges,

79 confidentiality, driving, 459 corpus callosotomy, 177 costs

carbamazepine, vs lamotrigine, 119 non-epileptic seizures, 385

counter measures, self control techniques, 261 cysticercosis, 497 cystic lesions, partial seizures, India, 497

daytime video-EEG monitoring, 79 death, see sudden unexpected death in epilepsy dentate gyrus, kindling, synapsin I vs synapsin II,

mRNA, 229 depression

and seizure phobia, 10 1 from topiramate, 207

developing countries, see also India attitudes to epilepsy, 133 childhood epilepsy, psychiatric disorders and cogni-

tive function, 321 epidemiology of epilepsy, 28 1

diagnosis, and learning disabilities, 3 diazepam, rectal, at school, 189 differential diagnosis, children, 74 diffusion weighted imaging, magnetic resonance imag-

ing, 429 discrimination (employment), 299 DNA studies, epileptic tissue, 428 doctors, views on driving and epilepsy, Sri Lanka, 305 dopamine antagonists, eyelid myoclonia with ab-

sences, 193 driving

confidentiality, 459 Sri Lanka, 305

drug rashes, see rashes drug resistance, and epilepsy surgery, 25

Dublin, incidence of sudden unexpected death in epilepsy, 355

dyslexia, and reading epilepsy, 27 1 dysphasic status epilepticus, 426

economics, epilepsy treatment, 119 education, see also patient education; training

students with epilepsy, 189 elderly patients, antiepileptic drugs on cognitive func-

tion, 159 electrocardiography, long QT syndrome vs epilepsy,

428 electrocorticography

automatic spike detection, 145 surgery for Sturge-Weber syndrome, 505

electroencephalography carbamazepine-induced abnormalities, 479 with functional magnetic resonance imaging, 80 interictal quantitative, 39 photoparoxysmal response, 249 requests, audit of appropriateness, 427

electrophoresis, transorbital, sodium oxibutirate, 73 Elizabethan medicine, 8 1, 82,407,411 employment, 299 epidemiology, see also India

developing countries, 28 1 epilepsy needs document, United Kingdom, 435 epilepsy surgery, see surgery ethics, confidentiality and driving, 459 Executive Letter 95/l 20, National Health Service, 185 experience of epilepsy, children and adolescents, 309 eyelid myoclonia with absences, 193

families, effects of epilepsy, 424 famous persons, and epilepsy, 82 fast days, and medication, 133 fast track clinics, 425 fear, see seizure phobia felbamate, structure-activity relationships, 347 first presentation, children, audit, 489 flash frequency, photoparoxysmal response, 249 folic acid, vs neural tube defects from sodium valproate,

421 free medication, rural health services, 133 frontal lobe epilepsy, nocturnal, 3 17, 341

gabapentin acute intermittent porphyria, 415 cognitive function and quality of life, 359 open-label study, 55 outpatient response, 379 post-marketing surveillance, 423 quality of life, 359, 417 vs topiramate, psychiatric effects, 207

Galenical medicine, 411 gating, sensorimotor, non-epileptic seizures, 78 gelastic epilepsy, hamartomas, hypothalamus, 167

Index xv

generalized tonic-clonic seizures juvenile myoclonic epilepsy, 43 in sleep, 369

general practice, see primary care genes, differential expression, epileptic tissue, 428 genetic factors, twin studies, 139 glucuronidation, lamotrigine, sertraline on, 163 glutamate receptors, association studies of idiopathic

generalized epilepsy, 429 gluten-free diet, epilepsy in coeliac disease, 49

Hall, John (17th-century physician), 82,407 hamartomas, hypothalamus, gelastic epilepsy, 167 health authorities, prescribing rates, primary care, 127 health care resources

fast-track one-stop clinics, 425 long-term management of non-epileptic seizures,

365 NHS Executive Letter 95/l 20, 185 non-epileptic seizures, 385

long-term management, 365 heart

pacing for reflex anoxic seizures, 74 period variability, vagal nerve stimulation, 2 13

hemifacial purpura, postictal, 337 hemispherectomy, 177 hereditary factors, twin studies, 139 high density cDNA array hybridization, epileptic tis-

sue, 428 hippocampus, memory deficits after surgery, 15 historical aspects, 8 1, 82,407,411

sudden unexpected death in epilepsy, 428 temporal lobectomy, 15

hot water epilepsy, Yelandur (South India), 28 1 hydrogen-3-flumazenil autoradiography, vs carbon- 1 l-

flumazenil PET, temporal lobe epilepsy, 77 hypnosis, and conditioned odour memory, 79 hypothalamus, hamartomas, gelastic epilepsy, 167 hypsarrhythmia, West syndrome, vigabatrin, 293

