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Semantic e-(Life)Science @Manchester Professor Carole Goble [email protected] c.uk

Semantic e-(Life)Science @Manchester Professor Carole Goble [email protected]

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Semantic e-(Life)Science @Manchester

Professor Carole Goble

[email protected]

Semantics

BiologyComputerScience

Bioinformatics

Clinical & Public Health

Social Science

BioHealth informatics

BiologyComputerScience

Bioinformatics

Clinical & Public Health

Social Science

BioHealth informaticsMIB

North West eHealth

e-Science North West CentreManchester Informatics

Research Computing ServicesNorth West Grid

eScience@Manchester

North West e-Health

Open Middleware Infrastructure Institute-UK

North West Institute for BioHealth Informatics

Manchester Centre for Integrative Systems Biology

National Centre for Text Mining

National Centre e-Social Science

Manchester Interdisciplinary BioCentre

BioHealth Informatics Group

Information Management Group

ComputerScienceBioinformatics

Clinical & Public Health

Social Science

BioHealth informatics

CLAHRC

ObesityeLab

Shared genomics

e-Lico

Biology

Collaboration for Leadership in Applied Health Research and

Care

Collaboration and Standards

• Bio-Standardisation: FUGE, OBI, SBML, SBRML, MIAME, BioPAX, MIBBI

• Networks: EMBRACE, CASIMIR, IPlant, BioSapien, Enfin

• Systems Biology Centres throughout UK and EU

• NBIC: Dutch National Bioinformatics Centre• caBIG: cancer Biomedical Informatics Grid • SysMO: Systems Biology of MicroOrganisms• EMBL-European Bioinformatics Institute

Semantics

ComputerScience

Bioinformatics

Clinical & Public Health

BioHealth informatics

Semantics@ManchesterOntologies

– Ontology for Psychosis http://www.neuropsygrid.org/

Research– Reasoners and expressivity– Languages– Ontology building, text mining– Explanation, modularisation– Methodologies– Collaborative ontology

development

Training– 1st-2nd April 2009 Building OWL ontologies

tutorial @ Manchester

Semantics@ManchesterLanguages and Standardisation

– OWL, SWRL, RDF, SKOS, Probabilistic OWL– SPARQL, SPARQL/OWL, RIF– WDSL, WS-Policy, OWL-S, SWSI

Tools– Protégé 4, SWOOP, SKOSed– Reasoners: Fact++, Pellet– OWL API, SKOS API and OPPL

ApplicationsSemantic Web Services, Risk Assessment, Medical Image Annotation, Semantic Document Hyperlinking, Classifying Entities/Data, Form Generation, Policy analysis, Semantic Grid metadata management

http://owl.cs.manchester http://www.co-ode.org/

Enterprise SearchDocument

Text MiningText Mining Semantic TechnologiesSemantic TechnologiesVisualisationVisualisation

Data Tools

Document

Semantic Grid Browser for the Life SciencesStudy of infectious disease, From cells, via tissues to patients- Evidence-based medicine- Patent and Literature mining- Molecular Biology

Connecting existing Web to e-science infrastructureText-mining, ontologies and workflows

GoPubMed: Semantic searchCOHSE: Conceptual Open Hypermedia ServiceCORESE: COnceptual REsource Search EngineSKOS: Simple Knowledge Organization Systemhttp://cohse.cs.manchester.ac.uk/http://www.biotec.tu-dresden.de/sealife

Papyro

Interactive tools for analysing protein sequence and structure based on a semantic platform.

Visualisation, semantic service annotations, semantic layout, workflows, RDF store. 2000+ registered users + many more anonymous users

http://utopia.cs.man.ac.uk/

Exploring the scientific literature and seamless linking between data, publications and methods. Typographic analysis of PDF documents; mimicked-reading; rich interaction with document content.

Scientific WorkflowDocument

ProcessProcess ProcessProcess

Data Tools

Scientific WorkflowDocument

ProcessProcess ProcessProcess

Data Tools

Workflow Enactor Engine

Workflow enactorLocal and remote enactorImplicit iteration over large data collectionsAutomation of data flowLogging and data provenance trackinglong running workflows, data reference handling, data streaming and staging, multiple extensibility points.

Graphical workbenchDrag and drop interfacePlug-in architectureNested WorkflowsIncorporate new service without coding. Access to local and remote resources and analysis tools

Taverna

2

Workflow Application Platform2

http://www.taverna.org.uk

• Access to 3000+ public service operations

• 57,048 sourceforge downloads

• 5822 downloads v1.7• 1239 downloads v2.0• 727+ active users at

the moment• 328 organisations• 17 known commercial• Users throughout UK,

Europe, North America, SE Asia, Latin America, and Australasia.

Netherlands Bioinformatics CentreGenome Canada Bioinformatics PlatformBioMOBYUS iPlant ConsortiumUS FLOSS social science programRENCIFrench SIGENAE farm animals projectThaiGridCARMEN Neuroscience projectSPINE consortiumEU Enfin, EMBRACE, BioSapian, CasimirEU SysMO ConsortiumNERC Centre for Ecology and HydrologyBergen Centre for Computational BiologyMax-Planck institute for Plant Breeding

ResearchGenoa Cancer Research CentreAstroGrid

30 USA academic and research institutions

1472 users129 groups

562 workflows157 files44 packs

16000+ unique Visits

Taverna, Triana, Trident,

GWorkflowDL, WSVLAM, Kepler,

BioExtractor, Pipeline Pilot…

http://www.myexperiment.org

• Started June 08• Closed pilot Dec 08• Pilot release April 09• BioCatalogue-Friends focus

group• Perpetual beta• Three year awardhttp://www.biocatalogue.org

Workflow Enactor Engine

Scientific Research Objects

Scientific Research Objects

Workflows

Data sets

Services

Scripts

Publications

Development e-Laboratory

Application e-Laboratory

ResearchMethodsExperts

Policy makers

Delivery Experts

Harnessing Local Ownership in a Federationof Service-Development and Research Assets

Local NHS

Local NHS

Local NHS

e-Lab

e-Lab

e-Lab

ResearchNetworks

Research

Service development

F I R

E W

A L

L

Federation of e-Labs scalable & sustainableFederation of e-Labs scalable & sustainable

Schedule10.00 - 10.10   Introductions 10.10 - 10.30   Presentation by Eli-Lilly10.30 - 10.50   Manchester: overview (Carole Goble) 10.50 - 11.20   SKOS (Sean Bechhofer) 11.20 - 11.50   Sealife (Simon Jupp) 11.50 - 12.30   Discussion 12.30 - 12.50   Lunch 12.50 - 13.10   e-Labs - (Sean Bechhofer) 13.10 - 13.40   Obesity e-Lab (Shoaib Sufi) 14.40 - 14.10   Discussion 14.10 - 14.40   Taverna and myExperiment (Katy Wolstencroft and Paul Fisher) 14.40 - 15.10   Biocatalogue (Carole Goble, Jiten Bhagat) 15.10 - 15.40   UTOPIA and Papyro (Steve Pettifer )15.40 - 16.30   Discussion and identification of other people to speak to.

Manchester Informatics Launch registration and dinner

Franck Tanoh

Simon JuppJiten Bhagat

Sean Bechhofer

Steve Pettifer

Paul Fisher

Katy Wolstencroft

Paolo Missier

Shoaib Sufi John Ainsworth