ictal dyslexia, 27 1 idiopathic generalized epilepsy

late onset, 485 twin studies, 429

imaging, partial seizures, children, 115 India

epidemiology, 28 1 imaging, partial seizures, 497 photoparoxysmal response, incidence, 397 rural health services, attitudes to epilepsy, 133

infantile spasms, West syndrome, vigabatrin, 293 information, see patient education intelligence, childhood epilepsy, 223 interictal electroencephalography, quantitative, 39 intermittent photic stimulation

juvenile myoclonic epilepsy, 427

photoparoxysmal response, 249 incidence in South India, 397

international comparison, attitudes to epilepsy, 219 intra-carotid sodium amytal, on memory, 77 intractable epilepsy

India, 497 self control techniques, 261

intranasal midazolam, learning disabilities, 509 intuitive calorimetry, 8 1 investigation, and learning disabilities, 3 Ireland, incidence of sudden unexpected death in

epilepsy, 355

jasmine oil massage, on spike-wave discharges, 79 Jeavons, P. (obituary), 1 job problems, 299 juvenile myoclonic epilepsy, 3 1,43

levetiracetam, 423 misdiagnosis, 63 photosensitivity, 427

Kerala (South India), childhood epilepsy, psychiatric disorders and cognitive function, 321

kindling, rat hippocampus, synapsin I vs synapsin II, mRNA, 229

King Lear (Shakespeare), 8 1,407 knowledge of epilepsy, patients, 77

lactate, monitoring on sodium valproate, 75 lamotrigine

vs carbamazepine, costs, 119 as first-line therapy, audit, 424 outpatient response, 379 on photosensitivity and pattern sensitivity, 76 post-marketing surveillance, 423 quality of life, 417 rashes, audit, 423 sertraline, interaction, 163 vs topiramate, psychiatric effects, 207

language skills, childhood epilepsy, 223 late onset, idiopathic generalized epilepsy, 485 learning disabilities, 3

intranasal midazolam, 509 treatment outcomes, 425,469,473 valproate, and status epilepticus, 237 West syndrome, vigabatrin, 293

legal medicine, confidentiality and driving, 459 Leicestershire, epilepsy and learning disabilities, 469,

473 levetiracetam, juvenile myoclonic epilepsy, 423 linear predictors, automatic spike detection software,

145 linear regression calculations, structure-activity rela-

tionships, carbamates, 347 Liverpool Seizure Severity Scale, 201 long QT syndrome, misdiagnosis of epilepsy, 428

xvi

long-term management, non-epileptic seizures, and health care resources, 365

magnetic resonance imaging diffusion weighted imaging, 429 functional, with EEG, 80 partial seizures

children, 115 India, 497

mathematics, structure-activity relationships, carba- mates, 347

measurement, Liverpool Seizure Severity Scale, 20 1 mechanics calculations, structure-activity relation-

ships, carbamates, 347 medical students, training, 425 Mediterranean countries, prescribing strategies, 5 13 memory, see also amnesia

childhood epilepsy, 223 intra-carotid sodium amytal, 77

mental retardation, see learning disabilities mesial temporal sclerosis, 78 metabotropic glutamate receptors type 7, association

studies of idiopathic generalized epilepsy, 429

midazolam, intranasal, learning disabilities, 509 misdiagnosis

epilepsy cardiac syncope, 428 incidence, 403

juvenile myoclonic epilepsy, 63 mnestic factors, and intra-carotid sodium amytal, 77 molecular pharmacology, carbamates, 347 mortality, see sudden unexpected death in epilepsy motor skills, childhood epilepsy, 223 mRNA probes, epileptic tissue, 428 multiple subpial transection, 179 myoclonic jerks, 3 I,43

National Health Service Executive Letter 95/l 20, 185 Nazi occupation of Norway, 82 Needs I, revision, 435 neural tube defects, sodium valproate, folic acid vs, 42 1 neurology clinic, audit of use of topiramate, 207 neuropsychological patterns, childhood epilepsy, 223 new patients, children, audit, 489 nicotinic acetylcholine receptors, a4 subunits, as-

sociation studies of idiopathic generalized epilepsy, 429

nocturnal frontal lobe epilepsy, 317, 341 autosomal dominant, association studies, 429

nocturnal wandering, episodic, 67 non-epileptic seizures, see also pseudoseizures

health care resources, long-term management, 365 misdiagnosis of epilepsy, 403 sensorimotor gating, 78

Northern England, antiepileptic drugs

pregnancy, 422 prescribing rates, 127

Norway, resistance to Nazi occupation, 82 nurse specialists

learning disabilities, in community, 3 perceived needs for, 329

odour memory, conditioned, on spike-wave discharges, 79

one stop epilepsy clinics, 425 outcome measurement, Liverpool Seizure Severity

Scale, 201 outpatients, response to novel anticonvulsants, 379 oxcarbazepine, sudden unexpected death in epilepsy,

SIADH, 419 oxibutirate, see sodium oxibutirate

pacing, cardiac, for reflex anoxic seizures, 74 pallid syncope, cardiac pacing for, 74 paramedical workers, epidemiology, developing coun-

tries, 28 1 parasomnias, 67 paroxysmal dystonic choreoathetosis, 427 partial seizures

imaging children, 115 India, 497

response to novel anticonvulsants, 379 sleep, 369

partial status epilepticus clobazam, 243 dysphasic, 426

patient education developing countries, 133 knowledge of epilepsy, 77 perceived needs, 329

primary care, 447 photosensitive epilepsy, 97

patient request, daytime video-EEG monitoring, 79 patient satisfaction

long-term management of non-epileptic seizures, 365

novel anticonvulsants, 417 primary care, 447

patient selection, epilepsy surgery, 175 pattern recognition, automatic spike detection soft-

ware, 145 pattern sensitivity, lamotrigine on, 76 perception of epilepsy, children and adolescents, 309 perioral myoclonia with absences, 426 phobias, 101 photoparoxysmal response

incidence in South India, 397 intermittent photic stimulation, 249

photosensitivity juvenile myoclonic epilepsy, 427 lamotrigine on, 76

index xvii

patient education, 97 tinted glasses, 8 1

pock-marks, King Lear, 407 polypharmacy, 55 polysomnography, nocturnal frontal lobe epilepsy, 3 17,

341 porphyria, see acute intermittent porphyria postictal hemifacial purpura, 337 potassium channels, see voltage-sensitive potassium

channel gene precipitants for seizures, perception, 391 pre-conception counselling, 422 pregnancy, antiepileptic drugs

Northern England, 422 pre-conception counselling, 422 register, 76, 42 1

prepulse inhibition, non-epileptic seizures, 78 prescribing rates, primary care, 127 primary care

patient satisfaction, 447 prescribing rates, 127

primary reading epilepsy, see reading epilepsy prognosis, and learning disabilities, 3 prolactin, serum levels, pseudoseizures vs epileptic

seizures, 85 proton emission tomography, vs autoradiography, tem-

poral lobe epilepsy, 77 pseudoseizures, see also non-epileptic seizures

vs epileptic seizures, prolactin serum levels, 85 vestibular pathology, 78

psychiatric disorders childhood epilepsy, developing countries, 32 1 epilepsy response to novel anticonvulsants, 379

psychogenic seizures, see non-epileptic seizures; pseu- doseizures

psychological disturbances and sleep disorders, 74 topiramate, 207

psychological evaluation childhood epilepsy, 223 temporal lobectomy, postoperative, 424

psychological methods, seizure control, 261 psychological stress, epilepsy triggering, 39 1 psychologists, perceived, needs for, 329 psychosis, topiramate, 207 psychosocial factors

on families, 424 intractable epilepsy, 261

public awareness, epilepsy, United Arab Emirates, 219 public opinion, driving, Sri Lanka, 305 purpura, postictal hemifacial, 337

quality of life gabapentin, 359,417 novel anticonvulsants, 417

quantitative interictal electroencephalography, 39

quantitative structure-activity relationships, carba- mates, 347

quantum mechanics, structure-activity relationships, carbamates, 347

rashes, lamotrigine, audit, 423 rat kindling model, hippocampus, synapsin I vs

synapsin II, mRNA, 229 reading epilepsy, 27 1, 325 rectal diazepam

learning disabilities, 509 at school, 189

recurrence of seizures, antiepileptic therapy with- drawal, children, 107

reflex anoxic seizures, cardiac pacing for, 74 register, antiepileptic drugs in pregnancy, 76,421 rehabilitation, perceived needs, 329 requests for EEG, audit of appropriateness, 427 respiratory changes, epileptic seizures, 73 risk factors, antiepileptic therapy withdrawal from chil-

dren, recurrence of seizures, 107 road traffic accidents, see driving R-R interval

measurement of parasympathetic function, 9 1 vagal nerve stimulation, 2 13

rule-based systems, automatic spike detection, 145 rural environment, perception of epilepsy triggering,

391 rural health services, developing countries, attitudes to

epilepsy, 133

Saudi Arabia, classification and outcome of epilepsy, 501

scales, severity, Liverpool Seizure Severity Scale, 201 school nursing, epilepsy services, 75, 189 seizure phobia, cognitive-behaviour therapy, 101 self control techniques, intractable epilepsy, 261 self-induction, eyelid myoclonia with absences, 193 sensorimotor gating, non-epileptic seizures, 78 sertraline, interaction with lamotrigine, 163 service provision, see health care resources seventeenth century, epilepsy treatment, 411 severity scales, Liverpool Seizure Severity Scale, 201 Shakespeare, W., see also Hall, John

King Lear, 8 1,407 single small cerebral calcific CT lesions, 153 slapped-face syndrome, 337 sleep deprivation

epilepsy triggering, 391 juvenile myoclonic epilepsy, 43 nocturnal frontal lobe epilepsy, 3 17

sleep disorders episodic nocturnal wandering, 67 and psychological disturbances, 74

sleep epilepsy, clinical courses, 369 smell memory, see odour memory social workers, perceived needs for, 329

. . . XVIII

sodium amytal, intra-carotid, on memory, 77 sodium oxibutirate, transorbital electrophoresis, 73 sodium valproate, see valproate somnambulism, 67 specialist nurses, learning disabilities, in community, 3 spectral analysis, interictal electroencephalography, 39 spike detection, computer software, electrocorticogra-

phy, 145 spike-wave discharges, aromatherapy on, 79 Sri Lanka, driving, 305 standards of care, and perceived needs, 329 status epilepticus

partial, clobazam, 243 and valproate, 237

stress, epilepsy triggering, 39 1 structure-activity relationships, carbamates, 347 students with epilepsy, mainstream education, 189 study modules, medical education, 425 Sturge-Weber syndrome, surgery, 505 sudden unexpected death in epilepsy

autonomic function, 9 1 carbamazepine, 289 historical aspects, 428 incidence, South Dublin and Wicklow, 355 syndrome of inappropriate ADH secretion, 419

surgery and learning disabilities, 3 rejection of, 25 Sturge-Weber syndrome, 505 trends, 173

sympathetic skin responses, 9 1 synapsin I vs synapsin II. mRNA, rat hippocampus kin-

dling model, 229 syncope

cardiac, misdiagnosis of epilepsy, 428 pallid, cardiac pacing for, 74

syndrome of inappropriate ADH secretion, sudden un- expected death in epilepsy, 4 19

syphilis, and King Lear, 407

teachers, mainstream education, 189 temporal lobe, see mesial temporal sclerosis temporal lobectomy, 173

amnesia, 15,424 temporal lobe epilepsy

carbon- 11 -flumazenil PET, vs hydrogen-3- flumazenil autoradiography, 77

monitoring before surgery, 79 vs transient global amnesia, 426

teratogenesis, see neural tube defects; pregnancy, antiepileptic drugs

tinted glasses, on photosensitive epilepsy, 81 topiramate

adverse effects, 76 audit, neurology clinic, 207 outpatient response, 379

Tourette’s syndrome, vs eyelid myoclonia with ab- sences, 193

training medical students, 425 school nurses, 75

transient epileptic amnesia, 426 transorbital electrophoresis, sodium oxibutirate, 73 triggers for seizures, perception, 391 twin studies, 139

idiopathic generalized epilepsy, 429

unemployment, 299 United Arab Emirates, attitudes to epilepsy, 2 19 United Kingdom, see also Northern England

epilepsy needs document, 435 urban environment, perception of epilepsy triggering,

391 utilization of resources, non-epileptic seizures, 385

vagal nerve stimulation, heart period variability, 2 13 valproate

biochemical monitoring, 75 neural tube defects, folic acid as protective, 421 reading epilepsy, 27 1 and status epilepticus, 237 withdrawal from children, recurrence of seizures,

107 vertigo, pseudoseizures, 78 vestibular pathology, pseudoseizures, 78 video-EEG monitoring

daytime, 79 nocturnal frontal lobe epilepsy, 3 17

videotelemetry, 79 resources, 80

vigabatrin with gabapentin, 55 outpatient response, 379 post-marketing surveillance, 423 quality of life, 417 visual field defects, 422 West syndrome, 293

visual field defects, vigabatrin, 422 visual hallucinations, complex, and episodic nocturnal

wandering, 67 visual motor integration, childhood epilepsy, 223 voltage-sensitive potassium channel gene, association

studies, 429

warning signs, recognising, 26 1 weather, epilepsy triggering, 391 West syndrome, vigabatrin, 293 Wicklow, incidence of sudden unexpected death in

epilepsy, 355 Winchester geese, 407 work problems, 299

Yelandur (South India), epilepsy study, 281 Yorkshire, antiepileptic drug prescribing, 127